Gene ARAF (Human)

ARAF

Species: Human
Alias: PKS2, RAFA1, A-RAF, ARAF, ARAF1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: Xp11.2,

Classification

Group: TKL
Family: RAF
Subfamily: RAF

Sequence

Name Sequence Type Origin Length Description Download
ARAF.AA Protein Sugen Kinome 606 None Fasta, JSON
ARAF.kin_dom Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON
ARAF.NA RNA Sugen Kinome 2510 None Fasta, JSON

Protein domain

Protein domains of ARAF.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RBD ARAF.AA RBD 19-91 48 2e-36 129.02 Pfam 1-77 (77) Show / Hide 
Range on Protein: 19-91
Range on HMM: 1-77/77
Sequence Identity: 48% (37 aa)

GTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIK---GRKTVTAWDTAIAPLDG-EELIVEVL
 ...|.|||.||.||.||.||.|.|.|.|..|..|||..||.|||...   |.|....|.|.|..|.| .||.||.|
KFCCVHLPNNQRCVVEVRPGMTVRDMLMKICKRHGLNPMCCHVYRVGDPHEGEKKPLDWHTDISWLPGPQELWVENL
RBD ARAF.AA RBD 19-91 46 4.1e-32 113.92 SMART 1-76 (76) Show / Hide 
Range on Protein: 19-91
Range on HMM: 1-76/76
Sequence Identity: 46% (35 aa)

GTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIK---GRKTVTAWDTAIAPLDGEELIVEVL
 ...|.||..|||||.||.||.|.|.|.|..|.||||..||.|.|. .   |.|..  |.. |. |.|.||.||..
KFCCVHLPDNQRTVVKVRPGMTVHDMLMKICKKRGLNPECCHVFRRHHPHEGEKKPLDWHQPISYLPGQELWVENR
C1_1 ARAF.AA C1_1 99-147 32 9.1e-16 61.53 Pfam 1-55 (55) Show / Hide 
Range on Protein: 99-147
Range on HMM: 1-55/55
Sequence Identity: 32% (18 aa)

HNFVRK-TFFSLAFCDFCLKFL-----FHGFRCQTCGYKFHQHCSSKVPTVCVDM
|..|.. .| . .||. | .|.     . |..||.|.|..|..|..|||. | . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 ARAF.AA C1 99-144 27 3.9e-14 54.21 SMART 1-61 (61) Show / Hide 
Range on Protein: 99-144
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HNFVRKTFFSLAFCDFCLKFLFH---------GFRCQTCGYKFHQHCSSKVPT-------VC
|......| . ..|. | |....         |.||. |.||.|..|..|||         |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase ARAF.AA RAF 310-569 66 1e-197 647.07 In-house 1-282 (282) Show / Hide 
Range on Protein: 310-569
Range on HMM: 1-282/282
Sequence Identity: 66% (188 aa)

VQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQA---FKNEMQVLRKTRHVNILLFMGFMTRPG---FAIITQWCEGSSLYHHLHVADT--RF
|.. .|||.||||||.||.||||||||.|.|..||.||.||   ||||..|..||||.|||||||.|..|    .||.|||||.||||||.||..|  .|
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

DMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWS--GAQPLEQPSGSVLWMAAEVIR-----------MQDPNPYSF
||..|||..||..|||||||||||||||||||||||||..|||||||||.|||||||  |.|..|||....||||.||||           ||| |||||
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF

QSDVYAYGVVLYELMTGSLPY-SHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIEL
|||||..|.|.|||||...|| .|| .|||||||.|||||.|||||. ..|||||.||..||.||||||||||.|||..|..
QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase ARAF.AA RAF 310-567 58 2e-181 609.01 In-house 1-275 (275) Show / Hide 
Range on Protein: 310-567
Range on HMM: 1-275/275
Sequence Identity: 58% (160 aa)

VQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTA-EQAQAFKNEMQVLRKTRHVNILLFMGFMTRP---GFAIITQWCEGSSLYHHLHVADT-RFDMV
||...|||.|.||||.||.||||||||.|.. .||  .|.||||||.....||||.||.||||....|    .||.||||.||.||||.||..| .||| 
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

QLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVK-TRWS--GAQPLEQPSGSVLWMAAEVIRMQ---------DPNPYSFQSDV
..|..|.|..||||||||||||||||||.|||||.|..|.|.||||.||| .||.  . | |.||.|...||| |||||.         | ||.||||||
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATI
||.|.|.||||.|..||.|| ...|||.||.||||..|.||....|||.|..||..|...|.||||.|.||...|
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase ARAF.AA TKL 316-567 25 1.9e-93 316.79 In-house 1-364 (364) Show / Hide 
Range on Protein: 316-567
Range on HMM: 1-364/364
Sequence Identity: 25% (96 aa)

IGTGSFGTVFRGRWHG-----------DVAVKVLKVS------------------------QPTAEQAQAFKNEMQ-VLRKTRHVNILLFMG--------
|| |.||.|..|.|.|           |||||..|.                         .|.|.... |..|   .....|| ||..|||        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-FMTRP-----GFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHA--------KNIIHRDLKSNNIFLHEGLT--------------V
 .. .|      ..|....|.| ||.|.||       . |... |...|.||.|||.        ..||||||||.||...| .|              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDFGLATVK------TRWSGAQP-----------LEQPSGSVLWMAAEVIRMQDP-------------NPYSFQSDVYAYGVVLYELMTGSLPYSHIG
||.||||....      .... ...           .  . |.  ||| ||.|.|..              .|| ..|||..|.||.|..|. .||....
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

CRDQI------IFMVGRG--YLSPDLS---------KISSNCPKAMRRLLSDCLKFQREERPLFPQILATI
....|      .......   | | .             ..||. |..|. || .   |.|| | .|| ..
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ARAF.AA Pkinase 310-567 22 6.7e-76 263.27 Pfam 1-293 (293) Show / Hide 
Range on Protein: 310-567
Range on HMM: 1-293/293
Sequence Identity: 22% (68 aa)

VQLLKRIGTGSFGTVFRGRWHGD---VAVKVLKVSQPTAEQAQAFKN--EMQVLRKTRHVNILLFMGFM-TRPGFAIITQWCEGS----SLYHHLH-VAD
 .....|| ||||.|......|.   ||||..|..    .. |.  .  | |.... .| ||. . ... ...   ... .|||     .|.....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TRF--DMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTV----KIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDV
..|  .. .......|...|..|.|...|||||||. ||....  ..    ||.||||| ..  .   . .  . |.  .|| ||||  . ..|.  .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM

YAYGVVLYELMTGSLPYSHI----GCRDQIIFMVGRGYLSPDLSKISSNC------------------PKAMRRLLSDCLKFQREERPLFPQILAT--I
...|..|||...| .|...     . .||.  .. ...  .. .   ...                  ..... ....||..  ..|| ..|||    .
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ARAF.AA KSR 310-567 36 5.7e-71 241.17 In-house 1-272 (272) Show / Hide 
Range on Protein: 310-567
Range on HMM: 1-272/272
Sequence Identity: 36% (100 aa)

VQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVS-QPTAEQ-AQAFKNEMQVLRKTRHVNILLFMG-FMTRPGFAIITQWCEG-SSLYHHLHVADTRFDMVQ
. .. .|| | ||.|.||.|||.||.|..       . . . .|| |   ...||| || |||| .|  | .||..  | |  .||||.||. ...||  
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

LIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVK---TRWSGAQPLEQPSGSVLWMAAEVIRMQDP---------NPYSFQSDVY
 .. |.| .||| ||||| ||| |||| |||.     | | ||||  ..       ..  |  | |    .| | ||   |         .|.| .||||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

AYGVVLYELMTGSLPYSHIGCRDQIIFMVGRG-YLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATI
|.| ..||...| .|. .  |  .||. ...|  . ..|. ..  | . |  .|. |  .  .||| | .|. ..
AFGTIWYEMICGEWPF-KYQCAESIIWQMCQGEGMRQVLRNVQ--CGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase ARAF.AA TKL-Unique 312-567 31 8.9e-64 218.2 In-house 1-290 (290) Show / Hide 
Range on Protein: 312-567
Range on HMM: 1-290/290
Sequence Identity: 31% (93 aa)

LLKRIGTGSFGTVFRGRWHGD-VAVKVLKV-SQPTAEQAQAFKNEMQVLRKTR-HVNILLFMGFMT----RPG-FAIITQWCEGSSLYHHLH--------
 .. ||.|..|.|..| |.|. ||.|.... . .  |  | |.||  .. | . | ||...||. .     |. . |..  |.|.||| .||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-VADTRFDMVQLIDVARQTAQGMDYLHAKN--IIHRDLKSNNIFLHEG-----LTVKIGDFGLATVKTRWSGAQPL-------EQPSGSVLWMAAEVIRM
    . ..| | .. |.. ||||.||| ..  |||||||| |. . ..     . .|| ||||...... .            . . || .||| ||.||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

QDPNPYSFQSDVYAYGVVLYELMTGSL------PYSHIGCRDQIIFMVGR--GYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATI
   . || .||||..|.||.|. |. .      ||...  ..|.. ||      . |   .|...|||  | |. .| . . ..|| | .|.  .
NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYMEENYRP---PIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase ARAF.AA MLK 310-567 31 2.4e-58 200.13 In-house 1-291 (291) Show / Hide 
Range on Protein: 310-567
Range on HMM: 1-291/291
Sequence Identity: 31% (96 aa)

VQLLKRIGTGSFGTVFRGRWHGDV-AVKVLKVSQPTAEQ---------AQAFKNEMQVLRKTRHVN----ILLFMGFMTRP-G-FAIITQWCEGSSLYHH
 |... || |||| |..|||..    .|...| . .|.          ...|. |   ||. .| |    |  |.|  ..|   |.|....|||.|||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHVADT-------------RFDMVQLIDVARQTAQGMDYLHAKN---IIHRDLKSNNIFLHE------GLTVKIGDFGLAT-VKTR---WSGAQPLEQPS
|| |..             . |. .... | | |.||.|||..    |||||||| || ..|      ..|.|| |||... ....     ...      
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNA------

GSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYS-HIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILAT
|.. ||| |||     ..||  .||. .||||.|..|. .||. |. .  .|...|.   | |    | |.||. . .|...| .   ..|| | ||.  
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPM-AIAWWVAYNGLRP---PIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQH

I
 
L
Kinase ARAF.AA S_TKc 310-570 23 1.1e-56 195.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 310-570
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

VQLLKRIGTGSFGTVFRGRWHG---DVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEG--SSLYHHLHVADTR----
 ..|. || |.||.|...|...    ||.|..|         . ...|.|.|.| .| ||  . ...    . ...  |.|   .|.....   ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSF-QSDVYAYGVV
 |.  .   ...|......|.| ..|||||||  ||.| |  ..||.|||||..              |.  .|| ||.      .|..  .|... |..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

LYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILA------TIELL
|||...|  |..     .| .| . .              .. .. ... ||..  |.||   ..|.        . .
LYEMLCGYPPFP----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ARAF.AA TK 310-567 15 1.5e-56 187.72 In-house 1-486 (486) Show / Hide 
Range on Protein: 310-567
Range on HMM: 1-486/486
Sequence Identity: 15% (75 aa)

VQLLKRIGTGSFG---TVFRGRWHG----------------------------DVAVKVLKV-SQPTAEQAQA--------------FKNEMQVLR--KT
..|.| .| | ||   .|..|.|.|                            .||||.||  .  ..|. ..              . .||....  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHVNILLFMGFMTRPG-------------FAIITQWCEGSS----LYHHLHVADTR--------------------------------------------
.| ||. . |  |...             . |.. .... .    | ..|.  . .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FDMVQLIDVARQTAQGMDYLHAK------NIIHRDLKSNNIFLHEGLT-----------VKIGDFGLAT
                               ..| ||.  ..| |.|| |||.|      |..||||   |. ..|...           .||.||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

VKT----RWSGA---------QPLEQPSGS--------------------VLWMAAEVIRMQD------PNPYSFQSDVYAYGVVLYELMT-G-SLPYSH
...    |  .          .    |                       . ||| |... .        . .. .|||...||...|..| |   .|  
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

IGC--------RDQIIFMVGRG-----------YLSPDLSKISSNCP-------------KAMRRLLSDCLKFQREERPLFPQILATI
.           .... .. ||                . .    ..             ... .|. .| ... |.|| | |..  .
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ARAF.AA Dicty4 310-569 32 4e-52 172.23 In-house 1-277 (277) Show / Hide 
Range on Protein: 310-569
Range on HMM: 1-277/277
Sequence Identity: 32% (92 aa)

VQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVSQPT--AEQAQAFKNEMQVLRKTRHVNILLFMGFMT----RP-GFAIITQWCEGSSLYHHLHV-----
 .  .|||.||||.|..|.| | .||||.|.  . .  ..  ..|..|   . | || ||.||||  |     |  . | |  .   .||  ||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-ADTRFDMVQLID---VARQTAQGMDYLHAKN--IIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQP-LEQPSGSVLWMAAEVIRMQDPNPYSFQ
   .  |    .     |. .|.|| .||. |  |||||||| |.   . ..||..||||.... . .  .  .  . |...||| || . |   ||   
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ---PYNEK

SDVYAYGVVLYELMTGSLPYS-HIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILAT--IEL
.||| .| ||.|. |.  ||. |.   .|... |..  | |   .|...||.  ..|. .|.    . || |..|.     | 
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRP---PIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase ARAF.AA Pkinase_Tyr 310-451 32 9.5e-48 162.33 Pfam 1-158 (270) Show / Hide 
Range on Protein: 310-451
Range on HMM: 1-158/270
Sequence Identity: 32% (52 aa)

VQLLKRIGTGSFGTVFRGRWH-------GDVAVKVLKVSQPTAEQ--AQAFKNEMQVLRKT-RHVNILLFMGFMT---RP-GFAIITQWCEGSSLYHHLH
....| .| |.||.|..|.|.        .||||.||  . . ||   ..| .|......  .| ||. ..|  |   .|    |..  ... .|...|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VA---DTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLA
     . ...| .|.. ..| |.||.||..||.|||||   |. ..|...|||.|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase ARAF.AA TyrKc 310-567 27 1.1e-46 162.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 310-567
Range on HMM: 1-280/280
Sequence Identity: 27% (80 aa)

VQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKT--RHVNILLFMGFMTR--------PGFAIITQWCEGSSLYHHLHVADT
..|.| .| | ||.|..|.|  .||||.|| .       ..| .|.....|   .| ||. . |  |         .   |..  ... .| ..|.    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRW------SGAQPLE---QPS--GSVLWMAAEVIRMQDPNPYSF
.. | .|.. . | |.||.||| ||.|||||   |. ..|..||||.||||.   .        .         .      . ||| |.|   . . ...
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTT

QSDVYAYGVVLYELMT-GSLPYSH-----IGCRDQIIFMVGRGYLSPDLSKISSN-------CPKAMRRLLSDCLKFQREERPLFPQILATI
.|||...||...|..| |  ||.      .  .. .|  | .||    . .  ..       ||..| .. ..| ... |.|| | .|   .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE-VIEYVKQGYR---MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ARAF.AA STE 310-558 20 5.6e-44 152.43 In-house 1-346 (359) Show / Hide 
Range on Protein: 310-558
Range on HMM: 1-346/359
Sequence Identity: 20% (72 aa)

VQLLKRIGTGSFGTVFRGRWH----GD--------------VAVKVLKVSQPTA---------------EQAQAFKNEMQVLRKTR--HVNILLFMGFMT
 .....|| |.||||.... |    ..              .|.|...... ..               |. | ...|.....| .  | ||  . |   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

RPG--------FAIITQWCEGSSLY---HHLHVAD----------TRFDMVQLIDVARQTAQG-MDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLAT
. |          |.  ...| ||    .| .             .||.  |.. ..||. .| ..||| ..|||||.|. ||.|     ||. |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VKTR--------------WSGAQPLEQPSGSVLWMAAEVIRMQD---PNPYSFQSDVYAYGVVLYELMTGSLPYSH-IGCRD--QIIFMVGRG-------
  |                ...|      |.  ||| |||. ..    ..|....|..  | .. |. ||  |..     |   .|.|. . .       
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---YLSPDLSKI----------------SSNCPKAMRRLLSDCLKFQREERP
     .| |                   .... . ..  .. ||.   ..||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP
Kinase ARAF.AA TK-Unique 310-567 26 1.5e-42 144.58 In-house 1-294 (294) Show / Hide 
Range on Protein: 310-567
Range on HMM: 1-294/294
Sequence Identity: 26% (81 aa)

VQLLKRIGTGSFGTVFRGRWHG--------DVAVKVLKVSQPTAEQAQAFKNEMQVLR-KTRHVNILLFMGFMTRPG--FAIITQWCEGSSLYHHLH---
. ....||.|.||.|.||   |        .... ..     | .. |.|..| |... ...| ||. ..|  |...  . ||  .|....| |.|.   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

----------------------VADTRFDMVQLIDVARQTAQGMDYLHA--KNIIHRDLKSNNIFLHEGLTVKIGDFGLAT-VKTRWSGAQPLEQP--SG
                      . ..  .. .|.  | | |.|| ||.   |.|.|||| . |..| |....||.|||.|. | |   |..  ..     
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRI

SVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNC-PKAMRRLLSDCLKFQREERPLFPQILAT
.. ||| |...  . . .. .|||...||...|..| |. ||. .  .| |. .. .||  |.     ..| ...|. |.. |..  .|||| | ||.  
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQ----PEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHR

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L
Kinase ARAF.AA Pkinase_Tyr 472-567 27 6.4e-16 54.54 Pfam 180-270 (270) Show / Hide 
Range on Protein: 472-567
Range on HMM: 180-270/270
Sequence Identity: 27% (27 aa)

WMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMT-GSLP-YSHIGCRDQIIFMV-GRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATI
||| |.|.      .. .|||...||...|..| |  | |  .    ... ..  .||      ..  |||. . .|. .| ... |.|| | .|.  .
WMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYR----MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL