Gene CLK4 (Human)

CLK4

Species: Human
Alias: DKFZp686A20267, CLK4
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 5q35.3,

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
CLK4.kin_dom Protein Kinase Domain Sugen Kinome 317 None Fasta, JSON
CLK4.NA RNA Sugen Kinome 2524 None Fasta, JSON
CLK4.AA Protein Sugen Kinome 481 None Fasta, JSON

Protein domain

Protein domains of CLK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CLK4.AA CLK 159-475 61 6.2e-263 798.56 In-house 1-350 (350) Show / Hide 
Range on Protein: 159-475
Range on HMM: 1-350/350
Sequence Identity: 61% (214 aa)

YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQ-VLEHLNST-DPNSVFR--CVQMLEWFDH-HGHVCIVFELLGLSTYDFIKEN
||||.|||||.|||||||.|| ... .||.||..||..|||||..||. .....| . |||. ..  |..|..|||. |||.||||||.|||.|||.|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

S------FLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKS-----DYVVKYNSKMK---------RDERTLKNTDIKVVDFGSAT---YD
.      ..|..|||||.||||.|....|||..||||||||||||.||.|     |. .|||.|.|         ......|||.|.|.||||||   .|
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRFD

DEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILG-PIPQHMIQKTR----KRKYFHHNQLDWDEHSSAGR
.|||||.|||||||||||||.||||||||||||||||.|.|.|||.|||||..|||||||||.| ||||.|||.||    |.|||.||.||||.|.|.||
HEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGR

YVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF
||...|||||..|.|.|.||..||||.|.||||||..|||...|||||||
YVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase CLK4.AA CMGC 159-475 21 5.2e-113 372.89 In-house 1-513 (513) Show / Hide 
Range on Protein: 159-475
Range on HMM: 1-513/513
Sequence Identity: 21% (115 aa)

YEIVDTLGEGAFGKVVECID-------------HGMDGMHVAVKIVKNVGRYREAAR-------------SEIQVLEHLN----------STDPNSVFR-
|||.. .|||..|.|..|.|             |  .. .||.|..||.  | | |.              ||. |.|||            ||..  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

-CVQMLEWFDHHG-----------------HVCIVFELLGLSTYDFIKENSF-------LPFQIDH------------IRQMA------YQICQSIN--F
 .|.....| |..                 |...|||... . |..||.|.|       .|.   |            |. .       |||.....  .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHHNK--LTHTDLKPENILFVKSDYVV--------KYNSKMKRDERTLKNTDIKVVDFGSATYDDEH------------------------HSTLVSTRH
.| ..    |.||||||||. .   ..        . .  ..     .||  .|. |||.|.. ..|                        ... |.||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSED-W-NPC-----QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRW

YRAPEVILALG----------WSQPCDVWSIGCILIEYYLG--------FTVFQTHDS-----------KEHLAMMERILGPIPQHMIQKTR--------
|||||..|  .          ...|.|.||.|||. | |.|         . |..|..            ..|... ..||... .||||..        
YRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKH

KRKYFHHNQLDWDEH----------------------SSAGRYVRRRCKPLKEFMLCHDE--------------------------------EHEKLFDL
..... ...|.| .                       .| .|. ....||.|... .|..                                ......||
EEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDL

VRRMLEYDPTQRITLDEALQHPFF
. .||.|||..||| ..|||||.|
LKKMLQYDPDKRITAEQALQHPYF
Kinase CLK4.AA Pkinase 159-475 25 5e-84 290.25 Pfam 1-293 (293) Show / Hide 
Range on Protein: 159-475
Range on HMM: 1-293/293
Sequence Identity: 25% (88 aa)

YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARS-----EIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGL-----STYD
|.|. ..|.|.||.| .|...| .|  |||||.| ...  .  ..     |||.. .||     . .  |....||  ..|...|.|...      . .|
YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPN-IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

FIK---ENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA----TYDDEHHSTLVSTR
.|.   ...|. |. .... ..|||.. ....| ..  | ||||||||.. ......               ..|. |||.|    .  ..  .|.. |.
YISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA--------------CVKICDFGLAKQFDY-NNS-MTTFCGTP

HYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTH----DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKE
.|.|||||. . ......|.||.||||.| ..| . |. |    .  ....|..||.||..   ..... . ||.  .  | .               . 
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------------F-

FMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF
...  .. .| . |.....|..||..|.| ...||||.|
HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CLK4.AA S_TKc 159-475 27 3.3e-79 270.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 159-475
Range on HMM: 1-231/231
Sequence Identity: 27% (90 aa)

YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGL---STYDFIKENSF
|||....|.||||||  |.... .| .||.||.|      | .|.|||.|..            |.....|.. .|...|.|...    . .|.||..  
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

----LPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA
     ||   |.| ..||||. ....| ..  | ||||||||. .                      ||. |||.|.      .|.. |..|.||||.  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------------HIKICDFGLARQL----TTFCGTPWYMAPEVL--

LGWSQ-PCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFD
 |..  .||.||.||||.| . | . |.     .. .|...|.                                                    . . |
-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------------------------------SPEAKD

LVRRMLEYDPTQRITLDEALQ-------HPFF
..|..|..||..|.|  ||||       ||.|
FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CLK4.AA DYRK 159-302 42 5.4e-56 192.34 In-house 1-147 (320) Show / Hide 
Range on Protein: 159-302
Range on HMM: 1-147/320
Sequence Identity: 42% (63 aa)

YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPF
|||.. .| | ||.|| | ||   . .||.||..|  |.   |  ||. ||.||  ||.  ..||.|.. | |..|.|||||||  . |.|.|.|.| .|
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

-QIDHIRQMAYQICQSINFLHHN-KLTHTDLKPENILFVK--SDYVVK
  . ..|..|.||.... ||| | .. | |||||||. ..  . . .|
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIK
Kinase CLK4.AA DYRK2 159-293 43 9.5e-51 163.08 In-house 1-134 (318) Show / Hide 
Range on Protein: 159-293
Range on HMM: 1-134/318
Sequence Identity: 43% (59 aa)

YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPF
|||.  .| | || ||.| ||  .  |||.|.. |  |. . |  ||..|.|. . |... . || ||. |   .|.||.||||... |..||.|.|  |
YEILEVIGKGSFGQVVKCYDHKTK-QHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGF

QIDHIRQMAYQICQSINFLHHNKLTHTDLKPENIL
    .| .|..| |...||| |.. | ||||||||
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL
Kinase CLK4.AA DYRK1 159-414 32 6.3e-47 162.23 In-house 1-241 (321) Show / Hide 
Range on Protein: 159-414
Range on HMM: 1-241/321
Sequence Identity: 32% (85 aa)

YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPF
|||   .| |.||.||   || ..  .||.||.||   . . |. ||..|| .|  |... .. |.. . | .  |.|.|||||    || ..  .|   
YEIDSLIGKGSFGQVVKAYDH-QEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV

QIDHIRQMAYQICQSINFLHHNKLT--HTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ
 .  .|..| |.|... |.    |   | |||||||| . .                 |   ||..||||.   ..     .  | ||.|||.| . .. 
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNP-----------------KRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDM

PCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRK-RKYFHHNQ
  |.||.||||.|   |  .|   .  . .  .  .||  |.|||... | .|||....
AIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDP
Kinase CLK4.AA Ciliate-E2 159-475 17 1.2e-41 140.75 In-house 1-365 (365) Show / Hide 
Range on Protein: 159-475
Range on HMM: 1-365/365
Sequence Identity: 17% (79 aa)

YEIVDTLGEGAFGKVVEC-------------IDHGM----------DGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFR--------------
|...  .|.|.||.| .|             ||  .          ... .|.||.|.  .  |.  .||...  .|. .    ..              
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKK--NQIEQIKQEIHIMREINC-F----YKKINEKNILEQLNHP

-CVQMLEWFD--HHGHVCIVFELL-GLSTYDFIKEN----------SFLPFQIDHIRQMAYQICQ---------------SINFLHHNK-LTHTDLKPEN
  ..| |.|      .. .|.|.. | . .|.||.|            ..| . .|... .||.|                ...|| ..   | |.||||
NIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPEN

ILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDD----------------------------------EHHSTLVSTRHYRAPEVILALG----
|||                        ||..||| ... |                                  . . |.. | .| |||..   .    
ILF------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ

-----WSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLC--------
     ..  ||.||.|.|| |   | . |                                                        ... . |        
QKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------------------------------------------------QQQIKQCKIDFPCPE

--------------HDEEHEKLFDLVRR----MLEYDPTQRIT-LDEALQHPFF
              ...  ..  || ..    ||..|| .|||  ...|.||.|
WQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CLK4.AA DYRK 315-475 30 6.1e-39 135.7 In-house 142-320 (320) Show / Hide 
Range on Protein: 315-475
Range on HMM: 142-320/320
Sequence Identity: 30% (55 aa)

KNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQK---TRKRKYFH
.. .|||.||||... ... .| .  |.|||||||| .  . . |.|| |||| | ..|   |.  .  . ||..  .||..|..||.|   .||.|.| 
NKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFD

HNQLDWDEHSSAGRYVR----------------RRCKPLKE--FMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF
   . ..|. ..    .                 |  | ..   ....  . ... |.....|..||..|||  .|||||.|
C--FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase CLK4.AA HIPK 159-295 39 1.2e-38 118.95 In-house 1-135 (329) Show / Hide 
Range on Protein: 159-295
Range on HMM: 1-135/329
Sequence Identity: 39% (54 aa)

YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPF
||... || | ||.|| |  .| . | ||.|| ||   |    . |...|. | . ...  .  | ..| |.|. |.|.|||.|    ||| |.| | | 
YEVLEFLGRGTFGQVVKCWKRGTNEM-VAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPL

QIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFV
 . ||| .  |.   .  | .  | | |||||||. |
PLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLV
Kinase CLK4.AA CAMK 164-367 18 4.6e-37 116.47 In-house 1-324 (425) Show / Hide 
Range on Protein: 164-367
Range on HMM: 1-324/425
Sequence Identity: 18% (63 aa)

TLGEGAFGKVVECIDH-GMD----------GMHVAVKIVKNV-----------------------------GRYREAARSEIQVLEHLNSTDP-NSVFRC
|||.|.|||| .||.               | .||.||..                               .. |.  |.||... .|....   .    
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQMLEWFDHHGH-------------------VCIVF---ELLGLS----T-YDFIKENSFL-------------PFQIDHIRQMAYQICQSINFLHHNKL
....|... . .                   ...|.   |.          .|.|.|..                |. .  |..  |||. ....| .. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

THTDLKPENILFVKS-------------DYVVKYNSKMKRDERTLKNTDIKVVDFGSATY--------------------------DDEHHSTLVSTRHY
 | ||||||||....             |               ..| .||..||| |..                          ...  .| . | .|
VHRDLKPENILLDDNNDDSDPVEHDEIFD---------------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEY

RA-PEVILA--------------LGWSQPCDVWSIGCIL
 | |||..                . ...||.||.|.||
MAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase CLK4.AA YAK 159-298 38 1.8e-35 117.67 In-house 1-143 (347) Show / Hide 
Range on Protein: 159-298
Range on HMM: 1-143/347
Sequence Identity: 38% (55 aa)

YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNS-TDPNSVF---RCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENS
| . | || | || || |   . . . .|||..||   |   |. |||.|. ||   |||      . . |.  | |  | |.|||.| .. |...| | 
YIVLDMLGQGTFGQVVKCQNCDTNEL-FAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNK

FLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSD
|  | .  |||   ||  ..  |   .. | |||||||.  | .
FCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPN
Kinase CLK4.AA STE 159-369 19 1.5e-34 119.46 In-house 1-260 (359) Show / Hide 
Range on Protein: 159-369
Range on HMM: 1-260/359
Sequence Identity: 19% (56 aa)

YEIVDTLGEGAFGKVVECIDH--------------GMDGMHVAVKIVKNVG------------------RYREAARSEIQVLEHLNSTDPNSVFRC---V
.|... .|.||||.|. ...|              |  |  .|.|...                       ..    ||... ..|.        .   |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH------M-HPNIV

QMLEWFDHHG-------HVCIVFELLG-LSTYDFIKENSFLPFQI------------DHIRQMAYQICQS-INFLHHNKLTHTDLKPENILFVKSDYVVK
. .  . . |       ...|. |...  |  |.||..   ...             . |. ...||..   ..|| ..  | |.|| |||.        
KYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------

YNSKMKRDERTLKNTDIKVVDFGSATYDDE-------------------HHSTLVSTRHYRAPEVILA------LGWSQPCDVWSIGCILIE
                .| .||| ..  ..                   .  |.| |  . |||||.        | .  ||.||.|| .||
----------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIE
Kinase CLK4.AA DYRK2 318-475 28 1.6e-33 106.15 In-house 142-318 (318) Show / Hide 
Range on Protein: 318-475
Range on HMM: 142-318/318
Sequence Identity: 28% (51 aa)

DIKVVDFGSATYDDE-HHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQK------TRKRKYF
.|||.|||| ..... .  | . .| |||||||| .  . . | || |||. | | |.  |   . .. .|.|  .||  |......      .|.. .|
GIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFF

H--------------HNQLDWDEHSSAGRYVRRRCKPLKEFML-CHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF
                ...     ...|.      |..|...  | ||    . | ..| .| ||..|.| ..||.||..
NSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDEN---FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase CLK4.AA YAK 314-377 37 2.3e-13 41.38 In-house 139-205 (347) Show / Hide 
Range on Protein: 314-377
Range on HMM: 139-205/347
Sequence Identity: 37% (25 aa)

LKN---TDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVF
|..    .||..||||. .      | .  ||||.||.|.    .   | || |||. | .||  .|
LCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIF
Kinase CLK4.AA HIPK 319-373 44 2.8e-13 37.66 In-house 144-199 (329) Show / Hide 
Range on Protein: 319-373
Range on HMM: 144-199/329
Sequence Identity: 44% (25 aa)

IKVVDFGSATYDDEH-HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLG
.||.||||| .  .   .| .  |.|||||.||.|   .  |.|| ||.. | .||
VKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG
Kinase CLK4.AA CAMK 450-475 46 4.2e-13 37.85 In-house 400-425 (425) Show / Hide 
Range on Protein: 450-475
Range on HMM: 400-425/425
Sequence Identity: 46% (12 aa)

DLVRRMLEYDPTQRITLDEALQHPFF
||.|.||..||..|.|....|.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CLK4.AA DYRK1 443-475 60 1e-10 33.37 In-house 289-321 (321) Show / Hide 
Range on Protein: 443-475
Range on HMM: 289-321/321
Sequence Identity: 60% (20 aa)

EEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF
|.  |  ||..|||.||| ||||  .||||.||
EDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase CLK4.AA TyrKc 159-475 17 3.1e-10 -57.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 159-475
Range on HMM: 1-280/280
Sequence Identity: 17% (62 aa)

YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHL--NSTDPNSVFRCVQMLEWFDHH-------GHVCIVFELLGL-STYD
 .  ..|||||||.|....      . |||| .|.    ||. ..|.... .|  .   ||     |...    ..       . ..||.|.  . .  |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGH--HPN----IVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH------HSTLVSTR-
.....    .. ..  ....||..  ..||.... | ||   |.| |....                   .|. ||| . . ...      ... ...  
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL-VGENH------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEH

-HYR--------APEVILALGWSQPCDVWSIGCIL-------IEYYLG-----FTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH
 . .        |||.|     .   |||| |  .        . | |      . .. .   ..  .|..   .    |                    
KGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------------

SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF
                |  |.||    .... ..  ..|| .| |  |   | .|
----------------FVCCPDE----MYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CLK4.AA STE 446-475 31 5.6e-07 20.82 In-house 328-359 (359) Show / Hide 
Range on Protein: 446-475
Range on HMM: 328-359/359
Sequence Identity: 31% (10 aa)

EKLFDLVRRMLEYDPTQRITLDEALQ--HPFF
... | ... |..|| .| | .. |.  |||.
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase CLK4.AA Pkinase_Tyr 159-193 34 5e-06 20.96 Pfam 1-38 (270) Show / Hide 
Range on Protein: 159-193
Range on HMM: 1-38/270
Sequence Identity: 34% (13 aa)

YEIVDTLGEGAFGKVVECIDH---GMDGMHVAVKIVKN
 ..  .|||||||.|.... .   . ....||||..|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE
Kinase CLK4.AA HIPK 438-475 28 5e-06 14.5 In-house 292-329 (329) Show / Hide 
Range on Protein: 438-475
Range on HMM: 292-329/329
Sequence Identity: 28% (11 aa)

MLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF
...     .   .. ..|.  |. .|||  |||.||| 
YRVEKIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase CLK4.AA YAK 448-475 32 0.00016 10.85 In-house 320-347 (347) Show / Hide 
Range on Protein: 448-475
Range on HMM: 320-347/347
Sequence Identity: 32% (9 aa)

LFDLVRRMLEYDPTQRITLDEALQHPFF
. |..  .|. .|  | .   | |||| 
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase CLK4.AA Pkinase_Tyr 230-287 22 0.18699 5.55 Pfam 75-137 (270) Show / Hide 
Range on Protein: 230-287
Range on HMM: 75-137/270
Sequence Identity: 22% (14 aa)

DHHGH--VCIVFELLGL-STYDFIKEN--SFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDL
|. ..  ..||.|.  . . .|. ...  .  |. . .. ||..||..  ..|. ... | ||
DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL