Gene CDK9 (Human)

CDK9

Species: Human
Alias: CDC2L4, CDK9, PITALRE, C-2k, TAK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 9q34.12,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK9

Sequence

Name Sequence Type Origin Length Description Download
CDK9.AA Protein Sugen Kinome 372 None Fasta, JSON
CDK9.kin_dom Protein Kinase Domain Sugen Kinome 297 None Fasta, JSON
CDK9.NA RNA Sugen Kinome 2472 None Fasta, JSON

Protein domain

Protein domains of CDK9.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK9.AA CDK9 19-315 70 2.7e-261 874.34 In-house 1-340 (340) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-340/340
Sequence Identity: 70% (241 aa)

YEKLAKIGQGTFG-----------EVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKG--SIYLVFDF
|||||||||||||           |||||||.|....||.|||||||||||||||||||||.||||||||||||||||||||..|||.|.  ..||||||
YEKLAKIGQGTFGQVLQGRKSRNSEVFKARHKKNKRMVAMKKVLMENEKEGFPITALREIKMLQLLKHENVVNLIEICRTKATAYNRYKDRATFYLVFDF

CEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR--YTNRVVTLWYRPPELLLGE
|||||||||||..|||.|..||..||.|.||||||||||||||||||||||||.||.|||||||||||||..||..|||  ||||||||||||||||||.
CEHDLAGLLSNMNVKFSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGILKLADFGLARAFSQPKNDAPNRPLYTNRVVTLWYRPPELLLGD

RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKL------ELVKGQKRKVKDRLKAYVR-------------
|.||||||.||||||||||||||||||||||||||.|||||||||||.||||..|.||..|.      ||.||||||||||.|.|..             
RNYGPPIDMWGAGCIMAEMWTRSPIMQGNTEQHQLQLISQLCGSITPDVWPNCENMELWNKMSSEPNSELPKGQKRKVKDRMKNYMKFDAPDSKTDPFGK

---------DPYALDLIDKLLVLDPAQRIDSDDALNHDFF
         |..|..||||||..||..|.|||.||.||.|
NVKQHDSATDQQACHLIDKLLNIDPKKRMDSDEALDHDWF
Kinase CDK9.AA CDK 19-315 42 1.2e-165 534.08 In-house 1-284 (284) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-284/284
Sequence Identity: 42% (138 aa)

YEKLAKIGQGTFGEVFKARHRKTG-----QKVALKKVLMEN-----EKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKG----SIYLVFD
||||.|||.||.|.|.|||...||     | |||||. |||     |||||||||.|||..|. | |.|.|.|...| ||....|. |.    ..|.||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

FCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV-----LKLADFGLARAFSLAKN-SQP--NRYTNRVVTLWYRP
...|||.....          ||  |..||.||.|.|.|.|.|||.| .| ||...|.     ||.|||||||||.  .. | .  . ||..|||||||.
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRA

PELLLGERDYG--PPIDLWGAGCIMAEMWT---RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL
||||||...|.  .|||.|..|||.|||.|   | |...|..|..|| .|...||. |...||.|  . .|                           ||
PELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DL

IDKLLVLDPAQRIDSDDALNHDFF
..|.|..||..|| ...||.|..|
LNKMLCYDPKKRISAEQALQHPYF
Kinase CDK9.AA CRK7 19-315 41 5.5e-135 454.75 In-house 1-343 (343) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-343/343
Sequence Identity: 41% (142 aa)

YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE---KEGFPITALREIKILQLLKHENVVNLIEICRTK--ASPYNRCKGSIYLVFDFCEHDLAGL
||... || ||.| | ||.  .||. |||||| |.||   |||||||| ||||||. |.|.|.||| ||   |  ||  .. |||.|.||.   |||.||
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LSNV-LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDY------
| .  ...| ....|  |  || |. |.|....|||| | .|.|.   | .|.||||||| .   ....   |||||.|||||||||||||  |      
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYN--SEEKRRPYTNRVITLWYRPPELLLGEERYTEQHIL

--------------------------------GPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRK
                                || || |. |||..|  |. || ||| |  || .|...||| .|..||.|.   ... .   .  .|.
KELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRR

VKDRLK----AYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
.         .   .. .||| ||.|.|||  |.   ..|.||.|
LREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK9.AA CMGC 19-315 25 9.3e-131 432.29 In-house 1-513 (513) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-513/513
Sequence Identity: 25% (129 aa)

YEKLAKIGQGTFGEVFKARH--------------RKTGQKVALKKVL---MEN------EKEGFPITALREIKILQLLK-----------------HENV
||.. |||.||.|.|.|.|.              ..|...||.||.    .|.      ||.||||.||||||||. |.                 |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNLIEICRTKASPYNRCK---------GSIYLVFDFCEHDLAGLLSNVL--------VKFTLSE------------IKRVM------QMLLNGLY--YIH
|.|..|...| |  |  .          ..||||....|||.... |          ....  .            ||  |      ...|.||   |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

RNK--ILHRDMKAANVLITRD--------------------GVLKLADFGLARAFSLA--KNSQPNR---------------YTNRVVTLWYRPPELLLG
...  |.|||.| .|.||. .                    |.||..||||||...    .. |...               ||..|||.|||.||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

E---------RDYGPPIDLWGAGCIMAEMWTR--------SPIMQGNTE-----------QHQLALISQLCGSIT---------------PEVWPNVDNY
          ..|..||| |..|||.|||.|.         |. .|..|           ..||..| ...|..|               .| |||. ..
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

ELYEK-------------------------LELVKGQKRKVKDRLKAYVR---------------------------------DPYALDLIDKLLVLDPA
  |.|                         . . . .... |.  . . .                                 || |.||..|.|..||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

QRIDSDDALNHDFF
.||  ..||.|..|
KRITAEQALQHPYF
Kinase CDK9.AA CDK7 19-315 40 2.3e-114 306.03 In-house 1-288 (288) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-288/288
Sequence Identity: 40% (124 aa)

YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVL----MENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL
|||...|| |.|. |.||.  .|||.|| ||.      .  | |   ||.||||||| ..|.||..|| |   |         .|.||||| . ||    
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKS--------NIQLVFDFMDWDLEVVI

SNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLWYRPPELLLGERDYGPPIDLW
    . .| ..||  | |.| ||.| ||| |||||.|  | |.  .|.||.|||||||..       ||| ||  ||| ||| |||| | | ||. .|.|
KDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFY-----GSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMW

GAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKG-QKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH
  |||.||   | |.. |  .  ||  | |  |  |.| |||.     | |.    |  .   ...  |   |  .|||. ... ..| .|.   ..|..
SVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDD--LLDLMCGMWTMNPCKRWTCTQCLKM

DFF
..|
PYF
Kinase CDK9.AA CDC2 19-315 36 7.29999999999e-109 335.78 In-house 1-301 (301) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-301/301
Sequence Identity: 36% (114 aa)

YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEG--FPITALREIKILQLLK-HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS
|.|. ||| ||.|.|.|.....|.| |||||.  |.| ||  .| ||.||| .|. || |.|.| | ..             ..|.||.....||  .. 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---------NKLYMVFEYLDMDLKKYMD

NVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT--NRVVTLWYRPPELLLGERDYGPPI
. ..   ..... .|  |  .|.|. . |...|.||| |  | || ..|..|.|||||||||.  .    . ||    |||||||.||.|||...|  |.
MSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPI----RTYTTEHEVVTLWYRAPEILLGCKRYSTPV

DLWGAGCIMAEM---WTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYE-------LYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
|.|  |||.|||    |. |. .|  |  ||  | .  |. . . ||.|...         ...  | |  ... |..      || ..||....|..||
DMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQ-SCLDPEGIDLLMQMLQYDP

AQRIDSDDALNHDFF
..|| ...||.| .|
QKRISAKEALQHPYF
Kinase CDK9.AA PITSLRE 19-315 38 3.3e-104 352.49 In-house 1-295 (295) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-295/295
Sequence Identity: 38% (119 aa)

YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLME--NEKEGFPITALREIK-ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS
...| .|. ||.|.|..|. ..|.  ||||.. ||   ||||||||.||||. ||  |.|.|.||. ||   .       . .||.|... ||||..|. 
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSN------MDKIYMVMEYVEHDLKSLME

NVL---VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDL
|      .|...|||  || ||.|  . | |.|.||| | .| |..  |.||..|||||| .  .       ||  ||||||| |||||| . | .|.|.
NMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSP----IKPYTPCVVTLWYRAPELLLGCKKYSTPVDM

WGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLE-LVKGQKRKVKDRLK--AYVRDPYALDLIDKLLVLDPAQRIDSDDA
|  |||.||. |  |..||. |  |.  | .. |  |   || .    .  ... . .      . | .  ... |  ..||  ..| ..|..||  .||
WSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISD-TGFDLLNQMLTYNPKNRITASDA

LNHDFF
| |..|
LKHPWF
Kinase CDK9.AA CDK5 19-315 39 4.3e-97 307.35 In-house 1-287 (287) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-287/287
Sequence Identity: 39% (118 aa)

YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL
|||. ||| ||.| |.||| ..|.  ||||.| ...| || | ||.||| .|. |||.|.| |. .  .           . ||| ||  ||   . .. 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEK--------KLTLVFEFCDQDLKKYMDSCN

VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI
..  .  ||  |  || || . | ...||||.|  | || . | ||||||||||||    .     |.  |||||||||  |.| . |  .||.| .|||
GEMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC----YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCI

MAEMW-TRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVR--DPYALDLIDKLLVLDPAQRIDSDDALNHDFF
.|||  .  |   || .. || .| .. |. . . || . .   | | . ..  .. ..  ..  |.  |   .||  |.|...|.|||. ..||.| .|
FAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDY-KPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK9.AA Pkinase 19-315 29 3.5e-95 327.33 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-293/293
Sequence Identity: 29% (94 aa)

YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR--EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-----DLA
|... |||.|.||.|.|..|..||..||.|..  ..||.....|..|  ||.|.. |.|.|.| |......        |..||.|...||.     ||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDLF

GLLS-NVLVKF--TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVL----KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGER
 ..|     .|  .  |.|..|  .| ||.|.|...|.|||.| .|.|| ..|..    |..|||||. |.    ...  .| ...|.||..||...| .
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS--MTTFCGTPWYMAPEVIRGGQ

DYGPPIDLWGAGCIMAEMWTRSPIMQGN----TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
.|||..| |..|||..|| .. |. .|     .   |...| .  | .... ||. ..  ... .   .        ... .  .. ..|.|...| .||
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCLCKDP

AQRIDSDDALNHDFF
..|.  ...|.|..|
KKRPTAEQILQHPWF
Kinase CDK9.AA S_TKc 19-315 26 9.5e-95 321.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-231/231
Sequence Identity: 26% (84 aa)

YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH---DLAGLLS
||.| |||.|.||.|.|.||.|||..||.|..          ....|||.||.  .|.|.|.|......         ...|.|...|..   ||  .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIK

NVLVK-----FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGP-P
.   .     |.  .....|. ....| |.|...|.||| | .|.|...  ..|..|||||| .           |  ..|.||..||.|     ||. .
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL----GYGKCK

IDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA
.| |  |||..|| .. |  .      |.... ...|                                      .| |.|.|.|.|. ||..|.   .|
CDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EA

LN-------HDFF
|.       | .|
LQDEWDIKCHPWF
Kinase CDK9.AA CDK10 19-315 38 4.1e-85 289.07 In-house 1-285 (285) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-285/285
Sequence Identity: 38% (113 aa)

YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL
.||| ..| ||.| |..||  ..   |||||| |. ||.| || .||||..|  ..|||.|.| |.   .         ||.|| ..|| ||| || |. 
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQH------LDSIFLVMQYCEQDLASLLDNMP

VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI
  || ...| .|  .| || |.|.| ..|||.| .|.|.| .| .|.|||||||....     .   | ..|||||| |||||| |.    ||.| .|||
QPFTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVP----VKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCI

MAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
..|.    |.| || | ||. .| .| |.   ..||   .  . ..  | |     .| . .   .    . |.. |.. .| .|  ....|.  .|
LGELLVHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQS--GRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CDK9.AA CDK-Unclassified 19-315 29 1.4e-78 258.12 In-house 1-324 (324) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-324/324
Sequence Identity: 29% (98 aa)

YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE----------GFPITALREIKILQLLKHENVVNLIEI--CRTKAS---PYNRCKGSIYLVF
|. . |.|.||||.|.||..  | ..|| ||.   |.|            ..||..|||..||...|.|.  ....   ... |    |     |.|.| 
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

DFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG-----VLKLADFGLARAFS----------LAKNSQPNRYTNR
.    .. . | |        .|.. |  .| |. |.| ||| ||| | .|..||  .     .||.||||.|.              |. .|   |.  
EYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQ--QYSTQ

VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYA
|.| ||| ||||.| . |.. .| |..|||.||.  . || ||.||  |.. |... |. . . ||.     .|.|.     ||..  .|   .      
VSTRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHA-SE

LDLIDKLLVLDPAQRIDSDDALNHDFF
....  .....|  |     .| |  |
NNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase CDK9.AA Pkinase_Tyr 19-173 30 1.1e-23 80.83 Pfam 1-160 (270) Show / Hide 
Range on Protein: 19-173
Range on HMM: 1-160/270
Sequence Identity: 30% (51 aa)

YEKLAKIGQGTFGEVFKARHR----KTGQKVALKKV---LMENE--KEGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH
 ... |.|.| ||||.|.. .    .|...|| |..    |. .  .| |    .||.||.  | .|.|.|.|. .|  .  |      .||.|. ...|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPH

-DLAGLLSNV---LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARA
 ||   | .      ..|....    .   .|. | ..... |||  | |.|.|...| | .||||||.
GDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase CDK9.AA TyrKc 19-240 18 3.6e-12 -25.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-240
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL--KHENVVNLIEICRTKASPYNRCK---GSIYLVFDFCEH-DLAG
 ... |.| | ||||.|.. .   ..|| |..  .          .||..|.  |  .|.|.|.|. .|...           . ...|. ...| ||  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKD

LLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA---------KNS----QPN----------------
 | .   |.....    .    .|  |.|.... |||  | |.|...... | .||||.|.             . .    . .                
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

RYTNRV------VTLW------YRPPE---------------LLLGERDYGPPI--------DLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
..|         |..|        |..               .  |.|   ||                || . | . | .  . ..    .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF