Gene CDK10 (Human)

CDK10

Species: Human
Alias: CDK10, PISSLRE
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 16q24.3,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK10

Sequence

Name Sequence Type Origin Length Description Download
CDK10.AA Protein Sugen Kinome 360 None Fasta, JSON
CDK10.kin_dom Protein Kinase Domain Sugen Kinome 285 None Fasta, JSON
CDK10.NA RNA Sugen Kinome 1815 None Fasta, JSON

Protein domain

Protein domains of CDK10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK10.AA CDK10 39-323 81 5.4e-231 773.67 In-house 1-285 (285) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-285/285
Sequence Identity: 81% (231 aa)

FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEA
||||||.|||||||||||||...|||||||||||||||||.|||.||||.||...||.|||||.|||||.||.||||||.||||||||||.|||.||.|.
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFTET

QVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPL
|||||.||.||||.|||.||.|||||||||||||||||.|.|||||||.|||||||||||.|||||||||||||..||||.||||||||||.|||.|.||
QVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHKPL

LPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF
.||.|||||||.|..||||||||||||||.||.|....|.|||||||||||.|||..|.|||.|||||.|||||||..|||||||
MPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CDK10.AA CDK 39-323 41 2.8e-165 532.88 In-house 1-284 (284) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-284/284
Sequence Identity: 41% (134 aa)

FEKLNRIGEGTYGIVYRARDTQTD-----EIVALKKVRMDK-----EKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLE---------SIFLVMGY
.|||..|||||||.||.|||.||.     .||||||.||..     ||.|.||...|||.||  | ||||| |..|.......         ....|. |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGC-----VKTADFGLARAYGV------PVKPMTPKVVTLWYRAPE
...||.....          .||. .| |||| |.|.|.|.||||| .|.|....|.     .| ||||||||.|.      |....|..||||||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLLGTTTQT--TSIDMWAVGCILAELLA---HRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFL
||||... .  |.||||.||||.||..     .||.||.|||.|...| ...|||.|..|||..|||.                           ||  .
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

FMYDPKKRATAGDCLESSYF
..|||||| .| ..|.. ||
LCYDPKKRISAEQALQHPYF
Kinase CDK10.AA PITSLRE 39-323 53 1.4e-163 549.74 In-house 1-295 (295) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-295/295
Sequence Identity: 53% (157 aa)

FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMD--KEKDGIPISSLREIT-LLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMP---
|..||||.|||||.||||.|..||||||||.. |.  |||.|.|| |||||  .|  |.||||| .||.|.|  . .|..|| | | ||.||.|||    
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

TPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAEL
 ||.. ..|| ..| ||| ...| | |.||||| ||||.. ||. | .|||||| || |.|| || ||||||||||||||. . .| .||| ||||.||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

LAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYS-LRKQPYNNLKHKFP---WLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF
.  .||..| ||| ||. | ...|||.| ||||...||..     ....|||||. .||    .|. |. ||  .  |.||.| || | |   .|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK10.AA CMGC 39-323 26 2.3e-136 451.06 In-house 1-513 (513) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-513/513
Sequence Identity: 26% (134 aa)

FEKLNRIGEGTYGIVYRARDTQTD--------------EIVALKKVR---MDK------EKDGIPISSLREITLLLRLR-----------------HPNI
.|....|||||||.||..||..|.              ||||.||..   ..       ||||.||..|||| .| .|.                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VELKEVVVGNH---------------LESIFLVMGYCEQDLASLLENMPT--------PFSEAQ------------VKCIV------LQVLRGLQ--YLH
| |..... ..               .....||. |...||. ...|...        |.|| .            .|...       |.||||   |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

RNF--IIHRDLKVSNLLMTDK--------------------GCVKTADFGLARAYGVP---------------------VKPMTPKVVTLWYRAPELLLG
..   ||||||| .|.|....                    |..| .||||||.|...                     ..|.|. |||.||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

TTTQT---------TSIDMWAVGCILAELLA--------HRPLLPGTSE-----------IHQIDLIVQLLGTPS---------------ENIWPGFSKL
 .  |         |.||||.||||.||..         ..|| || ||           |.|...|...||||.               |..||...||
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PLVGQ-------------YS------------LRKQPYNNLKHKFPW-----------------------------------LSEAGLRLLHFLFMYDPK
|   .             .|            . ..|....| .|||                                   ... .. ||  .. |||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRATAGDCLESSYF
|| || ..|.  ||
KRITAEQALQHPYF
Kinase CDK10.AA CDK7 39-323 41 1e-132 355.92 In-house 1-288 (288) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-288/288
Sequence Identity: 41% (121 aa)

FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVR----MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTP
.||.  ||||... ||.|.|.||..||| ||..     .  ||||  . .||| .|  ..|.|...|  .    |. .| ||. . . ||    .     
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFM--HKSNIQLVFDFMDWDLEVVIKDKSII

FSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLA
.  | .| . ...|.|| |.|||.| |||||  ||||   | .| |||||||.|| | .  |..||| |||||||| |    .|..|||.||||.|||. 
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML

HRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQY-SLRKQPY---NNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF
  | |||.|.| |.  | | ||||.|  ||. ....    |  ....|      |.| |   |.  | |.  ..  .| || |. .||.. ||
RVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMM---DYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK10.AA CDC2 39-323 41 1.9e-123 381.45 In-house 1-301 (301) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-301/301
Sequence Identity: 41% (127 aa)

FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDG--IPISSLREITLLLRLR-HPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLE-NMP--
..|...|||||||.||...|.||..||||||.| . | .|  .| ...||| .|  |. ||||| |..|..     ....|  |...||  ...   |  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

TPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPK--VVTLWYRAPELLLGTTTQTTSIDMWAVGCILA
...... || .  | |.|. ..|.. |.||||| .|.|  .|| .| |||||||| |.|... |.   ||||||||||.|||  . .|..|||..|||.|
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EL---LAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLP-------LVGQYSLRKQPYNNLKHK-FPWLSEAGLRLLHFLFMYDPKKRATAGDCLE
|.      .|| .| ||| |.  | . ||||.|..||| ..||          .  |.|. .||.|.| .  | . |. ||  .  ||| || .| . |.
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

SSYF
  ||
HPYF
Kinase CDK10.AA CDK5 39-323 42 7.1e-116 367.73 In-house 1-287 (287) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-287/287
Sequence Identity: 42% (122 aa)

FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEA
.||...|||||||.||.||. .| ||||||.||.| |  |.| . .||| ||  |.|.||| |  |.  .    . ||  .| |||   ....    . .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEK--KLTLVFEFCDQDLKKYMDSCNGEMDMH

QVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELL-AHRP
 .| . .| |.||.. | . . |||||  |||   .|  | ||||||||.|.||.  .  |||||||.|  |.|  . .|||||| .|||.||.  | ||
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRP

LLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVG--QYSLRKQPYNN-LKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF
| ||...  |  .| ...|||.|. ||. .|||        . . | .  ..   | |.| |. ||. . ...|..| .| . |.  ||
LFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK10.AA CRK7 39-323 37 3.7e-112 378.93 In-house 1-343 (343) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-343/343
Sequence Identity: 37% (129 aa)

FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKE---KDGIPISSLREITLLLRLRHPNIVELKEVVVG--------NHLESIFLVMGYCEQDLASL
.|... ||||||| || |....| |.||||||||| |   |.| || . ||| .|  | |.||| |||.|.         .|  |...|  |   ||. |
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LENM-PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPV--KPMTPKVVTLWYRAPELLLGTTTQ--------
||.     ||. |.||.  | | |..|.|.. ..|||.| ||.||  .| || ||||||| |      .| | .|.|||||.||||||..          
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------TTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRK----QPY
                              ...|||| .||||.||.  .|...|  |. |...| .. |.|  | ||   |||.      ..       
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

NNLKHKFP--WLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF
..  |..    .... | ||  .  .||||| || .||.. .|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK10.AA CDK4 39-323 41 1.7e-96 326.85 In-house 1-290 (290) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-290/290
Sequence Identity: 41% (121 aa)

FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKD--GIPISSLREITLLLRLR---HPNIVELKEVVVGNHLES----IFLVMGYCEQDLASLLE
..... |||| ||.||||||..|  .||||.||   . .  |.|.| .|||... .|    ||||| |..|            | .|.  |..||. .|.
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

NMPTP-FSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCI
..| |  .. ..| .  | |||. .|| . |||||||  |.| |  | || ||||||| |.   . .|| |||||||||| ||  .  |. .|||.||||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLLQSYYNTP-VDMWSVGCI

LAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF
 ||.   ||| .|.||  | . |  . |.| |  ||  . ||.    . . .   ..|   | ... |. ||     |...|| .|  ||. .||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPW---DHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK10.AA S_TKc 39-323 27 1.5e-89 304.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-231/231
Sequence Identity: 27% (82 aa)

FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQ---DLASLLENMPTP-
.|.|. ||.|..| ||..|.. |..|||.|...         .. .||| .| . .||||| |..| .    .....|| ||..   || ......... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTT-SIDMWAVGCIL
    |.| ...... |....|.|.|.. ||||||| .|.|...  ..| .|||||| .       |  ..|.||.|||.|      .. ..|.|..||||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

AELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLE-------SSY
.|.|. .|. |      |.... ...|                                    |. .. ..  .. .||.|| || ..|.         .
YEMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase CDK10.AA MAPK 39-323 32 2.1e-83 283.41 In-house 1-328 (328) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-328/328
Sequence Identity: 32% (107 aa)

FEKLNRIGEGTYGIVYRARDTQ------TDEIVALKKVR--MDKEKDGIPISSLREITLLLRL-RHPNIVELKEVVVG------NHL---ESIFLVMGYC
.. | .||.| ||.|  |.|.       ....||.||.    ... .      .||| || .. .|.||. |...         |.|   . | .|| ..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK--RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELM

EQDLASLLENMPTPFSEAQVKCIVLQVLRG--LQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGV-PVKP-------------MTPKVVTLWY
| ||  ... .. | |.  .. .. |.|||  |.|.|   .|||||| ||.|..  ...| .||||||       ..             ||. |.| ||
ETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWY

RAPELLLG--TTTQTTSIDMWAVGCILAELLA-HRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFS--KLP-LVGQYS--LRKQPYNNLKHKFPW----L
||||..|.  ..  |...|||.||||.||.|  ..||.||.. |.|. ||...||||||  .   .  . .  . |    |.|.|  .... ||      
RAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNA

SEAGLRLLHFLFMYDPKKRATAGDCLESSYF
.   . ||  .   ||.|| |. ..|.  ||
NPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDK10.AA Pkinase 39-323 32 3.9e-82 283.98 Pfam 1-293 (293) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-293/293
Sequence Identity: 32% (98 aa)

FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLR--EITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQ-----DLASLLE-N
.... .||.|..| ||....  | .|||.|... ..||.. ... .|  || ...||.|||||.|....      .| .|| |||      ||.....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

MPTPF--SEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCV----KTADFGLARAY-GVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMW
. ..|  || ..|....|.||||.|.|.. ||||||| .|.|. ..| .    | .|||||. .   .   ||  ..|.||.|||...| .  ....|||
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

AVGCILAELLAHRPLLPGT----SEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLE
..||||.|.|  ||. ||     . . |. .|.. .|.| .  ||  .  ..    .  . .   .. . . .||... ..  .. .||||| || ..|.
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

SSYF
. .|
HPWF
Kinase CDK10.AA Pkinase_Tyr 39-187 30 4.6e-20 68.57 Pfam 1-160 (270) Show / Hide 
Range on Protein: 39-187
Range on HMM: 1-160/270
Sequence Identity: 30% (49 aa)

FEKLNRIGEGTYGIVYRARDT----QTDEIVALKKVRMDKEKDG-IPISSLREITLLLRL-RHPNIVELKEVVVGNHLES--IFLVMGYCEQ-DLASLLE
 ...  .||| .| ||... .    .|.  || |... .  ..  .  . .||. ..  | .||||| |  |..  . |.  |..|| |..  || . | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT-DQGEPNQIYIVMEYMPHGDLLDYLR

NM---PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARA
.    . |..  .  .. .|. .|..||... .|||||   | | |....|| .||||||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase CDK10.AA TyrKc 39-323 20 1.3e-14 13.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-280/280
Sequence Identity: 20% (66 aa)

FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRL--RHPNIVELKEVVVGN-----HLESIFLVMGYCEQ-DLASLLEN
 ...  .||| .|.||... .   . || |... |.         .||. .. .|  .||||| |  |..         | ...|| |..  || . | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP--------VKPM-----TPKVVTLWYRAPELL-LGTTTQ
    .. ..   . .|. .| .|||.. .|||||   | | .....|| .||||.|. .          .. .     .  .. .   ||| .  |. | 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

TTSIDMWAVGCILAEL--LAHRPLLP------GTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDP
 .  | |. |  . |.  .   |           .|...       .  | ..  |  |                     |.  ...  ..     ..||
KS--DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS---------------------FVCCPDEMYQIMKQCWHEDP

KKRATAGDCLESSYF
..| |  ..   ..|
EDRPTFSEI--HECF