Gene EphA2 (Human)

EphA2

Species: Human
Alias: ECK, EphA2, EPHA2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 1p36,

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphA2.NA RNA Sugen Kinome 3963 None Fasta, JSON
EphA2.AA Protein Sugen Kinome 976 None Fasta, JSON
EphA2.kin_dom Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON

Protein domain

Protein domains of EphA2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphA2.AA Ephrin_lbd 28-201 56 9.5e-131 407.64 Pfam 1-190 (190) Show / Hide 
Range on Protein: 28-201
Range on HMM: 1-190/190
Sequence Identity: 56% (107 aa)

EVVLLDFAAAGGELGWLTHPYGKG---------WDLMQNI-MNDMPIYMYSVC-NVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCK
||||.|. .|...|||.|.||. |         |. .... .|..||..|.|| |||...|.|||||||..|..|.||..|||||.||||||||.|..||
EVVLMDTKTATSDLGWTTYPYN-GRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCK

ETFNLYYAESDL--DYG---TNFQKRLFTKIDTIAPDEI-TVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKC
|||||||.|||   |.|   .|.... .|||||||.||. .. .||. |..|||.| ||.|||...||||||||.|||.||.|||||||||
ETFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphA2.AA EPH_lbd 28-201 56 1.8e-114 387.54 SMART 1-184 (184) Show / Hide 
Range on Protein: 28-201
Range on HMM: 1-184/184
Sequence Identity: 56% (104 aa)

EVVLLDFAAAGGELGWLTHPYGKG-WDLMQNIMND-MPIYMYSVCNVMS---GDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGAS-SCKETFNL
||||.|. .. |||||.|.|...| |. ......  .||..|.|||||.   ..|.|||||.|.||..|.||..|||||.|||||.||.|. ||||||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

YYAESDLDYG---TNFQ-KRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKC
|| ||| |..   |.|. .. ..||||||.||..  .||..| .|.|.| ||.|||..|||||||||.|||.||.||||.||||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
FN3 EphA2.AA FN3 329-419 16 9.1e-11 43.01 SMART 1-69 (69) Show / Hide 
Range on Protein: 329-419
Range on HMM: 1-69/69
Sequence Identity: 16% (18 aa)

PSAPHY---LTAVGMGA-------KVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPH----MNYTFTVEA
|..|     |...  ..        |.|.|.||        . |.                                 .||..|.|.     .|.|.| |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR---------------------------------YTVTGLKPGQYPWTEYEFRVRA

R----NGVS
.    .| .
VNGNDAGEG
FN3 EphA2.AA FN3 436-516 21 2.6e-12 48.15 SMART 1-69 (69) Show / Hide 
Range on Protein: 436-516
Range on HMM: 1-69/69
Sequence Identity: 21% (21 aa)

QTEPPK---VRLEGRSTT------SLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPD----TTYLVQVQALTQ--EGQG
   ||    .|..  ..|      |...||. ||         .|.||                 .|...| |.    |.| ..|.| .    |.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK-PP---------IVGYR-----------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphA2.AA Eph 613-871 76 6.9e-213 713.53 In-house 1-264 (264) Show / Hide 
Range on Protein: 613-871
Range on HMM: 1-264/264
Sequence Identity: 76% (203 aa)

VTRQKVIGAGEFGEVYKGMLKTSSGKKEV---PVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDG
.. .|||||||||||..|.||..|||.||   ||||||||||||||||.|||.|| |||||.|.||||||||..|..|.||.|||||||.||.|||..||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

EFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDP--EATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVM
.|.|.||||||||||.|||||..||||||||||||||||||||||||||||||||||||  ||||||.||||||||||||||.||||||||||||.||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSIL
||||.|||||||..||..|.|||..|.|||.|||||.|..|||..|||..|..||.|..|||||
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphA2.AA Pkinase_Tyr 613-871 46 1.8e-150 510.23 Pfam 1-270 (270) Show / Hide 
Range on Protein: 613-871
Range on HMM: 1-270/270
Sequence Identity: 46% (127 aa)

VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQ--RVDFLGEAGIMGQF-SHHNIIRLEGVIS-KYKP--MMIITEYMENGALDKFLRE
.|  |..|.|.||||||| .| . .....|||.|.|| |....|  | ||. || || |. .|.||.|| ||.. . .|  ..|..|||..| |...||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K---DGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVL-EDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWS
.   .. ... .|..| . ||.|| ||...|..||||||||.||..|.|.|..||||.| . .||   .....|||.||.|.|||.|.|.|||..|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGIVMWEVMTYGERP-YWELSNHEVMKAI-NDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSIL
||..|||..|||| | |...||.||...|  || |.| |..||  ||.||.|||... ..|| |..|...|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphA2.AA TyrKc 613-871 41 1.1e-136 461.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 613-871
Range on HMM: 1-280/280
Sequence Identity: 41% (121 aa)

VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQF--SHHNIIRLEGVISKY-------KPMMIITEYMENGALDKF
.|  |..| |.|||||||..|       ..||.|.||..     | ||. || || ..  .| ||.|| ||...        .|.||..|||..|.|...
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD-----PEATYTTS---GGK--IPIRWTAPEAISYRK
||.. ..... .|. .   ||.|| ||. .|..||||||||.||..|...|.||||||| ..||      . .|...   |||  .||||.|||.| |.|
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FTSASDVWSFGIVMWEVMTYGERPYWE-----LSNHEVMKAINDGFRLPTPMD--------CPSAIYQLMMQCWQQERARRPKFADIVSIL
||..|||||||..|||..|||. ||..     .|| ||.. . .|.|.| | .        ||...||.| |||. . . || |..|....
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphA2.AA TK 613-871 25 6.1e-124 417.65 In-house 1-486 (486) Show / Hide 
Range on Protein: 613-871
Range on HMM: 1-486/486
Sequence Identity: 25% (124 aa)

VTRQKVIGAGEFG---EVYKGMLKTSSGKKE---------------------VPVAIKTLKAGYTEKQRV-------------DFLGEAGIMGQFS----
.|  |..|.|.||   |||||.... .....                     .|||.|.||.| .. |.              ||| || .| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HHNIIRLEGVISKY------------KPMMIITEYMENGA----LDKFLREKDGE--------------------------------------------
 | ||.|| ||...             .|.||..|||..|     |...||.....                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FSVLQLVGMLRGIAAGMKYLANM------NYVHRDLAARNILVNSNLV-----------CKVSDFG---
                               ... ||. | . ||.|| ||. .      |.|||||||||.||..|.|           ||..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRVLEDDPEATYTT-----------------------SGGKIPIRWTAPEAIS---------YRKFTSASDVWSFGIVMWEVMTYG-ERPYWEL
     |.| ...| . . ..                       ||||.||||.|||..          |.|||..|||||||..|||..||| | .|...
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------HEVMKAINDG--------------FRLPTPMDCP--------------SAIYQLMMQCWQQERARRPKFADIVSIL
||         .|||. . .|              .|.| |..||               ..|.||.|||. . ..|| |..... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphA2.AA Src 613-871 43 6.4e-112 378.12 In-house 1-255 (255) Show / Hide 
Range on Protein: 613-871
Range on HMM: 1-255/255
Sequence Identity: 43% (114 aa)

VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLR-EKDGE-
... . .|.| ||||..|.      .....||.||||.|    .  .|| || || ...| ....|  | |. .|  |.||||..| | ..|. ...|  
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

FSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATY-TTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWE
 .. ||. |   .|.||.||  |||.||||||||.||. |.|||| |||| |....| .  |   .| |.||.|||||||.|..||  |||||||| ..|
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

VMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQ-LMMQCWQQERARRPKFADIVSIL
..|||  ||   .||||....  |.|.| |. ||  .|. .|.|||...  .|| |. . . |
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphA2.AA UTK 613-871 37 2.2e-107 363.07 In-house 1-296 (296) Show / Hide 
Range on Protein: 613-871
Range on HMM: 1-296/296
Sequence Identity: 37% (110 aa)

VTRQKVIGAGEFGEVYKGMLKTSS-GKKEVPVAIKTLKAGYT-EKQRV---DFLGEAG---IMGQFS-HHNIIRLEGVISKYKPMMIITEYMENGALDKF
| . . .|.|.||||.|..... |   .|. ||.|..... . ....    ||. ||    .|.||. | |..|| || ....|.||.||||||| |...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------EKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSN-------LVCKVSDFG---LSRVLED--------DPEATYTTSGGK
||       . .  ..  |...| . ||.|| ||.....|||||||||.||...       .|||..|||   .|| . .        . .  . .. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAISYR-KFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDG--FRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSIL
.||||.||||. .. .||..|||||||.|.||..|.| .|| ..||..| ... .|   |.| | ||| ..|.||..||... ..|| | |.|. .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphA2.AA SFK-Src 613-875 43 7.4e-104 308.71 In-house 1-259 (259) Show / Hide 
Range on Protein: 613-875
Range on HMM: 1-259/259
Sequence Identity: 43% (115 aa)

VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGE-F
.  .|  |.| ||.|.||        .   ||.|||| | .  .   || ||..| .  | | |.|  |     |. |||| | .| |  .|.|  |.  
IRLEKKLGSGQFGDVWKGRW-----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSL

SVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVM
 . ||| |   .|.|| ||   |.|||||||||.||  | |||| |||.||||..| |      | | ||.|||||| .. .|   |||||||| | |. 
RMPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIV

TYGERPYWELSNHEVMKAIND--GFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLI
|||  ||  ..| ||.. ..   | |.| |  || . |..|..|||.|   || |      ..   
TYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphA2.AA Fer 613-872 34 1.8e-100 340.13 In-house 1-283 (283) Show / Hide 
Range on Protein: 613-872
Range on HMM: 1-283/283
Sequence Identity: 34% (97 aa)

VTRQKVIGAGEFGEVYKG------MLKTSSGKKEVPVAIKTL-KAGYTEKQRVDFLGEAGIMGQ-FSHHNIIRLEGVISKYKPMMIITEYMENGALDKFL
|| .|..| | |||||||      ...... .  |.|. |..  .. |..|. .|. || || . ..| |.... ||..   | ||. |.. .|.||..|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

REKDGE-FSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNS-NLVCK--VSDFGLSRVLEDDPEATYTT-SGGKIPIRWTAPEAISYRKFTSASD
......  |. ... |. ..|.||.||  .| .|||.||||.|.   ....|  .||||.|| ..|. .. .      |.||||.|||..... .....|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSFGIVMWEVMTYGERPYWE----LSNHEV----MKA-INDGFRLPTPMDCPSAIYQLMM-QCWQQERARRPKFADIVSILD
|||||...||..| |. || .    . . .|    .|. |..| ..| |  .|..|.|.|| ||||..   ||....|. .| 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphA2.AA TK-Unique 613-871 35 1.9e-95 323.39 In-house 1-294 (294) Show / Hide 
Range on Protein: 613-871
Range on HMM: 1-294/294
Sequence Identity: 35% (104 aa)

VTRQKVIGAGEFGEVYKGMLKTSSGKKEVP--VAIKTLKAGYTEKQRVDFLGEAGIMGQFS-HHNIIRLEGVISKYK-PMMIITEYMENGALDKFLREKD
.. ..||| |.||.|..|.... ... . .  ||.|.||.. |. .. ||| |. .| .   | ||....|.  |   |.||| ||...| |...||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GE-------------------------FSVLQLVGMLRGIAAGMKYLAN--MNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSG--GKI
..                          |  .|.  . .|| ||.|||   .. |||||.|||.|.....|||..|||..| ...  .  | ...  |.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRI

PIRWTAPEAIS--YRKF-TSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDC-PSAIYQLMMQCWQQERARRPKFADIVSIL
|||| |||...  .. . |. |||||||..|||..|.|..|| .... ..|..| ||.|.| |  | . ..|.|| .||| |.  || |..|...|
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphA2.AA Frk 613-875 42 9e-89 301.22 In-house 1-260 (260) Show / Hide 
Range on Protein: 613-875
Range on HMM: 1-260/260
Sequence Identity: 42% (114 aa)

VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLR---EKDG
.   . .|.| ||||. |.        ..|||.||||.|  . .  ||| || || .  |  .|.|  |    .|..|||| |..|.| ..|.   .|  
IQLIRRLGSGQFGEVWEGLW-----NNTTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGR

EFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATY-TTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMW
.  . ||| |   .|||| || ..||.||||||||.||. ...||. |||| |||  | |  | .  | ..||.||||||. | |||  ||||||||.. 
QCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

EVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLI
|..|||  ||  . | ||.. .. |.|.| | .||  .|..|..||...  .|| |  .   |.. .
EIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphA2.AA Tec 613-873 40 3.1e-86 292.78 In-house 1-254 (254) Show / Hide 
Range on Protein: 613-873
Range on HMM: 1-254/254
Sequence Identity: 40% (107 aa)

VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAG-YTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEF
 |  | .| | || |  | .     . .  ||||..| |   |    ||. || .|   || . ..| || |. .|. |.|||||.| |  .|||. ..|
LTFMKELGSGQFGVVHLGKW-----RHQYDVAIKMIKEGSMSEE---DFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHF

SVLQ--LVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSR-VLEDDPEATYTTSG-GKIPIRWTAPEAISYRKFTSASDVWSFGIVM
.  .  | .|   .  || ||   ...|||||||| ||... | ||||||..| || |.    || |.  | |..| .||  .| .. | ||||.||. |
QKNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQ----YTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLM

WEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDK
||| . |  || ..|| || ...  |.||  |  |.  ||| | .||. .   || |..  . . .
WEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase EphA2.AA SrcB 613-872 44 2.2e-85 288.82 In-house 1-251 (251) Show / Hide 
Range on Protein: 613-872
Range on HMM: 1-251/251
Sequence Identity: 44% (116 aa)

VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDG-EF
.   | .||| ||||. |       .... ||.||.| |    .   ||.|| .| .  |. ..||  |..|  |. ||||||..|.|  ||. ..|   
LKLVKKLGAGQFGEVWMGYY-----NNHMKVAVKTMKQGTMSPEA--FLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKL

SVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVM
|. .|. |   || || |. .|||.|||| | ||||   |.||. |||| |..||. | |    | | ||.||||||| .  ||  ||||||||.. |..
SLPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDN-EYT-AREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIV

TYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILD
|||  ||   .| ||..... |.|.| |  ||  .|..||.||..    || |  . |.||
TYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase EphA2.AA S_TKc 613-875 21 2.3e-48 167.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 613-875
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMEN--GALDKFLREKDGE
 .  ..|| | ||.|||.  |         |||| .|         ... |  |. .  | ||..| .|.   . . ...||...  | | ...... ..
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTS-ASDVWSFG
     |.  .   ... |. ...|. ... .||||   |||...  . |..||||.|.|          .       . ||| .   ...  ..|.||.|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

IVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVS-----ILDKLI
....| .. |. |..    ....| |            ..   .....|.| . ..||   ..        ..  .
CILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphA2.AA Pkinase 613-871 22 2.3e-41 147.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 613-871
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEK--QRVDFL-GEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENG----ALDKFLR
 .. ..||.| ||.|||.. | ..      ||.|..|   ...  .. ...  |. ||  ..| ||.|| ..    . . ...||.|.|     |  ...
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

-EKDGEF--SVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVC----KVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAIS-YRKFTSA
 ...| |  |  ..  ... |. |..|. .|. .||||   |||...| ..    |..||||.....        ...    ... ||| |  ... ...
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVWSFGIVMWEVMTYGERPYWEL----SNHEVMKAINDGFRLPTPMDCP-----------------------SAIYQLMMQCWQQERARRPKFADIVSI
.|.||.|....|... |. |...     . |. |. |.   . |.. |.|                       ..  ...  |...  ..|| ...|.  
VDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
SAM_1 EphA2.AA SAM_1 902-966 51 1.4e-30 111.28 Pfam 1-66 (66) Show / Hide 
Range on Protein: 902-966
Range on HMM: 1-66/66
Sequence Identity: 51% (34 aa)

EGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKR-IGVRLPGHQKRIAYSLLGLK
.. .|..|.||||||.||||..|||.|||. .... ||| .|... .||.||||.|.|.||. .||
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM EphA2.AA SAM 901-968 32 9e-25 89.54 SMART 1-67 (67) Show / Hide 
Range on Protein: 901-968
Range on HMM: 1-67/67
Sequence Identity: 32% (22 aa)

SEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQ
 .  ....|..|||||.|.||...|...|..  . . ... .|.|..|. .|||.|.|.... ..|||
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
Sam7 EphA2.AA sam7 904-966 32 1.6e-22 77.86 In-house 1-70 (70) Show / Hide 
Range on Protein: 904-966
Range on HMM: 1-70/70
Sequence Identity: 32% (23 aa)

VPFRTVSEWLESIKM---QQYTEHFMAAGY----TAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLK
 .|..|.||||.|.|   |||...|...|.    | .. . .|| .|....|. .|||.|.| ...  ..
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM_2 EphA2.AA SAM_2 901-966 36 6.4e-17 60.91 Pfam 1-71 (71) Show / Hide 
Range on Protein: 901-966
Range on HMM: 1-71/71
Sequence Identity: 36% (26 aa)

SEGVPFRTVSEWLESIKM-QQYTEHFMAAGYTAIEKV-VQMTNDDI--K-RIGVRLPGHQKRIAYSLLGLK
 .   | .|.|||.||.| .||.. |...|.| .| .  .|| ||   | |.|. ..||.|.|  ..  .|
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK