Gene CRIK (Human)

CRIK

Species: Human
Alias: CIT, KIAA0949, STK21, CRIK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 12q24.31,

Classification

Group: AGC
Family: DMPK
Subfamily: CRIK

Sequence

Name Sequence Type Origin Length Description Download
CRIK.kin_dom Protein Kinase Domain Sugen Kinome 264 None Fasta, JSON
CRIK.NA RNA Sugen Kinome 8649 None Fasta, JSON
CRIK.AA Protein Sugen Kinome 2069 None Fasta, JSON

Protein domain

Protein domains of CRIK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CRIK.AA DMPK 97-360 57 2.4e-265 665.89 In-house 1-270 (270) Show / Hide 
Range on Protein: 97-360
Range on HMM: 1-270/270
Sequence Identity: 57% (154 aa)

FEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDEN
||.....|.|||.||||||.|.|.|.||||.|.|...|.......|.|||.|.....|.||.||.|||||.|.||.||||.||||||.|..||||...|.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

LIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEM
...|||||..||.||.| ||||||||||.|.|.||.|||||.||||..|||...||..|...|||||..||||..|..||||.|| .||||||||..|||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

IYGRSPFAEGTSARTFNNIMNF-QRFLKFPDDPK--VSSDFLDLIQSLLCGQKERLK---FEGLCCHPFF
.||..|| ......|...|||. ...|.||||||  ||... |||..||| ..|||.   .|...|||||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase CRIK.AA CRIK 97-360 72 1.5e-247 797.96 In-house 1-272 (272) Show / Hide 
Range on Protein: 97-360
Range on HMM: 1-272/272
Sequence Identity: 72% (197 aa)

FEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDEN
|||..|.|||||..|||||||.|.||||||||.||..|||||||||||||.|.||..|||.|||||||||...|||.|||.||||||||.||..||.|||
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

LIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGD--GKGTYGLDCDWWSVGVIAY
...|||||||.||||.|.||||||||||||||.||||||||.|||||||||.|..||.|.|.|||||||||||..|||.  .||.||.||||||.|.|||
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMIYGRSPFAEGTSARTFNNIMN------FQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEGLCCHPFF
||..|..||.|....||..||||      |||||.||||||||....||||||||.|..|||.|.|||||||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPKVSPNYRDLIQSLLCNQSKRLKYEQLCCHPFF
Kinase CRIK.AA AGC 97-360 29 5.69999999999e-149 388.17 In-house 1-395 (395) Show / Hide 
Range on Protein: 97-360
Range on HMM: 1-395/395
Sequence Identity: 29% (119 aa)

FEVRSLVGCGHFAEVQVVREK------ATGDIYAMKVMKKKA--------LLAQEQVSF-------FEEERNILSRST----------SPWIPQ-LQYAF
||.  ..| |.| .|  ||.|      .||..|||||.|||          ... .. .       . ||||||..            .|.| . | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDKNH--LYLVMEYQP---------GG-DLLSLLN-R-YEDQLDENLIQFYLAE-------LILAVHSVHL-MGYVHRD-IKPENILVDRTGHIKLVDFG
|||.|  ||.|||| |         || .|.. |  |  |  .||. ..||.||       ..||... |  ||..||| .|||||| |. |||||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

SAAKMNSN-------------------------------------------------KMVNAKLPIG--TPDYMAPEVLTVMNGDGKGTYGLDCDWWS--
.. .....                                                 |.. ..   |  ||.|||||.|          ||  |||||  
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----------YGKACDWWSFG

VGVIAYEMIYGRSPFAEGTSA----------RTFNNIMNFQRFLKFP------------DDPKVSSDFLDLIQSLLC-GQKERLK----------FEGLC
.|.. |||..|..||   .             .|..||| ..|....            .|...|..  |||. |||   ..||           .| . 
LGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIK

CHPFF
 ||.|
NHPWF
Kinase CRIK.AA GEK 97-360 47 7.79999999999e-113 380.27 In-house 1-269 (269) Show / Hide 
Range on Protein: 97-360
Range on HMM: 1-269/269
Sequence Identity: 47% (129 aa)

FEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDEN
||.  ..| | |.|| ||. | |...||||...|  .|    .. | ||| .| .  . || .| ||||| |.|||||.|  ||||| || ..||.| |.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

LIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEM
. .||.||...|..||| ..||||||||.|.|.|. |||.| ||||  .|| . ||...  .|||||..||.|  | .|||| || .|||||.||..|||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAM-EDGKGRYGPECDWWSLGVCMYEM

IYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPK---VSSDFLDLIQSLLCGQKERLKFEGL---CCHPFF
.||. ||     . |.  |||..  ..||.. .   || .  |||..|.| | .||  .|.     ||||
LYGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase CRIK.AA ROCK 97-360 44 1.1e-98 334.12 In-house 1-263 (263) Show / Hide 
Range on Protein: 97-360
Range on HMM: 1-263/263
Sequence Identity: 44% (119 aa)

FEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDEN
|..  ..| | | |||.||.|..  .||||.. |  ..      || |||.|.    |.|| ||.|||||. .||.||.| ||||| .|.  |.  . | 
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYD--VPEK

LIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEM
  .|| .|..||. ..| ||..|||.||.|.|.|. ||.|| |||   ||| | || .   .|||||..||||    .||.  || .||||||||  |||
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQGQDGE--YGRECDWWSVGVFIYEM

IYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERL---KFEGLCCHPFF
. |  ||   .   |. .||. .  ||||||...| .  |||.  |  ...||     . .  |.||
LVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase CRIK.AA S_TKc 97-360 32 2.7e-90 307.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 97-360
Range on HMM: 1-231/231
Sequence Identity: 32% (91 aa)

FEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPG--GDLLSLLNRYEDQ--
.|.  ..| | |..|  .|.| || |.|.|..|            .. |..||..   |.| .| ..||| .|||.|||| .|  |||.... ..  .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGL-DCDWWS
   ..|  ..||......|.   | .| .|||.||||||.|.  |||. |||.|...        .  .|||.|||||||          ||   |||||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---------GYGKCKCDWWS

VGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLC-GQKERLKFEGLCC-------HPFF
.|.| |||..|. ||   . ...|..|.              |....|.|. .|.   ..|.    .         ||.|
CGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CRIK.AA RSK 99-360 35 1.4e-76 260.77 In-house 1-278 (278) Show / Hide 
Range on Protein: 99-360
Range on HMM: 1-278/278
Sequence Identity: 35% (100 aa)

VRSL--VGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQ-VSFFEEERNILSRST-SPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQ--
.. |   | | .  .. .. ..|| |||||| ||. . . .  .    .|||||.|.. .| | .| ||||.. .|||.||| .||.|.  | . .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDR---TGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSV
..|.  .||.||..|||   |  | .|||.|||||| |     |||||.||| . ... ..   .. ...| .|||||.|.. |  ..|...  ||||| 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN--QQGGHDKACDWWSL

GVIAYEMIYGRSPFAE---GTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQ-KERLK-----FEGLCCHPFF
||. |||  |..||.     ... ....|.. .  |..| ....| .. |||. .|.   . ||.      | .  ||.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase CRIK.AA NDR 97-241 50 3.9e-75 231.02 In-house 1-149 (350) Show / Hide 
Range on Protein: 97-241
Range on HMM: 1-149/350
Sequence Identity: 50% (75 aa)

FEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRST--SPWIPQLQYAFQDKNHLYLVMEYQPGGDLLS---LLNRYED
||. ...| | | || .||.| ||.|||||.|.|.  .  .||     || |.. .   .||.. | |.||||..||||||| ||||. .   ||... |
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKM-D

QLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFG
 ..|....|| ||...|..||| |||.||||||.|.|.|. ||||| |||
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase CRIK.AA Ciliate-E2 97-360 25 4e-68 232.65 In-house 1-365 (365) Show / Hide 
Range on Protein: 97-360
Range on HMM: 1-365/365
Sequence Identity: 25% (99 aa)

FEVRSLVGCGHFAEVQVVRE-----------------------KATGDIYAMKVMKKKALLAQEQVSFFE----------EERNILSRSTSPWIPQLQYA
...  . | | |. |  ..                        |... |||||.|||. . ...|.              .|.|||..  .| | .. ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DKNHLYLVMEYQPGGDLLSLLN-----------------RYEDQ-LDENLIQ-------FYLAELILAVHSVHLMG-YVHRDIKPENILVDRTGHI
||  |.|..||||||  ||||.....                  .| . . . ..|       ||.|..|||... |  .  .||||||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLVDFGSAAKMN-----------SNKMVNAKLP--------------------IGTPDYMAPEVLTVMNGDG--KGT-YGLDCDWWSVGVIAYEMIYGRS
|..||| . | .           .... . |                      .||| |||||.|   . |.  |.. |.  ||.||.||| |||..|. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFAEGTSARTFNNIMNFQRFLKFP----------------DDPKVSSDFLDLIQS-----LLCGQKERLK-FEGLCCHPFF
||           . . |  ..||                .  |.| .  |||.      | . ...|.  .| .  ||.|
PF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CRIK.AA Pkinase 97-360 31 2e-61 215.19 Pfam 1-293 (293) Show / Hide 
Range on Protein: 97-360
Range on HMM: 1-293/293
Sequence Identity: 31% (93 aa)

FEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFE-EERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGG----DLLSLLN-RYE
... . .| | |..|   ..| ||.|.|.|..||.    ..... .   |  |. |  .| | .| ..|.||.|.|.|||| .||    || ...  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DQL--DENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHI----KLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDC
  .  .|. ..||. ... ..   | || .|||.||||||.|..|||    |. |||.|....  . . .. . |||.||||||.      |   ||  .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-----GGQYYGPKV

DWWSVGVIAYEMIYGRSPFAEG------TSARTFNNIMNFQRFLKFPDDPKVS-----------------SDFLDLIQSLLC-GQKERLKFEGLCCHPFF
|.||.|.| |||. || || .       .    ...||  .    .| .  .|                 ....|.| ..||   |.|. .| ...||.|
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CRIK.AA MAST 97-241 40 2.8e-54 163.88 In-house 1-147 (337) Show / Hide 
Range on Protein: 97-241
Range on HMM: 1-147/337
Sequence Identity: 40% (60 aa)

FEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQD--KNHLYLVMEYQPGGDLLSLLNRYEDQLD
||   ... | .  |  |. | |.|..||||...  ..   ||     |||||.  . |..  . |.||   |..|..||||  |||  |||. |   ..
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFG
|.. ..|.||..|..   | .| ||||.||.|.| | .|||||.|||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase CRIK.AA MAST 97-241 43 3.2e-52 166.47 In-house 1-144 (334) Show / Hide 
Range on Protein: 97-241
Range on HMM: 1-144/334
Sequence Identity: 43% (63 aa)

FEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDEN
||   ... | .  |  |. | |.|..||||.||  ..   .|.    |||||. ...|..  . |.|| ||.|..||||  |||. |||. |   .||.
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG-YFDEW

LIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFG
. ..|.||..|..   | .| ||||.||.|.| | .|||||.|||
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase CRIK.AA NDR 258-360 38 1.8e-33 100.09 In-house 242-350 (350) Show / Hide 
Range on Protein: 258-360
Range on HMM: 242-350/350
Sequence Identity: 38% (44 aa)

IGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFL-----KFPDDPKVSSDFLDLIQSLLC-GQKERLK-
.||||||||||..     .|. |.  |||||.|.| |||. |  ||   |   |. .|||.. ..      || . ..| .  |||. |.|  ...||  
VGTPDYMAPEVFQ-----QKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGS

----FEGLCCHPFF
    ..    ||||
HGKGVDEIKSHPFF
Kinase CRIK.AA MAST 258-360 39 8e-26 75.32 In-house 229-337 (337) Show / Hide 
Range on Protein: 258-360
Range on HMM: 229-337/337
Sequence Identity: 39% (45 aa)

IGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSAR-TFNNIMNFQRFLKFPDD------PKVSSDFLDLIQSLLCGQ-KERL
.|||||.||||..     |.||||   ||||.|.| || . | .|| . |    .|.|| | .| . .|..       ..|..  |||. ||    |.||
CGTPDYIAPEVIL-----GQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRL

KFE---GLCCHPFF
 .       .||||
GANGADEIKQHPFF
Kinase CRIK.AA MAST 258-360 36 1.6e-21 65.84 In-house 225-334 (334) Show / Hide 
Range on Protein: 258-360
Range on HMM: 225-334/334
Sequence Identity: 36% (42 aa)

IGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRF-LKFPDD------PKVSSDFLDLIQSLLCG-QKERL
.|||||.||||..     |.||.|   ||||.|.| || . | .|| . |   .|.|| |  .   ..|..       . |..  |||. ||    ..||
CGTPDYIAPEVIL-----GQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRL

KFE----GLCCHPFF
 .        .||||
GANNGADEVKQHPFF
Kinase CRIK.AA S_TK_X 361-423 30 1.1e-19 72.64 SMART 1-79 (79) Show / Hide 
Range on Protein: 361-423
Range on HMM: 1-79/79
Sequence Identity: 30% (24 aa)

SKIDWNNIRN----SPPPFVPTLK----SDDDTSNFD-EPEKNSWVSSSPCQLSPSGFSGEE--------LPFVGFSYSK
..|||....|     .|||.|..|    |. |||||| | ......  .|..  .|. ....        .|| ||.|. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase CRIK.AA Pkinase_C 378-425 33 1.6e-11 43.79 Pfam 1-46 (46) Show / Hide 
Range on Protein: 378-425
Range on HMM: 1-46/46
Sequence Identity: 33% (16 aa)

TLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYSKAL
..||..||||||. . .  .. .|   ..  .||. .||.||.|.   
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD
Kinase CRIK.AA TyrKc 97-360 20 4.4e-11 -43.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 97-360
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

FEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRS--TSPWIPQLQYAFQDK-------NHLYLVMEYQPGGDLLSLLN
 .     |.|.| ||   . |      | |..|. |      .  | .| .|...     | | .|  .  ..         |..|||| |.|||.. | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RYEDQLDENLIQFYLAELILAVHSV-------HLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSN---------KMV----NAK--LPIGTPDYMA
.....       . ...|.   . .       | ....|||.   |.||.. ...|  ||| . .  .          ...    ..|  |||     ||
KHRPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR---WMA

PEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMI-YGRSPFAE-----GTSARTFNNIMNFQRFLKFPDD-----PKVSSDFLDLIQSLLCG-QKERLKFEG
||..       .|..    | || ||  .|.  || .|  .      . .. ......  |  . |.|     .  ...  .....      ..|  |. 
PECI------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

LCCHPFF
.  | .|
I--HECF
TMF_DNA_bd CRIK.AA TMF_DNA_bd 492-525 25 16.080198 1.31 Pfam 76-110 (75) Show / Hide 
Range on Protein: 492-525
Range on HMM: 76-110/75
Sequence Identity: 25% (9 aa)

ELKASETQRSLLE-QDLATYITECSSLKRSLEQAR
..|..|.| | |  . ..    | ..|...|..| 
KNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
TMF_DNA_bd CRIK.AA TMF_DNA_bd 714-746 20 32.85034 0.2 Pfam 42-75 (75) Show / Hide 
Range on Protein: 714-746
Range on HMM: 42-75/75
Sequence Identity: 20% (7 aa)

ENRLKDDIQTKS-QQIQQMADKILELEEKHREAQ
.. |  .|.  . ..| .   .| .||.....|.
NKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
TMF_DNA_bd CRIK.AA TMF_DNA_bd 756-792 31 0.014541 12.19 Pfam 38-75 (75) Show / Hide 
Range on Protein: 756-792
Range on HMM: 38-75/75
Sequence Identity: 31% (12 aa)

LKQKEQHYEEKIKVLD-NQIKKDLADKETLENMMQRHE
|..|... |..|. |. ..| |  .. | ||... |.|
LRKKNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
TMF_DNA_bd CRIK.AA TMF_DNA_bd 945-982 20 19.132689 1.04 Pfam 37-75 (75) Show / Hide 
Range on Protein: 945-982
Range on HMM: 37-75/75
Sequence Identity: 20% (8 aa)

QLRQAKTELEETTAEAE-EEIQALTAHRDEIQRKFDALR
.||.   |||.. .|.  ..|  |..  .. ... ..  
KLRKKNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
TMF_DNA_bd CRIK.AA TMF_DNA_bd 1020-1096 15 6.655276 2.68 Pfam 1-75 (75) Show / Hide 
Range on Protein: 1020-1096
Range on HMM: 1-75/75
Sequence Identity: 15% (12 aa)

SGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEK
. . . . .   ..  |. |  . . |   . .|.  |. .  .||.|. .|  . ... ..|.. |  ...|   .
NSLEKKLKEKDEQIAQLMEEGEKLSKQELKHNNTIKKLRKKNKELEKQISELK-H-KKIEKLEKEIENLEQRLKRAE
C1 CRIK.AA C1 1405-1453 20 1e-11 46.17 SMART 1-61 (61) Show / Hide 
Range on Protein: 1405-1453
Range on HMM: 1-61/61
Sequence Identity: 20% (13 aa)

HRFNVGLNMRATKCAVCLDTVHFG------RQASKCLECQVMCHPKCSTCLPA-------TC
|..  .   . |.|..| ... ..      .|. .| .|...|| ||....|.       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 CRIK.AA C1_1 1405-1456 27 1.8e-07 31.11 Pfam 1-55 (55) Show / Hide 
Range on Protein: 1405-1456
Range on HMM: 1-55/55
Sequence Identity: 27% (15 aa)

HRFNVG-LNMRATKCAVCLDTV-H-FGRQASKCLECQVMCHPKCSTCLPATCGLP
|.. ..    . |.|..| . . . .|.|. || .|.. || .|.. .|. ||. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
PH CRIK.AA PH 1486-1605 15 1.7e-13 51.29 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1486-1605
Range on HMM: 1-92/92
Sequence Identity: 15% (19 aa)

LHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNE-AREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLY
...|||...      .  .| . ..|| ......|... .|  |  |... ... ..                    . |..... .  .      ||.|
VIKEGWLHKKG----KRKSWKKRWFVLFNNCLYYYKDDKYRPKGSIPLSDCQVTKVPDN------------------KRPHCFQIRT-DR------RTYY

LLAPSFPDKQRWVTALESVVA
. |.|  ....|..|..|...
FQAESEEEMNDWMQAIQSACR
PH CRIK.AA PH 1486-1607 12 3.8e-11 44.28 SMART 1-82 (82) Show / Hide 
Range on Protein: 1486-1607
Range on HMM: 1-82/82
Sequence Identity: 12% (15 aa)

LHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYL
. .|||...         .| ... || .. ...|... .  |  |... ..   .                         ... ..         |.|.
VIKEGWLYKKS-----K-RWKKRWFVLFNDCLYYYKDK-KPKGSIPLSDCTVRE-P----------------------CFEIHH-DR---------TYYF

LAPSFPDKQRWVTALESVVAGG
 ..|  ..|.|..|......  
QCESEEEMQEWMQAIQKAIHNN
CNH CRIK.AA CNH 1634-1931 22 1.3e-109 371.41 SMART 1-375 (375) Show / Hide 
Range on Protein: 1634-1931
Range on HMM: 1-375/375
Sequence Identity: 22% (86 aa)

LDMNCTLPFSDQ-----VVLVGTEEGLYALNVLKN-------SLTHVPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKV----------KQSL
..|... |....     ..|||||.|.|.||. ..       ...| .....|...........|.||.|.   .....||.....          ....
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

AQSHLPAQPDISPNIFEAVKG-CHLFGA-GKIEN--GLCICAAMPSKVVIL--RYNENLSKYCIR------------------KEIETSEPCSCIHFTNY
...||..............|| ||.... .....   ...|.||...|.|.  .|| .....|..                  .||.......|.|....
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

---SILIGTNK----FYEIDMKQYTL----------EEFLDKNDHSLAPAVFAASS-----NSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYG---RR
   .|.||..|    .|...|.|...          |.....|||||.......|.     ....|..|| ...|||..||||...|||||..||   ||
ERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWRR

SRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSS-AGTPARA-YLDIPNPRYLGP-AISSGAIYLASSY
.|...|.|.. | .|||..||......|......|.....  ...... |. ....|.|.. ......|...|..
WRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
CNH CRIK.AA CNH 1639-1923 20 2.1e-76 264.92 Pfam 1-336 (336) Show / Hide 
Range on Protein: 1639-1923
Range on HMM: 1-336/336
Sequence Identity: 20% (71 aa)

TLPF-SDQVVLVG-TEEGLYALNV----LKNSLTHVPGIGA--VFQIYIIKDLEKLLMI--AGEERALCLVDVKKVKQSLAQSHLPAQPDI---------
. |. ..| .||| |.|||| .|.     .. .|.. ..    | |||.|... .|.||  ..... |.. .   ..|.  |.| ...|.          
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRIERI

------SPNIFEAVKGCHLFG--AGKIENGLCICAAMPS-----KVVILRYNENLSKY-------------CIRKE-IETS----EPCSCIHFT---NYS
       ..  . .|.||.|     ...||.|.|.|...     ..... ......|.             .. .| ....    ..|...|..    ..
MPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLPQEKPK

ILIG-TNKFYEIDMK-QYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGR-RSR--TDDLKWSRLPLAFAYREPY
. .| ...|. ...  ... ....| .|||..  . | ..| .|......|. . . |.|||..|..|.|...|. |||  .....|.  | .||...||
LCVGCQKGFHIVNLDGTGQPWWLHDPADHSVQQDFMARRENCKPICMHRIND-D-E-EFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQSFACCYPY

LFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPAISSG
|.. | |..|.  .. .    .  .|.. . . . . .  |..
LLAFHPNFIEIRHVETG----SEWDACVQCIPGQNIRFLHSGS