Gene BRAFps (Human)

BRAFps

Species: Human
Alias: BRAFps
External Links:
Annotation: Consensus chromosomal location: Xq12, Pseudogene: Confirmed Pseudogene,

Classification

Group: TKL
Family: RAF
Subfamily: RAF

Sequence

Name Sequence Type Origin Length Description Download
BRAFps.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON
BRAFps.AA Protein Sugen Kinome 577 None Fasta, JSON
BRAFps.NA RNA Sugen Kinome 1731 None Fasta, JSON

Protein domain

Protein domains of BRAFps.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RBD BRAFps.AA RBD 1-41 51 7e-12 43.96 Pfam 33-77 (77) Show / Hide 
Range on Protein: 1-41
Range on HMM: 33-77/77
Sequence Identity: 51% (23 aa)

MRGLIPECGAVYRIQD---GEKKTIDQDTGVSWLTG-EELHVEVL
..|| |.| .|||..|   |||| .| .| .|||.| .||.||.|
RHGLNPMCCHVYRVGDPHEGEKKPLDWHTDISWLPGPQELWVENL
C1_1 BRAFps.AA C1_1 49-97 29 4e-13 51.85 Pfam 1-55 (55) Show / Hide 
Range on Protein: 49-97
Range on HMM: 1-55/55
Sequence Identity: 29% (16 aa)

HNFVRK-TFFTLAFCDFCQKLL-----FQGFRCQTCGYKFHQCCSTVVPLMFVNY
|..|.. .|   .||. |....     .||..||.|.|..|. |.. || .    
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 BRAFps.AA C1 49-92 28 2.7e-09 38.11 SMART 1-52 (61) Show / Hide 
Range on Protein: 49-92
Range on HMM: 1-52/61
Sequence Identity: 28% (15 aa)

HNFVRKTFFTLAFCDFCQKLLFQ---------GFRCQTCGYKFHQCCSTVVPL
|......| . ..|. |.|....         |.||. |.||.|. |.. ||.
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQ
Kinase BRAFps.AA RAF 268-527 62 1.3e-169 554.46 In-house 1-282 (282) Show / Hide 
Range on Protein: 268-527
Range on HMM: 1-282/282
Sequence Identity: 62% (175 aa)

ITVGQRIGSGSFGTVYKGKWHGVVAVKMLNVAAPTPHQVEA---FKMKEEYSGKHXHMNILLFMGYSTKPQ---LAIVTQWC*GSSLYYLLHIIET--KS
..|..|||||||||||.|.||| ||||||||..||| |. |   ||       |  |.||||||||..|||   .||||||| .||||  .|..||  | 
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

EMIKLIDIAQQTAQGMDY*HAKSVIHRDLKSNNIVLHEDLTVEIGDFGLATVKS*WS--GSHQFEQLSGSFLCMAPEVIR-----------MQDKNSYSF
.|..||||..|..||||| |||..|||||||||| ||||.|| ||||||.|||. ||  |..||||.... | |||||||           |||.| |||
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF

QSDIYAFGIVLYELMTGQLPY-SNINNRDQIIFMVGQGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILTSIKL
|||.|.||||.|||||...|| ..|.||||||||.|.|||.|||||||..|||||.|||..|.|..|.|||||.||| .|..
QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase BRAFps.AA RAF 268-525 53 3.5e-146 491.93 In-house 1-275 (275) Show / Hide 
Range on Protein: 268-525
Range on HMM: 1-275/275
Sequence Identity: 53% (146 aa)

ITVGQRIGSGSFGTVYKGKWHGVVAVKMLNVAAPTP-HQVEAFKMKEEYSGKHXHMNILLFMGYSTKP---QLAIVTQWC*GSSLYYLLHIIET-KSEMI
...|.|||.|.|||||.|.||| ||||.||.  ||| || .|||       |  | ||.||||| .||   ..||||||| ||.||. .|  .| | .| 
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

KLIDIAQQTAQGMDY*HAKSVIHRDLKSNNIVLHEDLTVEIGDFGLATVK-S*WS--GSHQFEQLSGSFLCMAPEVIRMQ---------DKNSYSFQSDI
..|.||||..||||| |||  |||||||.|| ||....| |.||||.||| . |.  ...|..| .|. . ||||||||.         |.| .||||| 
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YAFGIVLYELMTGQLPYSNINNRDQIIFMVGQGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILTSI
||||.|.||||.|..||..|....|||.||. |||..|.||.|..|||.||.|..||......|||.|.||. .|
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase BRAFps.AA TKL 274-525 26 3.3e-86 292.73 In-house 1-364 (364) Show / Hide 
Range on Protein: 274-525
Range on HMM: 1-364/364
Sequence Identity: 26% (98 aa)

IGSGSFGTVYKGKWHG-----------VVAVKMLNV------------------------AAPTPHQVEAFKMKEE-YSGKHXHMNILLFMG--------
||||.||.||||||.|           .||||....                         .|.... . |. .|     .  | ||..|||        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-YSTKP-----QLAIVTQWC*GSSLYYLLHIIETKSEMIKLIDIAQQTAQGMDY*HA--------KSVIHRDLKSNNIVLHEDLT--------------V
 .. .|     ||.||...| | ||...||       . .....|...|.||.| |.        . .|||||||.|| ..|..|              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

EIGDFGLATVKS------------------*WSGSHQFEQLSGSFLCMAPEVIRMQDK-------------NSYSFQSDIYAFGIVLYELMTGQLPYSNI
 |.||||....|                    ... .     |..  |||||.|.|..              .|| ..|.|.|||||.|..|...||...
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

NNRDQI--------IFMVGQGYLSPDLS---------KVRSNCPKAMKRLMAECLKKKRDERPLFPQILTSI
.....|        . ||..  | | .             ..||. ||.|| .| . . ..|| | .||  .
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase BRAFps.AA Pkinase 268-525 25 4.9e-60 210.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 268-525
Range on HMM: 1-293/293
Sequence Identity: 25% (75 aa)

ITVGQRIGSGSFGTVYKGKWHGV---VAVKMLNVAAPTPHQVEAFKM-KEEYSGKHX-HMNILLFMGYS-TKPQLAIVTQWC*GS----SLYYLLH-IIE
...|..|||||||.|||....|    |||| ...    . . ..     | .  |.  | ||. . ..  .|. . .|. .| |     .|. ...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TKS--EMIKLIDIAQQTAQGMDY*HAKSVIHRDLKSNNIVLHEDLTV----EIGDFGLATVKS*WSGSHQFEQLSGSFLCMAPEVIRMQDKNSYSFQSDI
..   ..  ..... |...|..| |....||||||. || .... ..     |.||||| ... .  .. .  . |.   |||||||  . . |.  .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM

YAFGIVLYELMTGQLPYSNI-----NNRDQIIFMVGQGYLSPDLSKVRS----------------NCPKAMKRLMAECLKKKRDERPLFPQILTS--I
...|..|||...|..|...      .. .|.|...... |. | .. .|                | ....| ..  ||.|.  .|| ..||| .  .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase BRAFps.AA TKL-Unique 270-525 31 4.8e-58 199.14 In-house 1-290 (290) Show / Hide 
Range on Protein: 270-525
Range on HMM: 1-290/290
Sequence Identity: 31% (92 aa)

VGQRIGSGSFGTVYKGKWHGV-VAVKMLNV-AAPTPHQVEAFKMKEEYSGKHX-HMNILLFMGYSTK-----PQLAIVTQWC*GSSLYYLLH--------
..  ||.|..|.||||||.|  ||.| ... . . .  .. |..    . |   | ||...|||...     |.. ||.  | |.||| .||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-IIETKSEMIKLIDIAQQTAQGMDY*HAKS--VIHRDLKSNNIVLHED-----LTVEIGDFGLATVKS*WSGSHQF-------EQLSGSFLCMAPEVIRM
 . ..|  | . ...|.. ||||.| | ..  .||||||| |. . ..     . . | ||||....|  . .          .   |||. |||||.||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

QDKNSYSFQSDIYAFGIVLYELMTGQL------PYSNINNRDQIIFMVGQ--GYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILTSI
   . || .||.|.|||||.|. |...      ||... ...|.. || .    . | ..   ..|||  . |. .| .   ..|| | .|....
NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYMEENYRPPIP---NHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase BRAFps.AA MLK 268-525 29 5e-52 178.75 In-house 1-291 (291) Show / Hide 
Range on Protein: 268-525
Range on HMM: 1-291/291
Sequence Identity: 29% (88 aa)

ITVGQRIGSGSFGTVYKGKWHGVV------AVKMLNVAAPTPHQV-----EAFKMKEEYSGKHXHMN----ILLFMGYSTKP-Q-LAIVTQWC*GSSLYY
|.. . ||||||| |.||.|..        |||. .  .    ..     ..|.|  .   .  | |    |  |.| ...| . ..||...| |.||| 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLHIIETKSE-------------MIKLIDIAQQTAQGMDY*HAKS---VIHRDLKSNNIVLHE------DLTVEIGDFGLATVKS*WSGSHQFEQLSGSF
.|| ...|..             .  ....| | |.||.| |..    .||||||| ||...|      ..|. | |||... ..    .  . .  |..
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTY

LCMAPEVIRMQDKNSYSFQSDIYAFGIVLYELMTGQLPYSNINNRDQIIFMVGQGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILTSI
  ||||||     . ||  .|.. .|.||.|..|...||.....  .|...|..  | |    ..|.||. .|.|| .| . .  .|| | ||..  
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRP---PIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase BRAFps.AA TK 268-525 15 8.8e-52 171.46 In-house 1-486 (486) Show / Hide 
Range on Protein: 268-525
Range on HMM: 1-486/486
Sequence Identity: 15% (79 aa)

ITVGQRIGSGSFG---TVYKGKWHG----------------------------VVAVKMLNVAAPTPHQV-----------------EAFKMKEEYSGKH
||.|. .|.| ||   .||||.|.|                             ||||||   ...  .                  ||  ||   ... 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

XHMNILLFMGYSTKPQ-------------LAIVTQWC*-GS----SLYYLLHIIETKSE-----------------------------------------
 | ||. . |..|...             . ||. ..  |.     . ||    .....                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------------------------MIKLIDIAQQTAQGMDY*HAK------SVIHRDLKSNNIVLHEDLT-----------VEIGDFGLAT
                                 |  |. ...| |.|| | |.|       ..||||   |. ..|...           . |.||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

VKS*WSGSHQFEQLSGSFLC---------------------------------------------MAPEVIRMQD------KNSYSFQSDIYAFGIVLYE
..|               |.                                             ||||... .       .. .. .||...||....|
QGS-G------------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWE

LMT-G-QLPYSNINN--------RDQIIFMVGQG-YLSPD---------LSKVR-SNCP--------------KAMKRLMAECLKKKRDERPLFPQILTS
..| | . .| ...|         .... .. .|  | .          . . .  .||              ... .|| .| ... ..|| | |..  
IFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQ

I
.
L
Kinase BRAFps.AA KSR 268-525 34 1.7e-46 156.55 In-house 1-272 (272) Show / Hide 
Range on Protein: 268-525
Range on HMM: 1-272/272
Sequence Identity: 34% (96 aa)

ITVGQRIGSGSFGTVYKGKWHGVVAVKMLNVA-APTPHQ-VEAFKMKEEYSGKHXHMNILLFMGYSTKP-QLAIVTQWC*G-SSLYYLLHIIETKSEMIK
.  | .|| | ||.|..| ||| ||.| ..       |. .|.||       .  | || ||||.   | .||||.  | |  .|| ..|   .|  | .
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

LIDIAQQTAQGMDY*HAKSVIHRDLKSNNIVLHEDLTVEIGDFGLATVKS*WSGSHQFEQLSGSF--LC-MAPEVIRM------QDK---NSYSFQSDIY
 ..|||| .||| | |||  || |||| || .     | | ||||  ..          .|  ..  || .||| ||        ..   . .| .|| |
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

AFGIVLYELMTGQLPYSNINNRDQIIFMVGQG-YLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILTSI
||| ..||...| .|. .     .||. ..||  . ..|. |   | . || .. .|     .||| | .|.  .
AFGTIWYEMICGEWPFKY-QCAESIIWQMCQGEGMRQVLRNVQ--CGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase BRAFps.AA TK-Unique 268-525 27 1.1e-38 130.99 In-house 1-294 (294) Show / Hide 
Range on Protein: 268-525
Range on HMM: 1-294/294
Sequence Identity: 27% (84 aa)

ITVGQRIGSGSFGTVYKGKWHG---------VVAVKMLNVAAPTPHQVEAFKMKEEYSGKHXHMNILLFMGYSTKP--QLAIVTQWC*GSSLYYLLHIIE
..||..||.|.||.|..|.  |         .||||||.  |    . . .|  . .. .  | ||. ..|..||.  .  |.  .| ...|  .|.   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

TK----------------------SEMIK---LIDIAQQTAQGMDY*HA--KSVIHRDLKSNNIVLHEDLTVEIGDFGLAT-VKS*WSGSHQFEQLSGSF
 .                       | |.   |. .| | |.|| | .   | ..|||| . |. | ||... |.|||.|. |     | .. .. .|  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRI

LC--MAPEVIRMQDKNSY-SFQSDIYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGQGYLSPDLSKVRSNC-PKAMKRLMAECLKKKRDERPLFPQILT
    ||||...   .. | . .||...||....|..| |. ||... ..| |. .. .||  |    ....| ...|  || .|......||| | ||. 
PIRWMAPESLKCY-HGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMP----QPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKH

SI
 .
RL
Kinase BRAFps.AA RIPK 274-525 26 1.5e-38 128.98 In-house 1-290 (290) Show / Hide 
Range on Protein: 274-525
Range on HMM: 1-290/290
Sequence Identity: 26% (79 aa)

IGSGSFGTVYKG---KWHGVVAVKM---LNVAAP-TPHQVEAFKMKEEYSGKHXHMNILLFMGYSTKP------Q-LAIVTQWC*GSSLYYLLHIIETKS
.|.|.||.|.|    .|  .||.|    ......    .... |   .   |  . .|.   |   ..      . ..||..     ||  .||   ||.
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLH---TKW

------EMIKLID-IAQQTAQGMDY*HAKS--VIHRDLKSNNIVLHEDLTVEIGDFGLATVKS*WSGSHQ-----FEQLS-------GSFLCMAPEVIRM
         .|   . .... || | | .   .||||||  || .  .. | | |||||| .  || |||      | .|       |    |.|| .| 
PYQHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWM-MWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRT

QDKNS---YSFQSDIYAFGIVLYELMTGQLPYSNINNRDQIIFMVGQGYLSPDLSKVRSNCPKA-----MKRLMAECLKKKRDERPLFPQILTSI
  |..    .  .|.| |.||..|..|.  ||..  .  .|.. . ||   |.|. |  ..|..     |..|| .| .   ..|| |. .   .
DNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGH-RPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase BRAFps.AA Dicty4 323-529 30 3.1e-35 115.06 In-house 59-277 (277) Show / Hide 
Range on Protein: 323-529
Range on HMM: 59-277/277
Sequence Identity: 30% (70 aa)

NILLFMGYST----KP-QLAIVTQWC*GSSLYYLLHI------IETKSEMIKLID---IAQQTAQGMDY*HA--KSVIHRDLKSNNIVLHEDLTVEIGDF
||.||||..|    .|  . |||  .   .|| |||        ..|.. .  .    .|  .|.|| . |.    .||||||| |.   ....| ..||
NICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDF

GLAT----VKS*WSGSHQFEQLS--GSFLCMAPEVIRMQDKNSYSFQSDIYAFGIVLYELMTGQLPYS-NINNRDQIIFMVGQGYLSPDLSKVRSNCPKA
||..    ..     .|.. | .  |. . ||||| .   ...|   .| | |||||.|. |.| ||.  . . .|... |..  | | ..   ..||. 
GLSQYMKKHE-----DHKDNQMTACGTPCWMAPEVMM---HQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIP---DWCPPS

MKRLMAECLKKKRDERPLFPQILTSIKLLT
 |.|...|. .    || |..|.    | .
WKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase BRAFps.AA S_TKc 268-528 21 4.5e-34 120.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 268-528
Range on HMM: 1-231/231
Sequence Identity: 21% (61 aa)

ITVGQRIGSGSFGTVYKGKWHG---VVAVKMLNVAAPTPHQVEAFKMKEEYSGKHXHMNILLFMGYSTKPQLAIVTQWC*G--SSLYYLLHIIETK----
 .... ||.|.||.|||.....   .||.|...       . |   .|.    .| .   |. . ..    | .|.  | |   .|. ...   ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-SEMIKLIDIAQQTAQGMDY*HAKSVIHRDLKSNNIVLHEDLTVEIGDFGLATVKS*WSGSHQFEQLSGSFLCMAPEVIRMQDKNSYSF-QSDIYAFGIV
         ...|......| | . .||||||  || | |  .. |.|||||..            . |.   |||||.      .|..  .|....|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

LYELMTGQLPYSNINNRDQIIFMVGQGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILT------SIKLL
|||...|. |..   . .... ..|               .. .| ..  ||.|  ..||   ..|.      .   .
LYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase BRAFps.AA TyrKc 268-525 29 2.2e-29 104.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 268-525
Range on HMM: 1-280/280
Sequence Identity: 29% (87 aa)

ITVGQRIGSGSFGTVYKGKWHGVVAVKMLNVAAPTPHQVEAFKMKEEYS--GKH--XHMNILLFMGYSTK--------PQLAIVTQWC*GSSLYYLLHII
|| |. .|.| ||.||||.|   ||||||.  |          . .| .   |    | ||. . |. |.        ..| ||.  . . .|   |.  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

ETKSEMIKLIDIAQQTAQGMDY*HAKSVIHRDLKSNNIVLHEDLTVEIGDFGLATVKS*W-----SGSHQFEQL--SGSFLC----MAPEVIRMQDKNSY
. |  | .|.... | |.||.| | | .|||||   |. ..|..|| |.||||.           |..    .   .| ..     ||||.|   ... .
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKF

SFQSDIYAFGIVLYELMT-GQLPYSN-----INNRDQIIFMVGQGYLSPDLSKVRSN-------CPKAMKRLMAECLKKKRDERPLFPQILTSI
...||...||....|..| || ||..     ..|.. .|  | |||    . .  ..       ||..| ..| .| . . ..|| | .|   .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE-VIEYVKQGYR---MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase BRAFps.AA Pkinase_Tyr 268-409 35 6.9e-27 91.68 Pfam 1-158 (270) Show / Hide 
Range on Protein: 268-409
Range on HMM: 1-158/270
Sequence Identity: 35% (56 aa)

ITVGQRIGSGSFGTVYKGKWH-------GVVAVKMLNVAAPTPHQ--VEAFKMKEEYSGKHX--HMNILLFMGYST---KP-QLAIVTQWC*GSSLYYLL
|| |. .|.|.||.||||.|.         ||||||     ...|   |.|   |    |.   | ||. ..|  |   .| |. ||.  . . .|.  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HII---ETKSEMIKLIDIAQQTAQGMDY*HAKSVIHRDLKSNNIVLHEDLTVEIGDFGLA
.     . .  |  |.....| |.||.| ..|  |||||   |. ..|...| |.|||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase BRAFps.AA Pkinase_Tyr 431-525 27 2.8e-18 62.54 Pfam 181-270 (270) Show / Hide 
Range on Protein: 431-525
Range on HMM: 181-270/270
Sequence Identity: 27% (27 aa)

MAPEVIRMQDKNSYSFQSDIYAFGIVLYELMT-GQLP-YSNINNRDQIIFMV-GQGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILTSI
||||.|.      .. .||...||....|..| |. | | .. | . .. ..  .||    . .   |||. . .|| .| ... ..|| | .|.  .
MAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE-VYEYIYEDGYR---MPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase BRAFps.AA Dicty4 268-297 67 2e-12 37.95 In-house 1-31 (277) Show / Hide 
Range on Protein: 268-297
Range on HMM: 1-31/277
Sequence Identity: 67% (21 aa)

ITVGQRIGSGSFGTVYKGKWHGV-VAVKMLN
|...||||.||||.||||.| |  ||||.||
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLN