Gene CaMK2a (Human)
CaMK2a
Sequence
Protein domains of CaMK2a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | CaMK2a.AA | CAMK2 | 13-271 | 92 | 1.1e-221 | 742.8 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 13-271 Range on HMM: 1-259/259 Sequence Identity: 92% (239 aa) YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADA ||||||||||||||||||||...||||||||||||||||||||||||||||||.|||||||||||||.|||.|||.|||||||||||||||||||||||| YQLFEELGKGAFSVVRRCVKKCTGQEYAAKIINTKKLSARDHQKLEREARICRKLKHPNIVRLHDSIQEEGFHYLVFDLVTGGELFEDIVAREYYSEADA SHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPP |||||||||.| ||||.|.|||||||||||||||.||||||||||||||||.|.|||||||||||||||||||||||||||||.|||||||||||||||| SHCIQQILESVNHCHQNGIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPP FWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI |||||||||||||||||||.|||||||||||||.|||.||||||.|||||.|||||||| FWDEDQHRLYQQIKAGAYDYPSPEWDTVTPEAKNLINQMLTINPKKRITADEALKHPWI |
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| Kinase | CaMK2a.AA | CAMK1 | 13-271 | 43 | 5.70000000001e-150 | 439.18 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 13-271 Range on HMM: 1-276/276 Sequence Identity: 43% (120 aa) YQLFEELGKGAFSVVRRCVKVLA---GQEYAAKIIN-TKKLSARDH---QKLEREARICRL---LKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIV |....|.|.||||.|..|.. |..|| |.|. | .. | ..||.| | . ..||||. ... .. | ||. .||||||||. || YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV AREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVK--LADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK---DPYGKPVDLW ...|.| ||.|...|||.|| ..|..|.|||||||||||...| .. .| .|||||. .... . ||||| |||| .||.|..|.| EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMW ACGVILYILLVGYPPFWDED-QHRLYQQIKAGAYDFPSPEWDTVTPE-AKDLINKMLTINPSKRITAAEALKHPWI .|||.||||.|||||.||. .. |...|| . |.||||.|| . . |||.|..||. .|.||.|....|.|||| SIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | CaMK2a.AA | CAMK | 18-271 | 25 | 2.4e-134 | 435.61 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 18-271
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)
ELGKGAFSVVRRCVKVLAG------------QEYAAKIINTKKLS--------------------------ARDHQKLEREARICRL-------LKHPNI
.||.|.|..|..|. . . |..|.|||..|||. ..| ....|| .|... |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VRLHDSISEEGH-------------------HYLIF---DLVTGGEL----FEDIVAREY---------------YSEADASHCIQQILEAVLHCHQMGV
..|.. . . . |... ....|||| |. ||.... ..|..|.....||..|| .||....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
VHRDLKPENLLLASKLKG--------------AAVKLADFGLAIEVEG-----------------------EQQAWFGFAGTPGYLS-PEVLRK------
|||||||||.|| .. .. . .|..|||.|..... | | | |||.| . ||||..
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM
--------DPYGKPVDLWACGVILYILLVGYPPFWDE-------------DQHRLYQQIKAGAYDFPSPE------------WDTVTPE--------AKD
..||...| |.|||||||.|.|||||... ....|...|..| ||||.|. || .. | .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD
LINKMLTINPSKRITAAEALKHPWI
||.|||. .|.||.|....|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | CaMK2a.AA | RAD53 | 13-271 | 35 | 3.3e-112 | 335.61 | In-house | 1-305 (305) | Show / Hide |
Range on Protein: 13-271 Range on HMM: 1-305/305 Sequence Identity: 35% (109 aa) YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLS---ARD---HQKLEREARICRLLKHPNIVRLHDSISE-EGHHYLIFDLVTGGELFEDIVARE | . .|||.|.|..|..... .| .| |||..||.. .. ...|..| . |.||.|.|..|.. . . |.. |.||||||..||... YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK Y----YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGA---------------AVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR . ..|... |...||. | .| .|||||||| |.... .. ..|..||||. | ||.. . ||| |. |||.. RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFV-GEGSFMKTMCGTPQYVAPEVIT KD---------------PYGKPVDLWACGVILYILLVGYPPFWDE-DQ----HRLYQQIKA-GAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEA . |.| ||.| |.||||.| ||||| |. .| |..||| | | ||.|.|| .. ||||||..||...| ||.|..|| SKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEA LKHPWI | |||. LNHPWM |
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| Kinase | CaMK2a.AA | S_TKc | 13-271 | 36 | 2.1e-109 | 370.66 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 13-271 Range on HMM: 1-231/231 Sequence Identity: 36% (100 aa) YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTG--GELFEDIVAREY---- |.. ...|||||..|..|... |...| |||. ....|| .|.. .|||||.|.|.. . .| |...... | |.||. |. | . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGK-PVDLWACGVIL ..| .| . ..||..|. .||..|..||||||||.|| . .|..||||| .. | ||| |..|||| .||| ..| |.||.|| FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL YILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALK-------HPWI |..|.|||||. ........|. .|||||.|.|.|. .|.||.|| |||. |||. YEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | CaMK2a.AA | CDPK | 13-271 | 39 | 2.6e-109 | 336.39 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 13-271 Range on HMM: 1-271/271 Sequence Identity: 39% (107 aa) YQLFEELGKGAFSVVRRCVKV-LAGQEY-AAKIINTKKLSARDH-QKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFD--LVTGGELFEDIVAREYY |.. ..||||.|..||.... .|| | |||. .... . |.. .| | . | ||||... | ..|... ..||||||. |... .. YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF SEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGA----AVKLADFGLAIEVEGE----QQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWAC .| .|. ..||| || .||. ..|||||||||.|. || ... .|. |.|.. . ... . ..||| |..||||.| | . .|.| | TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSC GVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI ||||||||.|||||. . . ....| | |.| |||| .. ||||||.|||. .| ||..|..||.|||. GVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | CaMK2a.AA | DCAMKL | 13-271 | 38 | 5.8e-103 | 321.2 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 13-271 Range on HMM: 1-279/279 Sequence Identity: 38% (109 aa) YQLFEELGKGAFSVVRRCVKVLAG-QEYAAKI-----------------INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTG ||. |.| |.|| |.. | ..|| || |. .|. | . | .| ...|||.|..|... . | | ||.. .|.| YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGKEHM-IDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQG GELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLAS-KLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKP | ||. |. ..| ||. . .. .| . | |..||||.||||||. . .||.||||| .|.|. . ||| | ||.|.. || GDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILMETGYGCK VDLWACGVILYILLVGYPPFWDE--DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI || || ||||||||.|.||| . || .| || .|...||.|.|| .. |||||..|| .| || || . ..|||. VDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV |
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| Kinase | CaMK2a.AA | Pkinase | 13-271 | 34 | 1.6e-100 | 345.09 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 13-271 Range on HMM: 1-293/293 Sequence Identity: 34% (101 aa) YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLER--EARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGG----ELFEDIV--AR |.. . .|.|.|..|..|... |...| |||. .. . .| . | |..| . |.|||||||.|. ...| |...... || .||. | .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH EYY--SEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLA-SKLKGAAVKLADFGLAIEV-EGEQQAWFGFAGTPGYLSPEVLR-KDPYGKPVDLWAC . || .. ... |||... .||.||..||||||||.|. .| ||..||||| . . .. .|.|||.|..|||.| .||..|| |.| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVILYILLVGYPPFWDE------DQHRLYQQIKAGAYDFPSPEWDTVT-----------------PEAKDLINKMLTINPSKRITAAEALKHPWI |.|||..| |.|||... || ....|. . ..|..|.|... .|.||.|...|. .|.||.||...|.|||. GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | CaMK2a.AA | CAMKL | 13-271 | 34 | 6.2e-95 | 303.39 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 13-271 Range on HMM: 1-297/297 Sequence Identity: 34% (104 aa) YQLFEELGKGAFSVVRRCVK-VLAGQEYAAKIINTKKLS--------------ARDHQKLEREARICRLLK---HPNIVRLHDSISEEGH------HYLI |.. ..||||.|..|. .. . |...| |||. ||.. .| ...||..| ..|. ||||..|.. | . | ||. YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV FDLVTGGE--LFEDIVAREY----YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIE---V-EGEQQAWFGFAGTPG .. ||| ||. ||.... .| .| . .||..|| .||..|.||||.||||.|| .. . .|..|||.... . |. | | |.| MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP YLSPEVLRK--DPYG-KPVDLWACGVILYILLVGYPPFWDE--------DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALK | .||.. . .|| ..|| |.|||||| ...|| || |. .. .|| .|. | | .| | | ...||| |||. ||.||.|. . .. YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN HPWI ||| HPWM |
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| Kinase | CaMK2a.AA | CAMK-Unique | 13-271 | 24 | 7e-92 | 303.6 | In-house | 1-363 (363) | Show / Hide |
Range on Protein: 13-271
Range on HMM: 1-363/363
Sequence Identity: 24% (88 aa)
YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLS-ARDHQ-----------------KLEREARICRLLKHPNIVRLHDS----ISEEG-------
| . . .|.|.|..|..| | ..| |... .. . . .| ||.||..| ....||||..| | .
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI
--------HHYLIFDLVTGGELFEDIVA--------------------REYYSE--ADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLK-----
. |.. ....||.||. |.. . ..|| .|.. .|..|.|| . |. ..||||||.||... . .|
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH
--------GAAVKLADFGLAIEVEGEQQA--WFGFAGTPGYLSP--------------EVLRKDPYGKPV----DLWACGVILYILLVGYPPFWDEDQH-
.||.||||. .... . . ||| |..| ||. ..|. .. |.|..|||.|..|.|.||| |.
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR
-------RLYQQIKAGAY-DFPSPEWDT---VTPEAKDLINKMLTINPSKRITAAEALKHPWI
.... |..| | .|... |. ...||||.. . .|. |..|..|.|.|.|.||
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
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| Kinase | CaMK2a.AA | RSK | 15-271 | 33 | 2e-90 | 306.7 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 15-271 Range on HMM: 1-278/278 Sequence Identity: 33% (93 aa) LFEE--LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH-QKLER-EARICRLLK-HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY--- | . .|.|.....|.|. .||.|| |... .|. .|. .. . | .| . . ||.||.||.. .||. ||| ... |||||. . ... LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKG-AAVKLADFGLAIE-VEGEQQAWFGFAGTPGYLSPEVLR---KDP-YGKPVDLWACG || .|. . .| || | || |..|||||||| |.... . . .|| |||.. . . . | | .| |. ||.|. .. ..| .|.| | FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG VILYILLVGYPPFWD---EDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRIT-----AAEALKHPWI |..| .|.|.||| .... . ..|. | .....|.|.....||||||.|||. .|.||.. |.| ..|||. VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | CaMK2a.AA | Ciliate-E2 | 13-271 | 24 | 4.6e-87 | 295.55 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 13-271
Range on HMM: 1-365/365
Sequence Identity: 24% (94 aa)
YQLFEELGKGAFSVVRRCVKVL-----------------------AGQEYAAKIINTKKLSARDH-QKLEREAR----------ICRLLKHPNIVRLHDS
| . . .|.|.|..|..| . . ....|| ||.. ... . ... || . |...|.||||......
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
IS--EEGHHYLIFDLVTGGELFEDIV------------AREYYSEADASHCIQQILE---------------AVLHCHQMG-VVHRDLKPENLLLASKLK
. . ||..... ||.||. | . .|..| ... ..|||. |. ..|. . ..|||.||||.|.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----
GAAVKLADFGLAIEVEGE-------------------------------QQAWFGFAGTPGYLSPEVLRKDP---------YGKPVDLWACGVILYILLV
.|..||||. .. . |. . ..|||||..||.|.. . |.. .|.|..|||||..|
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF
GYPPFWDEDQHRLYQQIKAGAYDFPSPE--------------WDTVTPEAKDLINK----MLTINPSKRIT-AAEALKHPWI
|.||| .|||| . .|||.|| |. ...|.||||.| || .|.|||| . ..|.|||.
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | CaMK2a.AA | TyrKc | 13-271 | 20 | 6.5e-15 | 18.46 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 13-271 Range on HMM: 1-280/280 Sequence Identity: 20% (59 aa) YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLL--KHPNIVRLHDSISEE-------GHHYLIFDLVTGGELFEDIVA .| ..|| ||| .|.... .. | | .. . .. . ||||| . | .|||||||. .... . ..... .. .| | . . . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK REY-YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGE-----QQAWFGFA---GTPG-----YLSPEVLRKDP .. . .| . || . . |.....|||| | |..... || .||||. ... . . . |. . ..||.... HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK YGKPVDLWACGVILY-ILLVGYPPFWD-----EDQHRLYQQIKAGAYDFPSPE-----WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI . | |. || .. |. | .| .. . ......|.| . . |. . ..| ... . .|..| | .| | . FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | CaMK2a.AA | Pkinase_Tyr | 13-97 | 24 | 1.4e-08 | 29.72 | Pfam | 1-94 (270) | Show / Hide |
Range on Protein: 13-97 Range on HMM: 1-94/270 Sequence Identity: 24% (23 aa) YQLFEELGKGAFSVVRRCVKV----LAGQEYAAKIINTKKLSARD--HQKLEREARICRLL-KHPNIVRLHDSIS-EEGH--HYLIFDLVTGGEL .. ..||.||| .|.... ... | |.. . . .. .... |||.| . | .|||||||. .. .... .|... .. .| | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL |
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| Kinase | CaMK2a.AA | Pkinase_Tyr | 127-166 | 32 | 0.230861 | 5.24 | Pfam | 128-164 (270) | Show / Hide |
Range on Protein: 127-166 Range on HMM: 128-164/270 Sequence Identity: 32% (13 aa) HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGE .... .|||| | |... . || .||||| .. . ESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYND |
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| CaMKII_AD | CaMK2a.AA | CaMKII_AD | 357-484 | 64 | 2.9e-92 | 317.61 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 357-484 Range on HMM: 1-128/128 Sequence Identity: 64% (83 aa) RKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPR .||||.||||..||||..||...|||.|.|.||.||.||.||||||..|||||||..|....|.||||.||||.|..||..||.||.|.|||.| |... EKQEIWKVTERWIEAIYCGDWHTYTKLCHPDMTCFEWEACGNLVEGMEFHRFYFEMHWTKRCKAVHTTMLNPHVHMYGDDAACCAYVRLTQYMDKNGMAH TAQSEETRVWHRRDGKWQIVHFHRSGAP |.|||||||||.||||||.||.|||..| TRQSEETRVWHKRDGKWQCVHHHRSAMP |
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