Gene CCK4 (Human)
CCK4
Sequence
Protein domains of CCK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| IGc2 | CCK4.AA | IGc2 | 44-108 | 21 | 1.5e-08 | 35.65 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 44-108 Range on HMM: 1-56/56 Sequence Identity: 21% (14 aa) LQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVT ..|. . |.|.... . |. | |.. ...|.. | . |||. .|.|| . HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------WNWTLTIKNVT-PEDSGYYTCYARNPWG |
|||||||||
| IG | CCK4.AA | IG | 38-122 | 16 | 3.3e-05 | 24.56 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 38-122 Range on HMM: 1-58/58 Sequence Identity: 16% (15 aa) PSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDS---GTFQCVARDDVTGEEARS-ANASFNIK |. . . | .. |.| |. ...|. | . | ...|| ||..|.|. . .. | .. .. PP-VTVKEGETVTLTC-VS-----QIWWY------------------LTI-NV-QPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ |
|||||||||
| I-set | CCK4.AA | I-set | 32-77 | 27 | 0.011563 | 11.55 | Pfam | 1-47 (92) | Show / Hide |
Range on Protein: 32-77 Range on HMM: 1-47/92 Sequence Identity: 27% (13 aa) IVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQD-TER .|...|... . | .| . |.|. | | |. ||.|.. ..| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDR |
|||||||||
| V-set | CCK4.AA | V-set | 31-65 | 13 | 0.698545 | 4.87 | Pfam | 1-45 (128) | Show / Hide |
Range on Protein: 31-65 Range on HMM: 1-45/128 Sequence Identity: 13% (6 aa) AIVFIK-QPS----SQDALQGRRALLRCEVE----APGPV-HVYW ... .|. . . .| ...|.| . .... ..|| QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYW |
|||||||||
| IGc2 | CCK4.AA | IGc2 | 141-207 | 31 | 3e-14 | 54.6 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 141-207 Range on HMM: 1-56/56 Sequence Identity: 31% (21 aa) QPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFG .. ..|||.|. .| | |. .|.. |.||. .. ||.... ||.||.|.| | .. | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
|||||||||
| I-set | CCK4.AA | I-set | 128-217 | 27 | 4.2e-12 | 43.59 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 128-217 Range on HMM: 1-92/92 Sequence Identity: 27% (26 aa) PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKE---RNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTL |.....| . .|.| ... |...|.| |. .||.|| ||. . | .. .. || . . |. .| |.| | ||.| .. . | PKFTQKP-KDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
|||||||||
| IG | CCK4.AA | IG | 135-220 | 17 | 2e-08 | 35.23 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 135-220 Range on HMM: 1-58/58 Sequence Identity: 17% (16 aa) ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHS---GLYSCCAHSAFGQACSSQ--NFTLSIA . . .. |||.| . ...|. ||. .. ||.| | | | |. . .. ..||.. PP-VTVKEGETVTLTC-VS-----QIWWY---------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ |
|||||||||
| V-set | CCK4.AA | V-set | 128-200 | 17 | 0.003773 | 12.69 | Pfam | 1-110 (128) | Show / Hide |
Range on Protein: 128-200 Range on HMM: 1-110/128 Sequence Identity: 17% (19 aa) PVVLKH-PAS----EAEIQPQTQVTLRCHIDGHP----RP-TYQWFR-DGT--------------PLSDGQSNHTVSSKERN------------LTLRPA ..... | . . . |. . |||.|| . .. ...|.| . ..|... . . |.| ||.. . QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL GPEHSGLYSC |..|| | | QPSDSGTYYC |
|||||||||
| IG | CCK4.AA | IG | 231-320 | 15 | 4.7e-07 | 30.69 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 231-320 Range on HMM: 1-58/58 Sequence Identity: 15% (15 aa) PQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNA---GIYRCIGQGQRGPPIIL--EATLHLA |. |.| . | . ..| .| ...|. | . .|.| .. |.|.| . . . ..||. PP-VTVKEGETVTLTC-VS-----QIWWY--------------------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ |
|||||||||
| I-set | CCK4.AA | I-set | 225-302 | 26 | 6.4e-07 | 26.0 | Pfam | 1-76 (92) | Show / Hide |
Range on Protein: 225-302 Range on HMM: 1-76/92 Sequence Identity: 26% (22 aa) ARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLR--RATVFANG----SLLLTQVRPRNAGIYRCI ... |.||.| | | | || . .|||. .|. . |... . | . ..| .| ..| |. .|.|.|. PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKD-GQPLRP-------DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCV |
|||||||||
| IGc2 | CCK4.AA | IGc2 | 237-308 | 18 | 4.1e-05 | 23.94 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 237-308 Range on HMM: 1-56/56 Sequence Identity: 18% (13 aa) ARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG . . . | .. | |. .|.. ..|. |..| .. |.| .|.|.|.... | HEGQSVTLTCPATGNPDPNIHWYK--GQPLP--------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
|||||||||
| V-set | CCK4.AA | V-set | 225-301 | 14 | 0.003047 | 13.01 | Pfam | 1-110 (128) | Show / Hide |
Range on Protein: 225-301 Range on HMM: 1-110/128 Sequence Identity: 14% (16 aa) ARVVLA--PQ----DVVVARYEEAMFHCQFS-----AQPPPSLQWLF-EDE--------------TPITNRSRPPHLR--RATVFANGS-----LLLTQV . .| . | |.|.. . . ..|..| ... ...| . . .. ........ | |...|.| | .... QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL RPRNAGIYRC .| |.| | QPSDSGTYYC |
|||||||||
| I-set | CCK4.AA | I-set | 347-408 | 29 | 1.1e-12 | 45.6 | Pfam | 25-92 (92) | Show / Hide |
Range on Protein: 347-408 Range on HMM: 25-92/92 Sequence Identity: 29% (20 aa) KGLPEPSVWWEHAGVRLPT---HGRVYQKG---HELVLANIAESDAGVYTCHAANLAGQRRQDVNITV .| |.|.| | . | |.. . .. ..| . | |. .|.|.||| | | .|. ... || TGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
|||||||||
| IGc2 | CCK4.AA | IGc2 | 334-398 | 30 | 7.1e-08 | 33.4 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 334-398 Range on HMM: 1-56/56 Sequence Identity: 30% (20 aa) TAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAG | . || | |.|.. | . | .|| .. .| . |....|.|.||| | | .| HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP-------WNWTLTIKNVTPEDSGYYTCYARNPWG |
|||||||||
| IG | CCK4.AA | IG | 328-409 | 18 | 4.6e-07 | 30.71 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 328-409 Range on HMM: 1-58/58 Sequence Identity: 18% (16 aa) FEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDA---GVYTCHAANLAGQRRQ--DVNITVA . . .|. . || . ..|| |.. |. ..|. |.|.| | .|| . ...|| PP-VTVKEGETVTLTC-VS------QIWWY------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
|||||||||
| V-set | CCK4.AA | V-set | 376-408 | 29 | 0.089357 | 7.95 | Pfam | 95-128 (128) | Show / Hide |
Range on Protein: 376-408 Range on HMM: 95-128/128 Sequence Identity: 29% (10 aa) LVLANIAESDAGVYTCHAANL-AGQRRQDVNITV | . |. .|| |.|.| . | .. . .. || LTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV |
|||||||||
| I-set | CCK4.AA | I-set | 412-498 | 26 | 1.4e-14 | 52.03 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 412-498 Range on HMM: 1-92/92 Sequence Identity: 26% (24 aa) PSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISE-DSRFEVFKNG----TLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQV |. ..||.| . ||. ..| . .|.|.|.|... ... ..|. . .| ||.| |. | |.| . ..|. |. |...| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
|||||||||
| IG | CCK4.AA | IG | 418-499 | 17 | 4.6e-09 | 37.36 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 418-499 Range on HMM: 1-58/58 Sequence Identity: 17% (15 aa) PQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDG---TWYRCMSSTPAGSIEA--QARVQVL |. || . | | . .. || |.| .|.. | |.|. . .|.... ....|. PP-VTVKEGETVTLTC-VS-----QIWWY-------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
|||||||||
| IGc2 | CCK4.AA | IGc2 | 424-488 | 27 | 9e-05 | 20.61 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 424-488 Range on HMM: 1-56/56 Sequence Identity: 27% (18 aa) EEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAG .|| . | | . | |.. ||. .. .|.||.| .|.. | |.| . |.| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------WNWTLTIKNVTPEDSGYYTCYARNPWG |
|||||||||
| V-set | CCK4.AA | V-set | 412-498 | 14 | 0.311423 | 6.08 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 412-498 Range on HMM: 1-128/128 Sequence Identity: 14% (19 aa) PSWLKK--PQ----DSQLEEGKPGYLDCLTQ-----ATPKPTVVWYR-NQM------LI-----------------SEDSRFEVFKNGT-----LRINSV .|... | .||. | | . .. .. ||| . .| . |.... |.. |.|... QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL EVYDGTWYRCMSSTP-AGSIEAQARVQV .. | | | .... .. .. |..| QPSDSGTYYCAVWNCNEDYFGHGTRLTV |
|||||||||
| I-set | CCK4.AA | I-set | 502-588 | 30 | 3.7e-16 | 57.36 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 502-588 Range on HMM: 1-92/92 Sequence Identity: 30% (29 aa) LKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPE----WVTDNAG----TLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTV ||| .|......| . |. | .|| .|.. | . |. |.. . .. | || . .|..||.| |||.|.| |. ....||| PKFTQKPKDVEVQE-GETARFECQVTGDPPPQVSWFKD-GQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNS-FGEAECTAELTV |
|||||||||
| I-set | CCK4.AA | I-set | 592-669 | 33 | 1.4e-15 | 55.41 | Pfam | 1-80 (92) | Show / Hide |
Range on Protein: 592-669 Range on HMM: 1-80/92 Sequence Identity: 33% (28 aa) ITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGP--RMHIFQNG----SLVIHDVAPEDSGRYTCIAGNS .| | . .| | || ..|...|||.| ..|. ... | | . |... ..| .| | .| |.|.| |||.| || PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP----DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNS |
|||||||||
| IGc2 | CCK4.AA | IGc2 | 604-671 | 35 | 2.8e-14 | 54.7 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 604-671 Range on HMM: 1-56/56 Sequence Identity: 35% (24 aa) YQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCN .| .. |.|.| |.| | |.|. . |. |..| | .|.|||||.|||.| |. . HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
|||||||||
| IG | CCK4.AA | IG | 598-682 | 24 | 6e-14 | 53.59 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 598-682 Range on HMM: 1-58/58 Sequence Identity: 24% (22 aa) PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDS---GRYTCIAGNSCNIKH-TEAPLYVV |. .|| | |. |.| .. |.|. |.| .| |||| | |.| | . ... .. |.| PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ |
|||||||||
| IGc2 | CCK4.AA | IGc2 | 515-577 | 34 | 7.7e-13 | 49.9 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 515-577 Range on HMM: 1-56/56 Sequence Identity: 34% (22 aa) EFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQ . . .| .| |||.. |.|.| . |..|| . .||.. .||..|.|.|||.|.| HEGQSVTLTCPATGNPDPNIHWYK--GQPLP-----WNWTLTIKNVTPEDSGYYTCYARNPWG |
|||||||||
| IG | CCK4.AA | IG | 508-589 | 20 | 2.1e-11 | 45.13 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 508-589 Range on HMM: 1-58/58 Sequence Identity: 20% (18 aa) PQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDA---GNYTCIASNGPQGQIRA--HVQLTVA |. . .| .| .| .. .|.| |.. .|...|. |.|.| |. ||. . ..||| PP-VTVKE-GETVTLTC-VS-----QIWWY-----------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ |
|||||||||
| IGv | CCK4.AA | IGv | 519-666 | 9 | 0.000721 | 9.7 | SMART | 1-76 (76) | Show / Hide |
Range on Protein: 519-666
Range on HMM: 1-76/76
Sequence Identity: 9% (15 aa)
EATVPCSATGREKPTIKWERAD-----GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC
.|..|...| .. | | . . .||.
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY---------------------------------------------------------------
EAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNG---------SLVIHDVAPEDSGRYTCIA
.. | . . .|..... |||.|.|.|
----------------------SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
|
|||||||||
| V-set | CCK4.AA | V-set | 591-664 | 18 | 0.001472 | 14.1 | Pfam | 1-110 (128) | Show / Hide |
Range on Protein: 591-664 Range on HMM: 1-110/128 Sequence Identity: 18% (20 aa) FITFKV-EPE----RTTVYQGHTALLQCEAQGDP--------------KPL--------IQWKGKDRILDPTKLGPRM----HIFQNGS-----LVIHDV .. .. |. || .| ...|.| . |. |. ... .... . .. .|| ....|.| | |... QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL APEDSGRYTC |.||| |.| QPSDSGTYYC |
|||||||||
| V-set | CCK4.AA | V-set | 554-588 | 25 | 0.002227 | 13.48 | Pfam | 94-128 (128) | Show / Hide |
Range on Protein: 554-588 Range on HMM: 94-128/128 Sequence Identity: 25% (9 aa) TLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTV .|. ....| | |.| ..|.. .. . ..||| SLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV |
|||||||||
| Kinase | CCK4.AA | CCK4 | 796-1061 | 67 | 1.6e-226 | 758.85 | In-house | 1-273 (273) | Show / Hide |
Range on Protein: 796-1061 Range on HMM: 1-273/273 Sequence Identity: 67% (184 aa) LQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD ||||...|..||||||||||||...|..||||.||.|| .|||||..|||||.||||||||.|||||||||||.|||||||||||.|||||||.....|. LQPIIQIGHGEFGEVFLAKAQGIKDGATETLVMVKALQKTKDEQQCQDFRREIEMFGKLNHKNVVRLLGLCREKEPHYMVLEYVDWGDLKQFLQATRGKN -EKLK----SQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDV .|.| ..||.|.||.|.|.|||||||||.||||.|.||||||||.|.|.||||...||.|||||.||.|.||.|.|.|||.||.|.|...|||||| NTKNKGSSSPPPLTTSQKIAICYQVALGMEHLYNNRFIHRDLAARNCLISPQMQVKVCYMGLCKDVYNREYHHHRQKWIPIRWMPPECIFEDEYSTKSDV WAFGVLMWEVFTHG-EMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL ||.||.|||||..| .|||..|..|.|..|.||||...||||.||.||||.|.||||..||||.|||||...| WAYGVFMWEVFNQGTKMPHEQQDNDQVMQDMQAGKLMWPQPEDCPDKLYRMMHRCWADNPKDRHSFSEITHHL |
|||||||||
| Kinase | CCK4.AA | TyrKc | 796-1061 | 37 | 1.7e-118 | 400.86 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 796-1061 Range on HMM: 1-280/280 Sequence Identity: 37% (111 aa) LQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKL--NHANVVRLLGLCREA-------EPHYMVLEYVDLGDLKQF .. . .|| .||||..... . | ||.|.. . ||.||... || .| |.|||.| |.. ||...|.||...||||.. ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY LRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNS-------EYYHFR---QAW--VPLRWMS || .. | |..|... |.|.| |||.|. ....| |||||||||.....||.| |||.|.|. .||. . .. .|.|||. LRKHRPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA PEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGG-----QADDEVLADLQAGKARLPQPEG--------CPSKLYRLMQRCWALSPKDRPSFSEIASAL ||.| .| |.||||||.|||.|||.|| |..|. | ..||......|. |.|||. ||...|..|..||. |.|||.|||| . . PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY-RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | CCK4.AA | Pkinase_Tyr | 796-1061 | 41 | 1.9e-117 | 398.38 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 796-1061 Range on HMM: 1-270/270 Sequence Identity: 41% (115 aa) LQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSL-QSKDEQQ--QLDFRRELEMFGKL-NHANVVRLLGLCR-EAEP--HYMVLEYVDLGDLKQFLR .. . .||. .||||..... | ... .. | ||.| .. ...| . || ||... .| .| |.|||.| | . || .|.|.||. .|||. .|| ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR ISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAW---VPLRWMSPEAILEGDFST . |||..|... |.|.| |||.|......| |||||||||. ...||.. ||..|.|| .|| .|.. .| .||.||.| .| |.| KHR-----EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTT KSDVWAFGVLMWEVFTHGEMP-HGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL |||||.|||||||.|| ||.| | . ||.. . |.|.||.|| ..|.||..||. |.|||.|||| . | KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
|||||||||
| Kinase | CCK4.AA | TK | 796-1061 | 23 | 8.3e-111 | 372.83 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 796-1061
Range on HMM: 1-486/486
Sequence Identity: 23% (113 aa)
LQPITTLGKSEFG---EVFLAKAQGLE--------------------EGVAETLVLVKSLQ---SKDEQQQLD--------------FRRELEMFG--KL
.. . .||. .|| ||......|. .. ..| | || | . ......| . .|..|. ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
NHANVVRLLGLCREA------------EPHYMVLEYVDLGD----LKQFLRISKSKDEK-----------------------------------------
.| |.|||.| | . || ..|.||...|| |...|| .. | .
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
------LKSQPLSTKQKVA-------------------LCTQVALGMEHLSNN------RFVHKDLAARNCLVSAQRQ-----------VKVSALG----
. ..||.||. . | |.| |||.|. . .||| |||||||||. . . .|.. |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ
----LSKDVYN-SEYYHFR------------------------QAWVPLRWMSPEAIL---------EGDFSTKSDVWAFGVLMWEVFTHG-EMPHGGQA
|..|.|. ..|| . ....|.|||.||... .| |.||||||.|||||||.||.| |...||
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS
D---------DEVLADLQAG-------------KARLPQPEGCP--------------SKLYRLMQRCWALSPKDRPSFSEIASAL
. .||. |..| . |.|||..|| .|.|||.||.. |.|||.||.. ..|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
|
|||||||||
| Kinase | CCK4.AA | UTK | 796-1061 | 34 | 3e-95 | 322.72 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 796-1061 Range on HMM: 1-296/296 Sequence Identity: 34% (104 aa) LQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ--SKDEQQQL---DFRRELE---MFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQF .|. .||. .||||..|... | . | .| || .| ....|.. ||..| | .... | ||.||.|.| || ..|.|| ||| .. VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY LRISKSKDEKL-KSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQR-------QVKVSALG---LSKDVY---------NSEYYHFR-Q || ..... |. |.. . ..| ||..|.. .||| ||||||||| ..| ..|.. .| .|..|. .|.|| . | LR--RHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ AWVPLRWMSPEAILEG-DFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGK-ARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL .|.|||.|||. .. .|.||||||.|||..||..|.| .| .| ....|.. . .| .|.|.|..|| .||||.|||. .| .||.| .. ... DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
|||||||||
| Kinase | CCK4.AA | TK-Unique | 796-1061 | 32 | 3.4e-85 | 289.34 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 796-1061 Range on HMM: 1-294/294 Sequence Identity: 32% (97 aa) LQPITTLGKSEFGEVFLAKAQGLEEGVAET-LVLVKSLQ-SKDEQQQLDFRRELEMFGKLN-HANVVRLLGLCREA-EPHYMVLEYVDLGDLKQFLRISK | ..|. .||.|. ... |. .. .. |.|| |. . ..... || .|..|. .| | |.|..|| | . ||.....||. |.| .|| .. LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR SK-----------------DEKLKSQPLSTKQKVALCTQVALGMEHLSN--NRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQ--AWVPL . .| |.| |. . . |.| |||.|. ..||.||.|||.|.. ..|.. .|...|||. . | . .|. PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI RWMSPEAIL--EGDF-STKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGC-PSKLYRLMQRCWALSPKDRPSFSEIASAL |||.||... .| . .||||||.|||||||.|| |..| .| ..... ....|. |.||||.| . .| ||..|| ..|..||||..|.. | RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGY-RMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
|||||||||
| Kinase | CCK4.AA | Musk | 799-1061 | 37 | 1.4e-77 | 255.86 | In-house | 4-282 (282) | Show / Hide |
Range on Protein: 799-1061 Range on HMM: 4-282/282 Sequence Identity: 37% (104 aa) ITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLR-----ISKS . .| || || |.| || . .||.| || | ..| | || || | . | |.|.||| | | . .|| ||| ||. . | VRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHRTCS KDEKLKS----------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEG . . .. .|.. . . |.| || || .||| ||| ||||. . ||.. |||. .| .|| .| ||| ||.|. RTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESIWYN DFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL |.. |||||.||..||.| .. | | . ||. . | .| || || |.| || ||| | |||.| .| . QFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGN-ILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI |
|||||||||
| Kinase | CCK4.AA | ALK | 796-1063 | 37 | 1.9e-77 | 263.58 | In-house | 1-273 (273) | Show / Hide |
Range on Protein: 796-1063 Range on HMM: 1-273/273 Sequence Identity: 37% (102 aa) LQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD .. . ||. ||||. .. .... . | .|.| . .|...|| | || || ||||..|.| .. | . |||| ||.|.||| . . ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVS---AQRQVKVSALGLSKDV-YNSEYY-HFRQAWVPLRWMSPEAILEGDFSTKSDV | |. .| | .| || | | |.|.| | |||||| . ..| .|. | ..|. | ..|| .| | || ||| ..| | .|.|| ESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSKTDV WAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGD |.||||.||.| | || |. ||. . .| .|. | .|| ||.| || | |||.| | . . WSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEG-GRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY |
|||||||||
| Kinase | CCK4.AA | Trk | 796-1061 | 35 | 2.8e-76 | 258.06 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 796-1061 Range on HMM: 1-275/275 Sequence Identity: 35% (99 aa) LQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDE . . || || ||||. . | ..| || | |. ||.|| |. .| | ..|.. |.|.. .| || || |||...|| .. | IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLR-QHGPDA KL--KSQP------LSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYN-SEYYHF-RQAWVPLRWMSPEAILEGDFST .. . || | .| . |.| || . ||| |.|.||||| .. ||.. |.| ||| ..|| . | ||| ||.|. |.. MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTY KSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL |||| ||| |||.|| | | . || .|. || .|..|| .| .| || |. | . .| .. ESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII |
|||||||||
| Kinase | CCK4.AA | DDR | 796-1061 | 34 | 1.9e-72 | 247.02 | In-house | 1-306 (306) | Show / Hide |
Range on Protein: 796-1061 Range on HMM: 1-306/306 Sequence Identity: 34% (107 aa) LQPITTLGKSEFGEVFLAKAQGLEE-----------GVAETLVLVKSLQS-KDEQQQLDFRRELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDL-G | .| .|||| | . |.. ||| ||.| . ||..| ... | |.|||.| | . || |..||. | LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG DLKQFLRISKSKDEKLKSQP----------LSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALG--LSKDVYNSEYYHFRQ---- ||.||. .. . |. . .|. . | |||.| || .|.. .||| |||.||||| .|. | .| | ..|| DLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTGR --AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHG-EMPHGGQADDEV------LADLQAGKARLPQPEGCPSKLY-RLMQRCWALSPKDRPSFS . |.|||..|.|| | |.|||||||||| |||.|. | | . |. | . . | . ||.| ||...| || ||| .. ||||. QRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSFE EIASAL || | EIHKFL |
|||||||||
| Kinase | CCK4.AA | CTKA | 796-1061 | 32 | 2.3e-72 | 242.42 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 796-1061 Range on HMM: 1-290/290 Sequence Identity: 32% (94 aa) LQPITTLGKSEFGEVFLAKAQGLEE-----GVAETLVLVKSLQSKDEQQQL-DFRRELEMFG--KLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFL .. .| .|.|| | . . ..| ||.| . | | . .. | ||.||||.| .| .|. |. .|||. .| HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYL RISKSKD-------------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSE---YYHFRQAWVPLR | . . | ... .| |.| ||. |. ||| |||.||||. .|.. .|... .| || | | | RACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGR-TLRTESQYYYVSSQRVMPVR WMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAG-KARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL ||.|||. .| ||. |||||||||.||... || | . | || .. ||| | ||. || .|| || |. ||.| . | WMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML |
|||||||||
| Kinase | CCK4.AA | Src | 796-1061 | 34 | 1.4e-71 | 242.46 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 796-1061 Range on HMM: 1-255/255 Sequence Identity: 34% (93 aa) LQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDE .. . ||. ||||. .. .| .| | ||.| ... .. .| .| . || | ..|.|. | . || | | || | | ..|. IKLCRKLGQGQFGEVWMGYWNG------NTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK------ KLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVY--NSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFG . . . |. .| . . .||| ||. |. ....| |||||| ||. . .|| || . . || | .| .|. ||||..| |..||||| || DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFG VLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYR-LMQRCWALSPKDRPSFSEIASAL .|..|..|.| .| | ||| ...| |.|.|..|| .|| .|..|| .|..|| | . . | ILLTEIVTYGRVPYPGMTNHEVLQQVERG-YRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
|||||||||
| Kinase | CCK4.AA | Pkinase | 796-1061 | 19 | 8.7e-31 | 109.93 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 796-1061 Range on HMM: 1-293/293 Sequence Identity: 19% (61 aa) LQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLD--FRR--ELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLG----DLKQFL .. . ..|. ||.|.... .| .. .| || . ..| . | || |... .||| |.|||.. ... |||.||.. | ||. .. YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI RISKSKDEKLKSQPL--STKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQV----KVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAIL-E . .. .. | .. ..|.. |.|.. .....| || |.|.. . .. |.. ||.| ... . . . ...|.|| |. ST-------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG GDFSTKSDVWAFGVLMWEVFTHGEMPHGGQ------ADDEVLADLQAGKARLPQPEGCP-------------------SKLYRLMQRCWALSPKDRPSFS . ..|.|.|..|....|... |. | |. ...... .. . . |. |. . . .. .|... ||.||.. QYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE EIASA--L .| . QILQHPWF |
|||||||||
| Kinase | CCK4.AA | S_TKc | 796-1066 | 17 | 4.8e-30 | 107.05 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 796-1066 Range on HMM: 1-231/231 Sequence Identity: 17% (50 aa) LQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDL--GDLKQFLRISKSK . . ..|| ||.|.... . .| .| . ..|||... | .| |.|.|.. ... . |||.||.| |||..... ... YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH DEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFST-KSDVWAF . .|.. . .. |.....|.. .....| || | |.. ..|.. ||.. . . . . .|.|| . ... |.|.|.. GLR---FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSC GVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIAS----ALGDSTV |....| .. |. | ..... .. .. . ....|. |..||. |. . . . GCILYEMLC-GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||