Gene FLT1 (Human)

FLT1

Species: Human
Alias: VEGFR1, VEGFR-1, FLT-1, FLT, FLT1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 13q12.3,

Classification

Group: TK
Family: VEGFR

Sequence

Name Sequence Type Origin Length Description Download
FLT1.NA RNA Sugen Kinome 7123 None Fasta, JSON
FLT1.AA Protein Sugen Kinome 1338 None Fasta, JSON
FLT1.kin_dom Protein Kinase Domain Sugen Kinome 328 None Fasta, JSON

Protein domain

Protein domains of FLT1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG FLT1.AA IG 38-129 12 0.010097 14.58 SMART 1-58 (58) Show / Hide 
Range on Protein: 38-129
Range on HMM: 1-58/58
Sequence Identity: 12% (12 aa)

GTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHT---GFYSCKYLAVPTSKKKETES--AIYIFIS
   .  ..|.|. |.|  .   .|.                             ||.  .|....   | | |         .....|   ... ..
PP-VTVKEGETVTLTC-VS-QIWWY-----------------------------LTI-NVQPEDSQQHGTYYCQAT------HGQYWSIQGTTLTVQ
IG FLT1.AA IG 143-224 16 1e-05 26.32 SMART 1-58 (58) Show / Hide 
Range on Protein: 143-224
Range on HMM: 1-58/58
Sequence Identity: 16% (14 aa)

PEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEI---GLLTCEATVNGHLYK--TNYLTHR
|. .   ||  ....| |.    .....                     ..| |...      |  .|.|| .|  ..  . .|| .
PP-VTVKEGETVTLTC-VS----QIWWY---------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
IGc2 FLT1.AA IGc2 149-214 19 0.001019 10.54 SMART 1-56 (56) Show / Hide 
Range on Protein: 149-214
Range on HMM: 1-56/56
Sequence Identity: 19% (13 aa)

TEGRELVIPCR-VTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGH
 ||. ....|.   .|. ... .|   .. .|        ...   |.|.|.   |. ||.|. . .
HEGQSVTLTCPATGNPDPNIHWYK---GQPLP--------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FLT1.AA IG 237-329 18 9.9e-13 49.54 SMART 1-58 (58) Show / Hide 
Range on Protein: 237-329
Range on HMM: 1-58/58
Sequence Identity: 18% (18 aa)

PRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDK---GLYTCRVRSGPSFKS-VNTSVHIY
|. |   .| |..|.| ..       |..|.                            ||| . |  |    | |.|... . . .|  .| ....
PP-VTVKEGETVTLTC-VS-------QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
IGc2 FLT1.AA IGc2 243-318 21 9.9e-05 20.22 SMART 1-56 (56) Show / Hide 
Range on Protein: 243-318
Range on HMM: 1-56/56
Sequence Identity: 21% (16 aa)

LRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPS
. | ...|.| ||   |   . .| . ...                     . |||  ..  | |.|||..|.  .
HEGQSVTLTCPAT--GNPDPNIHWYK-GQPLP-----------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IGv FLT1.AA IGv 247-313 22 0.001022 8.18 SMART 1-76 (76) Show / Hide 
Range on Protein: 247-313
Range on HMM: 1-76/76
Sequence Identity: 22% (18 aa)

TLVLNCTATTPLNTRVQMTWSYPDE----KNKRA-----SVRRRIDQSNS-----HANIFYSVLTIDKMQNKDKGLYTCRV
.. | |....  .   .|.| .       | |.      |.. |.  | .       | ||  ||.  .. .| | |.| .
SVTLSCKFSGFTF---YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFY--LTMSNLRPEDTGTYYCAR
V-set FLT1.AA V-set 231-338 13 0.002097 13.57 Pfam 1-128 (128) Show / Hide 
Range on Protein: 231-338
Range on HMM: 1-128/128
Sequence Identity: 13% (19 aa)

DVQIST--PR----PVKLLRGHTLVLNCTATTPL--NTRV-QMTWSY-PDE-----------KNKRASVRRRIDQSNSHANIFYSV--------LTIDKM
..|...  ||    .|   .| .. |.|. ...   .... ...|..  .             .. .. ..   ..    ... |.        ||| ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

QNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKH
|  | | |.| | ..          ..|  . ...  
QPSDSGTYYCAVWNC---------NEDYFGHGTRLTV
I-set FLT1.AA I-set 296-314 47 7.435453 2.02 Pfam 60-78 (92) Show / Hide 
Range on Protein: 296-314
Range on HMM: 60-78/92
Sequence Identity: 47% (9 aa)

LTIDKMQNKDKGLYTCRVR
|||.. |  | | |||...
LTISNVQPDDEGKYTCVAT
I-set FLT1.AA I-set 354-405 33 3.8e-08 30.15 Pfam 19-75 (92) Show / Hide 
Range on Protein: 354-405
Range on HMM: 19-75/92
Sequence Identity: 33% (19 aa)

RLSMKVKAFPSPEVVWLKDGLPATE--KSARYLTRG---YSLIIKDVTEEDAGNYTI
|.. .|.  | |.|.|.||| | ..  .  ..  .|   |.|.|..|. .|.| ||.
RFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTC
IG FLT1.AA IG 344-425 15 3e-06 27.91 SMART 1-58 (58) Show / Hide 
Range on Protein: 344-425
Range on HMM: 1-58/58
Sequence Identity: 15% (13 aa)

LETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDA---GNYTILLSIKQSNVFKN-LTATLIVN
 . | .|.  .....  .    .. |.                   |.| .|..||.   |.|.   .   . . .   ..||.| 
PP-VTVKEGETVTLTC-VS---QIWWY-------------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ
IGc2 FLT1.AA IGc2 348-412 27 0.004616 4.26 SMART 1-56 (56) Show / Hide 
Range on Protein: 348-412
Range on HMM: 1-56/56
Sequence Identity: 27% (18 aa)

AGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQS
   .| .|  .. ..| |.. |.| | |           . .| ||.||.||.|.|| . . . .
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set FLT1.AA V-set 388-424 21 0.707935 4.85 Pfam 93-128 (128) Show / Hide 
Range on Protein: 388-424
Range on HMM: 93-128/128
Sequence Identity: 21% (8 aa)

YSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIV
.|| |......| | |.   .   . .      .|.|
FSLTISNLQPSDSGTYYCAVWNC-NEDYFGHGTRLTV
IG FLT1.AA IG 439-553 10 0.010397 14.47 SMART 1-58 (58) Show / Hide 
Range on Protein: 439-553
Range on HMM: 1-58/58
Sequence Identity: 10% (13 aa)

PDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS-----GIY
|   .  .|..  ||| .      .|.|.                                                      |.. . . .     |.|
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------------------------------------LTI-NVQPEDSQQHGTY

ICIASNKVGTVGR--NISFYIT
 | |.   |..    ..  ...
YCQAT--HGQYWSIQGTTLTVQ
I-set FLT1.AA I-set 447-467 33 0.023103 10.53 Pfam 15-35 (92) Show / Hide 
Range on Protein: 447-467
Range on HMM: 15-35/92
Sequence Identity: 33% (7 aa)

GSRQILTCTAYGIPQPTIKWF
|..  ..|.. | |.|.. ||
GETARFECQVTGDPPPQVSWF
I-set FLT1.AA I-set 530-544 40 0.140452 7.87 Pfam 70-84 (92) Show / Hide 
Range on Protein: 530-544
Range on HMM: 70-84/92
Sequence Identity: 40% (6 aa)

SGIYICIASNKVGTV
.|.| |.|.|..|..
EGKYTCVATNSFGEA
IG FLT1.AA IG 562-658 20 7.6e-10 39.96 SMART 1-58 (58) Show / Hide 
Range on Protein: 562-658
Range on HMM: 1-58/58
Sequence Identity: 20% (21 aa)

NLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDS---GTYACRARNVYTGEEILQKK--EITIR
       |||...|.| |.      ..|                               ||| ||...||   ||| |.|.         ...  ..|..
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------------LTI-NVQPEDSQQHGTYYCQAT------HGQYWSIQGTTLT

DQ
 |
VQ
IGc2 FLT1.AA IGc2 568-643 23 2.1e-08 35.17 SMART 1-56 (56) Show / Hide 
Range on Protein: 568-643
Range on HMM: 1-56/56
Sequence Identity: 23% (18 aa)

TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYT
 ||... | | .. .   ...|.   .  .                       ||| ||.. |||.|.|.|||   
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IGv FLT1.AA IGv 572-638 21 0.000115 17.7 SMART 1-76 (76) Show / Hide 
Range on Protein: 572-638
Range on HMM: 1-76/76
Sequence Identity: 21% (17 aa)

DLKLSCTVNKFLYRDVTWILLR------TVNNRTMHYSISKQKMAITKE-----HSITLNLTIMNVSLQDSGTYACRA
...|||..  | .  ..|.  .       .    |.|  .| .  ..|       . .  ||..|.   |.||| |  
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY-SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
I-set FLT1.AA I-set 621-640 55 0.000422 16.43 Pfam 60-79 (92) Show / Hide 
Range on Protein: 621-640
Range on HMM: 60-79/92
Sequence Identity: 55% (11 aa)

LTIMNVSLQDSGTYACRARN
||| ||   |.|.| |.|.|
LTISNVQPDDEGKYTCVATN
V-set FLT1.AA V-set 569-640 18 0.005164 12.22 Pfam 20-114 (128) Show / Hide 
Range on Protein: 569-640
Range on HMM: 20-114/128
Sequence Identity: 18% (18 aa)

EGEDLKLSCTVN-KF----LYRDVTWIL-LRT---------------VNNRTMHYSISKQKMAITKEHSI--TLNLTIMNVSLQDSGTYACRARN
||....|.|..           ...|.   ..                |... .|. ....      .    ...|||.|... ||||| | . |
EGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWN
I-set FLT1.AA I-set 661-748 31 3.3e-24 84.67 Pfam 1-92 (92) Show / Hide 
Range on Protein: 661-748
Range on HMM: 1-92/92
Sequence Identity: 31% (29 aa)

PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQ-EPGIILGPGS---STLFIERVTEEDEGVYHCKATNQKGSVESSAYLTV
|. .. ..| .| . .. ...|.. | |.||..|||.. .... .  .         .||.|..|. .|||.| |.|||  |..|..| |||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 FLT1.AA IGc2 673-738 36 6.2e-21 76.78 SMART 1-56 (56) Show / Hide 
Range on Protein: 673-738
Range on HMM: 1-56/56
Sequence Identity: 36% (24 aa)

AISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKG
 .  | || |.|.| |.|.|.|.| . ...         ...|| |..||.||.|.|.|.|.| .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FLT1.AA IG 667-749 27 3.4e-17 64.35 SMART 1-58 (58) Show / Hide 
Range on Protein: 667-749
Range on HMM: 1-58/58
Sequence Identity: 27% (24 aa)

LSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDE---GVYHCKATNQKGSVES--SAYLTVQ
 . .||   .. || | ..     ||.|.                    | | .|..||.   |.| | ||  .|...|  ...||||
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set FLT1.AA V-set 695-748 23 3e-05 19.94 Pfam 78-128 (128) Show / Hide 
Range on Protein: 695-748
Range on HMM: 78-128/128
Sequence Identity: 23% (13 aa)

FKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQ-KGSVESSAYLTV
||..  ... |.     .. .| |  ....|.|.|.| ..|  ... ...  |||
FKGRVTFSGNPS----KNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
Kinase FLT1.AA VEGFR 827-1154 71 2.2e-272 911.19 In-house 1-332 (332) Show / Hide 
Range on Protein: 827-1154
Range on HMM: 1-332/332
Sequence Identity: 71% (238 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTK--QGGPLMVIVEYCKYGNLSNYLKSK
|||||.|||||||.|..||||||.|..||.|||||||||||||||..|||.|||.|.||||||||||.||.|||  |.||||||||||..|||||||..|
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLA
|..|....|...||...||.|.|...|..|.|.||..|..|...|.|...||..|||..|... ..|.|.||||||.||||||||||||.||||||||||
RMYFVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLA

ARNILLSENNVVKICDFGLARD-IYKNPDYVRKGD-TRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAP
||||||.||||||||||||||. |||.|||||||| .|||.|||||||||||.|.|.||||||||.||||||||||||||||.||.||.||..|.|||||
ARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAP

EYSTPEIYQIMLDCWHRDPKERPRFAELVEKL
.|.|||||.|||||||..|.|||.|.||||.|
DYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FLT1.AA Pkinase_Tyr 827-1154 40 4.1e-156 529.35 Pfam 1-270 (270) Show / Hide 
Range on Protein: 827-1154
Range on HMM: 1-270/270
Sequence Identity: 40% (136 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASE--YKALMTELKILTHIGHHLNVVNLLGACTKQGGP--LMVIVEYCKYGNLSNYLK
...|| ||.||||.|... ..| ... |. .||||||||||. ..   ...| |.||....||| |.|.|.|.||.||.|  .....||...|.| .||.
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRD
..|                                                                 |.|.||.||.....|.|.|||.|.|..|||||
KHR---------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRD

LAARNILLSENNVVKICDFGLARDIYKNPDY-VRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSP-YPGVQMDEDFCSRL-REGMRM
|||||.|..|||||||||||||||||.   | . .|...|| ||||||.|......|||||||.|||.||||..|..| |||.  .|... .. ..| ||
LAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRM

RAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL
 .||. ..|||..|..||| ||..||.|.|..|.|
PCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FLT1.AA TyrKc 827-1154 35 2.3e-146 493.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 827-1154
Range on HMM: 1-280/280
Sequence Identity: 35% (127 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIG-HHLNVVNLLGACTKQG------GPLMVIVEYCKYGNLSN
..||| ||.||||.|... .         ..||||||||.|     ...| |..|....| || |.|.|.|.||.||      .|||...||...|.| .
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCI
||...|.                                                                   ..|.||.|...|.|.|||.|.|..||
YLRKHRPK------------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCI

HRDLAARNILLSENNVVKICDFGLARDIYKN------PDYVRKG---DTR--LPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGV----Q
||||||||.|..||..|||.||||.||||         || ||    ...  ||..|||||.|......|||||||.||..||||..|..||||.     
HRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMM

MDEDFCSRLREGMRMRAPEY--------STPEIYQIMLDCWHRDPKERPRFAELVEKL
 ...   ....|.||. |..         ..|.||||..|||.||..||.|.|..|..
SNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FLT1.AA TK 827-1154 24 1e-131 443.92 In-house 1-486 (486) Show / Hide 
Range on Protein: 827-1154
Range on HMM: 1-486/486
Sequence Identity: 24% (131 aa)

LKLGKSLGRGAFG---KVVQASAFGIK--------------------KSPTCRTVAVKMLKEG--ATASEYKA--------------LMTELKILTH-IG
..||| ||.|.||   .| .. ..|..                    |. .. .|||||||||  ... | ..              .. |.|.. | .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHLNVVNLLGACTKQG-----------GPLMVIVEYCKYGN----LSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGF
|| |.|.|.|.||...           .|.|...||...|.    | .||...|. |. . |   ....|.. .. ..       .              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LH-------HC-------------

QEDKSLSDVEEEEDSDGFYK------------------------------------------------EPITMEDLISYSFQVARGMEFLSSRKC-----
                 . |                                                ...||..|. ...|.|.|||.|.|..|     
-----------------M-KGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQN

-IHRDLAARNILLSENNV-----------VKICDFG--------LARDIYKNPDYVRKG------------------------DTRLPLKWMAPESIFDK
 .||||||||.|..||||           .||.|||        ||||||.. ||.||.                        ...||..|||||...|.
FVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDR

I---------YSTKSDVWSYGVLLWEIFSLG-GSPYPGVQM--------DEDFCSRLREG--------------MRMRAPEYST--------------PE
.         ..|||||||.|||.||||..| . .|.|.          ..... .||.|              ||| .|.. .              .|
VFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEE

IYQIMLDCWHRDPKERPRFAELVEKL
.|..|..|||.||..||.|..|.|.|
YYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FLT1.AA TK-Unique 827-1154 35 8.99999999999e-117 394.24 In-house 1-294 (294) Show / Hide 
Range on Protein: 827-1154
Range on HMM: 1-294/294
Sequence Identity: 35% (124 aa)

LKLGKSLGRGAFGKVVQASAFGIK-KSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKR
|..|...|.|||| |  . ..||. ..   . |||||||..||  . .... |.... ..| | |.|..||.||| ..| | | ||| .||| .||...|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

DLFFLN-KDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYK----------EPITMEDLISYSFQVARGMEFLS
.  . . . . |                                                     ..          |||...||... .|.|.|||.|.
PAMRQHQTYGNLK----------------------------------------------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLA

S--RKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRK-GDTRLPLKWMAPESIF--DKIY-STKSDVWSYGVLLWEIFSLGGSPYPGVQMDED
|  .|..||||.|||.||.|..|.||||||.|||.|.| .|... .  |.|..||||||.   ...| .|||||||.|||.||||.||. ||||.  .. 
SQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-

FCSRLREGMRMRAPEYS-TPEIYQIMLDCWHRDPKERPRFAELVEKL
.  ..|.|.||  ||.. ..|.|..|  ||...|.||| |.... .|
IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FLT1.AA PDGFR 973-1154 55 4.3e-104 335.14 In-house 182-358 (358) Show / Hide 
Range on Protein: 973-1154
Range on HMM: 182-358/358
Sequence Identity: 55% (101 aa)

EDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIF
... . . ..|.||     .. | .||...|.|||.||||| |  |.||||||||.|| .  ||||||||||||| .   || || .|||.|||||||||
IEQDVKNELMEDDS-----NVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIF

DKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL
| .| |.|||||||.||||||||||.||||. .|. |    .|| ||  |.. . |||.||  ||  ||. || | .|.. |
DCVYTTQSDVWSYGILLWEIFSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FLT1.AA FGFR 994-1154 58 1.3e-93 317.33 In-house 133-293 (293) Show / Hide 
Range on Protein: 994-1154
Range on HMM: 133-293/293
Sequence Identity: 58% (94 aa)

ITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRK-GDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEI
.|  ||.|  .|||||||.| |||||||||||||.| ....| ||||||||||| .. || || .. ||| ||||||. ||..| ..|||||||||||||
LTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCI-DYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEI

FSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL
. .||.|||..   |.  . |.|| ||  |.  . ||| .| .|||  |..|| |..||| |
MTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FLT1.AA UTK 827-1154 27 3.6e-86 292.58 In-house 1-296 (296) Show / Hide 
Range on Protein: 827-1154
Range on HMM: 1-296/296
Sequence Identity: 27% (98 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKA----LMTELK---ILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSN
..||. ||.|||| |  |..  ..   .   |||| ....|.|   ..    .| | .   .. .  .| ||..|.| ||.... .|...||.. |.|..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

YLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCI
|| . |. ..                                                              .  |........ ..||||..|.|....
YLRRHRPTPP-----------------------------------------------------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFV

HRDLAARNILLSEN-------NVVKICDFG---LARDIY---------KNPDYVRKGDTRLPLKWMAPESIFDK-IYSTKSDVWSYGVLLWEIFSLGGSP
||||||||.|. ..       .|.||.|||   ..|...           . | . ...|.|..|||||.. .   ..|||||||.||..|||.. |  |
HRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLP

YPGVQMDEDFCSRLREG-MRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL
|||   .. . . .. |  ||..|.    ..|..|..||| || |||.| .||...
YPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FLT1.AA Src 827-1154 32 4.4e-82 278.67 In-house 1-255 (255) Show / Hide 
Range on Protein: 827-1154
Range on HMM: 1-255/255
Sequence Identity: 32% (109 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRD
.|| . ||.| || | ..   |  |      |||| ||.|    . .|.  | .|..    | ..|.|.  |..   |   . || . |.|  |||    
IKLCRKLGQGQFGEVWMGYWNGNTK------VAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEE-PIYIVTEYMSHGSLLDYLKK---

LFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAAR
                                                          |..| .   . ...||. . |||.||..|.|.. ||||||||
----------------------------------------------------------DGEGRH---LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAAR

NILLSENNVVKICDFGLARDIYK--NPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEY
|.| .||||.|..|||||| . |     |. . . ..| ||.||| |    ...||||||.|.||.||.. |  |||| .  | .  ..  | ||  |. 
NVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVL-QQVERGYRMPCPHN

STPEIYQ-IMLDCWHRDPKERPRFAELVEKL
  .|.|. ||| |||.||..|| |. | ..|
CPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FLT1.AA Ret 991-1156 45 9e-71 240.94 In-house 124-293 (293) Show / Hide 
Range on Protein: 991-1156
Range on HMM: 124-293/293
Sequence Identity: 45% (77 aa)

KEPIT-----MEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSY
|..|.     | ..||.  |. .|| .||. | .||||||||.|. |  . || |||| ||.|    ||..   |.| ||||.|| .| .| |||||||.
KDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSF

GVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGD
|||.|||  .|..||||.   |  .. |. | ||  ||    |.| ||. ||   |  || |. .   .  
GVLCWEIVTMGANPYPGIPP-ERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FLT1.AA RTKB 993-1154 44 1.5e-65 219.97 In-house 105-264 (264) Show / Hide 
Range on Protein: 993-1154
Range on HMM: 105-264/264
Sequence Identity: 44% (72 aa)

PITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKS-DVWSYGVLLWE
..  . |.... |.|.|| ||.... |||||.|||.|.. .   ||||||.|| |    . .... |||| |||||||. ..||.||| ||||.||  ||
SLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDH--ECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWE

IFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL
|||||| ||.  .   |  . |. |.|.  |.   .... || .||  .. .|| |.|||. .
IFSLGGTPYQQYRN-GDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase FLT1.AA Tie 994-1154 50 1.3e-62 189.14 In-house 111-267 (267) Show / Hide 
Range on Protein: 994-1154
Range on HMM: 111-267/267
Sequence Identity: 50% (81 aa)

ITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIF
.. . .. .   |||||..|| ..||||||||||||  || | || ||||.|    .  ||.|   ||| .||| ||.   .| ||||||||||||||| 
LSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRG---DEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEIV

SLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL
|||| || |.   | .  .| .| ||  |     |.|..|  ||   | ||| ||... .|
SLGGTPYCGMTCAE-LYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase FLT1.AA PDGFR 827-951 52 5.2e-59 187.92 In-house 1-120 (358) Show / Hide 
Range on Protein: 827-951
Range on HMM: 1-120/358
Sequence Identity: 52% (67 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRD
|..|| || ||||||| | |.|. ||    .|||||||. | .||  ||| ||||..| |.|.|.||||||||. |||  .| ||| || | |||..||.
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTH-GGPIYIITEYCCYGDLLNYLHRKRH

LFFL---NKDAALHMEPKKEKMEPGLEQ
 |     .|       |||| . .....
SFHQHHPEK-------PKKETWSNQQDP
Kinase FLT1.AA Pkinase 827-1154 20 2.1e-45 161.6 Pfam 1-293 (293) Show / Hide 
Range on Protein: 827-1154
Range on HMM: 1-293/293
Sequence Identity: 20% (74 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATAS--EYKALM-TELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG----NLSN
...|. .|.|.||.|     .  ..  |...|||| .|   . |  .. ..  .|..|. .. .| |.| |.....  .. . .. |||  |     |. 
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFD

YLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPI--TMEDLISYSFQVARGMEFLSSRK
|..                                                                   .. ..  .......|  |..||.|.. |..
YIST-----------------------------------------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMG

CIHRDLAARNILLSENNVV----KICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIF-DKIYSTKSDVWSYGVLLWEIFSLGGSPYPGV----QMDED
.|||||   |||...|...    ||||||||. .. .  ..   .    . .|||| |  .. |..|.|.||.|..|.| .. |  |.||      .|..
IIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQM

FCSRLREGMRMRAPEYST---------------------PEIYQIMLDCWHRDPKERPRFAELVEK--L
.. ... | . . ... .                     .|  ... .|...|||.|| ......   .
QMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase FLT1.AA FGFR 827-925 49 3.3e-40 134.69 In-house 1-100 (293) Show / Hide 
Range on Protein: 827-925
Range on HMM: 1-100/293
Sequence Identity: 49% (50 aa)

LKLGKSLGRGAFGKVVQASAFGIKKS--PTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSK
| ||| || |.||.|. | |.||...      ||||||||...|  .   |  |. ..  || | |..||||.|| |.||| ||||||. |||  .|...
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCT-QEGPLYVIVEYCHHGNLRDFLRAR

R
|
R
Kinase FLT1.AA Ret 827-925 46 1.7e-37 125.59 In-house 1-100 (293) Show / Hide 
Range on Protein: 827-925
Range on HMM: 1-100/293
Sequence Identity: 46% (47 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEG-ATASEYKALMTELKILTHIGHHLNVVNLLGACTKQG-GPLMVIVEYCKYGNLSNYLKSK
| |.. || | ||.|| | || |.  |   ||||||||.. |. |||..| .|. .|  .  | .|. |.|||. ..  |...|||||||| |  .|   
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

R
|
R
Kinase FLT1.AA S_TKc 827-1158 23 6.3e-32 113.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 827-1158
Range on HMM: 1-231/231
Sequence Identity: 23% (80 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKY--GNLSNYLKSK
 .... .|.|||||| ..   .     | | ||.|..|        . .. |..|| .  || |.|.|....    . | .. |||    |.|  |.|..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR

RDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLA
.                                                                .. |..  .  .|  |.....|.. |.. ||||| 
GRHG-------------------------------------------------------------LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLK

ARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYST-KSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPE
  ||||.|  ..||||||||| .               . .|||| .    |.. |.|.|| |..|.| .. |  |.|  ||.. |   .          
PENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG----------

YSTPEIYQIMLDCWHRDPKERPRFAELVE-----KLGDLL
  .||  ...  |...||..||   |. .     |.   .
--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FLT1.AA Tie 836-927 41 3.1e-28 82.48 In-house 2-89 (267) Show / Hide 
Range on Protein: 836-927
Range on HMM: 2-89/267
Sequence Identity: 41% (38 aa)

GAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDL
| ||.|..|    |||      ||.||.||.|   . .  | || ..  .||| |..||.||| ..|  | | .|| .|||| ..|.. | .
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGY-LYVAIEYAPYGNLLDFLRKSRVI
Kinase FLT1.AA RTKB 827-925 37 3.4e-20 64.79 In-house 1-97 (264) Show / Hide 
Range on Protein: 827-925
Range on HMM: 1-97/264
Sequence Identity: 37% (37 aa)

LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKR
..||. || |||| | ||  .  . . | . .|.| || ||   |  .  .|. ..  .| | ||. ..| |  |  |... ||.| .|||  ||.  |
VWLGEKLGNGAFGEVFQA-WVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCL-QDEPYILLVELCELGNLRDYLRMCR