Gene EphB6 (Human)

EphB6

Species: Human
Alias: HEP, EPHB6, EphB6, MGC129910, MGC129911
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 7q34-q36,

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphB6.NA RNA Sugen Kinome 4040 None Fasta, JSON
EphB6.AA Protein Sugen Kinome 1021 None Fasta, JSON
EphB6.kin_dom Protein Kinase Domain Sugen Kinome 246 None Fasta, JSON

Protein domain

Protein domains of EphB6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphB6.AA Ephrin_lbd 33-232 41 4.2e-110 343.33 Pfam 1-190 (190) Show / Hide 
Range on Protein: 33-232
Range on HMM: 1-190/190
Sequence Identity: 41% (88 aa)

EEVLLDTTGETSEIGWLTYPPGG---------WDEVSVLDDQRRLTRTFEAC-HVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGG
|.||.||. .||..||.|||..|         |.|||..|.. |  ||...| .|      ..|.|||.|...||||||| ...|.|..| |.|. ...|
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNV----MEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAG

TCRETFTLYYRQAEE-PDSPDSVSSWHLKRWTKVDTIAADES-FPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACL
||.|||.||| ....  |  ... .|. ...||.|||||||| |. .                   |.|  ..||.. ||.|||..||||.||||.|||.
TCKETFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRD-----------------FGSRW-MKLNTEVRSIGPLSKRGFYLAFQDQGACM

ALVAVRLFSYTC
|||.|| ....|
ALVSVRVYYKKC
EPH_lbd EphB6.AA EPH_lbd 33-232 42 6.8e-99 335.76 SMART 1-184 (184) Show / Hide 
Range on Protein: 33-232
Range on HMM: 1-184/184
Sequence Identity: 42% (86 aa)

EEVLLDTTGETSEIGWLTYPPGG--WDEVSVLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGG-TCRETFT
|.||.||..||.|.||.||||.|  |.|||..|....  ||.. |.|.. . . .|.|||.||...|||||| ...|.|..| |.|.. ..| .|.|||.
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEIN-EPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFN

LYYRQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFS
||| .... . ...  .|. ....|.|||||||||  .                   |.|. ...|.. ||||||...|||.||||.|||.|||.||.| 
LYYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRD-----------------FGDRV-MKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFY

YTC
..|
KKC
GCC2_GCC3 EphB6.AA GCC2_GCC3 304-336 39 1.7e-05 20.82 Pfam 1-33 (49) Show / Hide 
Range on Protein: 304-336
Range on HMM: 1-33/49
Sequence Identity: 39% (13 aa)

GYQPARGDKACQACPRGLYKSSAGNAPCSPCPA
|..   | . |..|||| |....|.  | |||.
GTYYNKGQNPCEPCPRGTYQNEEGQDSCIPCPP
FN3 EphB6.AA FN3 370-469 15 9e-06 26.36 SMART 1-69 (69) Show / Hide 
Range on Protein: 370-469
Range on HMM: 1-69/69
Sequence Identity: 15% (18 aa)

PSAPQE---LWFE-VQGS------ALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLTESRVLVGGLRAH----VP
|..|.    | .. |  .       . |.|  |            | ..                                    . | ||...      
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----------IVGYR------------------------------------YTVTGLKPGQYPWTE

YILEVQAVNG--VSEL
|   |.||||  . | 
YEFRVRAVNGNDAGEG
FN3 EphB6.AA FN3 488-569 24 3.4e-13 51.1 SMART 1-69 (69) Show / Hide 
Range on Protein: 488-569
Range on HMM: 1-69/69
Sequence Identity: 24% (24 aa)

PSAVPV---VHQVSRASN------SITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPG----HIYGFQVRARTA--AGHG
|...|    .. ..  |.      |.|.||  |      |. |.                      .||| |.||    . | |.|||...  || |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphB6.AA Eph 670-915 57 1.7e-172 579.31 In-house 1-264 (264) Show / Hide 
Range on Protein: 670-915
Range on HMM: 1-264/264
Sequence Identity: 57% (152 aa)

IKIEEVIGTGSFGEVRQGRLQPR-GRREQ---TVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREG
||||.|||.|.||||..|||... |.||.   .|||..|.|| .|. ...||..|...|||.||||.|||||||||||.|..||.||.|.|||||||..|
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQ--------------GPSCLLRWAAPEVIAHGKHTTSSDVWSFGILM
||...|||.|.||.|..|.|||....||| |.|...||||.|||||...|.|..              | ....||.|||.||..|.|..|||||.||.|
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAF
|||||||||||||||.|.|..||||..|||||..||..|| ||||.|||||..||||.|.|...
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphB6.AA TK 670-915 20 1.2e-91 307.48 In-house 1-486 (486) Show / Hide 
Range on Protein: 670-915
Range on HMM: 1-486/486
Sequence Identity: 20% (101 aa)

IKIEEVIGTGSFG---EVRQGRLQPRGRRE----------------------QTVAIQALWAGGAESLQMTFL-------------GRAAVLGQFQ----
|......| | ||   ||..|....|.. .                      ..||.  | .| |.| .. |.               |... ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNILRLEGVVTKS------------RPLMVLTEFMELGP----LDSFLRQREG---------------------------------------------
 ||||.|| ||.|..            .|.|...|.|..|     |...||.. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFSSLQLVAMQRGVAAAMQYLSSF------AFVHRSLSAHSVLVNSHLV-----------CKVARLG---
                              |..  ||. | . .|..|.||.|        |||| | |. .||....|           ||.|  |   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----HSPQGPS-----------------------------------CLLRWAAPEVIA---------HGKHTTSSDVWSFGILMWEVMSYG-ERPYWDM
     ..   .|                                     .|| |||...         .||.|| |||||||.||||...|| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SE---------QEVLNAIEQE--------------FRLPPPPGCP--------------PGLHLLMLDTWQKDRARRPHFDQLVAAF
|          |||.. ....              .|.|.||.||              . ...||.. |..| ..|| |.||. ..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphB6.AA UTK 670-915 31 2.5e-76 259.9 In-house 1-296 (296) Show / Hide 
Range on Protein: 670-915
Range on HMM: 1-296/296
Sequence Identity: 31% (94 aa)

IKIEEVIGTGSFGEVRQGRLQPRG--RREQTVAIQALWAGGAESLQMT----FLGRAA---VLGQFQ-HPNILRLEGVVTKSRPLMVLTEFMELGPLDSF
... . .| | ||||. .|...    . |. ||. .. ....   ...    |.  |.   ...||. |||.||| ||.|.. |.|..||.|| | |.|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------QREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSH-------LVCKVARLG---HSPQGP------------------SCL
||       ... .... |.. | . .|..||||.|  |||| | |  .||..|       .|||.| .|    | . .                   . 
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

--LRWAAPEVIAHG-KHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQE--FRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAF
  .|| |||...|. ..||.|||||||...||....| .|| .||...|. ...     |.|.|..||  .  ||.. |..| ..|| |..||...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphB6.AA TyrKc 670-915 30 1.9e-71 244.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 670-915
Range on HMM: 1-280/280
Sequence Identity: 30% (89 aa)

IKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQF--QHPNILRLEGVVTKS-------RPLMVLTEFMELGPLDSFL
|. ....| | ||||..|..       ..||.  | ..     .. |.  | .. ..  .||||.|| ||.|..        |||...|.|..| |...|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKV-----ARLGHSP----------------QGPS-CLLRWAAPEVIAHGKH
| ......  .|. .   .|. |.||.|  ..|| | |  .||.. ...|.     .| ...                 .| .   .|| |||.| .|| 
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTSSDVWSFGILMWEVMSYGERPYWD-----MSEQEVLNAIEQEFRLPPPPG--------CPPGLHLLMLDTWQKDRARRPHFDQLVAAF
|| |||||||..|||...||. ||..     || |||.. ..| .|.|.||         ||. .. .|.. |. | . || | ...  |
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphB6.AA TK-Unique 670-915 28 8.3e-69 234.9 In-house 1-294 (294) Show / Hide 
Range on Protein: 670-915
Range on HMM: 1-294/294
Sequence Identity: 28% (85 aa)

IKIEEVIGTGSFGEVRQGRLQPRG--RREQ-TVAIQALWAGGAESLQMTFLGRAAVLGQFQ-HPNILRLEGVVTKSR-PLMVLTEFMELGPLDSFLRQRE
.....|||.|.||.|  | . ..   . .|  ||. .| ..  .  .. || ..... .   ||||....|. |||  | | . |... | |...||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GQ-------------------------FSSLQLVAMQRGVAAAMQYLSS--FAFVHRSLSAHSVLVNSHLVCKVARLGHSP-------QGPSC-----LL
..                          |. .|.    ..| .|.||.|    .||| |.|. ||.....|||.. .| ..       .  .|      .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWAAPEVIA--HGKH-TTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGC-PPGLHLLMLDTWQKDRARRPHFDQLVAAF
|| |||..   || . || |||||||.||||....|..|| .|.  .....|.. .|.| |..| .. .. ||  .||...  || |.|..  .
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphB6.AA Frk 670-919 34 7e-55 188.55 In-house 1-260 (260) Show / Hide 
Range on Protein: 670-919
Range on HMM: 1-260/260
Sequence Identity: 34% (91 aa)

IKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLR--QREGQF
|..   .|.| ||||  |.       .  ||.. | .| ..     ||  | .. . .|| ...|  | |   |....|| |. | |  .|.  ...|. 
IQLIRRLGSGQFGEVWEGLWN----NTTPVAVKTLKPGTMD--PNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

SSL-QLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSP-------------QGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWE
  . ||| |   ||| | || |  ..|| | |  |||. |..||.|  |                .|    ..| ||| .   | |. |||||||||. |
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

VMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMI
.. ||  ||  | ..|||. .....|.| ||.||. |  .||. |..|  .|| |. |   ... .
IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphB6.AA Csk 670-915 34 9e-55 185.33 In-house 1-251 (251) Show / Hide 
Range on Protein: 670-915
Range on HMM: 1-251/251
Sequence Identity: 34% (89 aa)

IKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSR-PLMVLTEFMELGPLDSFLRQREGQ-F
... | || | || |.|| .|      . ||.  .   | . .|  ||  |.|  | .|||  .| ||. ..   | . .|.|  | |  .|| |. . .
LHLGECIGHGEFGDVMQGEYQ-----NRKVAVKCIKCDGNGMAQA-FLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVI

SSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCLL---------RWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYG
.  ||      |...| || .  |||| | |  .||   .| ||   | . .  | .           | |||   |.| .| |||||||||.||. |.|
TRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFG

ERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAF
  ||  .. ..| ...|  .|  .| ||||  . .| ..|. . |.|| | |..   
RVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase EphB6.AA Abl 670-915 33 4.3e-53 175.22 In-house 1-252 (252) Show / Hide 
Range on Protein: 670-915
Range on HMM: 1-252/252
Sequence Identity: 33% (86 aa)

IKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMT-FLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQ-F
| ... .| | .||| .|  .   | ..|||...|     .....  ||  ||.. . .|||. .| || |.  |  ..||||  | |  .||. . .  
IMMKHKLGGGQYGEVYEGVWK---RHDCTVAVKTLK---EDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREEL

SSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHS----------PQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSY
... |. |   .| .|.|| .  |.|| | |   ||  | . |||  | .            |    ..| ||| .|. |  . |||| ||.|.||.  |
PAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATY

GERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAF
|  ||  .  ..| . .|...|.  |.||||    ||.  || . . || | ..  |.
GMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase EphB6.AA Src-Echino1 670-915 32 2.6e-51 176.23 In-house 1-252 (252) Show / Hide 
Range on Protein: 670-915
Range on HMM: 1-252/252
Sequence Identity: 32% (84 aa)

IKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQ-FS
 .... || | .||| .|  .     .  ||...|  .     .  ||  | |. . .| .|...  |   . |. ..|| |. | | ..|.. ...   
LRMDKKIGKGHCGEVWKGVWN----GNTPVAVKTLKEKT--MSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVK

SLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGH----------SPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYG
  .|. |   .|. |.|| |  .||| |.|. |||.   |||.| .|           . ||    ..| ||| . .|. |  |||||||||| |.. .|
MTTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFG

ERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLL-MLDTWQKDRARRPHFDQLVAAF
  || .| ..|||. ... .|.| .  ||  |. . |.  | ||  .|| |. |   |
RYPYPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase EphB6.AA Pkinase_Tyr 826-915 46 5e-44 149.74 Pfam 179-270 (270) Show / Hide 
Range on Protein: 826-915
Range on HMM: 179-270/270
Sequence Identity: 46% (43 aa)

RWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERP-YWDMSEQEVLNAI-EQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAF
.| |||.|..|| || |||||||.||||...||| | |..|| .||...| |.  |.|.|..||. .. ||.. |..| ..|| | ...  .
KWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphB6.AA Pkinase_Tyr 670-812 30 2.8e-39 133.65 Pfam 1-153 (270) Show / Hide 
Range on Protein: 670-812
Range on HMM: 1-153/270
Sequence Identity: 30% (46 aa)

IKIEEVIGTGSFGEVRQGRLQ-PRGRREQTVAIQALWAGGAESL--QMTFLGRAAVLGQF-QHPNILRLEGVVT-KSRP--LMVLTEFMELGPLDSFLRQ
|.. ...| |.||||..|..    .  ...||.  |  |  ..   .  |.  |... |. .||||.|| ||.| ...|  ... .|.|..| |...||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---EGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVA
.   .....  .|. | . .|..|.||.|  ..|| | |  .||.. .|.|..
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKIC
Kinase EphB6.AA Src 826-915 45 1.1e-36 122.14 In-house 165-255 (255) Show / Hide 
Range on Protein: 826-915
Range on HMM: 165-255/255
Sequence Identity: 45% (41 aa)

RWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHL-LMLDTWQKDRARRPHFDQLVAAF
.| ||| | .|. |. |||||||||..|...||  ||  |. .||| ..|. .|.| |..||. |.  .||  |.||  .|| |. |   .
KWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphB6.AA CTKA 826-915 43 6.9e-32 104.33 In-house 199-290 (290) Show / Hide 
Range on Protein: 826-915
Range on HMM: 199-290/290
Sequence Identity: 43% (40 aa)

RWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQE--FRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAF
|| ||| .  ||... ||||.||.|.||.|| || |.  || ||| .|.      |||.|. ||  |  .|   |.   . || | .|    
RWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase EphB6.AA Src 670-812 33 9.3e-27 87.9 In-house 1-139 (255) Show / Hide 
Range on Protein: 670-812
Range on HMM: 1-139/255
Sequence Identity: 33% (49 aa)

IKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLR-QREGQ-F
|| .. .|.| |||| .|      . .  ||.  | .|     .  ||  | .. ...|.....|  |...  |    ||.|. | |  .|. ..||.  
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

SSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVA
.  ||. |   ||. |.||.|  ..|| | |  |||. ..|||||
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVA
Kinase EphB6.AA CTKA 670-761 33 5.2e-19 60.4 In-house 1-101 (290) Show / Hide 
Range on Protein: 670-761
Range on HMM: 1-101/290
Sequence Identity: 33% (34 aa)

IKIEEVIGTGSFGEVRQGRLQPRGR-------REQTVAIQALWAGGAESLQMTFLGRAAVLG--QFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFL
  |   || | .|.| .  | |.         . . ||.  | . . |     ||. | ||   .| |||.||| ||.|.. |.   .|.| .| | ..|
HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYL

R
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R
Kinase EphB6.AA S_TKc 670-919 19 3.6e-18 67.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 670-919
Range on HMM: 1-231/231
Sequence Identity: 19% (53 aa)

IKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMEL--GPLDSFLRQREGQ-
 .| ..|| |.||.|...|        . |||  .          ...   ..| . .|||| .| .|      | . .|...   | | .....| .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCK-----VARLGHSPQGPSCLLRWAAPEVIAHGKHTT-SSDVWSFGILMWEVMS
    |.  .   . . .. |..|. |  ..|| |    .|...  . |     .||.          . . ||||.   .... ..|.||.|....| ..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

YGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAF-----DKMI
 |. |..   .|.... |            .| .  ..   .||| ..||   .. ..      .  .
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphB6.AA Pkinase 670-794 22 1.4e-14 52.63 Pfam 1-132 (293) Show / Hide 
Range on Protein: 670-794
Range on HMM: 1-132/293
Sequence Identity: 22% (31 aa)

IKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAES--LQMTFL-GRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELG----PLDSFLR-
..|...|| ||||.|.... .  |.   .||.  ..  ...|  .|  ..   ....  ..||||.|| .... .. . . .|..| |     | .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

QREGQF--SSLQLVAMQRGVAAAMQYLSSFAFVHR
.|.| |  |  ..  . . .. ...|. |  ..||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR
Kinase EphB6.AA Pkinase 825-915 17 3.3e-13 47.8 Pfam 175-293 (293) Show / Hide 
Range on Protein: 825-915
Range on HMM: 175-293/293
Sequence Identity: 17% (21 aa)

LRWAAPEVIA-HGKHTTSSDVWSFGILMWEVMSYGERPYWDM------SEQEVLNAIEQ-EFRLPPPPGCP-------------------PGLHLLMLDT
....|||||  . ......|.||.|....|... |. |...       ....... | . ... . |  |.                   . .  .. . 
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

WQKDRARRPHFDQLVAA--F
..|| ..|| ..|..    |
LCKDPKKRPTAEQILQHPWF
Kinase EphB6.AA CTKA 773-817 37 2.1e-07 20.78 In-house 134-178 (290) Show / Hide 
Range on Protein: 773-817
Range on HMM: 134-178/290
Sequence Identity: 37% (17 aa)

VAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHS
| | . .|| | ||..  |||| | .  .|. .  . |.| .||.
VYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHG
SAM_2 EphB6.AA SAM_2 945-1010 30 3.3e-22 79.06 Pfam 1-71 (71) Show / Hide 
Range on Protein: 945-1010
Range on HMM: 1-71/71
Sequence Identity: 30% (22 aa)

LDFPCLDSPQAWLSAIGL-ECYQDNFSKFGLCTFSDV-AQLSLEDL--P-ALGITLAGHQKKLLHHIQLLQ
 ....... ..||..||. ..| |||...|. .|... |.....||    ..|||..||.||....|| ..
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
SAM EphB6.AA SAM 945-1012 36 5.8e-19 70.25 SMART 1-67 (67) Show / Hide 
Range on Protein: 945-1012
Range on HMM: 1-67/67
Sequence Identity: 36% (25 aa)

LDFPCLDSPQAWLSAIGLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQH
 | .. .. ..|| .||.. | |||.| |. ..  ....|.|||  .|||..||.||.|. || ....
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
Sam7 EphB6.AA sam7 948-1010 31 9.9e-19 64.42 In-house 1-70 (70) Show / Hide 
Range on Protein: 948-1010
Range on HMM: 1-70/70
Sequence Identity: 31% (22 aa)

PCLDSPQAWLSAIGL---ECYQDNFSKFGL----CTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQ
.  .. . || .||.   . | |||...|      ..........||| ..|||. ||.||...||| ..
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM_1 EphB6.AA SAM_1 954-1010 37 7.4e-14 52.06 Pfam 9-66 (66) Show / Hide 
Range on Protein: 954-1010
Range on HMM: 9-66/66
Sequence Identity: 37% (22 aa)

QAWLSAIGLECYQDNFSKFGLCTFSDVAQLSLEDLPA-LGITLAGHQKKLLHHIQLLQ
. || .||.. | |.| . |. ......|.. ||| . .|.||.||.||... || | 
CEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK