Gene FGFR1 (Human)

FGFR1

Species: Human
Alias: HBGFR, H4, H2, C-FGR, CEK, FLJ14326, H5, N-SAM, KAL2, BFGFR, H3, FGFBR, CD331, LOC51033, FLT2, FLG, FGFR1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 8p11.1-p12,

Classification

Group: TK
Family: FGFR

Sequence

Name Sequence Type Origin Length Description Download
FGFR1.NA RNA Sugen Kinome 5917 None Fasta, JSON
FGFR1.AA Protein Sugen Kinome 822 None Fasta, JSON
FGFR1.kin_dom Protein Kinase Domain Sugen Kinome 277 None Fasta, JSON

Protein domain

Protein domains of FGFR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 FGFR1.AA IGc2 46-108 25 3.9e-14 54.2 SMART 1-56 (56) Show / Hide 
Range on Protein: 46-108
Range on HMM: 1-56/56
Sequence Identity: 25% (16 aa)

HPGDLLQLRCR-LRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSG
|.|. ..|.|.   ... .| |.. | .|.       .. ......  |.|||.|.|. ..| |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FGFR1.AA IG 40-119 16 4e-06 27.76 SMART 1-58 (58) Show / Hide 
Range on Protein: 40-119
Range on HMM: 1-58/58
Sequence Identity: 16% (14 aa)

VESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADS---GLYACVTSSPSGSDTT--YFSVNVS
 .  .| .|. ..|.|       .| |.                   .. .  |.||   | | |. .  .|...    . . |.
PP-VTVKEGETVTLTC-VS----QIWWY------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set FGFR1.AA I-set 63-118 24 6.4e-05 19.21 Pfam 31-92 (92) Show / Hide 
Range on Protein: 63-118
Range on HMM: 31-92/92
Sequence Identity: 24% (15 aa)

SINWLRDGVQLAE-SNRTRITGEE-----VEVQDSVPADSGLYACVTSSPSGSDTTYFSVNV
.. |..|| .|.. |.| ..| ..      ....  |.|.| | || . ..|.... ....|
QVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
V-set FGFR1.AA V-set 31-118 14 0.102122 7.75 Pfam 12-128 (128) Show / Hide 
Range on Protein: 31-118
Range on HMM: 12-128/128
Sequence Identity: 14% (18 aa)

AQPWGAPVEVESFLVHPGDLLQLRCRLR--D----DVQSINWLRDGVQL-------------------------AESNRTRITGEEV------EVQDSVP
. ||       .  | .|. . |.| ..       ....|.| |.  ..                           ..|....|           ..  |
C-PW-------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQP

ADSGLYACVTSSP-SGSDTTYFSVNV
.||| | |. ...  ..  .   . |
SDSGTYYCAVWNCNEDYFGHGTRLTV
I-set FGFR1.AA I-set 172-247 30 2.5e-14 51.15 Pfam 16-92 (92) Show / Hide 
Range on Protein: 172-247
Range on HMM: 16-92/92
Sequence Identity: 30% (24 aa)

KTVKFKCPSSGTPNPTLRWLKNGKEFKP-DHRIGGYKVRYAT---WSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDV
.|..|.|  .|.| |.  |.|.|.. .| ..|   ....|      . ... | |.| | |||...|..|.   | .| |
ETARFECQVTGDPPPQVSWFKDGQPLRPDSDR---HQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 FGFR1.AA IGc2 169-237 27 2.1e-11 45.12 SMART 1-56 (56) Show / Hide 
Range on Protein: 169-237
Range on HMM: 1-56/56
Sequence Identity: 27% (19 aa)

PAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYG
    .| ..|| .| |.|. .|.| |..                |.    .| |.| |.|||...|. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FGFR1.AA IG 163-248 16 1.1e-09 39.47 SMART 1-58 (58) Show / Hide 
Range on Protein: 163-248
Range on HMM: 1-58/58
Sequence Identity: 16% (15 aa)

KKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK---GNYTCIVENEYGSINH--TYQLDVV
 . . | .  ||...|  |     ...|.                       ... .| |.|    |.|.| ..  .|..    . .| | 
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGv FGFR1.AA IGv 173-232 20 0.001283 7.19 SMART 1-76 (76) Show / Hide 
Range on Protein: 173-232
Range on HMM: 1-76/76
Sequence Identity: 20% (16 aa)

TVKFKCPSSGTPNPTLRWLKN-------GKEFKPDHRIGGYKVRY----AT--------WSIIMDSVVPSDKGNYTCIV
.|.  |  ||  . .. |..        ||. .  ..  .|| |.     .        ... | .. |.| |.|.| .
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY--SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
V-set FGFR1.AA V-set 172-247 16 0.014153 10.71 Pfam 22-128 (128) Show / Hide 
Range on Protein: 172-247
Range on HMM: 22-128/128
Sequence Identity: 16% (18 aa)

KTVKFKCPSSGTP----NP-TLRWLK-NGK------------EFKPD----HRIGGYKVRYA--------TWSIIMDSVVPSDKGNYTCIVENE-YGSIN
..|...|  | ..    .. .. | .                 ....    .  . .| |.         ..|. . .. ||| | |.| | |. ...  
QSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFG

HTYQLDV
| ..| |
HGTRLTV
IG FGFR1.AA IG 262-359 20 3.5e-16 61.0 SMART 1-58 (58) Show / Hide 
Range on Protein: 262-359
Range on HMM: 1-58/58
Sequence Identity: 20% (21 aa)

PANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDA---GEYTCLAGNSIGLSH-HSAWLT
|   || .|..|.. | |      .|.|.                                   |.. ||..||.   |.|.| |  .   .  ....||
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLT

VL
|.
VQ
IGc2 FGFR1.AA IGc2 268-348 25 6.3e-12 46.86 SMART 1-56 (56) Show / Hide 
Range on Protein: 268-348
Range on HMM: 1-56/56
Sequence Identity: 25% (21 aa)

ALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG
  | .|.. |..  .| | |.|.|     |...                         |...||..||.|.|||.| |..|
HEGQSVTLTCPATGNPDPNIHWYK-----GQPLP--------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set FGFR1.AA V-set 255-358 16 4e-06 22.97 Pfam 1-128 (128) Show / Hide 
Range on Protein: 255-358
Range on HMM: 1-128/128
Sequence Identity: 16% (23 aa)

PI-LQAGLPA----NKTVALGSNVEFMCKVYSDP----QP-HIQWLK-HIEVNGSKIGPDNLPYVQI-----LKTA----GVNTTDKEMEV---------
.. ...  |.      ||..| .|.. |.. .|.    .. .|.| . .          .. |   |     ...     ..    |. .          
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPP--------GQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKND

--LHLRNVSFEDAGEYTCLAGNS-IGLSHHSAWLTV
  |...|.. .| | |.| . |. ..  .|. .|||
FSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set FGFR1.AA I-set 326-358 48 7e-06 22.48 Pfam 60-92 (92) Show / Hide 
Range on Protein: 326-358
Range on HMM: 60-92/92
Sequence Identity: 48% (16 aa)

LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTV
|  .||  .|.|.||| | || | .  .| |||
LTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGv FGFR1.AA IGv 272-343 18 0.001065 8.0 SMART 1-76 (76) Show / Hide 
Range on Protein: 272-343
Range on HMM: 1-76/76
Sequence Identity: 18% (15 aa)

NVEFMCKVYSDPQPHIQWLKHI-EVNGSKIGPDNLPYVQILKT--AGVNTT----DKEMEVLHLRNVSFEDAGEYTCLA
.|.  ||.  .   .. |...    ..   |.  . |   .|    ..  .    .|    |...|.  || | |.|  
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY--SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
I-set FGFR1.AA I-set 262-291 36 0.001649 14.42 Pfam 7-36 (92) Show / Hide 
Range on Protein: 262-291
Range on HMM: 7-36/92
Sequence Identity: 36% (11 aa)

PANKTVALGSNVEFMCKVYSDPQPHIQWLK
| . .|  |. ..| |.|  ||.| ..|.|
PKDVEVQEGETARFECQVTGDPPPQVSWFK
Kinase FGFR1.AA FGFR 478-754 72 1.2e-237 795.74 In-house 1-293 (293) Show / Hide 
Range on Protein: 478-754
Range on HMM: 1-293/293
Sequence Identity: 72% (211 aa)

LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR
|.|||.|||||||||..|||.|.|.|.|.. ..|||||||...|.||||||.||||||||||||||||||||.|||.|||||||||...||||..|.|||
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PPGLEYCYNPS-------HNPEEQ--------LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL
||| .|.....       ..||.|        |..|||||||||||||||||||.|||||||||||||||.|.||||.|||||||||.||||.|||||||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
|.|||||||||||.|||||||||.|||||||.|.||.|||..| ||||.|.|||||||.||.||..|.|.||..|||..|.||||||||||.|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FGFR1.AA Pkinase_Tyr 478-754 47 4.6e-161 546.12 Pfam 1-270 (270) Show / Hide 
Range on Protein: 478-754
Range on HMM: 1-270/270
Sequence Identity: 47% (135 aa)

LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD--LSDLISEMEMMKMIGKHKNIINLLGACT-QDGP--LYVIVEYASKGNLREY
...|| ||||.||.|..... |   |. |  ..||||||| .|....  . |...|...|| .|.|.||..|.|.|| |..|  .|...||. .|.|..|
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY-KKTTNGRLPVKWMAPEA
|...|            .....|. |||.. ..|.|.|||||.||.||||||||||.||||.||.||.||||||||.. ||| .|...|.||.||||||.
LRKHR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC

LFDRIYTHQSDVWSFGVLLWEIFTLGGSP-YPGVPVEELFKLL-KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
......|..|||||||||.|||||.|..| |||.. ||..... ..|.||..| ||. |.|..|..|||. |..||||....|.|
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FGFR1.AA TyrKc 478-754 41 4.7e-158 532.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 478-754
Range on HMM: 1-280/280
Sequence Identity: 41% (128 aa)

LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG-KHKNIINLLGACTQD-------GPLYVIVEYASKGNL
..||| ||||.||.|......          ..|||||||.||    . |...|...|...| .|.||..|.|.|||.       .||....||...|.|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHI-------DYYKKTT--NG
..||...||                |. |||.| ..|.|.|||||.||.||||||||||.||.|....||.||||.|||..        |||.|..  .|
KDYLRKHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

R--LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG-----VPVEELFKLLKEGHRMDKPSN--------CTNELYMMMRDCWHAVPSQRP
.  ||..|||||.......|..||||||||..|||||.|..||||     .. .|.....|.|.||..| |        |. |.|..|..|||. |..||
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

TFKQLVEDL
||....|..
TFSEIHECF
Kinase FGFR1.AA TK 478-754 28 7.29999999999e-139 467.63 In-house 1-486 (486) Show / Hide 
Range on Protein: 478-754
Range on HMM: 1-486/486
Sequence Identity: 28% (138 aa)

LVLGKPLGEGCFG---QVVLAEAIGLDKDKPNR------------------VTKVAVKMLK--SDATEKDLSD--------------LISEMEMMKM-IG
..||| |||| ||   .| ..|..|.......|                  .|.|||||||  .......  |              . .||.||.. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHKNIINLLGACTQD------------GPLYVIVEYASKGN----LREYLQARRPPGLEYCYNPSHNPEEQ-----------------------------
.|.||..|.|.|||.            .|.....||...|.    ||.||...||.. .....|..... .                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------LSSKDLVS-------------------CAYQVARGMEYLASKKC------IHRDLAARNVLVTEDNV-----------MKIADFG----
           |. |||..                   ...|.|.|||||.||.|      .||||||||.||.|.||            ||||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LARDIHH------------------------IDYYKKTTNGRLPVKWMAPEALFDRI---------YTHQSDVWSFGVLLWEIFTLG-GSPYPGVP
    |||||..                         |||.....|.||..|||||.|.||.         .|..|||||||||.|||||.| . .|.|..
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

V---------EELFKLLKEG--------------HRMDKPSNCT--------------NELYMMMRDCWHAVPSQRPTFKQLVEDL
          .|....|..|              .|| .| .|.               |.| .|..|||. |..||||.||.| |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FGFR1.AA Ret 478-756 46 9.60000000001e-127 427.36 In-house 1-293 (293) Show / Hide 
Range on Protein: 478-756
Range on HMM: 1-293/293
Sequence Identity: 46% (137 aa)

LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD-ATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDG--PLYVIVEYASKGNLREYLQ
|.|.. |||| ||||| | |. . . .|   | ||||||| . |.   . || ||... | .  | ..| |.|||.||.  |. .||||.  | |||.| 
LQLDDTLGEGHFGQVVKAQAFHI-RGHPG-YTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLR

ARRPP--------GLEYCYNPSHNP-EEQLS-----SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
  |          | . |  . |   .. .       |...| | |. .|| ||.. | .||||||||||| |  ..|| |||| ||.   | | |   .
LSRKIGPYYEYSIGNRNCSIVDHPDGKDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKD

RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
|.||||||.|.|.| .|| .|||||||||.||| |.|..||||.| | |. ||| |.||| | ||  |.| .|| ||   |  || || .  |. .
RIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FGFR1.AA TK-Unique 478-754 45 3.2e-125 422.33 In-house 1-294 (294) Show / Hide 
Range on Protein: 478-754
Range on HMM: 1-294/294
Sequence Identity: 45% (133 aa)

LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNLREYLQAR
|..|. .||| ||||  .|. |..  . .. ..||||||| .||. | .|. .| .||| .|.|.||...||.|| .. | . | ||...|||. ||. .
LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

RPP--GL--------EYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS--KKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH-IDYYKKTTNGRLP
||.  .            ..|. ...| .|.|||.. |.|.|.|||||||  ||..||||.|||||.|||.| ||.|||.|||...  .| .... ||.|
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VKWMAPEALF--DRIY-THQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNC-TNELYMMMRDCWHAVPSQRPTFKQLVEDL
..|||||.|   ...| | .|||||||||.|||||||. ||||.| ... .....|.||..|..| ..|.|  |. ||. .|..||.| |..  |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FGFR1.AA UTK 478-754 35 6e-105 354.96 In-house 1-296 (296) Show / Hide 
Range on Protein: 478-754
Range on HMM: 1-296/296
Sequence Identity: 35% (108 aa)

LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDAT-EKDLS---DLISEME---MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR
. ||..||.| ||.| .|..   . . .  . .|||| ....|. ...     |.. |     |||.   | |...|.| |||..|.....||...|.||
VQLGRQLGQGAFGEVHKARF--TQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

EYLQ-ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED-------NVMKIADFG---LARDIH---------H
 ||. .|. |.          ....|.. .....|...||||.||.|....||||||||.||...       .| ||||||   ..|...          
SYLRRHRPTPP---------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWE

IDYYKKTTNGRLPVKWMAPEALFDR-IYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEG--HRMDKPSNCTNELYMMMRDCWHAVPSQRPTF
 .||... ..|.|..||||||| ..  .|..||||||||..|||.| |  ||||   ..... . .|  .|| .|  |  ..|..|..|||. |. ||.|
SYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDF

KQLVEDL
..||. .
EDLVQQM
Kinase FGFR1.AA VEGFR 595-754 60 1.7e-101 343.5 In-house 170-332 (332) Show / Hide 
Range on Protein: 595-754
Range on HMM: 170-332/332
Sequence Identity: 60% (98 aa)

LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD-IHHIDYYKKTTN-GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWE
| ..||.. ..|||||||.|||.|||||||||||.|..|.|| || ||||||. |   . |.. .. |||| ||||||..||..|| .|||||.||.|||
LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWE

IFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
||.|||||||||   ||... ||.| || .|  || |.|  | ||||  | .||.|  ||| |
IFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FGFR1.AA Src 478-754 41 9.9e-100 337.63 In-house 1-255 (255) Show / Hide 
Range on Protein: 478-754
Range on HMM: 1-255/255
Sequence Identity: 41% (117 aa)

LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR
. | . ||.|.|| |  .        . |  |||||| ||..    .  ..  | . ||   .|.....|.  |.|. | | . || |.|.| .||..  
IKLCRKLGQGQFGEVWMG--------YWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK--

PPGLEYCYNPSHNPEEQ-LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDR
            ..|.. |. ..|.. | |||.||.|| |.. |||||||||||| |.|| |.||||||| | .  | |   .  ..|.||.||||.  .
------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYG

IYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYM-MMRDCWHAVPSQRPTFKQLVEDL
 .|  |||||||.||.||.| |  ||||   .| .. .. | || .|.||  |||.  |. |||. | |||||. | . |
RFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FGFR1.AA RTKB 478-754 42 2.5e-97 328.66 In-house 1-264 (264) Show / Hide 
Range on Protein: 478-754
Range on HMM: 1-264/264
Sequence Identity: 42% (119 aa)

LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR
. ||. ||.| ||.| .|    .     |    .|.| || .| . .  |  ||| .|| .| | |.| ..| | || |. . ||..  ||||.|| ..|
VWLGEKLGNGAFGEVFQAW---VRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCR

PPGLEYCYNPSHNPEEQ-LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRI
         ..|||  | |... ||. . |.|.|| .| ... |||||.||||||. .   ||.|||.|| | | .|  .||  |||.|||||| . .||
--------ASQHNP--QSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECY--ETTCTRLPIKWMAPESWAHRI

YTHQS-DVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
|| .| |||||||  ||||.||| ||.  .. ..|..|  |||. ||.    . . .|..|| . ...||.|. ||. .
YTTKSGDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase FGFR1.AA InsR 478-756 38 2.9e-95 320.41 In-house 1-278 (278) Show / Hide 
Range on Protein: 478-756
Range on HMM: 1-278/278
Sequence Identity: 38% (109 aa)

LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR
.||....|.| || | .  | |. .| . |  ..|.| .. .|. ..  .  .| . || . .......||| |..  | ||. |   .|.|. || .||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEF-NCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRR

PPGLEYCYNPSHN-PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRI
|  .|   ||  |   .. .  .... | ... || |||.|| .|||||.|| .| .|   ||.|||..|||   |||.| . | ||| ||||| | | .
P--EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGV

YTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL-KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
.| .||||||||.|||. |||  || |   |.  |   ..|  ...| || . .. .|. ||.  |. ||||..... |  
FTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase FGFR1.AA PDGFR 592-754 57 3.4e-95 306.07 In-house 195-358 (358) Show / Hide 
Range on Protein: 592-754
Range on HMM: 195-358/358
Sequence Identity: 57% (95 aa)

EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLW
.. |. .||.. .||||.|||.|||| |.||||||||||...  | || |||||||| .   |    | |||||||||| .|| .|| ||||||.|.|||
SNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLW

EIFTLGGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
|||.|||.||||.||.. | |. ||| ||..|   . | |  |. || . | .||||.||.. |
EIFSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FGFR1.AA S_TKc 478-758 24 4.6e-56 193.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 478-758
Range on HMM: 1-231/231
Sequence Identity: 24% (71 aa)

LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK--GNLREYLQA
  .....|.| ||.| ..  ..          .||.|..|         ....|....|.  .|.||..|....   . ||.. ||..   |.|..|.. 
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

RRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDR
|...||            ...  .  . .||.....||. |.. |||||   |.|..|  . ||.|||||| .         |       .|||| |   
RGRHGLR----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---

IYTH-QSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE-----DLDRIV
 |..  .|.||.|..|.| .. |  |.|   ....||...           . |.  ..| |..  |..|||  .. .      ..  .
GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FGFR1.AA Pkinase 478-754 22 2.8e-47 168.17 Pfam 1-293 (293) Show / Hide 
Range on Protein: 478-754
Range on HMM: 1-293/293
Sequence Identity: 22% (72 aa)

LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLI---SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG----NLR
...|...|.| ||.| ..  .|  |       .|||| .| . ....        || ..||.. .|.||. |..... .. .|.. ||. .|     | 
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

EYLQARRPPGLEYCYNPSHNPEEQL--SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM----KIADFGLARDIHHIDYYKKTTNGRLPV
.|...                .  .  | ... ...||..||.||. |...|||||   |.|. ....     ||.|||||. .  .  .  .|      
DYIST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTP

KWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV----PVEELFKLLKEGHRMDKPSNCT-----------------------NELYMMMRDC
 .|||| .  .. |.. .|.||.|..|.| .. |  |.||     .  .  .....  . . ....                         |.   ...|
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

WHAVPSQRPTFKQLVED--L
..  |..|||..|....  .
LCKDPKKRPTAEQILQHPWF
Kinase FGFR1.AA VEGFR 478-577 50 5.9e-42 145.7 In-house 1-101 (332) Show / Hide 
Range on Protein: 478-577
Range on HMM: 1-101/332
Sequence Identity: 50% (52 aa)

LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT---QDGPLYVIVEYASKGNLREYLQ
| |||.||.| ||||. |.|.|..| .....  |||||||. ||      | ||..|.. ||.| |  |.||.||   | ||| |||||  .|||  || 
LKLGKMLGRGAFGQVHEASAFGIRKMETCTT--VAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLR

ARR
. |
TKR
Kinase FGFR1.AA PDGFR 478-577 51 9e-36 112.06 In-house 1-98 (358) Show / Hide 
Range on Protein: 478-577
Range on HMM: 1-98/358
Sequence Identity: 51% (51 aa)

LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR
|..|| || | ||.|| | | || |  .  | ||||||||. |       | ||  .|   |.| ||.|||||||  || |.| ||   | | .||  .|
LQFGKTLGSGAFGKVVEATAYGLSKSQA--VMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR