Gene CDKL3 (Human)

CDKL3

Species: Human
Alias: NKIAMRE, LOC51265, CDKL3
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 5q31.1-q32 ,

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
CDKL3.kin_dom Protein Kinase Domain Sugen Kinome 283 None Fasta, JSON
CDKL3.NA RNA Sugen Kinome 1940 None Fasta, JSON
CDKL3.AA Protein Sugen Kinome 607 None Fasta, JSON

Protein domain

Protein domains of CDKL3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDKL3.AA CDKL 4-286 58 5.6e-202 677.28 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-286/286
Sequence Identity: 58% (167 aa)

YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYE-RPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRL
||.||||||||||.||||..|.||||||||.|.| .....|.||||||||.|||..|||.||||||||.|.|.|||||..|||||.||..|..|......
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

RKYLFQILRAIDYLHSNNIIHRDIKPENILVS-QSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYL
|||..|||.||...|..|.|||||||||||.. ..|..|||||||||.||.||.||||||||||||||||...||.|||||||||.||...||..|.|..
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLN-GLLADIVHACLQIDPADRISSSDLLHHEYF
|..||.|.|..|. ..|.| |. |.||||.|.|.|...|...|.....|.||... ....|....||..||..|.....|.||.||
PGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase CDKL3.AA CMGC 4-286 21 1.1e-115 381.78 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-513/513
Sequence Identity: 21% (112 aa)

YETLGKVGEGSYGTVMKCKH--------------KNTGQIVAIKIFYERPEQSVNK----------IAMREIKFLKQF-----------------HHENL
|| ..|.|||.||.| ||..              ..|..|||||.. .....   |          .| ||||.||..                 ||.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNLIEVFRQKK-----------------KIHLVFEFIDHTVLDELQH--------YCHGLESKR------------LRKYL------FQILRAID--YLH
|.|...|. |.                 ...||||..||. .. ...        . ..|.                ....      .||||...  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SNN--IIHRDIKPENILVSQSGIT--------------------KLCDFGFARTLAAP---------------------GDIYTDYVATRWYRAPELVLK
|..  |||||.||||||... .                      |.||||.|| .  .                     .  ||.||.||||||||. | 
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

D---------TSYGKPVDIWALGCMIIEMATG--------NPYLP-----------SSSDLDLLHKIVLKVGNLS---------------PH--------
.         . |..|.|.|..||.. || ||         |  |            .|..| |.||.   |. .               .         
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

-----------------LQNIFSKSPIFAGVVLPQVQ--HPKNARKKYPK--------------------------------LNGLLADIVHACLQIDPA
                  ...| . .|. .  .|...  . ||  ...|.                                .. .. | .  .||.||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

DRISSSDLLHHEYF
.||. .. | |.||
KRITAEQALQHPYF
Kinase CDKL3.AA S_TKc 4-286 31 3.6e-99 336.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-231/231
Sequence Identity: 31% (93 aa)

YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDH---TVLDELQHYCHG----
|| | |.|.|..|.|.||.||.||.||||||          . ..|||. ||. ||.|.|.|..||.  .....|.|..|.   ...| .... ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK-PVDIWALGCMIIEM
 .   . |.|. ||..|..|.||..|||||.||||||...    |.||||.|| |       | .. |.||.|||..    .||| ..|.|..||...||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

ATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLH-------HEYF
..| |  |   ..... |...                                           . |..  ||| ||..|..  ..|.       |..|
LCGYPPFP---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDKL3.AA Pkinase 4-286 31 2.3e-95 327.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQS-VNKIAMR--EIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHT----VLDELQH--YC
|....|.|.||.|.| ||.||.||.|||.||.  | | | ..... |  ||. .| ..|.| | |...|. |..|..|.|. ...     | .. .  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HGL--ESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGIT----KLCDFGFARTL-AAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWAL
 ..  . . ...|. ||||...|.||..|||||.||||||... | .    |.||||.|. .   ..  .|... |.||.|||...... ||..||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCMIIEMATGNPYLPSS----SDLDLLHKIVLKVG-NLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLH
||...||..|.|  |..    . .| ...|... |  |. . ..  |.|. |  .   .    . .... ....  . |..  ||. ||..|..  ..|.
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF--FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HEYF
|..|
HPWF
Kinase CDKL3.AA CDK 4-213 36 8.1e-91 290.78 In-house 1-237 (284) Show / Hide 
Range on Protein: 4-213
Range on HMM: 1-237/284
Sequence Identity: 36% (92 aa)

YETLGKVGEGSYGTVMKCKHKNTG-----QIVAIKIFY------ERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQK-----------KKIHLVFEF
|| | |.|||.||.| |...|.||     ||||.| .       |. .  ..  | |||. ||.  |.| |.|..|. .|           .|. .|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

IDHT---VLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGI-----TKLCDFGFARTLAA------PGDIYTDYVATRWYR
.||    ..|              . |..|.||...|.|||.|.|||.|| |||..  |.      |. |||.||          |   ||  | |.|||
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

APELVLKDTSYG--KPVDIWALGCMIIEMAT---GNPYLPSSSDLDLLHKI
|||| | .. |.   |.|.|..|| ..||.|   . | .| .|..| |.||
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKI
Kinase CDKL3.AA CDC2 4-213 39 1.6e-75 231.45 In-house 1-221 (301) Show / Hide 
Range on Protein: 4-213
Range on HMM: 1-221/301
Sequence Identity: 39% (87 aa)

YETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQS--VNKIAMREIKFLKQFH-HENLVNLIEVFRQKKKIHLVFEFIDH---TVLDELQHYCHG
|. . |.|||.|| | |||.. |.||||.| |  |. .    |   |.|||  ||    |.|.| | .|. | .|. .|||..|.     .|...     
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYT--DYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEM
...  ...|..|||......|.. |.|||.|| |||.. .|  |. ||| ||.   | . ||    | |.||||||. | .  |  |||.|..|| ..||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ATGNPYLPSSSDLDLLHKI
   .|  |  .  |  | | ||
FMDVTKKPLFHGDSEIDQLFKI
Kinase CDKL3.AA RCK 4-214 35 1.4e-74 236.0 In-house 1-227 (298) Show / Hide 
Range on Protein: 4-214
Range on HMM: 1-227/298
Sequence Identity: 35% (81 aa)

YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFH-HENLVNLIEVFRQKK--KIHLVFEFIDHTVLDELQH---YCHGL
| .. ..|.|.||.||| . | ||.|||||    . .     .  ||||.|. .. |.|...|.||.|...    ..|||. |  .   ...     . |
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

ESKR--LRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQ---------SGITKLCDFGFARTLA--APGDIYTDYVATRWYRAPELVLKDTSYGKPVDI
 ..   ......||| .....|.... |||.|||||...          ... |..||| .|      |   ||||| ||||||||. |..| | .|.||
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPP---YTDYVSTRWYRAPECLLRCTYYNSPMDI

WALGCMIIEMATGNPYLPSSSDLDLLHKIV
||.|| ..|  . .|  | || .| ..||.
WAVGCIMYELYMLRPLFPGSSEIDQIFKIC
Kinase CDKL3.AA CDK5 4-286 33 2.5e-71 224.47 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 33% (96 aa)

YETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRL
|| . |.||| |||| | . |.|. |||.| .  .     |   |.|||  ||   |.| | |. |    ||. |||||.|      .     ... .  
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMA-TGNPYL
. ...| |. . . |.... ||| || | |... |. || ||| ||    |   |.  | | |||.|   .    |  ..|.|  || . ||| .| |  
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNA--RKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF
| ... | | .|   .|  .       .| | .   . .   .| .    .  |||.. . |. .  ||..|. |||  . ||| ||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDKL3.AA STE 4-286 22 1.4e-65 224.16 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-359/359
Sequence Identity: 22% (86 aa)

YETLGKVGEGSYGTVMKCKHKN---------------TGQIVAIKIFYERPEQ----------------SVNKIAMREIKFLKQFH--HENLVNLIEVFR
.| ..|.|.|..||| |.....               ||.|.|||.   ....                .  .  ..|||..|...  |.| |. .  . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QK-------KKIHLVFEFIDH-TVLDELQHYCHGLES-------------KRLRKYLFQILRA-IDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFAR
..        ..... |..|  .. | ..|..  ...             . ......|||..  .||||..|||||||| |||.      ||||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

TLAA---------------PGDIYTDYVA-TRWYRAPELVLK-----DTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLS------
 |.                 ..  .. .. |  . ||| ...     |  |.  .||| |||.|||||||.| .   ...  .  |  . .  .      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

------PHLQNIFS-----------KSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLH--HEYF
      | |.. .|           . .                     |.   . | .  |||.|| .| ..|.||.  |. .
IVNGPPPPLPDHLSQNEMISYGGSGT-T------------------YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase CDKL3.AA ERK7 4-286 36 1.1e-63 216.59 In-house 1-292 (292) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-292/292
Sequence Identity: 36% (107 aa)

YETLGKVGEGSYGTVMKCKHKNTGQIVAI-KIFYERPEQSVNKIAMREIKFLKQFH-HENLVNLIEVFRQK--KKIHLVFEFIDHTVLDELQHYCHGLES
|| . ..| | || | |   | |.|.||. |||    .|       ||| ||..|| |.|.. ||.|.| .  . | ||||| . | |       . |. 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFME-TDLHAVIRKGNILKD

KRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPG------DIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIE
   .  ..|.|||| |.|| |.||||.|| |||.      |.|||| ||..|          . |.|||||||||||  |  . | | || | .|| . |
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

MATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLA----DIVHACLQIDPADRISSSDLLHHEYF
| .| |  | .| .. . ||.  ...  |  ..| .  . .| ..| |..  .. ||.  ..         |.. . |.  |  |..  . |.| | 
MLRGKPMFPGTSTMNQIEKILETIPK--PTQEDIEAIGSHYAWNMLEQMN--QQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase CDKL3.AA MAPK 4-286 30 4e-61 209.39 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-328/328
Sequence Identity: 30% (103 aa)

YETLGKVGEGSYGTVMKCKHKN------TGQIVAIKIFYERPEQSVN--KIAMREIKFLKQF-HHENLVNLIEVFRQK-----------KKIHLVFEFID
|. | ..|.|.||.| ....|       .|..|||| . .|| |..   | . ||||.|. | |||| ..|...|. .           . | .|.|. .
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKI-SRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELME

HTVLDELQHYCH-G--LESKRLRKYLFQILRA--IDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAA-PGDIY-------------TDYVATR
.     |..  . .  |. .. .  ..||||.  . |.|| |.||||.||.|||| . .  |.|||| ||...    ...             |.|||||
TD----LHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

WYRAPELVLKD--TSYGKPVDIWALGCMIIEMAT-GNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVL----PQVQHPKNARKKYPK---
||||||. |    . | | ||.|..||   || | . | .| .. .| . .|.  .|. |... .  ..|.  . ..     .. . .|. .| .|.   
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF

-LNGLLADIVHACLQIDPADRISSSDLLHHEYF
  | .  | .   |..|| .||.  . | |.||
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDKL3.AA CDK7 105-213 46 1.4e-50 132.68 In-house 107-215 (288) Show / Hide 
Range on Protein: 105-213
Range on HMM: 107-215/288
Sequence Identity: 46% (51 aa)

YLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSS
|  ..|. . |.| | | |||.|| | |... |. |. ||| ||   .|  |||  | |||||||||     .||  ||.|. || . |    .||||  
YMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPGD

SDLDLLHKI
||.| | .|
SDIDQLTRI
Kinase CDKL3.AA CDK7 4-83 41 1.4e-31 81.06 In-house 1-85 (288) Show / Hide 
Range on Protein: 4-83
Range on HMM: 1-85/288
Sequence Identity: 41% (35 aa)

YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFY-----ERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFID
||.. ..||| ..|| |   ..||||||||        .  .  .|  |.|||| |.  .|.| ..|| .| .|  | |||.|.|
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMD
Kinase CDKL3.AA Pkinase_Tyr 4-200 32 5.2e-24 81.93 Pfam 1-216 (270) Show / Hide 
Range on Protein: 4-200
Range on HMM: 1-216/270
Sequence Identity: 32% (71 aa)

YETLGKVGEGSYGTVMKCKHK----NTGQIVAIKIFYERPEQSV--NKIAMREIKFLKQF-HHENLVNLIEVFR-QKKK--IHLVFEFIDH-TVLDELQH
 . . | |||..|.|.|.. |    ||.. ||.|.  |   ..    .  |||.| .||. ||.|.|.|. |   |..   | .|.|.  |   || |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

Y---CHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVAT------RWYRAPELVLKDTSYGKPVD
     . |  |.| .. .|| .. .||.|.|.||||.   |.||. ... | |||| ||..  . | |  ....      .|. |||       .    |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSD

IWALGCMIIEMAT-G-NP-Y
.|. |  . |. | |  | |
VWSFGVLMWEIFTYGEQPTY
Kinase CDKL3.AA TyrKc 4-286 24 5.8e-17 51.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-280/280
Sequence Identity: 24% (78 aa)

YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQF--HHENLVNLIEVFRQK-------KKIHLVFEFIDHTVLDELQHYC
 . . | ||| .|.|.|.. |   . ||.|   |     .  . |||.. ....  ||.|.|.|. | .|.       . . .|.|. .|  |..  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

HG-LESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAP------GDIYT------DY--VATRWYRAPELVLKDTSYG
.. |  | | .. .|| .  .||||.|.||||.   |.||.  .. | .||| .| .         .| |.          .  ||. ||| ....  . 
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APE-CINYGKFT

KPVDIWALGCMIIEMAT--GNPYLPS----SSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPAD
   |.|. | .. |. |  . ||        |. .....  .| |.  |  .|.    |.                  ..     . .|   | . ||.|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEY--VKQGYRMPQPPNDY---PMS-----------------FVCCPDEMYQIMKQCWHEDPED

RISSSDLLHHEYF
| . |..  ||.|
RPTFSEI--HECF
Kinase CDKL3.AA CDK 266-286 47 3.3e-08 22.19 In-house 264-284 (284) Show / Hide 
Range on Protein: 266-286
Range on HMM: 264-284/284
Sequence Identity: 47% (10 aa)

CLQIDPADRISSSDLLHHEYF
.|. ||. |||... |.|.||
MLCYDPKKRISAEQALQHPYF
Kinase CDKL3.AA CDC2 267-286 55 1.4e-07 18.82 In-house 282-301 (301) Show / Hide 
Range on Protein: 267-286
Range on HMM: 282-301/301
Sequence Identity: 55% (11 aa)

LQIDPADRISSSDLLHHEYF
||.||..|||. . | | ||
LQYDPQKRISAKEALQHPYF
Kinase CDKL3.AA RCK 261-286 38 2.6e-07 18.93 In-house 273-298 (298) Show / Hide 
Range on Protein: 261-286
Range on HMM: 273-298/298
Sequence Identity: 38% (10 aa)

DIVHACLQIDPADRISSSDLLHHEYF
.... .||.||  ||. . .| | ||
ELMEKMLQWDPQKRITAQQALQHPYF
Kinase CDKL3.AA CDK7 267-286 25 9.7e-05 8.07 In-house 269-288 (288) Show / Hide 
Range on Protein: 267-286
Range on HMM: 269-288/288
Sequence Identity: 25% (5 aa)

LQIDPADRISSSDLLHHEYF
.  .|  |.. .. | ..||
WTMNPCKRWTCTQCLKMPYF