Gene AMPKa1 (Human)

AMPKa1

Species: Human
Alias: AMPK, MGC33776, MGC57364, AMPKa1, PRKAA1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 5p12-p14,

Classification

Group: CAMK
Family: CAMKL
Subfamily: AMPK

Sequence

Name Sequence Type Origin Length Description Download
AMPKa1.AA Protein Sugen Kinome 574 None Fasta, JSON
AMPKa1.kin_dom Protein Kinase Domain Sugen Kinome 268 None Fasta, JSON
AMPKa1.NA RNA Sugen Kinome 5130 None Fasta, JSON

Protein domain

Protein domains of AMPKa1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AMPKa1.AA AMPK 27-294 67 2e-223 670.04 In-house 1-254 (254) Show / Hide 
Range on Protein: 27-294
Range on HMM: 1-254/254
Sequence Identity: 67% (181 aa)

YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVI-STPSDIFMVMEYVSGGELFDYICKNGRKSDV
||.|.|.|.|||||||.|.|.|||.|||.||||.|||...|.|..|.|||..||||||||||.||.|| .||.||||||||||||||||||.|.      
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKH------

PGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS
         . |.|.|..|.||||.|||.||||||.|||||||||.|||...| ||.||||||||.|||||.|.||||.|||||.|||.||.||||||||
---------GRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWS

SGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF
.||||||.|||.|||||...|||.|||..| .|.|..|.|.. .|.|||||||||||.||.|||.|.||
CGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase AMPKa1.AA CAMKL 27-294 44 2.2e-163 525.36 In-house 1-297 (297) Show / Hide 
Range on Protein: 27-294
Range on HMM: 1-297/297
Sequence Identity: 44% (140 aa)

YILGDTLGVGTFGKVKVGKH-ELTGHKVAVKILNRQKIRS-------------LDVVGKIRREIQNLKLFR---HPHIIKLYQVI-------STPSDIFM
|..|.||| |.||||| ..|  .||.|||.||....||.              .... .|||||| .|...   ||.|||||.||       .| ..|..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYL

VMEYVSGGE--LFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHM--NAKIADFGLSNMMSD-----G
||||.||||  |||||.|.|..            . ..|.| ||.|.||.|.|.|||.|..||||.||||.||| ..  |.||.|||.|||. .     |
VMEYCSGGEMDLFDYIVKHGHRR-----------GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPG

EFLRTSCGSPNYAAPEVISG--RLYAGPEVDIWSSGVILYALLCGTLPFDDD--------HVPTLFKKICDGIFYTPQYLNP-SVISLLKHMLQVDPMKR
..|.|.||||.|.|||...|  . | ||.||||| ||||||..||.||||||        .. .|..||  | .| | .. . ....|...||||.|.||
QKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKR

ATIKDIREHEWF
.||..|..|.|.
PTIHQIMNHPWM
Kinase AMPKa1.AA CAMK 32-294 29 1.8e-131 426.16 In-house 1-425 (425) Show / Hide 
Range on Protein: 32-294
Range on HMM: 1-425/425
Sequence Identity: 29% (128 aa)

TLGVGTFGKVKVGKHELTG------------HKVAVKILNRQKIRS-------------------------LDVVGKIRREIQNLKL-------FRHPHI
||| |.||||| ..| .|.            .|||.||....|...                              ..||||. .|.        .||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYQVIS------------TPSD--------IFMVM---EYVSGGEL----FDYICKNGRKSDVPGVVKTGST-------KELDEKESRRLFQQILSGV
||||.|.             | |.        ..|||   ||.|||||    ||||...|...                  . ..|.| ||.|.||.|.|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF-------DQFDIVERGRFTEREARRYFRQICSAV

DYCHRHMVVHRDLKPENVLLDAHM-----------------NAKIADFGLSNMMSD------------------------GEFLRTSCGSPNYAA-PEVI
.||| | .|||||||||.||| ..                 | ||.|||..|.. .                        |. ..|.||.| |.| |||.
HYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVL

SG-------------RLYAGPEVDIWSSGVILYALLCGTLPFDDD-------------HVPTLFKKICDGIFY-TPQYLNP-------------------
.|             . | ||..|.|| |||||..|||..||..|             . . ||.||. | ..  | |. |                   
NGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH

----SVISLLKHMLQVDPMKRATIKDIREHEWF
    ....|...|||||| ||.||... .|.|.
FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase AMPKa1.AA NuaK 27-294 47 2.4e-130 345.06 In-house 1-252 (252) Show / Hide 
Range on Protein: 27-294
Range on HMM: 1-252/252
Sequence Identity: 47% (128 aa)

YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVP
| .  ||| ||.|||| .  . || .||.|   ..||..     .|||||. .    |||||. | |    . | .|||| |||||.||| .        
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISE--------

GVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSS
        |.| |.| |..| || | | |||.| ..||||| ||.|||.  |||||||||||. .|..|| | |||| || ||.. |. | ||||| || 
-------CKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSL

GVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVIS-LLKHMLQVDPMKRATIKDIREHEWF
||.||..  ||.||| .   .| | |  | .| |.   ||. . |  .||.|.| .|||| || .| | 
GVLLYTMVYGTMPFDGHDFKHLVKQISQGAYYEPC--KPSDACMLIRWMLMVNPRRRATIYDICHHWWV
Kinase AMPKa1.AA MARK 27-294 42 1.4e-117 385.87 In-house 1-262 (262) Show / Hide 
Range on Protein: 27-294
Range on HMM: 1-262/262
Sequence Identity: 42% (117 aa)

YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVIS--TPSD-IFMVMEYVSGGELFDYICKN--GR
| .. |.| |...|||.. | .|| |||.||....|.       ...|||. .|.  ||.||||..||   |..  |...|||.|||||.||| .   ||
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

KSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHM--NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGP
               | |.| ||.|.||.|.| |||....||||.||||.|.|...  |.||.|||.|.    |. | | ||.| |.|||..... | ||
---------------LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGP

EVDIWSSGVILYALLCGTLPFDDDH--VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF
.||||| ||.||...||..|||.|     .|.|||  | .  | .. ..  .|.. .|.|.|..|.||..| .|.|.
KVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase AMPKa1.AA QIK 27-294 46 1e-114 387.44 In-house 1-272 (272) Show / Hide 
Range on Protein: 27-294
Range on HMM: 1-272/272
Sequence Identity: 46% (128 aa)

YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR-----
| .. |.| | |. ||...|  |  |||.||. . .. . .   |. ||.| .|. .||||||||||. | . ...|.|| |.||.|||.||.||     
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQ-KCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM

--KSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGP
    |.   |  |    . |.| || |.||.|.|.|||.. .|||||| ||.|||. || ||||||.||    |. | | |||| |||||.  |. | ||
VNSPDIGDQVLMGVP--MAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGP

EVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF
.||||| ||.||.| || |||| . ...| ...  | |  | ..     .| .||| ||| .| ||. |..| | 
KVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase AMPKa1.AA BRSK 27-294 47 1.2e-111 377.23 In-house 1-254 (254) Show / Hide 
Range on Protein: 27-294
Range on HMM: 1-254/254
Sequence Identity: 47% (127 aa)

YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIR-SLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDV
|.|. ||| |. |.||.| |  || |||.|| |. |      .  |. |||  .||  |||..|.| |  .    ....|.|||||||||  | ||    
YRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGR----

PGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS
           |  || |. |.|| |..|.|| | . |||||||| |||   | ||||||.  .  ..  | |||||| || ||||.|  | |   |.||
-----------LTPKEARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWS

SGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF
 |||||||| | |||||| .  |  |.  |.|  | .  | . .||. |. ||| || ..|.|..| |.
CGVILYALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase AMPKa1.AA S_TKc 27-294 38 6e-100 339.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-294
Range on HMM: 1-231/231
Sequence Identity: 38% (107 aa)

YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSG--GELFDYICKNGRKSD
| .....| |.||||. ..|  ||..||.||..           .|||||| ||  .||.|.||| |. . ....|||||..|  |.|||||.|.||.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH--

VPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW
       |  . ..| . |....||.....|||.| ..||||||||.|||   . ||.||||.  .      .| ||.|.| ||||.    | ....|.|
-------GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWW

SSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIRE-------HEWF
| |.||| .|||  ||.  .. ..||||.           |.........||.|| || |. .. .       |.||
SCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AMPKa1.AA Pkinase 27-294 33 5.2e-95 326.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 27-294
Range on HMM: 1-293/293
Sequence Identity: 33% (103 aa)

YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIR-REIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGG----ELFDYICKNGR
| .| ..| |.||.|. ..|  ||..|||||.......|   . ..| .||| .| ..||.|..|| .  ....| |||||. ||    .|||||     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

KSDVPGVVKTGSTKEL--DEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNA----KIADFGLSNM--MSDGEFLRTSCGSPNYAAPEVISG
           . . .  .|.| .. . |||.|..|||.. ..||||||||.|.| ...     ||.||||.       .. . | ||.|.|.||||| |
----------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG

RLYAGPEVDIWSSGVILYALLCGTLPFDDD------HVPTLFKKICDGIFYTPQYLN---------------------PSVISLLKHMLQVDPMKRATIK
. | ||.||.|| |.||| .||| .||...          ....| ....  . .                       .. ....| .|..|| || |..
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

DIREHEWF
.| .|.||
QILQHPWF
Kinase AMPKa1.AA CAMK1 27-294 35 1.8e-94 275.03 In-house 1-276 (276) Show / Hide 
Range on Protein: 27-294
Range on HMM: 1-276/276
Sequence Identity: 35% (104 aa)

YILGDTLGVGTFGKVKVGKHELT---GHKVAVKILN-RQKIRSLDVV--GKIRREIQNLKLF---RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYIC
|..|...| |.|..|. ..|  |   |...|.|... .. .   |.    ....||. .| .    ||.|||.| .  ..... .|||.|.|||||| | 
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

KNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNA---K--IADFGLSNMMSDGE-FLRTSCGSPNYAAPEVI
..|                  ||. |.. .|||| | |.| . .||||||||| |.    .    |  ||||||| . ...| .. | ||.| | ||||.
EKG---------------NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVL

SG---RLYAGPEVDIWSSGVILYALLCGTLPFDDDH-VPTLFKKICDGIFY--TPQYLN--PS-VISLLKHMLQVDPMKRATIKDIREHEWF
 .     | . ..|.|| |||.| ||||  || |.   ..||.||  . .   .|.  |   . .  ..|||| ||| || |.... .| |.
ECKKDKPY-DKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase AMPKa1.AA MELK 27-294 43 1.7e-93 316.9 In-house 1-254 (254) Show / Hide 
Range on Protein: 27-294
Range on HMM: 1-254/254
Sequence Identity: 43% (119 aa)

YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVP
| . |..| | |.|||.  | ||...||.||...... .   . ... |.. || .|| || .|| .| |   ||||||| .|||.|||| .. |     
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGH--DLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDR-----

GVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI
          |.|.|.| .|.||.| . | |     ||||||||.|.| ... |. ||||        |   | | |||| |||||.|.|. | | | |.
----------LEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADV

WSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF
|| |..||.|.|| |||||| .  ..|||  |... |..| |. . ||.||||||| ||  .|.. .|.| 
WSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase AMPKa1.AA Ciliate-E2 27-294 25 2.6e-79 269.82 In-house 1-365 (365) Show / Hide 
Range on Protein: 27-294
Range on HMM: 1-365/365
Sequence Identity: 25% (100 aa)

YILGDTLGVGTFGKVKVGKHELTGHK-----------------------VAVKILNRQKIRSLDVVGKIRREIQ----------NLKLFRHPHIIKLYQV
|..   .| |.||.|. .|. .....                       .|.||.. ..|...  . .| |||.          .|..  ||.|||.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IS--TPSDIFMVMEYVSGGELFDYICKNGRKS----DVPGVVKTGSTKELDEKESRRLFQQILS---------------GVDYCHRHM-VVHRDLKPENV
    . . |..||||..||.||||| .|  |.    .          | ..||| .....|||.               .. |.|    ..|||.||||.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENI

LLDAHMNAKIADFGLS-----------------NMMSDG----------------EFLRTSCGSPNYAAPEVISGRLYAG--------PEVDIWSSGVIL
|.      ||.|||||                 ..|  .                .  .| ||.|.| |||...|  | .         ..|||| ||||
LF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

YALLCGTLPFDDDHVPTLFKKICDGIFYTP------------------QYLNPSVISLLKH----MLQVDPMKRAT-IKDIREHEWF
| .|.| .||        ...|... .  |                  ... .... |.|     |||.|| || | ...| .|.||
YEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AMPKa1.AA TyrKc 27-294 25 2.1e-22 81.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-294
Range on HMM: 1-280/280
Sequence Identity: 25% (77 aa)

YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLF--RHPHIIKLYQVISTP-------SDIFMVMEYVSGGELFDYIC
  ||..|| | ||.|  |.      .|||| |.  .      .  ..||.. .. .  .||.|..|| |....         ...||||...| | ||. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-------EFLRTSC--GSP-----
|...|              |  |.      || .| .| |.. ..||||   |.|...   .||.|||||    |.       .  |..   |.      
KHRPK--------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

NYAAPEVISGRLYAGPEVDIWSSGVILYALL-CGTLPFDD-----DHVPTLFKKICDG-IFYTPQY--------LNPSVISLLKHMLQVDPMKRATIKDI
   |||.|  . .  .. |.|| || .. ..  |  |  .          ..... .|     |..          . . .. |   . || .| | ..|
RWMAPECINYGKF-TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

REHEWF
  || |
--HECF
Kinase AMPKa1.AA Pkinase_Tyr 27-187 30 9.5e-22 74.28 Pfam 1-158 (270) Show / Hide 
Range on Protein: 27-187
Range on HMM: 1-158/270
Sequence Identity: 30% (51 aa)

YILGDTLGVGTFGKVKVGKHE----LTGHKVAVKILNRQKIRSLD-VVGKIRREIQNLKLF-RHPHIIKLYQVISTPSD---IFMVMEYVSGGELFDYIC
 ..| .|| | ||.|. |.       |. .||||.| ...  . .    .  ||.. .| . .||.|..|| |..  ..   |..||||. .| | ||  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS
|.             . . |. |.     .|| .| .| ...  .||||   |.|..  . .||.||||.
KHR-----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
UBA_CAMKL AMPKa1.AA UBA_CAMKL 315-354 24 6e-11 37.46 In-house 1-41 (41) Show / Hide 
Range on Protein: 315-354
Range on HMM: 1-41/41
Sequence Identity: 24% (10 aa)

DDEALKEVCEKF-ECSEEEVLSCLYNRNHQDPLAVAYHLII
|.|...|.|...  ...||. ..| |..... . ..|.|..
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL