Gene CCRK (Human)

CCRK

Species: Human
Alias: CDCH, CCRK, p42
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 9q22.2,

Classification

Group: CMGC
Family: CDK
Subfamily: CCRK

Sequence

Name Sequence Type Origin Length Description Download
CCRK.AA Protein Sugen Kinome 346 None Fasta, JSON
CCRK.kin_dom Protein Kinase Domain Sugen Kinome 285 None Fasta, JSON
CCRK.NA RNA Sugen Kinome 2406 None Fasta, JSON

Protein domain

Protein domains of CCRK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CCRK.AA CCRK 4-288 87 3.5e-245 820.8 In-house 1-285 (285) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-285/285
Sequence Identity: 87% (249 aa)

YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQ
||||.||||||||||||||||||||||||||||||||.||.|||||||||||||.||||||||||.|||||.||||.||||||||||||||||||||.||
YCILDRIGEGAHGIVFKAKHVETGEIVALKKVALRRLDDGIPNQALREIKALQEIEDNQYVVQLKDVFPHGTGFVLVFEFMLSDLAEVVRHAQRPLAEAQ

VKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPL
||||.||||||||.||.|||.||||||||||||.||.|||||||||||||.|..|.|||||||||||||||||||||||||||||.||||||||||.||.
VKSYMQMLLKGVAHCHENNIMHRDLKPANLLISESGHLKIADFGLARVFSNDEGRQYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNNSPI

FPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF
|||.|||||||.||||||||.|.||||...||||||||||||.|||||.|.||.||||||||.|||.|||.||||||.|||||||
FPGENDIEQLCCVLRILGTPTPKVWPEMKDLPDYNKISFKEQPPMPLEQVVPDASPQALDLLKQFLVYPPRQRIAASQALLHQYF
Kinase CCRK.AA CDK 4-288 38 9.1e-151 485.71 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-284/284
Sequence Identity: 38% (123 aa)

YCILGRIGEGAHGIVFKAKHVETG-----EIVALKKVALRR-----LEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHG-----------GGFVLAFE
|..| .||||..|.|.||.. .||     .||||||. .        ..|||  |.|||. |.|.  ....|.|. |...              ... ||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

FMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQ-----LKIADFGLARVFSP--D---GSRLYTHQVATRWYRAP
.|  ||... .          .|.|...||.|...|| |.|.||||||.|.||.  |.     |||||||||| |.   .    .| |||.| |.|||||
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

ELLYGARQYD--QGVDLWSVGCIMGELLN---GSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQ
||| |...|.   ..|.||||||..|...   . |||||...|.||. . ||.|||....||..|.||||                         ||| .
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNK

FLLYPPHQRIAASKALLHQYF
.| | |..|| |. || |.||
MLCYDPKKRISAEQALQHPYF
Kinase CCRK.AA CDK7 4-288 45 4.90000000001e-136 364.95 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-288/288
Sequence Identity: 45% (133 aa)

YCILGRIGEGAHGIVFKAKHVETGEIVALKKVA----LRRLEDGFPNQALREIKALQEME-DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRP
| ..  ||||  . |.||   .||.||| ||.         .||    |.|||| ||||. ||  |. |  .| |     | |.||  || .|..  .  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDN--VIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSII

LAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVF-SPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGEL
| .| .|.|  |.|.|. .||.| | |||||| |||..  |||||||||||| . ||   | ||||| ||||||||||.|||.|  |||.||||||. ||
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPN--RIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAEL

LNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVP---MPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF
.   | .|| .|| ||  . ..||||... ||......||.|  ||.. .   .||...    |  .|||.   ..  | .|. .. .| . ||
MLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIK--FKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CCRK.AA CMGC 4-288 25 2.9e-129 427.31 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-513/513
Sequence Identity: 25% (133 aa)

YCILGRIGEGAHGIVFKAKH--------------VETGEIVALKKVALRR---------LEDGFPNQALREIKALQEME----------------DNQYV
| |...||||. |.|.|...               ||.||||.||. ..          ..||||  |||||| |...                 .  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VQLKAVFPHGG-----------------GFVLAFEFMLSDLAEVVRHAQ--------RPLAQAQ------------VKSYL------QMLLKGVA--FCH
|.|. .| | .                  . | ||.|  ||... .. |        .|| . .            .|...      ...|.|..  .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

ANN--IVHRDLKPANLLISAS--------------------GQLKIADFGLARVFSPDG--------------------SRLYTHQVATRWYRAPELLYG
 ..  |.||||||.|.||.                      |.|||.|||||| ..|                      .| |||.|.||||||||.| |
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

ARQYD---------QGVDLWSVGCIMGELLNG--------SPLFPGKND-----------IEQLCYVLRILGTPN---------------PQVWPELTEL
...|.         ...| ||||||..|...|         |||||...           |.||    ..||||.               .. ||. ..|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PDYNK-------------IS------------FKEQVPMPLEEVLPD-----------------------------------VSPQALDLLGQFLLYPPH
|.|||             .|            |... | |.... |.                                    .|||.||| . | | |.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

QRIAASKALLHQYF
.|| |. || | ||
KRITAEQALQHPYF
Kinase CCRK.AA CDC2 4-288 42 3e-122 377.69 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-301/301
Sequence Identity: 42% (130 aa)

YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDG--FPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVR-HAQ--RP
|. . .||||  |.|.|.|...|..||||||. | . ..|  .|  |.|||  |.|. | . .|.|. |.       . ||..  || .  .   .   .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYT--HQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGE
. .. ||||.  .|.||.|||.. |.|||||| |.||...|..||||||||| |.   .| ||  | | |.||||||.| |...|. .||.||.|||. |
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIP-IRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAE

L---LNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPD---------VSPQALDLLGQFLLYPPHQRIAASKALL
.    .  |||.|.  |.||. . ||||||| | ||..|.|||| | .| .  |  |....|.         . |...||| | | | | .|| | .|| 
MFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDY-KNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

HQYF
| ||
HPYF
Kinase CCRK.AA CDK5 4-288 41 6.4e-106 335.73 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-287/287
Sequence Identity: 41% (121 aa)

YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQ
|  . .||||  |.|.||.  ||.||||||.| |     | |  |.|||  |.|.   . .| |  |       .| |||.  ||       .  . .. 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKH-KNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHI

VKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFS-PDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELL-NGS
.||..  ||||.||||.... |||||| ||||.  |.|| ||||||| |  |   | |.| | | |||.|  | |...|   .|.||.|||. |.  .| 
IKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIP--VRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGR

PLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYN--KISFKEQVPMP-LEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF
||||| .. .||  . .|.|||.   || .|.||||.     .    . . .... |  . . .|||.. | . |.||| | .|| |.||
PLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CCRK.AA PITSLRE 4-288 39 6.7e-92 311.61 In-house 1-295 (295) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-295/295
Sequence Identity: 39% (119 aa)

YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALR--RLEDGFPNQALREIK-ALQE-MEDNQYVVQLKAVF--PHGGGFVLAFEFMLSDLAEVVRHAQ-
. .| ||.||. |.|..||  .|.||||||.. .   .  .|||  .||||.  | .   .|  .|..| .     .    ...|..  ||. .    . 
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPN--IVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKR

--RPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVF-SPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCI
   |    ..|. .| ||.||.. | | | ||||| .|||.| .|.|||.|||||| . ||   . ||  | | |||||||| |.. |   ||.||||||
RNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSP--IKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCI

MGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKIS-FKEQVPMPLEEVLP---DVSPQALDLLGQFLLYPPHQRIAASKALLHQYF
..|.. . |||.||..|.|.  .   .|||. . ||  ||||  ...  |... .  | .  |    .| ...||| |.| | | .|| ||.|| | .|
FAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CCRK.AA S_TKc 4-288 27 1.2e-88 301.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-231/231
Sequence Identity: 27% (82 aa)

YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLS---DLAEVVRHAQRP--
| ||  ||.|| | |.|..|..||.|||.|..          ....|||. |..  .  ..|.|. || . . . . .|..     || .. .. .|.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQ-GVDLWSVGCIM
   .   ....|.. .......|| ..|.||||||.|.|..   ..||.||||||..        |... |.||.|||.|    .|.   .| ||.|||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

GELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALL-------HQY
 |.| | |.||   .....  ...                                       ||.|.|.. . | . | .|. | .||        |..
YEMLCGYPPFP---QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase CCRK.AA CRK7 4-288 34 1.2e-88 300.81 In-house 1-343 (343) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-343/343
Sequence Identity: 34% (118 aa)

YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRL---EDGFPNQALREIKALQEMEDNQYVVQLKAVFPHG----------GGFVLAFEFMLSDLAE
| ... ||||  | | |||  .|||.|||||| .      ..|||  | |||| |... . | .|.|| .              | | . || |  ||. 
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQL-NHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMG

VVRHA-QRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDG-SRLYTHQVATRWYRAPELLYGARQY-------
  .       .. |.|...  || |.. || .|. |||.| .|.|.  .|..||||||||| . ..  .| ||  | | |||.|||| |. .|       
LLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILK

-------------------------------DQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPL
                                  .| ||.|||.|||... |.|.|.| ..||  . .| |.|||..|||...|| .| .  | |    |
ELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRL

EEVLP------DVSPQALDLLGQFLLYPPHQRIAASKALLHQYF
 |           ....|||| . | . |  |. |. .| |..|
REEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CCRK.AA RCK 4-288 35 2.3e-87 277.21 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-298/298
Sequence Identity: 35% (106 aa)

YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHGG--GFVLAFEFMLSDLAEVVRH---AQRP
| |. ..|.|. | |.||. .||||||| ||   .....    . |||||.|  .  .  ...|| |. .       . ||.|  .| .  ..    ...
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKY

LAQAQ--VKSYLQMLLKGVAFCHANNIVHRDLKPANLLISA---------SGQLKIADFGLARVFSPDGSRL-YTHQVATRWYRAPELLYGARQYDQGVD
| . |  .|...  .|.| |..| ... |||||| |....          .. .|||||||.| .    |.  ||  | ||||||||.|  . .|.  .|
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIR---SKPPYTDYVSTRWYRAPECLLRCTYYNSPMD

LWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQ
.|.||||| ||    ||||| . | |.   . ..||||.. ||.  .|     . |   ..|||....|. |.....|.   | . |  ||.|..|| |.
IWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHP

YF
||
YF
Kinase CCRK.AA CDK-Unclassified 4-288 29 5.3e-87 286.26 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-324/324
Sequence Identity: 29% (96 aa)

YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLED----------GFPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFV-------------LA
| ..  .|||..|.|.|| . .|  .|| ||...    .           ..  ..|||. || ...  ..  .  ...   .               . 
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNH-MNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMV

FEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASG-----QLKIADFGLARVFS----------PDG-SRLYTHQV
 | |  ..  .      .|   |.. ..  .|.| |. | | | |||.||.|..|.  .      |||||||.|.             | . ...|. ||
MEYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQV

ATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMP-LEEVLPDVSPQALD
.|||||||||| | ..|| ||| ||.|||. |.. | |.|.|...|||.  . ..||||.   ||... .|||.|| ||  ..    .. .   .   ..
STRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASENN

LLGQFLLYPPHQRIAASKALLHQYF
...| . | |  |  ....| | .|
CEFQMVMYQPYNRWKCMEILQHPWF
Kinase CCRK.AA Pkinase 4-288 29 6e-82 283.36 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALR--EIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLS-----DLAEVVR-HA
|.|...||.|. | |.|..|. ||.|||.|.. .|. ..... ...|  ||. .... .  ..|.|. .|  ..   . .|..       ||..... ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QRPL--AQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQL----KIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWS
....     ..|.|.  .|.|...||...|.||||||.|.||.  |..    ||.|||||..|.   .. .|. . |.||.|||.. |.. |.. || ||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGCIMGELLNGSPLFPGK----NDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLH
.|||. |.|.| |.|||.    | ..|.  . ||.|.|..  ||.. . .... ... .     .... . .|. ..|..   | . |..|. |  .| |
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

QYF
 .|
PWF
Kinase CCRK.AA TyrKc 4-288 20 7.8e-13 -15.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEM-EDNQYVVQLKAVFPHG-------GGFVLAFEFMLS-DLAEVVRH
   .  .|||| |.|.|..     . || |..             .||.. . .   ... .|.| .|  ..       .   . .|.|   || .  | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

AQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPD-----GSRLYT------HQ--VATRWYRAPELLYGARQY
 .. |  ..  |.     .| .. | .|..||||   | |... .. ||.||||.|    |      .  |.          .  ||. ||| .   . .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

DQGVDLWSVGCIMGELL-NGSPLFPG-----KNDIEQLCYVLRILGTPNPQV----WPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLY
    | || |  | |.. .| .  ||     ....| . || .    | |.                                .  ..   ..  |   .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------F-VCCPDEMYQIMKQCWHE

PPHQRIAASKALLHQYF
 |..|   . . .|..|
DPEDR--PTFSEIHECF
Kinase CCRK.AA Pkinase_Tyr 4-150 26 1.8e-11 39.46 Pfam 1-159 (270) Show / Hide 
Range on Protein: 4-150
Range on HMM: 1-159/270
Sequence Identity: 26% (43 aa)

YCILGRIGEGAHGIVFKAKHV----ETGEIVALKKVALRRLEDGFPNQA------LREIKALQEMEDNQYVVQLKAVFP-HGGG--FVLAFEFMLS-DLA
  ..  .|||| | |.|..      .|.  || |..      .|   ..      .||.| . .. ... .|.| .|   .|.     . .|.|   || 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

EVVRHA---QRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLAR
.  |     ..||   .  .. .   || .. ...|..||||   | |.. ... ||.||||||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR