Gene ANPb (Human)

ANPb

Species: Human
Alias: ANPRB, ANPb, GUCY2B, GC-B, NPR2, NPRBi, NPRB, AMDM, GUC2B
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 9p12-q13,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
ANPb.AA Protein Sugen Kinome 1047 None Fasta, JSON
ANPb.kin_dom Protein Kinase Domain Sugen Kinome 277 None Fasta, JSON
ANPb.NA RNA Sugen Kinome 3447 None Fasta, JSON

Protein domain

Protein domains of ANPb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor ANPb.AA ANF_receptor 44-400 21 9.8e-76 262.71 Pfam 1-364 (364) Show / Hide 
Range on Protein: 44-400
Range on HMM: 1-364/364
Sequence Identity: 21% (84 aa)

RVGPAVALAVEALGRALP-------VDLRFVSSELEGACSEYLAPLSAVDLKLYHD-PDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFSAK-ND
...||. .|.| . ..         .....  ..    ||.  ....|.|.... . .. ..||.| | .. |||.|.||..|....|. ..... |  .
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCY---CSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKN

HYRTLVRTGPSAPKL-GEFVVTLHGH-FNWTARAALLYLDAR-TDDRPHYFTIEGVFEALQGSNLSVQHQ-------VYAREPGGPEQATHF-IRANGRI
 | ...||.||. .. |...| .. | |.|.  |.. . |.   .....|| .|.....|.  .. . ..        . ...  ..   .  |. ..|.
RYPYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYF-MEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARV

VYICGPLEML----HEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRARE
...|.. ...    ..|..||.......|.||..| | ...|.. .          .... .   ..|||.. ||..|.. | .||.|||  |.      
IVMCCYPDDMGLLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-W--------WYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQRWKK----

DFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGL---------RIVEKMQG-RRYHGVTGLVVMDKNNDRETDFVLWAMGDL
      ....|| .|...||...|||. |... .... . .|.          ... |.  ... |||| |..|.|..| .|. .|.| . 
------TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase ANPb.AA RGC 544-788 44 5.2e-142 478.08 In-house 1-300 (300) Show / Hide 
Range on Protein: 544-788
Range on HMM: 1-300/300
Sequence Identity: 44% (133 aa)

KGNVVAIKHVNKK----RIELTRQVLFELKHMRDVQFNHLTRFIGACIDPP------NICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAF
.|..|.|| .|..    ....||... |||.||..|. .|..|||.|||||      |.|||.|||.|||||||||||.|..||||.||.|.|.|||| .
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHNSIISSHGSLKSSNCVVDSRFVLKITDYGL-----ASFRST-------------AEPDDSHALYAKKLWTAPELLSGNPLPTTGM---------QKAD
||.| | .||.|||.|||||||.|.||||.||      .|..               .. |.|. |.| ||||||.| ....| .           ||.|
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFGIILQEIALRSG-----PFYLE--GLDLSPKEIVQKVRN----GQRPYFRPSIDRT------QLNEELVLLMERCWAQDPAERPD-FGQIKGFIRR
|||||||..||..|.|     ||...  ...|||.||...|..    |....|||||...      ..|..|. ||..||| ||.|||| | ||.  ...
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase ANPb.AA RGC 544-788 44 5.2e-142 478.08 In-house 1-300 (300) Show / Hide 
Range on Protein: 544-788
Range on HMM: 1-300/300
Sequence Identity: 44% (133 aa)

KGNVVAIKHVNKK----RIELTRQVLFELKHMRDVQFNHLTRFIGACIDPP------NICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAF
.|..|.|| .|..    ....||... |||.||..|. .|..|||.|||||      |.|||.|||.|||||||||||.|..||||.||.|.|.|||| .
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHNSIISSHGSLKSSNCVVDSRFVLKITDYGL-----ASFRST-------------AEPDDSHALYAKKLWTAPELLSGNPLPTTGM---------QKAD
||.| | .||.|||.|||||||.|.||||.||      .|..               .. |.|. |.| ||||||.| ....| .           ||.|
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFGIILQEIALRSG-----PFYLE--GLDLSPKEIVQKVRN----GQRPYFRPSIDRT------QLNEELVLLMERCWAQDPAERPD-FGQIKGFIRR
|||||||..||..|.|     ||...  ...|||.||...|..    |....|||||...      ..|..|. ||..||| ||.|||| | ||.  ...
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase ANPb.AA TKL 541-786 21 7.4e-53 181.91 In-house 12-364 (364) Show / Hide 
Range on Protein: 541-786
Range on HMM: 12-364/364
Sequence Identity: 21% (79 aa)

GHFKG----------NVVAIKHVNKKRIELT---------------------------RQVLFELKHMRDVQFNHLTRFIGACIDPPN------------
|...|          ..||.|  ...   ..                            .  .|...|.  .  .. .|.|.|..||.            
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

-ICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSII-------SSHGSLKSSNCVVDSRFV--------------LKITDYGLASFR
 .|||.||||.||| ..|        |  | ... |  .||..||...          |  |||.|. ||. .               .||.|.||. | 
QLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM

STAEPDDSHA---------------LYAKK---LWTAPELLSGNPLPTTGM------------QKADVYSFGIILQEIALRSGPFY-LEGLDLSPK----
|. . .   .               .. .     | |||.| |..  |               .|.|||||||.| ||. |  |.| .   .  .     
SQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFE

-EIVQKVRNGQRPYFRPSIDR-------TQLNEELVLLMERCWAQDPAERPDFGQIKGFI
 .... . .|.||   |   .       ..  ...  ||..||..|| .|| | .|.  .
EMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ANPb.AA TKL-Unique 579-786 31 1.2e-41 144.67 In-house 58-290 (290) Show / Hide 
Range on Protein: 579-786
Range on HMM: 58-290/290
Sequence Identity: 31% (76 aa)

LTRFIGACI----DPPNICIVTEYCPRGSLQDILE---------NDSINLDWMFRYSLINDLVKGMAFLHNSI--ISSHGSLKSSNCVVDSR-----FVL
.....|.|.    .||| |||.||||.||| | |          |....|..  |.....| ..|| .||...  |  |. |||||  ||..     .  
IVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPI-IHRDLKSSNFLVDNNSNIAEWNI

KITDYGLASFRS--TAEPDDSH------ALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSG------PFYLEGLDLSPKEIVQKVRNGQ
|| | ||. |.|  ....   |         .  .| |||.|..|   ..  .|.|||||||.| ||| |        |.     ....... ..|.   
KICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF--CQYSEKSDVYSFGIVLWEIATRKITKTYKKPY----QGMDQEQWCEMVHYM-

RPYFRPSI-DRTQLNEELVLLMERCWAQDPAERPDFGQIKGFI
   .|| | ..  ...|.  |...||..|| .|| | .|   .
EENYRPPIPNH--CPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase ANPb.AA DRK 582-724 40 8.1e-34 111.94 In-house 62-202 (258) Show / Hide 
Range on Protein: 582-724
Range on HMM: 62-202/258
Sequence Identity: 40% (59 aa)

FIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNS---IISSHGSLKSSNCVVDSRFVLKITDYGLAS-FRSTAEPDDS
|.|.|  || |||..|| |||||  || ..|| .||  . ..  |  ||| .||..   ||  |  ||| |  ||  .  |. |.||.  |.   .    
FMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIII--HRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFA

HALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPF
        ||||| |   .       |||||||.|.| |.. |  |.
MTMCGTPCWTAPEVLRNQRY----TEKADVYSFAIVLWECVTRQDPY
Kinase ANPb.AA RIPK 545-786 26 2.5e-32 107.47 In-house 18-290 (290) Show / Hide 
Range on Protein: 545-786
Range on HMM: 18-290/290
Sequence Identity: 26% (73 aa)

GNVVAIKHVN-KKRIEL-----TRQVLFELKHMRDVQFNHLTRFIGACIDP-----PN-ICIVTEYCPRGSLQDILENDS----INLDWMFRYSLINDLV
| .||.|... |....        ... | |||   ...|  .  | |...     .. . ||.|| . ||| . |   .      . |  |  .|   .
GDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEIS

KGMAFLHNSI---ISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTA-EPDDSH-----ALYAKKL------WTAPELLS-GNPLPT-TGMQKADVYSFG
 || .||.     |  |  || .|  ||. |  || | |||... .    .| .       ...|.        .||..  .|. |.     | |||||.
CGMCYLHSMNPPII--HRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFA

IILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLN---EELVLLMERCWAQDPAERPDFGQIKGFI
|.. |.  .  |.  .....    |. ..  |.||   |  . .      |... ||.|||.||| .|| |  ..  .
IVMWEVLTQKHPYEDRKCMM---MIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase ANPb.AA Dicty4 578-724 34 3.6e-30 97.93 In-house 59-217 (277) Show / Hide 
Range on Protein: 578-724
Range on HMM: 59-217/277
Sequence Identity: 34% (56 aa)

HLTRFIGACI----DPPNICIVTEYCPRGSLQDILEN------DSINLDWMFRYS---LINDLVKGMAFLHNSI-ISSHGSLKSSNCVVDSRFVLKITDY
..  | |||.     |. .||||||.|.|.|  .| .      .|| |||  . .   .  | ..||. ||... .  |  |||.|  ||  .. |..| 
NICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDF

GLAS-FRSTAEPDD-SHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPF
||.  ..   .  |   .     .|.||| . ..|      .|||||||||.| ||. |  |.
GLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPY----NEKADVYSFGIVLWEILTRQEPY
Kinase ANPb.AA TK 548-786 16 4.5e-29 93.99 In-house 55-486 (486) Show / Hide 
Range on Protein: 548-786
Range on HMM: 55-486/486
Sequence Identity: 16% (73 aa)

VAIKHVNKKRIELTRQVLF-----------------ELKHMRD--VQFNHLTRFIGACIDP------------PNICIVTEYCPRGS----LQDILENDS
||.| . ..  .  .. .                  |.| |.    .  .. |..|.| ..            . ..||.||.| |.    |.| | . .
VAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCR

IN---------------------------------------------------------------------------LDWMFRYSLINDLVKGMAFLHNS
 .                                                                           |.   .     .. .||..||  
PKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSK

IIS-----SHGSLKSSNCVVDSRFV-----------LKITDYGLA------SFRSTAEPDDSHALY------------------------AKKL---WTA
 ..      |. |   || |... |            ||.|.||.        |   . || ..                            ||   |.|
NCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMA

PELLSGNP--------LPTTGMQKADVYSFGIILQEIALRS-GPFYLEGL-------DLSPKEIVQKVRNGQRP---------YFRPSIDRTQLN-----
|| | ..           ||   | ||.|||. . ||  .  .|.| .         . ...|.....|.|.|.         |  .     .       
PECLNDRVFSEAEKYGKFTT---KSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRY

---------EELVLLMERCWAQDPAERPDFGQIKGFI
         ||. .|| .||. ||..||.| |.. ..
RMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ANPb.AA Pkinase 545-786 19 3.6e-25 90.06 Pfam 24-293 (293) Show / Hide 
Range on Protein: 545-786
Range on HMM: 24-293/293
Sequence Identity: 19% (55 aa)

GNVVAIKHVNKKRIELTRQVLF----ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRG----SLQDILE-NDSINL--DWMFRYSLINDLVKGMAF
| .||.| ..|....   ..      |.. |. ..  .  |..... |...|..|.|||. |    .| |...  .. ..  ..    . .  ...|...
GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEY

LHNSIISSHGSLKSSNCVVDSRFVL----KITDYGLAS-FRSTAEPDDSHALYAKKLWTAPELLS-GNPLPTTGMQKADVYSFGIILQEIALRSGPFYLE
.|.  |  |  ||..|. .|.. ..    ||.| |||  |. .      . .     . |||..  |.. ..    |.|..|.|.|| | ...  ||. .
CHSMGI-IHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP----KVDMWSCGCILYEMLCGRPPFP-G

G----LDLSPKEIVQKVRNGQRPYFRPSIDRTQ---------------LNEELVLLMERCWAQDPAERPDFGQIKGF--I
       ........... .. .. .|  ..                 ..||.  ....|...||..|| . ||.    .
HCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ANPb.AA LRRK 583-788 27 3.9e-24 82.26 In-house 123-351 (351) Show / Hide 
Range on Protein: 583-788
Range on HMM: 123-351/351
Sequence Identity: 27% (66 aa)

IGACIDPPNICIVTEYCPRGSLQDILE---NDS-----INLDWMFRYSLINDLVKGMAFLHNS---IISSHGSLKSSNCVV---D---------SRFVLK
.| ||.|  .|.|.|| | |.|.. |.   .|.     ....||... .  .  |||..||..   ||  |  ||| |  .   .            . |
KGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPII--HRDLKSPNILLWSSPQNHSPNYPNAHVCAK

ITDYGLAS-FRSTAEPDDSHALYAKKLWTAPELLS--GNPLPTTGMQKADVYSFGIILQEIALRSGPFYLE--GLDLS--PKEIVQKVRNGQRPYFRPS-
| |.|. . | ..  .     .   ..| ||| .   |.   |   .|.|.||||.|| |.  |..... |  . | .    .| .|. .|.|| . .. 
IADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYT---EKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHY

IDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRR
  ..|.  ..  |.. ||..|| .|| | ||  ..  
CPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
TyrKc ANPb.AA TyrKc 517-786 21 3.6e-16 38.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 517-786
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

LSLRGS----SYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDV--QFNHLTRFIGACIDP-------PNICIVTEYCPRGS
..|        .|  . .. |              ||.| ...      .  . |.. |. .  .  .. |..|.|...       . ..||.||.| |.
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

LQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGS-----LKSSNCVVDSRFVLKITDYGLASFRSTA-----EPDDSHALY--AKK--L---W
|.| | .   .| .    |   .  .||..||              |   || |..... ||.| ||. .         . |  ..     .|  |   |
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

TAPELLSGNPLPTTGM--QKADVYSFGIILQEIALRSGPFYLE---GLDLSPKEIVQKVRNGQRPYFRPS-----IDRTQLNEELVLLMERCWAQDPAER
.||| .       .|.   | ||.|||. . ||  . .. | .     ..|..|....|..| |.   |.            .|.  .|..||. ||..|
MAPECI------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDR

PDFGQIKGFI
| | .|. ..
PTFSEIHECF
S_TKc ANPb.AA S_TKc 513-786 17 8.2e-16 54.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 513-786
Range on HMM: 1-231/231
Sequence Identity: 17% (50 aa)

SRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPR--GSLQDILEN
 ..   .   ..|. . .. |           | .|||| ..       .... |.. ..  .  .. ...... |  ....|.|||.   |.| |....
YEILRKIGKGAFGKVYKCRHKK---------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

DSIN-----LDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKA
   .     ..     ...  ........|.  |  |  || .|  .|.  ..||.| ||| .         . .     . |||.|        |  |.
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGI-IHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL------GYGKCKC

DVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKG---------FI
|..|.|.|| | . .  ||.       .... .|..                 .|.  ....|.  ||..||   ..           ..
DWWSCGCILYEMLCGYPPFP------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ANPb.AA MLK 581-666 31 3.3e-14 45.78 In-house 73-180 (291) Show / Hide 
Range on Protein: 581-666
Range on HMM: 73-180/291
Sequence Identity: 31% (35 aa)

RFIGACIDPPN-ICIVTEYCPRGSLQDILEN-DS--------------INLDWMFRYSLINDLVKGMAFLHN-S---IISSHGSLKSSNCVVDS------
.| |.|..||.  |||.|||. ||| ..| . .|              . .| ... .|  .  .||..||.     ||  |  |||.| ..|       
QFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWAL--QCARGMHYLHSMAPKPII--HRDLKSHNILIDEICHDMH

RFVLKITDYGLA
  .|||.| |..
HGTLKICDFGTS
Kinase ANPb.AA MLK 704-786 34 8.3e-13 40.88 In-house 216-291 (291) Show / Hide 
Range on Protein: 704-786
Range on HMM: 216-291/291
Sequence Identity: 34% (29 aa)

KADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKV-RNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFI
|.||.|.|..| |.  |  |.     ...| .|  .|  ||.||  ...      .| .  ||..|| |||..||.| ||  . 
KCDVWSWGVVLWEMLTREVPYK---QHYDPMAIAWWVAYNGLRPPIPST-----CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase ANPb.AA Pkinase_Tyr 567-636 28 3e-10 35.33 Pfam 53-129 (270) Show / Hide 
Range on Protein: 567-636
Range on HMM: 53-129/270
Sequence Identity: 28% (22 aa)

ELKHMRDV-QFNHLTRFIGACI--DPP-NICIVTEYCPRGSLQDILEND---SINLDWMFRYSLINDLVKGMAFLHN
|.| |.   .  .. |..|.|.  . | .|.||.||.| |.| | | .      .|.     .   .  |||..|..
EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase ANPb.AA Pkinase_Tyr 759-786 39 1.9e-07 25.81 Pfam 243-270 (270) Show / Hide 
Range on Protein: 759-786
Range on HMM: 243-270/270
Sequence Identity: 39% (11 aa)

EELVLLMERCWAQDPAERPDFGQIKGFI
.|.  || .||..||..|| | .|  ..
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ANPb.AA DRK 764-782 42 0.000373 10.01 In-house 234-252 (258) Show / Hide 
Range on Protein: 764-782
Range on HMM: 234-252/258
Sequence Identity: 42% (8 aa)

LMERCWAQDPAERPDFGQI
|| .||  ||  || . ..
LMNDCWNEDPQHRPSMQEC
Kinase ANPb.AA Dicty4 764-782 47 0.00409 6.43 In-house 251-269 (277) Show / Hide 
Range on Protein: 764-782
Range on HMM: 251-269/277
Sequence Identity: 47% (9 aa)

LMERCWAQDPAERPDFGQI
|...||  ||  || | .|
LIQWCWDHDPQHRPSFEEI
Kinase ANPb.AA Pkinase_Tyr 649-666 55 1.538586 2.45 Pfam 141-158 (270) Show / Hide 
Range on Protein: 649-666
Range on HMM: 141-158/270
Sequence Identity: 55% (10 aa)

NCVVDSRFVLKITDYGLA
|| |.. .| ||.| |||
NCLVTENNVVKICDFGLA
CYCc ANPb.AA CYCc 825-1019 48 1.8e-113 384.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 825-1019
Range on HMM: 1-231/231
Sequence Identity: 48% (111 aa)

EEKRKAEALLYQILPHSVAEQLKRGE-TVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFD-----VYKVETIGDAYMVVSGL
.||.|.. ||.|.||..||.|||.|. .|.....|.|||.|.||||||.|....||||||..|||.||.|| |||...     .|||||||||||||||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PGRNG-------------------QRHAPEIARMALALLDAVSSFRIRHR----PHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQ
| ||.                   ..|| .|| .||  .... .| ..|.    |...||.|||.|||||..||||..|||||.||||||.||||||.| 
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

ALKIHVSSTTKDAL-------DELGCFQLEL
. .||||..|...|        . | |..| 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc ANPb.AA Guanylate_cyc 852-1038 46 4.5e-107 366.83 Pfam 1-214 (214) Show / Hide 
Range on Protein: 852-1038
Range on HMM: 1-214/214
Sequence Identity: 46% (99 aa)

VQAEAFDSVTIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAIIDNF--DVYKVETIGDAYMVVSGLPGR-----NGQRHAPEIARMALALLDA
|.|. .|.|||.|.|||||||......    |||.|..|||.||||| ..|..  ..|||.||||.||.|||||..     ..  ||  .| |||.....
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VSSFRIRHRPHDQ-----LRLRIGVHTGPVCAGVVG--LKMPRYCLFGDTVNTASRMESNGQAL--KIHVSSTTKDALDELGCFQLEL----RGDVEMKG
...... | .  .     ...|||.|||||.|||.|  ..|||||..|||||.||||||.|...  ||||| .|.. | ....|| |.    ||....||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGK---MRTYWLLG
|||   | ||.| |
KGKMGEMETYFLHG
HNOBA ANPb.AA HNOBA 799-846 38 1.3e-07 29.15 Pfam 190-234 (234) Show / Hide 
Range on Protein: 799-846
Range on HMM: 190-234/234
Sequence Identity: 38% (19 aa)

DNLLLRME-QYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQL
. | .||| |  ..||.     ...  |||.| ..|||...|.|||..|
YKLMCRMEQQLKDKLEQM----HRELEEEKKKTDDLLYSMFPKSVANRL