Gene CASK (Human)

CASK

Species: Human
Alias: LIN2, CASK, hCASK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: Xp11.3-p11.4,

Classification

Group: CAMK
Family: CASK

Sequence

Name Sequence Type Origin Length Description Download
CASK.AA Protein Sugen Kinome 926 None Fasta, JSON
CASK.kin_dom Protein Kinase Domain Sugen Kinome 265 None Fasta, JSON
CASK.NA RNA Sugen Kinome 8282 None Fasta, JSON

Protein domain

Protein domains of CASK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CASK.AA CASK 12-276 58 5.1e-210 688.3 In-house 1-330 (330) Show / Hide 
Range on Protein: 12-276
Range on HMM: 1-330/330
Sequence Identity: 58% (193 aa)

YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPG-----LSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKR
|..|.|..||||..|||||.||..|...||||||.|||..||     |.|||.||||.|||.||||||.||..||.||.|.|||||||.|.|.|||||.|
YYMCQVMEKGPFCHVRRCIHRESNQHCVVKIVDVNKFTQHPGGFGIALPTEDIKREARICHCLKHPHICELCRTYNSDHMRYMVFEFMEGNDVCFEIVQR

----ADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKEN-------------------------------------SAPVKLGGFGV
    |.|||||||.||.||||||||||.|||....|||||.|||...|||.|                                     ||||||.||||
GLGPAKAGFVYSEYVACHYMRQILEALMYCHQWDHIHRDVRPHCRVMASKDNRQRITVEEALAHPWLRERDKFAPKVHLLETVEELKKFSAPVKLCGFGV

AIQLGES-------------------GLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHIS
||||...                   ...|.||||.|||||||||.|||||.|.|.|||||.|||||||||||.|||.||||.|.||.|.|.||.|.|||
AIQLSHKFTSFYSDPNTKHITDFADEDPMACGRVGCPHFMAPEVVRREPYGCPCDIWGCGVMLFILLSGCLPFFGTKDRLFEMIMKGRYDMDPRYWPHIS

ESAKDLVRRMLMLDPAERITVYEALNHPWL
||||||||||||.||..||..||||||||.
ESAKDLVRRMLMADPHHRISIYEALNHPWI
Kinase CASK.AA CAMK 17-276 24 8.99999999999e-118 381.24 In-house 1-425 (425) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-425/425
Sequence Identity: 24% (104 aa)

VIGKGPFSVVRRCINRETG------------QQFAVKIVDVAKFTSS-----------------------PGLSTEDLKREASICHM-------LKHPHI
..|.| |..|..||...|.            |..|.||.|  | ...                        . . . ..|| .|. .       |.||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VELLETYS------------SDGM--------LYMVF---EFMDGADLCFEIVKRADAG---------------FVYSEAVASHYMRQILEALRYCHDNN
. |.|.|             .  .        .|||.   |...| .|....  .  .                . ..|. |..|.|||..|..|||..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDVKPHCVLLASKENS--------------APVKLGGFGVAIQLGES-----------------------GLVAGGRVGTPHFMA-PEVVKR-----
|.||| ||  .|| .....              ...|.  || |... ..                       |     ..|||..|| |||...     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EPYGKPVDVWGCGVILFILLSGCLPFYG--------------TKERLFEGIIKGKYKMNPRQ------------WSHISES--------AK
         ..||...|.| |||||.|.|.|..||||              . ..||| |.|||| . | .            |..||..        .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLVRRMLMLDPAERITVYEALNHPWL
||.|.||  || .|.|. ..|||||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CASK.AA CAMK1 12-276 35 4.3e-105 306.44 In-house 1-276 (276) Show / Hide 
Range on Protein: 12-276
Range on HMM: 1-276/276
Sequence Identity: 35% (101 aa)

YELCEVIGKGPFSVVRRCINRET---GQQFAVKIVDVAKFTSSPGLST----EDLKREASICH---MLKHPHIVELLETYSSDGMLYMVFEFMDGADLCF
||. ..||.| ||.|..|...||   |.|.|.|. |     ..   ..    | |..| .| .    ..||.|. . | | ||  .|.| | . | .|  
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK---KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFD

EIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVK--LGGFGVAIQLGESGL-VAGGRVGTPHFMAPEVVKR---EP
 ||..     .|.|  |.| |.|||.|. |.|...| ||| ||   |...|.. ...|  .  || . ... ..  .   ..||| ..||||...   .|
RIVEKG----NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFD-HDENLMKTACGTPGYVAPEVLECKKDKP

YGKPVDVWGCGVILFILLSGCLPFYGTK-E-RLFEGIIKGKYKMNPRQWSHISES-AKDLVRRMLMLDPAERITVYEALNHPWL
|.|..|.|..|||..||| |. |||.   .  ||| |.|..| .   .| .||.. |||... || .|| .|.|....|||||.
YDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase CASK.AA S_TKc 12-276 36 7.50000000001e-103 348.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-276
Range on HMM: 1-231/231
Sequence Identity: 36% (102 aa)

YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDG--ADLCFEIVKRADA
||. ..|||| |..|..|....||...|.||..            |...|| .|... .||.|| |.... . . ||||.|..||   ||   |.||   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G--FVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGK-PVDVWGCG
|  |...| .| .||.||..|| |||...|||||.||  .|| .      .|.. ||.| ||          .|||..|||||.   .||| ..|.| ||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

VILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALN-------HPWL
.||...|.|. ||. . ...|. |               |..|||..|..|  ||..|.|. |||.       |||.
CILYEMLCGYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CASK.AA CAMK2 12-276 45 2e-87 296.73 In-house 1-259 (259) Show / Hide 
Range on Protein: 12-276
Range on HMM: 1-259/259
Sequence Identity: 45% (122 aa)

YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGF
|.| | .||| |||||||..  ||| .| ||..  | .         | ||| || .|||| || | .  . .|  |.||. . | .|  .|| |     
YQLFEELGKGAFSVVRRCVKKCTGQEYAAKIINTKKLSA---RDHQKLEREARICRKLKHPNIVRLHDSIQEEGFHYLVFDLVTGGELFEDIVARE----

VYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFI
 |||| ||| ..||||.. .|| |.|.|||.||  .|||||   | |||  ||.|| . .      |  ||| ...|||....|||||||.| |||||.|
YYSEADASHCIQQILESVNHCHQNGIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYI

LLSGCLPFYGT-KERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWL
|| |  ||.   . ||.. |  | |      |  .   ||.|. .|| ..|. |||  ||| |||.
LLVGYPPFWDEDQHRLYQQIKAGAYDYPSPEWDTVTPEAKNLINQMLTINPKKRITADEALKHPWI
Kinase CASK.AA RAD53 12-276 31 1.4e-86 257.89 In-house 1-305 (305) Show / Hide 
Range on Protein: 12-276
Range on HMM: 1-305/305
Sequence Identity: 31% (97 aa)

YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFT---SSPGLSTEDLKREASICHMLKHPHIVELLETYSS-DGMLYMVFEFMDGADLCFEIVKRA
| . ...|.| |..|.......|.|..|.||.|  ||.   ..   ..... .|. |   |.|| |..... . . .  .||| |.|.| .|   || . 
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

DAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSA---------------PVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVK
     ..|. .  | .|...|..| |||.|.||| ||  .|.....                   .|.  || .  .|| | ..    ||| . ||||. 
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGE-GSFMKTMCGTPQYVAPEVIT

---R------------EPYGKPVDVWGCGVILFILLSGCLPFY-GTK-----ERLFEGIIK-GKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEA
   .            . |.| ||.|  |.||.|.|.| .||  . .       ||| |.. |||   . .|. |||.||||...|| .|| .|.|. ||
SKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEA

LNHPWL
|||||.
LNHPWM
Kinase CASK.AA Pkinase 12-276 30 8.7e-86 296.1 Pfam 1-293 (293) Show / Hide 
Range on Protein: 12-276
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLK-REASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGA----DLCFEIVKR
|.. ..||.| |..|..|... ||...||||...   . ...   .... .|..| ..|.||.||.|.... ... .|||.|...|     ||. .....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYIST

ADAGFVY--SEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLA-SKENSAPVKLGGFGVAIQL-GESGLVAGGRVGTPHFMAPEVVK-REPYGKPVD
 ... ..  || .. .||.|||..| |||...|||||.||  .|.    ...|.||.. ||.| |.   ..  . ...|||..|||||.. ...||..||
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWGCGVILFILLSGCLPFYGT-------KERLFEGIIKGKYKMNPRQWSHIS-----------------ESAKDLVRRMLMLDPAERITVYEALNHPWL
.|.||.||...|.| .||.|        .  ... | ..... .  .|. ||                 |..||.....| .||..|.|  ..|.|||.
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CASK.AA CAMK-Unique 12-276 24 7.1e-83 273.4 In-house 1-363 (363) Show / Hide 
Range on Protein: 12-276
Range on HMM: 1-363/363
Sequence Identity: 24% (88 aa)

YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLS---------------TEDLKREASICHMLKHPHIVELLET----YSSDG-------
|.. ..||.| |..|..|..||||  .|.|.|  ..  .. ..                   ||||..|  |..||.|..|...    .  .        
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------MLYMVFEFMDGADLCFEIVKR----------------ADAGFVYSE--AVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKEN-----
         .|.| |. .| ||  .|.|.                 .   ..||  . .. .|...|.|. | |...|.||| |.  ... . ..     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------SAPVKLGGFGVAIQLGESGLVA--GGRVGTPHFMAP--------------EVVKREPYGKPV----DVWGCGVILFILLSGCLPFYGTKER-
           .||  || . .. ..   .    ..||| .|||              ||... .|. ..    | | .|||....|.||.||... |  
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

--------LFEGIIKGKY-KMNPRQWSH---ISESAKDLVRRMLMLDPAERITVYEALNHPWL
        .|| | ||.| .   ..|.    ||..|||.| . . .||. |..  |.| |.|.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase CASK.AA CAMKL 12-276 31 1.7e-78 250.05 In-house 1-297 (297) Show / Hide 
Range on Protein: 12-276
Range on HMM: 1-297/297
Sequence Identity: 31% (95 aa)

YELCEVIGKGPFSVVRRCIN-RETGQQFAVKIVDVAKFTSSPGLSTED----------LKREASICHMLK---HPHIVELLETYSSDGM------LYMVF
|......||| |..|. ... | ||.. |.||.|  | .  |  .  .          ..||..|  ||.   ||.|. |.|..  . .      .|.| 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFMDGAD--LCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE----SGLVAGGRVGTPHF
|  .| .  |   |||. . .   .|  | .| |||..|. |||...|.||| ||  .|| .. |.  .|.  || ...  .    .|     . |.|..
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

MAPEVVKR--EPYG-KPVDVWGCGVILFILLSGCLPFYGT---------KERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNH
||||....  .||  ..||.| |||||. .. | ||| .          . .|.. |..| |....  |.|.| ...|| |.||. .| .|.|. . .||
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPI--WYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWL
||.
PWM
Kinase CASK.AA CDPK 12-276 35 3.7e-78 239.36 In-house 1-271 (271) Show / Hide 
Range on Protein: 12-276
Range on HMM: 1-271/271
Sequence Identity: 35% (100 aa)

YELCEVIGKGPFSVVRRCINR-ETGQQF-AVKIVDVAKFTSSPGLSTED----LKREASICHMLKHPHIVELLETYSSDGMLYMVFE--FMDGADLCFEI
| . .|.||| |..||.....  |.|.  |.||.   .      .. ..    ...|  |   | ||.|. . |.|  .   | |.|  .  | .| |. 
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSR------VKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGEL-FDY

VKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSA----PVKLGGFGVAIQLGES----GLVAGGRVGTPHFMAPEVVKREP
.  .. |  ..|  |. .||||| |. |||.|||.|||.||  .|. ||....    ..|.  .| . . . .    . .   |.|||. .|||| ..  
I--IEKGH-FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-

YGKPVDVWGCGVILFILLSGCLPFYGT-KERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWL
| . .|.| |||||.|||.|  ||||   .  .| . ||||... ..|.|||..||||.|.||  ||  |..  .||.||| 
YNEKCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase CASK.AA RSK 14-276 30 1.2e-71 244.35 In-house 1-278 (278) Show / Hide 
Range on Protein: 14-276
Range on HMM: 1-278/278
Sequence Identity: 30% (87 aa)

LCEV--IGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLK-HPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAG
| .   .|.| ....|.|... |||..|.|... ||.  .   .|.. ..| .|  . . || ||.| ...  .| ||.. |.. | .|   . |.   |
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQ-KDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG

-FVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENS-APVKLGGFGVAIQ-LGESGLVAGGRVGTPHFMAPEVVK---REP-YGKPVDVW
 |  ||  |. ||..|  |... |.  ||||| ||  .|..... . . .||  || . |   . .  .   ..| ..||||..|   ..  ..| .|.|
CF--SEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWW

GCGVILFILLSGCLPFYG----TKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERIT-----VYEALNHPWL
  ||... .|.||.||.|    ... ... | |||. ..   |. .|. ||||.|.||. ||. |..     . | ..|||.
SLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase CASK.AA Ciliate-E2 12-276 22 2.4e-70 240.03 In-house 1-365 (365) Show / Hide 
Range on Protein: 12-276
Range on HMM: 1-365/365
Sequence Identity: 22% (85 aa)

YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSP--------------GLSTEDLKREASICHMLK-------------------HPHIVELL
|.. ..||.| |..|..| ......||| || |  |  ...               ..  ...   .. |...                   ||.|... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

ETYS--SDGMLYMVFEFMDGADLCFEIVKR---------ADAGFVYSEAVASHYMRQILE---------------ALRYCHDNN-IIHRDVKPHCVLLAS
|..   .|  .|.|.|. .| ||   | ..           .   ..|  ....|.|||.               ||.|.| .| ||||| ||  .|.  
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

KENSAPVKLGGFGVAIQLGES----------GLVAGGR----------------------VGTPHFMAPEVVKREP---------YGKPVDVWGCGVILF
      .|.  || . .. ..          ..    .                      .|||..||||......         |.. .|.| .||||.
------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

ILLSGCLPFYGTKERLFEGIIKGKYKMNPR--------------QWSHISESAKDLVRR----MLMLDPAERIT-VYEALNHPWL
..|.| .||       .. |...|.. ..                | ..|...||| ..    ||  || .|||   ..|||||.
EMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CASK.AA CASK 277-339 52 4e-23 71.62 In-house 168-232 (330) Show / Hide 
Range on Protein: 277-339
Range on HMM: 168-232/330
Sequence Identity: 52% (34 aa)

KERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDP-PEELPDFS-EDPTSSG
.|||..| |.|| |||| |.||.|..||.|...|.. |||| ||| ||    . ||  |||...|
RERDKFAPKVHLLETVEELKKFSAPVKLCGFGVAIQLSHKFTSFYSDPNTKHITDFADEDPMACG
Kinase CASK.AA TyrKc 12-276 21 9.8e-14 -0.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-276
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHML--KHPHIVELLETYSSD-------GMLYMVFEFMDGADLCFE
 .| ...| | | .|.... .   .| ||| .   .         ||. |||.| ..|  .||.|| |.   ...       . |..|.|.|.. ||   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGES-------GLVA-----GGR-VGTPHFMAPE
. |. .     . .   ... || .  .| |..|.||||     .|....     || . || .  ...                 ||. .     ||||
LRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VVKREPYGKPVDVWGCGVILFILLSGCLPFYGT-------KERLFEGIIKGKYKMNPRQ-----WSHISESAKDLVRRMLMLDPAERITVYEALNHPWL
. .   .    |||  || .. ... . . |          ....| . .|.. . |         . ..   .. ..  . ||..| |  |   |  .
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CASK.AA Pkinase_Tyr 12-99 27 3.9e-08 28.16 Pfam 1-94 (270) Show / Hide 
Range on Protein: 12-99
Range on HMM: 1-94/270
Sequence Identity: 27% (26 aa)

YELCEVIGKGPFSVVRRCINR----ETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHML-KHPHIVELLETYS-SDGM--LYMVFEFMDGADL
 .. ...|.| | .|.... .    .|... |||..     .... .  ||. |||.| . | .||.|| |.   .  ..   .|.|.|.| . ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
L27 CASK.AA L27 346-401 32 2e-18 71.1 Pfam 1-56 (56) Show / Hide 
Range on Protein: 346-401
Range on HMM: 1-56/56
Sequence Identity: 32% (18 aa)

AVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNP
||..||. ||....|......||..|. ..|..|.|.||...||...|. .. ...
AVQRVLELLEQLQSLSEHHPEDLQELQQILQSPHMHSLLQVHDKVACKVYDPPSPE
L27 CASK.AA L27 346-401 29 1.9e-16 61.89 SMART 1-62 (62) Show / Hide 
Range on Protein: 346-401
Range on HMM: 1-62/62
Sequence Identity: 29% (18 aa)

AVSQVLDSLEEIHALTDCSE---KDLDFLHSVFQD---QHLHTLLDLYDKINTKSSPQIRNP
||..|...|||........|   .||..|. ..|.   .|.|.||...||. .. . . . |
AVQRVYEVLEELQSHLQHHEDMQEDLQELRQILQSMFMPHFHALLKIHDKVACTKYQPPPPP
L27 CASK.AA L27 405-458 42 3.8e-19 73.69 Pfam 1-56 (56) Show / Hide 
Range on Protein: 405-458
Range on HMM: 1-56/56
Sequence Identity: 42% (24 aa)

AVQRAKEVLEEISCYPEN--NDAKELKRILTQPHFMALLQTHDVVAHEVYSDEALR
||||..|.||..... |.  .|..||..||..||...|||.||.||..|| ... .
AVQRVLELLEQLQSLSEHHPEDLQELQQILQSPHMHSLLQVHDKVACKVYDPPSPE
L27 CASK.AA L27 405-458 40 3.6e-18 67.62 SMART 1-62 (62) Show / Hide 
Range on Protein: 405-458
Range on HMM: 1-62/62
Sequence Identity: 40% (25 aa)

AVQRAKEVLEEISCYPEN-----NDAKELKRILTQ---PHFMALLQTHDVVAHEVYSDEALR
||||..|||||... ...     .|..||..||..   |||.|||..||.||...| ..  .
AVQRVYEVLEELQSHLQHHEDMQEDLQELRQILQSMFMPHFHALLKIHDKVACTKYQPPPPP
PDZ CASK.AA PDZ 490-568 23 5e-23 81.46 Pfam 1-86 (86) Show / Hide 
Range on Protein: 490-568
Range on HMM: 1-86/86
Sequence Identity: 23% (20 aa)

LVQFQKN-TDEPMGITLKMNELN----HCIVARIMHG-GMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRG-SITFKIV
.|...|. . ...|...|... .    .......|.| |...|.| .|.|| | .||| ...| |... ...... .| ... .| 
QVTLEKQDKRGGLGFSIKGGNDQRHDQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ
PDZ CASK.AA PDZ 499-571 23 2.2e-16 61.65 SMART 1-80 (80) Show / Hide 
Range on Protein: 499-571
Range on HMM: 1-80/80
Sequence Identity: 23% (20 aa)

EPMGITLKMNELNHCIVARIMHGGMIHRQGT-----LHVGDEIREING-ISVANQTVEQLQKMLREMRG-----SITFKIVPSY
...|....     .........||  .. |.     |..||.| |.|| ..| | | || ..||.. .|     ..|.....  
GGLGFSIVG----GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
SH3_2 CASK.AA SH3_2 616-680 27 3.3e-16 59.65 Pfam 1-68 (68) Show / Hide 
Range on Protein: 616-680
Range on HMM: 1-68/68
Sequence Identity: 27% (20 aa)

YVRAQFEYDP-AKDDLIPCKEAGIRFRVGDIIQII---SKDDHNWWQG-KL--ENSKNGTA--GLIPSPELQEW
|.|. ..|.| .. . ..  |....|..||.| .|   .||..|||..     .    |..  |..||  ..|.
YYRVHCDYVPATYCNENH--EPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWG----GRRMRGWFPSQWVEEC
SH3 CASK.AA SH3 615-681 31 7.1e-15 56.66 SMART 1-58 (58) Show / Hide 
Range on Protein: 615-681
Range on HMM: 1-58/58
Sequence Identity: 31% (21 aa)

IYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWR
 ||||.. |..       . .  . |. ||||....||| .||.|.. .  .|  |..||  ..| .
PYVRALYDYQA-------QNPDELSFKKGDIITVLEKDDDGWWKGRCNR--TGQEGWFPSNYVEEID
SH3_1 CASK.AA SH3_1 640-674 44 2.8e-09 34.4 Pfam 16-49 (49) Show / Hide 
Range on Protein: 640-674
Range on HMM: 16-49/49
Sequence Identity: 44% (16 aa)

FRVGDIIQIISKDDH-NWWQGKLENSKNGTAGLIPS
|. ||||..|.|.|  .|| |.. |.  |  |..||
FKKGDIIHVIEKSDDWDWWKGRCNNT--GQEGWFPS
Guanylate_kin CASK.AA Guanylate_kin 738-913 36 1.1e-82 284.42 Pfam 1-198 (198) Show / Hide 
Range on Protein: 738-913
Range on HMM: 1-198/198
Sequence Identity: 36% (73 aa)

KRKTLVLLGAHGVG---RRHIKNTLITKHPDRF-A-YPIPHTTRPPKKDEENGKNYYFV-SHDQMMQDISNNEYLEYGS-HEDAMYGTKLETIRKIHEQG
.....||.|..|||   ..|||..|...||..| . |..||||||| ..|..|| |.|| |...|. .|.|.|..|... ... ||||..||||.|||||
QMRPIVLSGPSGVGYEVKSHIKKALWDEHPHKFDGRYCVPHTTRPPRPGEVDGKHYHFVSSREEMWNMIQNHEFIEWAQVFNGNMYGTSKETIRQIHEQG

LI---AILDVE-PQALKVLRTA-EFAPFVVFIAAPTITPGLNE-----DESLQRLQKESDILQRTYAHY-----FDLTIINNEIDETIRHLEEAVELV
 |   .|||.. .|..|.||.. |..|..|||..|. .  . .     .|... ..|... .. ...||     ||. |.|...|... ||.|..|  
KIMQLCILDIDTWQGVKQLRKTYELHPIMVFIKPPSMQELQRRLRCRNTEQEEKINKRMEAAEQEMQHYDEPGMFDYIIVNDDFDKAYWHLKEILEAE
GuKc CASK.AA GuKc 738-914 34 2.5e-79 270.76 SMART 1-203 (203) Show / Hide 
Range on Protein: 738-914
Range on HMM: 1-203/203
Sequence Identity: 34% (70 aa)

KRKTLVLLGAHGVGRRHIKNTLITKHPD--RFAYPIPHTTRPPKKDEENG--KNYYFVS-HDQMMQDISNNEYLEYGSHEDA-MYGTKLETIRKIHEQGL
.|...||.|..|||....|..|. ..||  .|....|||||||.. |.||  . |.||| ...|.|.|..|..||.|..... .|||..||.|..|||| 
HRRPIVLSGPSGVGKSTLKHMLMQEYPDYPKFEFSVPHTTRPPRPGEVNGCVVDYHFVSLKEEMEQMIKHNKFLEWGEYHGNLYYGTSKETVRQVHEQGK

IAILDVEPQALKVLRTA----EFAPFVVFIAAPTITPGLNEDES--------LQRLQKESDI-LQRTYAHY------FDLTIINNEIDETI-RHLEEAVE
..|||..||....||.|    .| |.|.||..|..  .......        ..|.||...   |....||      ||..|.|....... ..| |..|
HCILDIDPQGVRQLRYARRYSYFYPIVIFIKPPSMEELEERLRQPCQRGTETEERIQKRLAHQAQKEMQHYPKCHHEFDYVIVNDDLEDACYKELKEIME

LVC
. .
QEQ