Gene CHK1 (Human)

CHK1

Species: Human
Alias: CHEK1, CHK1, p56Chk1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 11q24,

Classification

Group: CAMK
Family: CAMKL
Subfamily: CHK1

Sequence

Name Sequence Type Origin Length Description Download
CHK1.NA RNA Sugen Kinome 2748 None Fasta, JSON
CHK1.AA Protein Sugen Kinome 476 None Fasta, JSON
CHK1.kin_dom Protein Kinase Domain Sugen Kinome 257 None Fasta, JSON

Protein domain

Protein domains of CHK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CHK1.AA CHK1 9-265 52 1.4e-185 622.86 In-house 1-276 (276) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-276/276
Sequence Identity: 52% (146 aa)

WDLVQTLGEGAYGEVQLAVN-RVTEEAVAVKIVDMKRAV--DCPEN-IKKEICINKMLN----HENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDI
...||||||||.|.|.|..| | .|||||.|....|..   ....| |.||.||.|||.    ||||....|.|......|||.||..||.|||.||||.
YEVVQTLGEGAFGQVKLCENQRNPEEAVAMKEIHIKGQHKMCFMDNDIRKEYCIQKMLSKIGKHENVIRMMGMRMDPEFYYLFMEYADGGDLFDKIEPDC

GMPEPDAQRFFHQLMAGVVYLHGIG-ITHRDIKPENLLLDERD------NLKISDFGLATVFR-YNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVW
|||. .|.|.|.||..|..|.|..| .|||||||||||||..|      ||||.||||||..| ....||.|.|.|||.||.|||..........|||.|
GMPSDEAHRYFKQLISGLKYIHCCGGVTHRDIKPENLLLDKHDSNDMPDNLKIADFGLATWYRRHDGEERMLDKRCGTPPYMAPEVCTGKQYRGPPVDIW

SCGIVLTAMLAGELPWDQPS-DSCQEYSDWKEKK--TYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWY
|||.||.|||.||||||||| ..||||..|...|  ....||.|||.....||.|||.|||..|.||..|.||.||
SCGVVLMAMLTGELPWDQPSHMDCQEYCWWMDNKHWMHWCPWSKIDCRAICLLRKILCENPNKRATIEQIEKDPWY
Kinase CHK1.AA CAMKL 9-265 36 6.1e-130 416.92 In-house 1-297 (297) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-297/297
Sequence Identity: 36% (110 aa)

WDLVQTLGEGAYGEVQLAVN-RVTEEAVAVKIVDMKRAVDCPENIKK--------------EICINKMLN---HENVVKFYGHRREGNI------QYLFL
.....|||.|..|.|.||.. | |.| ||.||.| |.. . | . |.              ||.| ||||   |.|..|.| ..   .        ||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCSGGE--LFDRI--EPDIG--MPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERD--NLKISDFGLATVFR-Y-NNRERLLNKMCGTLPYV
|||||||  |||.|  ... .  |||..|.|.| |....| |.|  || ||||||||.||||..  |.||.|||... .| . ......|.  ||..|| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APELLKR--REFHAEPVDVWSCGIVLTAMLAGELPWDQPSD-----SCQEYSDWKEKK-TYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWY
|||....  ..... .||.||||..| ||. |.||.|....     ... |  ||... .| ..|....     |..|.|. ||. |.|| .|....|.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCGYYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase CHK1.AA CAMK 14-265 22 1e-101 328.55 In-house 1-425 (425) Show / Hide 
Range on Protein: 14-265
Range on HMM: 1-425/425
Sequence Identity: 22% (95 aa)

TLGEGAYGEVQLAVNRVTE------------EAVAVKIVDMKRAVD---------------------------CPENIKKEICINKM-------LNHENV
|||.|..|.| |.... |             . ||.||.| |.. |                             .|...||.| |.       |.|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFYGHRREGNI-------------------QYLFL---EYCSGGEL----FDRI--EPD-------------IGMPEPDAQRFFHQLMAGVVYLHGIGI
.|.| .   ..                     |...   ||||||||    ||.|   ..               ..| .|.|.|.|.  .| |.|  .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

THRDIKPENLLLDERD-----------------NLKISDFGLATVFRYNNRER---------------------LLNKMCGTLPYVA-PELLKR------
 |||.||||.|||...                 |.||.|||.|..|. .. ..                     ... .|||..|.| ||.|..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------REFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEY-----------------SDWKEKKTYLNP---------WKKIDSA--------PLA
       .. . ...|.||||..| .|| |..|.. ..|....                   ..     |. |         |..|              
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLHKILVENPSARITIPDIKKDRWY
|. |.|. .|. |.|| ..... |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CHK1.AA S_TKc 9-265 30 8.2e-90 305.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-231/231
Sequence Identity: 30% (82 aa)

WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSG--GELFDRIEPDIG-----
.......|.||.|.| ..... | . ||.||..        |.|..|| | |. .|.|.||.|.. .. .  |...|||.|  |.|||.|.   .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-MPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTA
 .|| .|.....|.  .. |.|  || |||.||||.||||  ..||.|||||...         . .|||. |.|||.|    .  ...|.||||..|  
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKK-------DRWY
||.|. |..       ..    .|          ..  . .. |.|. .|. |.|. .. .       . | 
MLCGYPPFP-------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CHK1.AA Pkinase 9-265 26 2.3e-77 268.12 Pfam 1-293 (293) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD-CPENIKK--EICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGG----ELFDRIE--PD
. .....|.|..|.| ..... |.. |||||.. ... . ....  .  ||.| |.|||.|.|..|.  ....  |. .||| ||    .|||.|.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

IGM--PEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL----KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWS
 ..  .| ...... |.  |. |.|  || |||.||||.|.|.....    ||.||||| .|. . . . ..  |||..|.|||... .. .  .||.||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

CGIVLTAMLAGELPWDQP----SDSCQEYSDWKEKK--TYLNPWKKID-------------------SAPLALLHKILVENPSARITIPDIKKDRWY
||..|  || |..|...     .  .| .   . ..  .  . .....                   .. . .. ..|  .|. |.|...|... | 
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CHK1.AA MARK 9-224 36 6.9e-70 227.66 In-house 1-219 (262) Show / Hide 
Range on Protein: 9-224
Range on HMM: 1-219/262
Sequence Identity: 36% (83 aa)

WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD-CP-ENIKKEICINKMLNHENVVKFYGHRR--EGNI-QYLFLEYCSGGELFDRIEPD--IG
  ...|.|.|.|..| ||... |.. ||.||.. ..  | .  .|.. || | |.|.|.|..|..      . .   || .||.|||||.|.|.      
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

MPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERD--NLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLT
..|..| |.|.|.  .| |.| ..| ||||||||.|.||.   | ||.|||... .   . ...||  |||.|| |||......  . .||.||.|.|| 
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICI---PPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLY

AMLAGELPWDQPSDSCQEYSDWKEK
.|. | .|.|   ...|.| . ..|
FMVCGYFPFD---GDTQDYKELYKK
Kinase CHK1.AA AMPK 9-209 40 2.9e-64 189.7 In-house 1-201 (254) Show / Hide 
Range on Protein: 9-209
Range on HMM: 1-201/254
Sequence Identity: 40% (82 aa)

WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR--AVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQ-YLFLEYCSGGELFDRIEPDIGMPEP
  . .|.|||..| | ...   | |.||.|| . ..   .|  | |..|| | |...| .... |    | . . ....|| ||||||| |     ..| 
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

DAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGE
.|.||| |  .|| |.| ..| ||| ||||||||.  |.|| ||||  .   .    .|   ||   | |||.   .      ||.||||..| ||| | 
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDG---EFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGY

LPWD
|| |
LPFD
Kinase CHK1.AA GIN4 49-265 38 3.7e-56 177.68 In-house 78-293 (293) Show / Hide 
Range on Protein: 49-265
Range on HMM: 78-293/293
Sequence Identity: 38% (85 aa)

PENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDN-LKIS
| .| .|| | |...| ||.. |    . |  || |||  .||||. .     .|| .| ..|.|.. || | | ..| |||.||||||||.. | .|| 
PYGIEREIVIMKLISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIA

DFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWK-KIDSAPLALLHKIL
|||.| .   .  . ||.  ||   | |||.   . .|  . ||||||..| |.| | ||.|.     ..      |  |  |   .| .    |. |||
DFGMAAL---ETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKIL

VENPSARITIPDIKKDRWY
|  |  ||.. || |    
VVDPEKRIKTRDILKHPLI
Kinase CHK1.AA Ciliate-E2 9-265 23 4.6e-55 187.46 In-house 1-365 (365) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-365/365
Sequence Identity: 23% (88 aa)

WDLVQTLGEGAYGEVQLAVNRVTEE------------------AVAVKIVDMKRAV-DCPENIKKEICINK----------------MLNHENVVKFYGH
 .... .|.|..| | .. .. . .                   |..||. ||.   .  |.||.|| |..                 ||| |..|.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

RR---EGNIQYLFLEYCSGGELFDRIE--PDIG---------MPEPDAQRFFHQLMA---------------GVVYLHGIG-ITHRDIKPENLLLDERDN
     . || || .|||.||.|||.|.  .            . |  ..... |.                 .. |||  . | ||||||||.|.     
FQEKDDNNI-YLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LKISDFGLAT---VFRYNNRE--------------------------RLLNKMCGTLPYVAPELLKR--------REFHAEPVDVWSCGIVLTAMLAGEL
.||.||||..    ...|...                           . |  |||..|.||| |..        .. . . .|.||.|..|  || |..
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PWDQPSDSCQEYSDWKEKKTYLN----------------PWKKIDSAPLALLHK----ILVENPSARIT-IPDIKKDRWY
|.         .   |..|  ..                 |||..     |. |    .|. .|. ||| . .|..  | 
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CHK1.AA QIK 9-213 37 7.5e-54 185.23 In-house 1-223 (272) Show / Hide 
Range on Protein: 9-213
Range on HMM: 1-223/272
Sequence Identity: 37% (86 aa)

WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKK---EICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEP-------
 |. .|.| | .. | || .|.| . ||.||.| | . |  ||..|   |. | |||.| ...| |   .  .  |.  ||||.||.|| .         
YDIERTIGKGNFAVVKLARHRITKTKVAIKIID-KSQLDE-ENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVK

-----DIG--------MPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFH
     |||        |.|..|.| | |....| |.|  .| |||.| ||.|||.  | || |||.   |     . ||.  ||. || |||... .|. 
MVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFK---QGQLLMTWCGSPPYAAPEMFEGKEYD

AEPVDVWSCGIVLTAMLAGELPWDQPSD
   ||.|| |.|| .. .| || | ...
GPKVDIWSMGVVLYVLVCGALPFDGKTL
Kinase CHK1.AA MELK 9-265 31 4.1e-52 176.24 In-house 1-254 (254) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-254/254
Sequence Identity: 31% (80 aa)

WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQ
... ...| | .. |.||.  .|.. ||.||.| ..  .    .| |.   | | |... ..|      .  .. .|||.|||.|| |     . | ...
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETR

RFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPW
 || |... . |.|  |  |||.||||||.||  .||. ||||    . .  .  |.  || . | ||||.. ...  .  |||| ||.| ... | ||.
HFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPF

DQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWY
|   |  .       .  |  | | .      ||...|  .|  || . .. .  | 
DD--DNMMIMYKKIMSGCYEEP-KWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase CHK1.AA ULK 9-265 24 9.3e-51 174.95 In-house 1-329 (329) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-329/329
Sequence Identity: 24% (80 aa)

WDLVQTLGEGAYGEVQLAVNRVTE----EAVAVKIVDMKRAVDCPEN---------IKKEICINKMLN--------HENVVKFYGHRREGNI--QYLFLE
. | . ||.|..| |  . |  |.    |.||.|..| .     . .         .|.|| | |.|.        |.|.||.|   .. |    |...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCSGGELFDRIEPDIGMPEPD----------AQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDN------------LKISDFGLATVFRYN-NRER
|| || |.. |. . ..||.           |. ||.|...|  .||  .| ||||||.| |... .             |||.|||.| .. .. . ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LLNKMC------GTLPYVAPELLKRR----EFH-AEPVDVWSCGIVLTAMLAGELP---WDQPSDS---CQEYSDWKEKKT----YLNPW-------KKI
..  .       ||  | ||..|...    ... .. .|.|| |...  || |. |   |   ..    .|.  ... .        ..        ..|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYK-CDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

DSAPLALLHKILVENPSARITIPDIKKDRWY
 .    |. . |. ... ||..... .  | 
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase CHK1.AA TyrKc 9-264 23 6.4e-16 34.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKML--NHENVVKFYGHRREG-------NIQYLFLEYCSGGELFDRIEPD
  | ..|||||.||| ... .   . |||| .         | . .|. | ..|  .|.|.|..||  ...          .. .||...| | |..   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

IG-MPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRE-------RLLNKM---CGT--LPY--VAPELLKRREF
 .  . .|   | .|  .|  |||  .. |||.   | |..|.   |||||||.   |.   .           |.   .|   ||.   ||| .. ..|
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS---RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

HAEPVDVWSCGIVLT--AMLAGELPWD---QPSDSCQEYSDWKEKKTYLNPWKK--------IDSAPLALLHKILVENPSARITIPDIKKDRW
  .  |||| |...     . .. ...   |   | ||   . ..  .. . .           ..   .  .   |.|. | |  .| ....
TTK-SDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase CHK1.AA Pkinase_Tyr 9-152 30 3.1e-13 45.43 Pfam 1-158 (270) Show / Hide 
Range on Protein: 9-152
Range on HMM: 1-158/270
Sequence Identity: 30% (49 aa)

WDLVQTLGEGAYGEVQLAVNR----VTEEAVAVKIVDMKRAVDCP----ENIKKEICINKML-NHENVVKFYGHRR-EGNI--QYLFLEYCSGGELFDRI
  . ..|||||.||| ... .     |.  ||||..  |   . .    |   .|. | | | .|.|.|..||    .|     |. .||. .| | |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

EP----DIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLA
      .   . .|   . .|  .|  ||. ... |||.   | |..|    ||.|||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase CHK1.AA GIN4 9-45 45 3.2e-09 25.15 In-house 1-37 (293) Show / Hide 
Range on Protein: 9-45
Range on HMM: 1-37/293
Sequence Identity: 45% (17 aa)

WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRA
| | .||| |. | |||| |  | .  |||..  |..
WKLGETLGFGSTGKVQLAKNMETGQRAAVKVISKKKI
Kinase CHK1.AA AMPK 241-265 40 1.4e-08 21.67 In-house 230-254 (254) Show / Hide 
Range on Protein: 241-265
Range on HMM: 230-254/254
Sequence Identity: 40% (10 aa)

LLHKILVENPSARITIPDIKKDRWY
|....|  .|  |||| ||... |.
LIKHMLQVDPMKRITIHDIRNHPWF
Kinase CHK1.AA MARK 241-265 40 2.2e-07 20.35 In-house 238-262 (262) Show / Hide 
Range on Protein: 241-265
Range on HMM: 238-262/262
Sequence Identity: 40% (10 aa)

LLHKILVENPSARITIPDIKKDRWY
|....|. ||. |.|| .| |..| 
LIQRLLTVNPEERPTIEEIMKHPWM
Kinase CHK1.AA QIK 241-265 40 0.002692 9.11 In-house 248-272 (272) Show / Hide 
Range on Protein: 241-265
Range on HMM: 248-272/272
Sequence Identity: 40% (10 aa)

LLHKILVENPSARITIPDIKKDRWY
|  . || .|. |.||  |.. || 
LIRHMLVVDPEHRYTIMQICQHRWM