Gene COT (Human)

COT

Species: Human
Alias: ESTF, EST, COT, Tpl-2, MAP3K8, TPL2, TPL-2, FLJ10486, c-COT
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 10p11.23,

Classification

Group: STE
Family: STE-Unique

Sequence

Name Sequence Type Origin Length Description Download
COT.NA RNA Sugen Kinome 3096 None Fasta, JSON
COT.AA Protein Sugen Kinome 467 None Fasta, JSON
COT.kin_dom Protein Kinase Domain Sugen Kinome 253 None Fasta, JSON

Protein domain

Protein domains of COT.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase COT.AA STE-Unique 201-388 34 1.7e-103 350.13 In-house 367-616 (616) Show / Hide 
Range on Protein: 201-388
Range on HMM: 367-616/616
Sequence Identity: 34% (85 aa)

ETVHLFMEAGEGGSVLEKLESCGP---------MREFEIIWVTKHVLKGLDFLHSKK--VIHHDIKPSNIVFMS------TKAVLVDFGLSVQMTED---
..|..|||..|.|.. .....||.         ..|.|.||.|...|.||..|||..  .||.|.||.||..|.      .|....|||.......|   
NWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFE

-----------------------------------VYFPKDLRGTEIYMSPEVILCR-----GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYL
                                   .|..|...||..||.||||.||     ...||.||.|||....||..|.|||..||...||....
KDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMC

YIIHKQAP--PLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEAL
..||.|.|  |.|.|...|.|.....||..|||||.|||.|..||.|..|
IHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase COT.AA STE 138-388 25 5.6e-81 275.33 In-house 1-359 (359) Show / Hide 
Range on Protein: 138-388
Range on HMM: 1-359/359
Sequence Identity: 25% (92 aa)

NIGSDFIPRGAFGKVYLAQDIK---------------TKKRMACKLIPVDQFKP----------------------SDVEIQACFR--HENIAELYGAVL
  | ..| .||||.||.| ..|               |...|| | ..... ..                       ...|  ...  |.|| . ||. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

WG-------ETVHLFMEAGEGGSVLEKLE-SCGPMR-------------EFEIIWVTKHVLKG-LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQ
 .       ......||  .|||. . ..  .|. .             | .|..... .||| |..|||...|| ||||.|| .    . |.|||.. |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

MTEDVY----------------FPKDLRGTEIYMSPEVILC------RGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYL--YIIH--------
.|...                   . . ||  .|.||||..       |..||.||.||| |.|.| || ||| . .| .|.   .  |...        
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--KQAPPLEDIAD----------------DCSPGMRELIEASLERNPNHRPRAADLLK--HEAL
  .. |||.|  .                 .|| ... |.  |...||.|| | .|||  |. .
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase COT.AA S_TKc 138-388 25 9.7e-58 199.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 138-388
Range on HMM: 1-231/231
Sequence Identity: 25% (68 aa)

NIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEG--GSVLEKLESCGP------MREFE
    . | .|||||||.....||....|.| |.  .   . ..|    .|.||  ||..    . ....||  .|  |.... ....|.      . | .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

IIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHST-KADIYSLGATLIHMQTGTPPWV
.  ... ....|...||...|| |.||.|| . .    . ||||. |.       . . ||  ||.|||.   |... |.|..|.| .|. | .| ||. 
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP

KRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLK-------HEAL
          .  ...|            || ....|.  |...|..|| | ..|.       |. .
---------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase COT.AA Pkinase 146-388 25 1.2e-50 179.43 Pfam 9-293 (293) Show / Hide 
Range on Protein: 146-388
Range on HMM: 9-293/293
Sequence Identity: 25% (72 aa)

RGAFGKVYLAQDIKTKKRMACKLIPVDQFKP---------SDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGG----SVLEKLE--SCGPM--REF
.|.||.||......| |. |.| |...  |.         | ..| . ..|.|| .||...  .  ... ||  |||    .  . ..  . |..   | 
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEW

EIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-----LVDFGLSVQM-TEDVYFPKDLRGTEIYMSPEVIL-CRGHSTKADIYSLGATLIHMQ
|.. . . .|.||...||...|| |.||.|| . ..  .     . ||||. |. .     .... ||  ||.||||. ......|.|..|.| .|. | 
ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML

TGTPPWVKR--YPRSAYPSYLYIIHKQAPPLEDIADDCS-------------------PGMRELIEASLERNPNHRPRAADLLKHEAL
.| ||.  .   .. . . ...   ...|. .|.  .||                   . ....|.  |...|. || |...|.|. .
CGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase COT.AA STE20 146-388 31 3.3e-46 159.85 In-house 9-288 (288) Show / Hide 
Range on Protein: 146-388
Range on HMM: 9-288/288
Sequence Identity: 31% (89 aa)

RGAFGKVYLAQDIKTKKR----MACKLIPVDQFK---PSDVEIQA-------CFRHENIAELYGAVLWG----ETVHLFMEAGEGGSVLEKLE---SCG-
.|..||||.| ...|..      | | ..... .   ..  .||        |  |.|| . ||. | .    .   . ||  .|||... ..   .|| 
QGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGK

-----PMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMST-KAVLVDFGLSVQMTE----DVYFP-KDLRGTEIYMSPEVILC-----RGHSTK
     || | .|  ... ||.|||.|||...|| |||  ||   .  .. |.|||.. |.|.       |. . . ||  .|.||||.|      |. .|
NHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYK

ADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYII--HKQAPPLEDI-ADDCSPGMRELIEASLERNPNHRPRAADLLKHEAL
.||.||| |.| | .| ||  .  | .|    ..|.   .. |.|.|.  . .||  .....  |...|. || | .||||. .
CDIWSLGITAIEMAEGEPPYFDMHPMRAM---FMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase COT.AA CAMK 143-388 15 4e-39 123.23 In-house 1-425 (425) Show / Hide 
Range on Protein: 143-388
Range on HMM: 1-425/425
Sequence Identity: 15% (65 aa)

FIPRGAFGKVYLAQDIKTK------------KRMACKLIPVD---------------------------------QFKPSDVEIQAC-------FRHENI
 . ||.||||.|.....|.            .. |.| |. .                                 .. .. .||           .|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

AELYGAVL------------WGET--------VHLFM---EAGEGG----SVLEKLESCGP---------------MREFEIIWVTKHVLKGLDFLHSKK
  || .                ..        ....|   |  .||     ..... . |.               . | |   . . .. .....||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHHDIKPSNIVFMST------------------KAVLVDFGLSVQMTEDV-----------------------YFPKDLRGTEIYMS-PEVILC-----
..| |.|| || . .                   .  ..|||.. .....                           |.  ||  ||. |||..      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------RGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAY--------PSYLYIIHKQAP---PLED---------------IADD----CSPGMR
         .... |.|. |.|  |  | .|.||.   .  . .        .. |.   ...    | .                | |.    .|.  .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

ELIEASLERNPNHRPRAADLLKHEAL
 ||   |...|..|. ... |.|. .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase COT.AA ASK 144-388 31 4.4e-38 124.15 In-house 2-254 (254) Show / Hide 
Range on Protein: 144-388
Range on HMM: 2-254/254
Sequence Identity: 31% (80 aa)

IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPS-----DVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESC-GPMR--EFEIIWVTK
. .|..| || . | .|..|.| | ||. . . .     ....    ||.|| .  |..  .. ...|||   |||. . |.|  |||.  |  . . ||
LGKGTYGIVYAGRDMHTQVRIAIKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYTK

HVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVL--VDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL--CRGHSTKADIYSLGATLIHMQTGTPPWVK-R
 .|.|| .|| ....| |||  |..      |.   ||| .  .       .  .||  || ||||    ||.   |||.|.| |.. | || ||..   
QILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPPFHELG

YPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEAL
 |. |   .   ..|. |.   | .. |   .. |    | .|..|. |.|||. . |
EPQAAM--FKVGMYKKHPE---IPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase COT.AA Ciliate-E2 146-388 19 8.5e-38 127.31 In-house 9-365 (365) Show / Hide 
Range on Protein: 146-388
Range on HMM: 9-365/365
Sequence Identity: 19% (72 aa)

RGAFGKVYLAQDIKTKKRM------------------ACKLIPVDQFKPSDVEIQA----CFR-------------------HENIAELYGAVL--WGET
.|.||.||.....|..|.                   . |.. . ..|....|..      .|                   | || ..| .      ..
QGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNN

VHLFMEAGEGGSVLEKLESC-----------GPMREFEIIWVTKHVLK---------------GLDFLHSKK-VIHHDIKPSNIVFMSTKAVLVDFGLSV
. | ||  .||. .. ....           ... |.||. ..|..|.               .| .||||. .|| ||||.||.|      ..||||| 
IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSK

QMTED----------VYFPKDL----------------------RGTEIYMSPEVILCRG---------HSTKADIYSLGATLIHMQTGTPPWVKRYPRS
. ..|            ..                          ||  ||.||..   .         ...|.||.||| .|  | .| ||.       
KYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------

AYPSYLYIIHKQAPPLED----------------IADDCSPGMRELIEA----SLERNPNHRPR-AADLLKHEAL
      ....|| .   .                . ...|. .  ||       |...|. |.  . ..|.|. .
------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase COT.AA STE11 142-388 28 2.1e-37 130.57 In-house 5-303 (303) Show / Hide 
Range on Protein: 142-388
Range on HMM: 5-303/303
Sequence Identity: 28% (89 aa)

DFIPRGAFGKVYLAQDIKTKKRMACKLIPV-DQFK----------P------SDVEIQA--CFRHENIAELYGAVL---WGETVHLFMEAGEGGSVLEKL
..| .||||.||.. ...| ..|| | |.. .. .          .         ||.    ..|.||   ||. |     ..|  |||  .|||. . |
EIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSML

E-SCGP--MREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV---LVDFGLSVQMTEDVY--------------FPKDLR----GTEIYMS
.   ||  . | .|   || .|.|| .|||...|| |||. || .. .. .   |.||| .... .. .              ... .     ||  .|.
RHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANI-LLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMA

PEVILCRG---HSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPS------YLYIIH-KQAPP-LEDIADDCS---PGMRELIEASLERNPNHRPRAAD
||||   |   ...|||| |||.| | | || |||      . | .      . .. . |..||  |..    |   .  |. .   .|..|. || |..
PEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPW------HNYDHNHMAAMFKIGMGHKPHPPIPEHMSP-ISWISEECRDFLRHCFEHDPKKRPTANQ

LLKHEAL
||.|  .
LLQHPFI
Kinase COT.AA SLK 136-388 31 5.3e-35 115.43 In-house 1-259 (259) Show / Hide 
Range on Protein: 136-388
Range on HMM: 1-259/259
Sequence Identity: 31% (84 aa)

YRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKP-----SDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLE-KLESCGPMREFE
.  ||   .  ||||||| ||.  .|.  | | | ...         ...| .   | || .||.|  . . . ...|  .|| | .  .|   |..|  
WEIIGE--LGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQ

IIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVF-MSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC-----RGHSTKADIYSLGATLIHMQTG
|  | ||.. .|..|||.|||| |.|  ||.. |  .  | ||| | . ....       ||  .| |||..|     .    ||||.||| ||| |  .
IQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQM

TPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEAL
 ||     |       |  | |  ||        |   ..... .|...|. |. .|.|..|. .
EPPHHEMNPMRV----LLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase COT.AA MEKK15 178-388 32 4e-34 119.68 In-house 51-264 (264) Show / Hide 
Range on Protein: 178-388
Range on HMM: 51-264/264
Sequence Identity: 32% (70 aa)

DVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFG----
.|..    .| ||    |  |   .| .||.   |||.   .   ||. |      || .|.|  .||   |.| |||  |.. |.|  . |.|||    
EVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKR

LSVQ-MTEDV-YFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLE
|..| .        | .|||  .| ||||   |.  |.||.|.| |   | |. |||    .  |    .. |  .  |. .. .  |   |. ... | 
LCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCTVFEMATRKPPWADMDRMAA----MFYIGAHRDPMPQLPVKFSEDARMFVRMCLT

RNPNHRPRAADLLKHEAL
|  . || | .||||  .
RDQHERPTASQLLKHPFI
Kinase COT.AA TKL 144-386 17 8.9e-34 118.54 In-house 1-364 (364) Show / Hide 
Range on Protein: 144-386
Range on HMM: 1-364/364
Sequence Identity: 17% (66 aa)

IPRGAFGKVYLAQDIKTK--------KRMACKLIPVDQ-----------------------------FKPSDVEIQAC---FRHENIAELYGAVLWGET-
| .|.||.|| ..   .         | .| | .....                             |.   .|   .   .||.||  ..|... ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------VHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHS--------KKVIHHDIKPSNIVFMS-TK--------------AV
             .. ||  .||| |. |          ..   . . .|...|||        ...|| |.|..||   .  .              . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

LVDFGLSVQMTEDVY-------------------FPKDLRGTEIYMSPEVIL----------------CRGHSTKADIYSLGATLIHMQTGTPPWVKRYP
. |||||  |...                          .||  .|.|||.                 ..  |.|.|.|| |  |  . |. .|. .  .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

RSAYPS-------YLYIIHKQAPPLE---------DIADDCSPGMRELIEASLERNPNHRPRAADLLKHE
.. ...       .. . ... ||.             .|| |.|..|..   . .|. || . ..||. 
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase COT.AA STE-Unique 139-200 36 1.3e-25 87.54 In-house 1-73 (616) Show / Hide 
Range on Protein: 139-200
Range on HMM: 1-73/616
Sequence Identity: 36% (27 aa)

IGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFK-----------PSDVEIQACFRHENIAELYGAVLWG
.....|.||.||.|...|..|...|.|.|.|...|||           .|..||..|..|.||...||..|||
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWG
Kinase COT.AA TyrKc 141-388 21 1.9e-11 -37.7 SMART 4-280 (280) Show / Hide 
Range on Protein: 141-388
Range on HMM: 4-280/280
Sequence Identity: 21% (61 aa)

SDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQAC----F--RHENIAELYGAVLWG-------ETVHLFMEAGEGGSVLEKLESCGP-MR
 . . .||||.||... .      | | .  |     |    |     .  .|.||  |||... .       | . . ||  ..|. .. | ...|   
GKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

EFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTK-AVLVDFGLSVQMTED--------VYFPK---DLR--GTEIYMSPEVILCRGHSTKADIYS
  . .     . .| ..||||..|| |.   |.   . . .   |||||   ..|        .| .|   . .       |.||.|  .  .|| |..|
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS

LGATL--IHMQTGTPPWV----KRYPRSAYPSYLYIIHKQAPPLEDIADD-----CSPGMRELIEASLERNPNHRPRAADLLKHEAL
 | ..  |    ..|..     .  .. ..  |.   .   .| .|         |.. | ....   ...|. ||. ...  || .
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVI-EYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase COT.AA Pkinase_Tyr 185-254 28 0.001739 12.43 Pfam 60-137 (270) Show / Hide 
Range on Protein: 185-254
Range on HMM: 60-137/270
Sequence Identity: 28% (22 aa)

F-RHENIAELYGAVL-WGET--VHLFMEAGEGGSVLEKLESC----GPMREFEIIWVTKHVLKGLDFLHSKKVIHHDI
. .|.||  |||...  ||   . . ||  ..|. |. | .     .|    ...     . ||...|.||. || |.
LGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase COT.AA Pkinase_Tyr 355-388 23 4.067315 1.02 Pfam 239-270 (270) Show / Hide 
Range on Protein: 355-388
Range on HMM: 239-270/270
Sequence Identity: 23% (8 aa)

DDCSPGMRELIEASLERNPNHRPRAADLLKHEAL
..|.. . .|.    . .|..||. ...  || |
ENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL