Gene CDKL4 (Human)

CDKL4

Species: Human
Alias: CDKL4
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP , GeneCards
Annotation: Consensus chromosomal location: 2p22.1,

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
CDKL4.AA Protein Sugen Kinome 342 None Fasta, JSON
CDKL4.kin_dom Protein Kinase Domain Sugen Kinome 283 None Fasta, JSON
CDKL4.NA RNA Sugen Kinome 1696 None Fasta, JSON

Protein domain

Protein domains of CDKL4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDKL4.AA CDKL 4-286 70 6.7e-225 753.44 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-286/286
Sequence Identity: 70% (201 aa)

YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVI
||||.| ||||||||.||||| .||.||.|||.||||||.|||||.|||.|||||||.|.||||||||||||.||||||||||.|.|||..|||| ..|.
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

KSVLWQTLQALNFCHIHNCIHRDIKPENILIT-KQGIIKICDFGFAQILI-PGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLW
....||.|.|.||||.|||||||||||||||| |.|..|.||||||..|  ||..|||||||||||||||||||||||..|||||||||.||...|||||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPEPEDMETLEEKFSDVH-PVALNFMKGCLKMNPDDRLTCSQLLESSYF
||.||.||||.|...||.||||||.||..| ||||...||.|.||.||....... ..||.|||.||.|.||.|.||.||....||
PGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase CDKL4.AA CMGC 4-286 23 9.69999999999e-130 428.88 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-513/513
Sequence Identity: 23% (122 aa)

YEKLAKTGEGSYGVVFKCRN--------------KTSGQVVAVKKFVESEDDPVVKK----------IALREIRMLKQLK-----------------HPN
||.. | |||.||||.|||.              . ....||.||. . . ..  .|          .|||||..||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNLIEVFRRKR-----------------KMHLVFEYCDHTLLNELERNPN--------GVADGV------------IKSVL------WQTLQALN--FC
.|.|...|..|                  ...|||||.||.|.. ...|..        .  . .            ||. .      .| |..|.  .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HIHN--CIHRDIKPENILITKQ--------------------GIIKICDFGFAQILIPGD----------------------AYTDYVATRWYRAPELLV
| |.   ||||.|||||||...                    |..||||||.| .. | .                      .||.||.||||||||.|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GD---------TQYGSSVDIWAIGCVFAELLTG--------QPLWPGKSD-----------VDQLYLIIRTLGKLI---------------PR-------
|.         ..|....|.|..||.|||..||        .||.||.|.           .|||..|...||.                 ..       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------HQSIFKSNGFFHGISIPEPE--DMETLEEKFSD--------------------------------VHPVALNFMKGCLKMNP
                  |.|.|  | .. ... |..   . . |. ....                                 .| |....|..|...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DDRLTCSQLLESSYF
|.|.|..| |.  ||
DKRITAEQALQHPYF
Kinase CDKL4.AA Pkinase 4-286 31 1.6e-107 368.27 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALR--EIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDH-----TLLNELE-RNP
|... | |.||.|.|.||..| .|..||||..  ..... ......|  ||...| |.||| | |...|..|.....|.|||..      |   .. .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NGV--ADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGII----KICDFGFAQI--LIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAI
...   . ..|....|.|..|..|| ...||||.||||||| ..| |    ||||||.|    . ..  .|... |.||.|||.. |.. ||..||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVFAELLTGQPLWPGK----SDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLES
||...|.|.|.|..||.    . .||...| |..|. .... .   |.  |. ... . .  . ....   ... .. |.|.||...| .|.|. |.|..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

SYF
 .|
PWF
Kinase CDKL4.AA CDK 4-218 41 1.2e-103 332.49 In-house 1-242 (284) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-242/284
Sequence Identity: 41% (104 aa)

YEKLAKTGEGSYGVVFKCRNKTSG-----QVVAVKKF-VESE----DDPVVKKIALREIRMLKQLKHPNLVNLIEVFRRK-----------RKMHLVFEY
||||.| |||.||||.|.|.| .|     |.|| ||. .|.|    ..  .   |.||| .||.| ||| |.|..|.  |           .|  .||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGI-----IKICDFGFAQIL-I------PGDAYTDYVATRWYRAPE
.|| |   ..          ||. .|| |..|..|| .. .|||.|| ||||...|.     .|| |||.| .  |      |  .||  | |.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLVGDTQYG--SSVDIWAIGCVFAELLT---GQPLWPGKSDVDQLYLIIRTLG
|| |...|.   ..|.|..||.|||..|   ..|| ||.|. ||| .|.|..|
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICG
Kinase CDKL4.AA S_TKc 4-286 30 1.8e-100 340.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-231/231
Sequence Identity: 30% (90 aa)

YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDH---TLLNELERNPNG---
||.| | |.|..|.|.|||.| .|..||.|.           . ..|||..||. .|||.|.|..||.   ....|.||||.   .|.  ..... .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGS-SVDIWAIGCVFAEL
      .......|...||..|| |. ||||.||||||...   |||||||.| .|      | .. |.||.|||.|    .||  ..|.|..||...|.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

LTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLE-------SSYF
|.|.|..|      |...... .|                                      | |..|...||...|..|.|. ..|.         .|
LCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDKL4.AA CDC2 4-218 46 2.4e-92 284.08 In-house 1-226 (301) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-226/301
Sequence Identity: 46% (105 aa)

YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKF-VESEDDP-VVKKIALREIRMLKQLK-HPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELE-RNP--NG
|.|. | |||.||||.||... ..|.||.||. .|.||.   |   |.|||  || || |||.| | .|.   .|  .||||.|. | . ..  .|    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

VADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYT--DYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAEL
.   ..|| ..| ||...||| .  .|||.|| |||| |.| ||| ||| |    || ..||    | |.||||||.| |. .|  .||.|.|||.|||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---LTGQPLWPGKSDVDQLYLIIRTLG
    |  || .|.|  |||. | |.||
FMDVTKKPLFHGDSEIDQLFKIFRILG
Kinase CDKL4.AA CDK7 4-218 41 2.1e-90 240.92 In-house 1-220 (288) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-220/288
Sequence Identity: 41% (92 aa)

YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFV----ESEDDPVVKKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVA
|||... ||| ...|.| . . .||.||.||       || .  .   |.||| .|. ..|.| ..|| .|  |    |||.. |  |    . .     
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

DGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFA-QILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQ
   ||.   .||| | .|| .   |||.|| | |. . |..|| ||| | ..  |  .||  | |||||||||| |  .||..||.|..||.||||.   
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLWPGKSDVDQLYLIIRTLG
|  || ||.|||  | .|||
PYLPGDSDIDQLTRIFQTLG
Kinase CDKL4.AA CDK5 4-218 43 1.7e-85 270.07 In-house 1-217 (287) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-217/287
Sequence Identity: 43% (95 aa)

YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVI
|||. | ||| ||.|.| |||... .|| |.    ..|  |   |.||| .|| |||.| | |. |    .|. ||||.||  |   ..    ..   .|
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELL-TGQPLW
|| ..| |. | ||| |.  ||| || | || |.|. |  ||| |    ||   |.  | | |||.|  | |  .|  |.|.| .||.|||.  .|.|| 
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGKSDVDQLYLIIRTLG
|| .. ||| .| . .|
PGNDVEDQLKRIFKIMG
Kinase CDKL4.AA RCK 4-218 39 1.6e-80 255.12 In-house 1-231 (298) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-231/298
Sequence Identity: 39% (91 aa)

YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLK-HPNLVNLIEVFRRKR--KMHLVFEYCDHTLLNELER---NPNG
|  ... |.|.||.|.| .||..|..|| ||    .       . ||||. |. |. |||...|.||.| .     ..||||.|  |   ..        
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKY

VADGV--IKSVLWQTLQALNFCHIHNCIHRDIKPENILITK---------QGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWA
.   .  ||. . |.||.|...| |.  |||.|||||..|.         |..|||.||| .        ||||| ||||||||.|  .|.| | .||||
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWA

IGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG
.||...|| . .||.|| | .||.. |.  .|
VGCIMYELYMLRPLFPGSSEIDQIFKICKVMG
Kinase CDKL4.AA MAPK 4-286 29 3.8e-74 252.63 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-328/328
Sequence Identity: 29% (97 aa)

YEKLAKTGEGSYGVVFKCRNKT------SGQVVAVKKFVESEDDPVVKKIALREIRMLKQL-KHPNLVNLIEVFRRK-----RKMH------LVFEYCDH
|. | . |.|.||||.... |       .|. ||.||..   ..|.  | ..|||..|. . .|.| ..|...|. .     . ..      .|.|....
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

TLLNELERNPNGVADGVIKSVLWQTLQA--LNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAY---------------TDYVATRWYRA
 | . .....    |  |.. ..| | .  | . |  | ||||.||.|||... .  |||||| | .. | . .               |.|||||||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PELLVGD--TQYGSSVDIWAIGCVFAELLT-GQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKS-N----GFFHGISIPEPEDMETLEEKFSD----VH
||.. .   . |  .||.|..|| |||.|| ..|| |||. .||. ||. .||.  ...   . . .     ....   . . .  ..|. |..    . 
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTP-SEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

PVALNFMKGCLKMNPDDRLTCSQLLESSYF
| |.....  | ..||.|.|  . |.  ||
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDKL4.AA ERK7 4-286 34 5e-68 231.68 In-house 1-292 (292) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-292/292
Sequence Identity: 34% (102 aa)

YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLK-HPNLVNLIEVFRRK--RKMHLVFEYCDHTLLNELERNPNGVAD
|| . . | | ||.| |   | ..||||.||      ...      ||| .|.... |||.. ||.|.| .  | . ||||. . | |.   |  |   |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFME-TDLHAVIRKGNILKD

GVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGD-------AYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAE
   .....| |.|. . |  | ||||.|| |||.  .  .|.|||| |  .   .       . |.||||||||||| |.| ..|   || | |||. .|
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

LLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF
.|.|.|. || | ..|. .|..|..|         .|.     ..  . .  .||.. . .  . |.. .|  | .||. |||  | |.  | 
MLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase CDKL4.AA CDK-Unclassified 4-218 30 3.1e-67 220.21 In-house 1-256 (324) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-256/324
Sequence Identity: 30% (77 aa)

YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKK-FVESEDD---------PVVKKIALREIRMLKQLKHPNLVNLIEVFRRKRKMH-------------LVF
|. . | ||| .| |.| .     . || || .|  . .          . | ...|||  |....| |.  .....    ..              .| 
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

EYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQG-----IIKICDFGFAQILI-------------PGDAYTDYVA
|| . |. | |. | .      |.  . | |  ... |    .||||||.||.|| ..     ..|| ||| |                 |.. |.  |.
EYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVS

TRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG
|||||||||| |. .|.  ||||..||..||.. | |. .|.....|.  |...||
TRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLG
Kinase CDKL4.AA Pkinase_Tyr 4-186 27 1.7e-18 63.26 Pfam 1-199 (270) Show / Hide 
Range on Protein: 4-186
Range on HMM: 1-199/270
Sequence Identity: 27% (56 aa)

YEKLAKTGEGSYGVVFKCRNK----TSGQVVAVKKFVESEDDPVV--KKIALREIRMLKQL-KHPNLVNLIEVFR-RKRK--MHLVFEYCDH-TLLNELE
 ... | |||..|.|.|.. |      .. ||||.      ..    ..  .||....||| .|||.|.|. |   ...   . .|.||. |  ||. | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RN---PNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVAT------RWYRAPELLVGDTQYGSSVD
..   .. .    . .  ||  ..... . .||||||.   |.|.|.....|||||| |  . . | |  ....      .|. ||| .     . .  |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSD

IWA
.|.
VWS
Kinase CDKL4.AA TyrKc 4-286 23 1.6e-17 60.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQL--KHPNLVNLIEVFRRK-------RKMHLVFEYCDH-TLLNELER
 ... | ||| .|.|.|.. |   . ||||.  |.      ..  .||.|....|  .|||.|.|. | . .         . .|.||..|  |.. | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPG-------DAYT------DY--VATRWYRAPELLVGDTQY
. . .      |  ||  .  .. | .||||||.   |.|.......||.||| .  .  .       | |.          .  ||. ||| .  .  .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

GSSVDIWAIGCVFAELLT-GQPLWPG----KSDVDQLYLIIRTLGKLIPRHQ----SIFKSNGFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKM
 .  |.|. | .  |..| ||. .||    . . ....  ... . . . .     |                         |   ..   . || | . 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMKQCWHE

NPDDRLTCSQLLESSYF
.|.|| | |..   ..|
DPEDRPTFSEI--HECF
Kinase CDKL4.AA CDK7 259-286 46 2.1e-11 26.21 In-house 261-288 (288) Show / Hide 
Range on Protein: 259-286
Range on HMM: 261-288/288
Sequence Identity: 46% (13 aa)

ALNFMKGCLKMNPDDRLTCSQLLESSYF
.| .|.| . |||  |.||.| |.. ||
LLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDKL4.AA CDK 261-286 26 8.6e-08 20.84 In-house 259-284 (284) Show / Hide 
Range on Protein: 261-286
Range on HMM: 259-284/284
Sequence Identity: 26% (7 aa)

NFMKGCLKMNPDDRLTCSQLLESSYF
... ..| ..|. |....| |.. ||
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDKL4.AA CDK-Unclassified 256-286 22 1.9e-05 13.76 In-house 294-324 (324) Show / Hide 
Range on Protein: 256-286
Range on HMM: 294-324/324
Sequence Identity: 22% (7 aa)

HPVALNFMKGCLKMNPDDRLTCSQLLESSYF
| . .|.  . .  .|. |..|...| ...|
HASENNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase CDKL4.AA CDK5 260-286 25 0.00019 9.43 In-house 261-287 (287) Show / Hide 
Range on Protein: 260-286
Range on HMM: 261-287/287
Sequence Identity: 25% (7 aa)

LNFMKGCLKMNPDDRLTCSQLLESSYF
...... |..||. |..  . |.  ||
MDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDKL4.AA RCK 259-286 32 0.002267 6.23 In-house 271-298 (298) Show / Hide 
Range on Protein: 259-286
Range on HMM: 271-298/298
Sequence Identity: 32% (9 aa)

ALNFMKGCLKMNPDDRLTCSQLLESSYF
... |. .|. .|. | | .|.|.  ||
CIELMEKMLQWDPQKRITAQQALQHPYF