Gene DYRK1A (Human)

DYRK1A

Species: Human
Alias: MNBH, DYRK, DYRK1, HP86, DYRK1A, MNB
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 21q22.13,

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK1

Sequence

Name Sequence Type Origin Length Description Download
DYRK1A.NA RNA Sugen Kinome 5212 None Fasta, JSON
DYRK1A.AA Protein Sugen Kinome 763 None Fasta, JSON
DYRK1A.kin_dom Protein Kinase Domain Sugen Kinome 321 None Fasta, JSON

Protein domain

Protein domains of DYRK1A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DYRK1A.AA DYRK1 159-479 86 1.6e-249 835.2 In-house 1-321 (321) Show / Hide 
Range on Protein: 159-479
Range on HMM: 1-321/321
Sequence Identity: 86% (279 aa)

YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVS
||||||||||||||||||||..|||.||||||||||.|.||||||.||||||||||.||||||||||||||||||||||||.||||||||||||.|||||
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGE
|||||||||||||||||..||||.|||||||||||||||||||||||.|||||||||||||||||||||||||||||..||.||||||||||||||||||
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILR
|||||.||||||||||||||.||.|..||||||.|.|||.||.||..|||.|.|..|| |.|||||.|||||||||||||.||.||.|.|||||||||.|
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIKR

MLDYDPKTRIQPYYALQHSFF
||.||||.||.||||||||||
MLQYDPKQRITPYYALQHSFF
Kinase DYRK1A.AA DYRK 159-479 51 6.8e-201 673.69 In-house 1-320 (320) Show / Hide 
Range on Protein: 159-479
Range on HMM: 1-320/320
Sequence Identity: 51% (169 aa)

YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGV-
|||.. |||||||||||..|.  .|.||||||.|.|.|..|||||...||..|..| ..||..||....|..|||||.|||.||.|||..|.|..|.|. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNP-KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT
||||.||||||..|.|.||...| .|||||||||||.|..| ..|.||..||||||. .||||.||||||||.|||.||.||. |||||||||||.|..|
SLNLVRKFAQQILTCLKFLHKNE-NIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFT

GEPLFSGANEVDQMNKIVEVLGIPPAHILDQA--PKARKFFEKLPDGTWNLKKTKDG-KREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFK
|.|||.|.||.||...|.||||.|| ...|..  ....|||..    ..  ...... ..... ..|.|.|.... ....|.||| ....|. .|...||
GWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFK

DLILRMLDYDPKTRIQPYYALQHSFF
|.|...|..||. || |..||||..|
DFIKKCLQWDPHKRITPSQALQHPWF
Kinase DYRK1A.AA DYRK2 159-427 47 1.2e-128 420.59 In-house 1-283 (318) Show / Hide 
Range on Protein: 159-427
Range on HMM: 1-283/318
Sequence Identity: 47% (134 aa)

YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVS
|||.. |||||||||||.||   .. ||||.| ||| |.|||..|.| |. . ..|    . .||..  |.||||.|..|| || |||..... .| | |
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTG
|.| |.||... ..| ||   .  |||||||||||||  . || ||..||||||   | ||| ||||||||.||| ||..|. ||||||.|||..|. ||
LQLVRRFAHSILQCLRFLH--KNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

EPLFSGANEVDQMNKIVEVLGIPPAHILDQA-----PKARKFFE---------KLPDGTWNLKKTKDGKR-EYKPPGTRKLHNIL
 ||| | ||.||.  . ||||.||....|..      ... ||.          ..|..  ..| .   . . .|||.... ..|
YPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVL
Kinase DYRK1A.AA CMGC 159-479 20 1.7e-118 391.27 In-house 1-513 (513) Show / Hide 
Range on Protein: 159-479
Range on HMM: 1-513/513
Sequence Identity: 20% (111 aa)

YEIDSLIGKGSFGQVVKAYD--------------RVEQEWVAIKIIKNKKAFLNQAQ-------------IEVRLLELMN-KHDTEM-----------KY
|||.. ||.|..|.|.|..|              .  .| ||||.|||.. . .||.              |...|. .| .||. .           . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

YIVHLKRHFMFRN-----------------HLCLVFEMLSYNLYDLLRNTN--------------------------FRGVSLNLTRKFAQQMCTALL--
.||.|. .|...|                 ||.|||| . ..||....|..                           .  .. . | ...|....|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

FLATPELSIIHCDLKPENILLCNPKRS------------------AIKIVDFGSSCQLGQR------------------------IYQYIQSRFYRSPEV
..    ..|||.||||||||... ...                   .|| |||........                        ...|...|.||.||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

LLGMP----------YDLAIDMWSLGCILVEMHTG--------EPLFSGANE-----------VDQMNKIVEVLGIPPAHILDQ-------APKARKFFE
|||..          |. .|||||.|||. || ||        .||| | .|           .||..||..||| |. .....       ... .....
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

KLPDGTWNLKKT-----------KDG----------KREYKPPGTRKLHNI-----------------LGVETGGPGGRRAGESGHTVA-----------
...  ..|.. .           ...          . ...|.  ..|.                   .  |             ....           
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIY--E-------------EKFKSHKFNHQFKRK

-DYLKFKDLILRMLDYDPKTRIQPYYALQHSFF
 .  .. ||. .|| |||. || .  |||| .|
CCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase DYRK1A.AA YAK 159-398 44 1.3e-105 357.17 In-house 1-242 (347) Show / Hide 
Range on Protein: 159-398
Range on HMM: 1-242/347
Sequence Identity: 44% (108 aa)

YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMN-KHDTEMKY---YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNF
| .    |.| ||||||       | .|.|.|||. |.. ||  |...|.. | .|| . |     |. .   | ..||.|||||||| |||..| ...|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

RGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEM
.| | .| | .  |   ..  |.  .  |||||||||||.||.| . .|||.|||||||  . .| |||.|.|||||....|.|  .|||||||||..| 
CGFSFQLIRQWTKQILDGMCVLE--NKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL

HTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKL
  | |.| |. | .|.  |...||.||  ..||     |.|  .
FLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYFHCH
Kinase DYRK1A.AA S_TKc 159-479 26 4e-81 276.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 159-479
Range on HMM: 1-231/231
Sequence Identity: 26% (89 aa)

YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY---NLYDLLRNTNFR
|||  .||||.||.| |....  .. |||||||      .... |...|.           .||.|. .|   .||..|.|...    .|.|.... . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----VSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDL-AIDMWSLGCI
|     .   .|....|.| || ..   .. |||.|||||||||..     ||| |||...||    . .. ...|..||||   .|.  ..|.||.|||
GLRFPFPE-HARFYMYQICCALEYCH--SHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYL
| || .|.|.|.      ||... ...|                                                                        
LYEMLCGYPPFP------QMQMMFKKIG----------------------------------------------------------------------SP

KFKDLILRMLDYDPKTRIQPYYALQ-------HSFF
 .||.| ..|..||. |.    |||       | .|
EAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DYRK1A.AA HIPK 159-400 42 1.2e-76 240.85 In-house 1-242 (329) Show / Hide 
Range on Protein: 159-400
Range on HMM: 1-242/329
Sequence Identity: 42% (104 aa)

YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVS
||.  ..|.| ||||||.  |  .| |||||.||   .  | ||||..|. . . . .  | .|     |  .|| |||||||  |||| ... .|    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMH
|.  |   ||  |||. |   ||..|| |||||||.|  |.|    .|..||||   . . . . |.|||.|| ||..||.|.  ..|||||||.. | .
LKHIRPILQQVLTALMKLK--ELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELF

TGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPD
 | ||. ||.| ||   | .  . |  |.| .| |. .||... .
LGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQ
Kinase DYRK1A.AA Pkinase 159-479 25 6.6e-60 210.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 159-479
Range on HMM: 1-293/293
Sequence Identity: 25% (90 aa)

YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI-----EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-----NLYDL
|.| . ||.||||.| |.... ... ||.|||| ...  .. |.     |....  . .|.      || |.. |. ..|...|.| .        |.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPN-----IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LR---NTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAI----KIVDFGSSCQL---GQRIYQYIQSRFYRSPEVLL-GMP
..   ...|   | .  .... |.. .| ..     .|||.||||||||.   ..  |    || |||...|.   ..  . .  ...|..|||.. | .
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS--MGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQY

YDLAIDMWSLGCILVEMHTGEPLFSGA----NEVDQMNKIVEVLG-IPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETG
|. ..||||.|||| || .|.|.|.|.    | .||| .|....| ... ..    .. . |  .  . .                              
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------------------------

GPGGRRAGESGHTVADY---LKFKDLILRMLDYDPKTRIQPYYALQHSFF
           |..  .     .||.| ..|..||| |. .  .||| .|
---------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DYRK1A.AA PRP4 159-363 39 9.3e-58 198.2 In-house 1-207 (320) Show / Hide 
Range on Protein: 159-363
Range on HMM: 1-207/320
Sequence Identity: 39% (82 aa)

YEIDSLIGKGSFGQVVKAYDRVEQE-WVAIKIIKNKKAFLNQAQIEVRLLELMNKH--DTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRN-TNF
|.. . .|.| |. |... |       |||||| |.         |.  |  .|    | . |. .| ..||| .|.|.||||| .| || ..|      
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

RGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLG-QRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVE
 | .|.  | .|||.  ||  |    . |.| |.|| |||  |  .. .|..||||  .   . |  | .|||||.||...|.||| .||||| || | |
VGLHLKAVRSYAQQLFLALKHLK--KCNILHADIKPDNILV-NESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYE

MHTGEPLFSG
. ||  .|.|
LYTGKIMFPG
Kinase DYRK1A.AA CDK 159-479 26 2.3e-52 165.78 In-house 1-284 (284) Show / Hide 
Range on Protein: 159-479
Range on HMM: 1-284/284
Sequence Identity: 26% (95 aa)

YEIDSLIGKGSFGQVVKAYDRVEQ-----EWVAIKIIK---N-----KKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR-----------NHL
||.   || |..|.| || |.  .     . ||.| |.   .     |  |   |  |. ||  .  |.     .|| |.  ..             | |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HP-----NIVKLHDVCHTKNMDRNNKDKHENKL

CLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPK---RSAIKIVDFGSSCQLG--------QRIYQ-YI
 .||| . . |. ...            . . .|.  .| ..   .  |.| |||| |||. |     .  .|| ||| ..  |        .| |   .
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCH--SNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEV

QSRFYRSPEVLL-GMPYD--LAIDMWSLGCILVEMHT---GEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYK
  . ||.||.||    |.   .|||||.|||..|| |   ..||| | .| ||. || ...| |   .     |   .                      
VTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------

PPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF
                                     ||. .|| |||| ||    |||| .|
-------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase DYRK1A.AA CLK 159-298 30 6.5e-44 129.09 In-house 1-150 (350) Show / Hide 
Range on Protein: 159-298
Range on HMM: 1-150/350
Sequence Identity: 30% (46 aa)

YEIDSLIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVR-LLELMNKH-DTEMKYY--IVHLKRHFMF-RNHLCLVFEMLSYNLYDLLRNT
||| .  | | || ||.  |.      ||.|||.| . .  .|..|..  ..  |.  | . ||   ....   | .  .| |.|||..  ..||... .
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------FRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNP
|      ...  .. .|..| | |.|. ||   .....| |||||||.....
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH--DMKLTHTDLKPENICFVDS
Kinase DYRK1A.AA MAPK 283-399 35 1.7e-35 120.05 In-house 138-279 (328) Show / Hide 
Range on Protein: 283-399
Range on HMM: 138-279/328
Sequence Identity: 35% (51 aa)

IIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-----------------IYQYIQSRFYRSPEVLLG---MPYDLAIDMWSLGCILVEMHT-GEPLF
.||.||||.|||.   .    || ||| .... .                    .|.  |.||.||..|.   | |. |.||||.|||. || | . |||
VIHRDLKPSNILV--NENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLF

SGANEVDQMNKIVEVLGIPPAHILDQAP---KARKFFEKL---P
 | . .||.|.|.|||| |. . . . .   .||.... |   |
PGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLP
Kinase DYRK1A.AA CLK 303-397 29 2.8e-19 53.77 In-house 186-287 (350) Show / Hide 
Range on Protein: 303-397
Range on HMM: 186-287/350
Sequence Identity: 29% (30 aa)

IKIVDFGSSC---QLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLG--IP--PAHILDQAPKARKFF
|...||||     .     .  ...| || ||| ||...    | || ||||.|  ||. || . .... .  . ...|  ||  ...  ..    .|.|
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYF

EK
 .
YH
Kinase DYRK1A.AA MAPK 159-214 27 1.7e-10 32.27 In-house 1-65 (328) Show / Hide 
Range on Protein: 159-214
Range on HMM: 1-65/328
Sequence Identity: 27% (18 aa)

YEIDSLIGKGSFGQVVKAYDRV------EQEWVAIKIIK---NKKAFLNQAQIEVRLLELMNKHD
|.|.. ||.|..|.|..|.|.       ... |||| |    ... .   .. |..||  ...|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHE
Kinase DYRK1A.AA TyrKc 159-478 16 2.5e-09 -71.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 159-478
Range on HMM: 1-280/280
Sequence Identity: 16% (57 aa)

YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELM-NKHDTEMKYYIVHLK---RHFMFRNHLCLVFEMLSY-NLYDLLRNTN
 . .  .| | ||.|.|.  .   . ||.| .|. .  .     | |..     .|.   . | | ..   . ||    |..|.|  .. .| | ||.. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRKHR

FRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-------IYQYI----QSR-----FYRSPEVLLGMP
 . ...    .|. | .    .|.  .  .|| ||   |.|. ...   .|| ||| |  ..          |       ...        .||..    
PK-LCMKDLLSFCWQIACGMEYLH--SKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDLAIDMWSLGCILVEMHT-GEPLFSGA----NEVDQMNKIVEVLGIPPAHIL----DQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG
.  . | || |  . |. | |..  .|      . ... . |.  . .|                                                   
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------------

VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF
             .   |    .  .....  ..||. |     .. . |
-------------F---VCCPDEMYQIMKQCWHEDPEDR-PTFSEIHECF
Kinase DYRK1A.AA CLK 454-479 61 8.6e-09 21.74 In-house 325-350 (350) Show / Hide 
Range on Protein: 454-479
Range on HMM: 325-350/350
Sequence Identity: 61% (16 aa)

DLILRMLDYDPKTRIQPYYALQHSFF
||| .|| |||  ||    |||| ||
DLIRKMLEYDPSKRITCKDALQHPFF
Kinase DYRK1A.AA PRP4 452-479 50 8.5e-08 24.7 In-house 293-320 (320) Show / Hide 
Range on Protein: 452-479
Range on HMM: 293-320/320
Sequence Identity: 50% (14 aa)

FKDLILRMLDYDPKTRIQPYYALQHSFF
||||. ..|  ||| || .  ||.|.|.
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase DYRK1A.AA HIPK 446-479 32 2e-06 15.62 In-house 296-329 (329) Show / Hide 
Range on Protein: 446-479
Range on HMM: 296-329/329
Sequence Identity: 32% (11 aa)

VADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF
..|.  | ..  .|.  |.. || |  ||.|.| 
KIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase DYRK1A.AA DYRK2 452-479 39 3e-06 16.12 In-house 291-318 (318) Show / Hide 
Range on Protein: 452-479
Range on HMM: 291-318/318
Sequence Identity: 39% (11 aa)

FKDLILRMLDYDPKTRIQPYYALQHSFF
| | |.| .. ||..|. |  ||.| ..
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase DYRK1A.AA YAK 452-479 39 0.003569 6.19 In-house 320-347 (347) Show / Hide 
Range on Protein: 452-479
Range on HMM: 320-347/347
Sequence Identity: 39% (11 aa)

FKDLILRMLDYDPKTRIQPYYALQHSFF
| |.|  .|. .|. |  |  | || | 
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase DYRK1A.AA MAPK 454-479 50 0.029329 3.35 In-house 303-328 (328) Show / Hide 
Range on Protein: 454-479
Range on HMM: 303-328/328
Sequence Identity: 50% (13 aa)

DLILRMLDYDPKTRIQPYYALQHSFF
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DLLEKMLVFDPDKRITVEEALQHPYF