Gene GCN2 (Human)

GCN2

Species: Human
Alias: GCN2, KIAA1338, EIF2AK4
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 15q13-q15, Secondary Group: STE, Secondary Family: STE-Unique,

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
GCN2.NA RNA Sugen Kinome 5532 None Fasta, JSON
GCN2.AA Protein Sugen Kinome 1649 None Fasta, JSON
GCN2.kin_dom Protein Kinase Domain Sugen Kinome 412 None Fasta, JSON
GCN2.kin_dom2 Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of GCN2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RWD GCN2.AA RWD 25-137 33 1.5e-34 122.0 SMART 1-128 (128) Show / Hide 
Range on Protein: 25-137
Range on HMM: 1-128/128
Sequence Identity: 33% (44 aa)

HELQALEAIYGADFQDLRPDACGPVKEPPEINLVLYPQG------------LTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAK-GLSNESV--NLLKSR
.|| |||.||. ||.... |. . | ....| ... |.             . ||. |....| ..||..|||..|.|.|.| . .||.| .  . |.. 
MELEALESIYPDDFECIDEDRHHWV-INCCIQIHIHPHEDEMQITNYDNFYE-GEDHYWCITLHFHCPENYPDEAPPIFLENPQKWLSDEQKYYQELQKH

LEELAKKH--CGEVMIFELAYHVQSFLSEH
|.|.....  .|..||||.. .||.|||||
LQEIWEENWCRGMCMIFEWVQWVQEFLSEH
RWD GCN2.AA RWD 18-134 29 1.7e-33 122.41 Pfam 1-119 (119) Show / Hide 
Range on Protein: 18-134
Range on HMM: 1-119/119
Sequence Identity: 29% (36 aa)

SYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLYPQGLTGEEVYVKVDLRVKCPPTYP-DVVPEIE-LKNAKGLS---NESVNLLKSRLEE
 . ..|. ||.|||.||. ||.|||. .| ....|..... .      ... .....| ..||..|| |..|.|. ... ..|.   .. .. |...|.|
MCQEEQEDELEALESIYPDDFEDLRGTICWTEISPWHFTIKI---DECESSHHPPLVLHFQCPEDYPSDEPPIISIISC-WNLHKLPDYQIQQLCKKLQE

LAKKHC-GEVMIFELAYHVQSFL
... .| |.|||||.. ..| .|
YWEENCHGMVMIFEWIEWLQENL
Kinase GCN2.AA GCN2 353-539 24 9e-83 281.3 In-house 260-511 (511) Show / Hide 
Range on Protein: 353-539
Range on HMM: 260-511/511
Sequence Identity: 24% (62 aa)

LSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQ-LRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKR--
..|.|.|.|..|| |.........|. |...| .|. .....|... |. |.||..|.|.||.|.||....|..|..||...|..|.|||.|......  
NQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNK

----------------------LADICKEDVFEQTRVRFSDN-------ALPYKTG---------------KKGDVWRL-GLLLLSLSQGQECGEYP---
                      ...||..|.|.|....||..       ....|.|               .|.|...| |...........|....   
MESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQKSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQ

-------VTIPSDLP-------ADFQDFLKKCVCLDDKERWSPQQLLKHSFI
       ...|.|..       .|.||....|...|...|.|.||||.|.|.
ILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase GCN2.AA PEK 373-539 14 1.1e-47 163.84 In-house 356-655 (655) Show / Hide 
Range on Protein: 373-539
Range on HMM: 356-655/655
Sequence Identity: 14% (42 aa)

IVVDILVEHISGVSLAAHLSHSG--------------------------------------------PIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSA
... |. |. .. .|  .....|                                             .. .|..|...|.|.||.|.||. ..|. | .
HYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKP

SNVLVDAEGT-----VKITDYSISKR----------------------LADICKEDVFEQT-----------------------------------RVRF
||...| .|.     ||| |......                      ..| |......|.                                   ....
SNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLY

SDN-ALPYK------TGKKGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPAD--------------------FQDFLKKCVCLDDKERWSPQQLLKHSFI
...  |...       ..|.|.. ||............ ... ... . . |                    ..||.......|...|.|.||.|.| |.
MSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase GCN2.AA PEK 280-371 28 2.5e-29 98.77 In-house 1-89 (655) Show / Hide 
Range on Protein: 280-371
Range on HMM: 1-89/655
Sequence Identity: 28% (26 aa)

VHKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDD
.....|.|.... |  ||.. . . | .  . ...|.|.....|..| ||.. |.||||... .. |. .|..|.|||.||| .... . ..
FEEIQCLGKGGF-GGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCIT-QECM-IHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEE
Kinase GCN2.AA GCN2 281-352 15 6.6e-23 76.73 In-house 1-72 (511) Show / Hide 
Range on Protein: 281-352
Range on HMM: 1-72/511
Sequence Identity: 15% (11 aa)

HKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVK
... |.......|. |.|. ....| ......|...|.....|.......|....|....|. .........
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIE
Kinase GCN2.AA STE11 337-454 33 1.3e-18 64.13 In-house 45-171 (303) Show / Hide 
Range on Protein: 337-454
Range on HMM: 45-171/303
Sequence Identity: 33% (43 aa)

KKQIQG------TETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLS-HSGP--IPVHQLRRYTAQLLSGLDYLHSNSVVHKVLS
.|..|        . | . . .|.|.| |||.   | . ...  | |  |...| ||.. |.   ||   . .  |.|| |.|.|| ||||. ..|. . 
EKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDH-VNIFMEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIK

ASNVLVDAEGT-VKITDYSISKRLADIC
. |.|.|..|. .|..|  ..|||| ||
GANILLDSDGNVCKLADFGCAKRLAWIC
Kinase GCN2.AA Pkinase 332-443 26 1.8e-16 59.33 Pfam 31-155 (293) Show / Hide 
Range on Protein: 332-443
Range on HMM: 31-155/293
Sequence Identity: 26% (34 aa)

KIDKCKKQIQGTET-----EFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGV----SLAAHLS--HSGPI--PVHQLRRYTAQLLSGLDYLHS
.|.|...  .  .|     |   . .|.|||.||.. .     .|.|   .  |.  |     .|....|   .|..  . .....|  |.|.||.|.||
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIY--MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS

NSVVHKVLSASNVLVDAEGTV----KITD
....|  |  .|.|.| .|..    ||.|
MGIIHRDLKPENILIDNNGHIDACVKICD
Kinase GCN2.AA STE 332-452 22 1.8e-16 54.81 In-house 48-199 (359) Show / Hide 
Range on Protein: 332-452
Range on HMM: 48-199/359
Sequence Identity: 22% (35 aa)

KIDKCK----------------KQIQGTETEFNSLVKLS--HPNVVRYLAMNLKE---QDDSIVVDILVEHISGVSLAAHLSHS--------------GP
....|.                ...|  . | . . |..  |||.|.|. . .||   ...   . |  |...| ||   . |               ..
NLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHR

IPVHQLRRYTAQLLSG-LDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLAD
.| .|..... |.| | |.||||. ..|  . ..|.|.     ||..|  ....|.|
FPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTD
Kinase GCN2.AA S_TKc 286-539 17 3.1e-13 17.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 286-539
Range on HMM: 1-231/231
Sequence Identity: 17% (52 aa)

IGSDEQLGK----LVYNALETATGGFV---LLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDIL
    ...||     || . .. ||  |    .                              . .. | . | |  |||.|... .          . . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------------------------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMV

VEHISG--VSLAAHLSHSGP------IPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRV------
 |...|   .|  .. . |.      .|  . |.|..|....|.|.||. ..|  |  .|.|.|   ..||.|  ....|           | .      
MEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYM

---RFSDNALPYKTGK-KGDVWRLGLLLLSLSQGQE-----CGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLK-------HSFI
    .       . || | |.| .| .|  .  |.         . .      . .. ||..|| . | ..|..  ..|.       | ..
APEVL-------GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GCN2.AA STE 501-539 28 1.1e-11 37.68 In-house 300-359 (359) Show / Hide 
Range on Protein: 501-539
Range on HMM: 300-359/359
Sequence Identity: 28% (17 aa)

PVTIPSDLP-------------------ADFQDFLKKCVCLDDKERWSPQQLLK--HSFI
| ..|..|                     .|.||..||   | ..|....||||  |.||
PPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GCN2.AA STE-Unique 377-457 24 7.1e-11 34.3 In-house 371-467 (616) Show / Hide 
Range on Protein: 377-457
Range on HMM: 371-467/616
Sequence Identity: 24% (24 aa)

ILVEHISGVSLAAHLSHSGP---------IPVHQLRRYTAQLLSGLDYLHSNS--VVHKVLSASNVLVDAEG-----TVKITDYSISKRLADICKED
|  |  .. .|   .  .|.         .|  .  .|| |.| ||.||||    ..|  | ..|.. . .|      ||| |. ...... . .|.
IFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEK
Kinase GCN2.AA CAMK 330-443 18 1.9e-10 29.16 In-house 56-239 (425) Show / Hide 
Range on Protein: 330-443
Range on HMM: 56-239/425
Sequence Identity: 18% (34 aa)

KEKIDKCKKQ----------IQGTETEFNSLVKLS-------HPNVVRYLAMNL------------KEQD-----DSIVVDIL--VEHISGV----SLAA
. |||| |..           .  . | . . ||.       |||... . .                ..     |. .. ..   |..||      |  
Y-KIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFD

HLSHSGP---------------IPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAE-----------------GTVKITD
..   |.               .. .. |||  |..|...|.||. .||  |   |.|.|                   ...||.|
YIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIID
Kinase GCN2.AA CMGC 397-443 23 1.9e-10 29.57 In-house 179-247 (513) Show / Hide 
Range on Protein: 397-443
Range on HMM: 179-247/513
Sequence Identity: 23% (17 aa)

IPVHQLRRYTAQLLSGLD--YLHSNS--VVHKVLSASNVLVDAE--------------------GTVKITD
... . | |. |.| ||.  |.||.   ..|  |  .|.|.. .                    |..|| |
FMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICD
Kinase GCN2.AA STE20 511-539 48 4.8e-10 33.19 In-house 260-288 (288) Show / Hide 
Range on Protein: 511-539
Range on HMM: 260-288/288
Sequence Identity: 48% (14 aa)

DFQDFLKKCVCLDDKERWSPQQLLKHSFI
.|.||..|| . | ..|....|||||.||
EFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase GCN2.AA CMGC 503-539 21 2.1e-09 26.07 In-house 467-513 (513) Show / Hide 
Range on Protein: 503-539
Range on HMM: 467-513/513
Sequence Identity: 21% (10 aa)

TIPSD----------LPADFQDFLKKCVCLDDKERWSPQQLLKHSFI
...|.          .. .. |.|||. ..| ..|....| |.| ..
KFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase GCN2.AA Pkinase_Tyr 352-443 27 4.9e-09 31.22 Pfam 59-154 (270) Show / Hide 
Range on Protein: 352-443
Range on HMM: 59-154/270
Sequence Identity: 27% (27 aa)

KL-SHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSH----SGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITD
.| .|||.||...  ..... .  . | .|.  . .|  .|       .|.....|  . .|  .|..||.|.  .|  | | |.||. ...|||.|
QLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICD
Kinase GCN2.AA STE20 408-443 47 1.3e-08 27.87 In-house 125-160 (288) Show / Hide 
Range on Protein: 408-443
Range on HMM: 125-160/288
Sequence Identity: 47% (17 aa)

QLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITD
..| |||||||| ..|  . | |.|.. .| ||..|
EVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLAD
Kinase GCN2.AA Ciliate-E2 405-452 32 1.5e-08 25.48 In-house 165-208 (365) Show / Hide 
Range on Protein: 405-452
Range on HMM: 165-208/365
Sequence Identity: 32% (16 aa)

YTAQLLSGLDYLHSNS-VVHKVLSASNVLVDAEGTVKITDYSISKRLAD
| |.....| ||||.  ..|  .  .|.|.     .||.|  .||.. |
YIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDD
Kinase GCN2.AA STE11 504-539 35 1.5e-08 27.36 In-house 262-303 (303) Show / Hide 
Range on Protein: 504-539
Range on HMM: 262-303/303
Sequence Identity: 35% (15 aa)

IPSDLP------ADFQDFLKKCVCLDDKERWSPQQLLKHSFI
||...       .. .|||..|   | |.|.. .|||.|.||
IPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase GCN2.AA Pkinase 508-539 34 2e-06 24.01 Pfam 262-293 (293) Show / Hide 
Range on Protein: 508-539
Range on HMM: 262-293/293
Sequence Identity: 34% (11 aa)

LPADFQDFLKKCVCLDDKERWSPQQLLKHSFI
.. ...||.|.| |.| |.|....|.|.| ..
WSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GCN2.AA CAMK 508-539 21 2e-06 15.86 In-house 394-425 (425) Show / Hide 
Range on Protein: 508-539
Range on HMM: 394-425/425
Sequence Identity: 21% (7 aa)

LPADFQDFLKKCVCLDDKERWSPQQLLKHSFI
. .. .|...|. . | ..|.. .| |.| ..
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GCN2.AA Ciliate-E2 504-539 19 2.2e-05 14.4 In-house 325-365 (365) Show / Hide 
Range on Protein: 504-539
Range on HMM: 325-365/365
Sequence Identity: 19% (8 aa)

IPSDLPADFQDFLKK----CVCLDDKERWS-PQQLLKHSFI
.. ... . .|..||    . . | ..| . ..|.|.| ..
SWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GCN2.AA STE-Unique 346-372 33 0.004224 6.19 In-house 51-77 (616) Show / Hide 
Range on Protein: 346-372
Range on HMM: 51-77/616
Sequence Identity: 33% (9 aa)

EFNSLVKLSHPNVVRYLAMNLKEQDDS
|. ....|.|.|.|.|. ..| .  ||
EIEIMKCLHHQNIVKYYGHWLWGGCDS
Kinase GCN2.AA STE-Unique 504-539 33 0.011266 4.65 In-house 581-616 (616) Show / Hide 
Range on Protein: 504-539
Range on HMM: 581-616/616
Sequence Identity: 33% (12 aa)

IPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFI
||...  ..|.|. ||  ..   | |. |||.| . 
IPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase GCN2.AA STE20 332-368 25 0.080725 2.79 In-house 37-76 (288) Show / Hide 
Range on Protein: 332-368
Range on HMM: 37-76/288
Sequence Identity: 25% (10 aa)

KIDKCK---KQIQGTETEFNSLVKLSHPNVVRYLAMNLKE
...||.   ....  ..| . . .. |||.|.|.   ||.
NLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKD
Kinase GCN2.AA GCN2 590-1001 37 6.4e-219 733.57 In-house 1-511 (511) Show / Hide 
Range on Protein: 590-1001
Range on HMM: 1-511/511
Sequence Identity: 37% (192 aa)

FEELQLLGKGAFGAVIK-VQNKLDGCCYAVKRIPINPASR-QFRR--IKGEVTLLSRLHHENIVRYYNAWIERHERPAGPGTPPPDSGPLAKDDRAARGQ
|||...||||.||.|.| |.|..||..||.|..|||...| ....  |..||.||.||||...||||.||||....|. ..|...|. . ..........
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESEC

PASDTDGLDSVEAAAPPPILSSSVEWSTSGERSASARFPATGPGSSDD----------------------------------------------------
...... ..||...........|.|||.| ||. |.........|..|                                                    
FSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDWDIESNN

-----EDDDEDEHGGVFSQSFLPASDSESDIIFDNEDEN---------SKSQNQDEDCNEKNGCHE---SEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQ
     .||.|.|. ....|||.|..........|.||.|         .|||.||..|........   ...... ..||||||||||||..|||..||.
VRDMESDDNEWEQEQQNNQSFQPKQEDHQNQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDN

G-LYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLAT--------------------DHLAFSADSKQDDQTGD-LIKSDP
. ...|...|||.||.||.||.|||..|||||||||.|||||....||||||||||                    .|.|. ....||||... ......
HGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQ

SG------HLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSL-GIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFD---DGEHAKQKSVISWLLNH
..      |.||.|||..|..||.|   ||.||||||..|| |||||||.|.|..|..||...|.|||   |..||.|||   |..|..|...|.|.|||
WDQQDEQVHHTGKVGTPFYMCPEQQ---KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR---SCEFPQDFDKKVDNHHKDQQDMIRWCLNH

DPAKRPTATELLKSELL
||.|||.| .||..|.|
DPQKRPSAQQLLQHEFL
Kinase GCN2.AA PEK 590-1001 27 3.3e-184 618.27 In-house 1-655 (655) Show / Hide 
Range on Protein: 590-1001
Range on HMM: 1-655/655
Sequence Identity: 27% (182 aa)

FEELQLLGKGAF-GAVIKVQNKLDGCCYAVKRIPINPAS----------------RQFRRIKGEVTLLSRLHHENIVRYYNAWIERHERPAGPGTPPPDS
|||.|.||||.| | |.|||||||||.||.|||..|...                 .....  ||..|.||.|.|||||.|||||..|..  . ......
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

GPLAKDDRAAR-------------------------------GQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSASA--------------------
.. ..|.....                               ..  ....   ..... .. ....|.|||.| ... |                     
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENES

----RFPATGPGSSDD-----------------------------------------------------------EDDDEDEHGGVFSQSFLPASDSES-
    ... .  .||.|                                                           ..| .||| ....||....|...| 
HISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQSH

------DIIFDNEDEN--------SKSQNQDEDCNEKNGCHES---EPSVTTEAVHYLYIQMEYCEKSTLRDTIDQG-----------------------
      ..|.|.||..        |.||.|.|..|..| ....   ....... .||||||||||||.|||| ||..                       
KKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIM

---------------------LYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDH-----VKIGDFGLAT-----------------DHL
                     ...|....||.||.||.||.|||..|||||||||.|||||.|..     ||||||||||                 ...
NQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYW

AFSADSKQDDQTGD-LIKSDPSG---------------------HLTGMVGTALYVSPEVQ---GSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIF
...|........ .  .......                     |.||.|||.||.|||..   ...||.||.|||..|||||||||.|... | .||. 
KYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVK

VLNQLRDPTSPKFPEDFD----DGEHAKQKSVISWLLNHDPAKRPTATELLKSELL
.|..||| .|..||.||.    | .. ||.. |.|.|.|||..||.| ..|..|..
TLTDLRD-ESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase GCN2.AA STE 590-1001 16 1.3e-55 191.05 In-house 1-359 (359) Show / Hide 
Range on Protein: 590-1001
Range on HMM: 1-359/359
Sequence Identity: 16% (86 aa)

FEELQLLGKGAFGAVIKVQNKL---------------DGCCYAVKRIPINPAS----------------RQFRRIKGEVTLLSRLH--HENIVRYYNAWI
.| .. .|||||| | |  |.                 |. .|.|...... .                 .. .|. |. ......  |.|||.|| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ERHERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSASARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSE
  ..                                                                                                
KEGHN-----------------------------------------------------------------------------------------------

SDIIFDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQ--GLYRD------------TVRLWRLFREILDG-LAYIHE
                                   ... ..|.| |||..  .|.| |..  |  ..               . .  |.|| | |.|.|.
-----------------------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS

KGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSG----------HLTGMVGTALYVSPEV--QGSTK--SAYNQKVDLF
.. ||||.|| ||.|     ||. |||...     .|.. |            ..          . . .|||  . .|||  |....  . |. |.|  
HHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANI-Q-S----------NNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIW

SLGIIF-------FEMSY-HPM--VTASERIF-------VLNQLRDPTSPKFPEDFDDGEH---------------AKQKSVISWLLNHDPAKRPTATEL
|||.          ...  |||    .  . .       .| .  ....|..|......|                 . |  |.  |. || |||||..|
SLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQL

LK--SELL
||   . .
LKSEHPFI
Kinase GCN2.AA S_TKc 590-1001 17 4.8e-48 166.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 590-1001
Range on HMM: 1-231/231
Sequence Identity: 17% (77 aa)

FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHERPAGPGTPPPDSGPLAKDDRAARGQPASD
.| |...|||||| | |...| .|  .|.|.|.                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

TDGLDSVEAAAPPPILSSSVEWSTSGERSASARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEKNGCHESEPS
                                                                        . . | .  ..   ..     ....  .
-----------------------------------------------------------------------EHIRREIQILKK---HHPNIVKLYDVFQD

VTTEAVHYLYIQMEYCEK--STLRDTIDQGLY------RDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSK
      ..||. ||||.    .|.| |..  .       .  . ......|...|.|.|..| ||||||| ||.||.  |.||.|||||.          
------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------

QDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQ-KVDLFSLGIIFFEMSY-HPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVIS
                 | ..||  |..|||       |.  |.|  |.|.|..|| .  |     .   ......                   |. |.
-----------------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIR

WLLNHDPAKRPTATELLK-------SELL
 .|. ||.||||| |.|.        . .
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GCN2.AA Pkinase 797-1001 26 1.6e-40 144.39 Pfam 74-293 (293) Show / Hide 
Range on Protein: 797-1001
Range on HMM: 74-293/293
Sequence Identity: 26% (64 aa)

YLYIQMEYCEKS----TLRDTID---QGLY--RDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHV----KIGDFGLATDHLAFSADSKQD
..|. |||||.      | | |    .| .   . .   . ...|| ||.|.|..| ||||||| ||..|...|.    ||.|||||  .          
HIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECK-FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------

DQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASE------RIFVLNQLRDPTSPKFPEDFDDGEH------
          ... .|. .||  |..|||   . . | .||| .|.|.|..||        ..      .  .. ... .. ..|... .. .       
--------Y-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRH

-----------AKQKSVISWLLNHDPAKRPTATELLKSELL
              |..|.|.|. ||.|||||...|... .
WHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GCN2.AA CAMK 595-932 14 8.4e-40 125.45 In-house 1-323 (425) Show / Hide 
Range on Protein: 595-932
Range on HMM: 1-323/425
Sequence Identity: 14% (64 aa)

LLGKGAFGAVIKVQNKLDG------------CCYAVKRIPINPASR---------------------------QFRRIKGEVTLLSR-------LHHENI
 ||.|.|| | ....|...              .|.| |. . ..                              .... |. ....       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYYNAWIERHERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSASARFPATGPGSSDDEDDDEDEHGGVFSQS
.. | ..  .|  . .  |                                                                                 
IKLYEVYEDPHYFK-N--T---------------------------------------------------------------------------------

FLPASDSESDIIFDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHY------------LYIQM---EYCEKS----TLRDTIDQG-----------L
                                                |            .|. |   |||.       | | | .            .
---------------------------------------------ND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDI

YRDTVRL-----WRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDD-----------------HVKIGDFGLA--TDHLAFSADSKQDDQTGDLIKS--
  .. |.      |.|| |.....|.|... .|||||| || ||...                  .|| |||.|   |.   . . .  ..   . ..  
V-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQW

---DPSGHLTGMVGTALYVS-PEVQGS-T-----------KSAYNQKVDLFSLGII
   ..   .. ..||  |.. |||  . .           |  |..|.|  |.|.|
TTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI
Kinase GCN2.AA Ciliate-E2 796-1001 20 2e-36 122.52 In-house 107-365 (365) Show / Hide 
Range on Protein: 796-1001
Range on HMM: 107-365/365
Sequence Identity: 20% (57 aa)

HYLYIQMEYCEKSTLRDTID------------QGLYRDTVRLWRLFREILD---------------GLAYIHEKG-MIHRDLKPVNIFLDSDDHVKIGDF
...|. ||||.  .|.| |             . .| .     .....||.               .| |.|.|.  ||||.|| ||..     .|| ||
NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDF

GLATDHLAFSADSKQDDQTGDLIKSDP---SGHLTGM------------VGTALYVSPEVQGSTKSA-------YNQKVDLFSLGIIFFEMSYH--PMVT
||...   .. .  .  |   ...      |.. . |            .||. |..||. .. |         |. |.|..|||.|..|| .   |   
GLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--

ASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISW--------------------LLNHDPAKRPT-ATELLKSELL
       ..|  .     .......  .   . ...|                    .|. || ||.| . ..|. . .
-------QQQIKQCKIDFPCPEWQKD-TQ-CI-QCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GCN2.AA CMGC 590-936 14 4e-36 115.54 In-house 1-328 (513) Show / Hide 
Range on Protein: 590-936
Range on HMM: 1-328/513
Sequence Identity: 14% (67 aa)

FEELQLLGKGAFGAVIKVQNKLDG--------------CCYAVKRIPINPASRQF-----------RRIKGEVTLLSRL-----------------HHEN
.| .. .|.|..| | | ..|. .                .|.|.|  ..                .|.  |. .| .|                 ||.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRYYNAWIER----------HERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSASARFPATGPGSSDDEDDD
||. |.    .          |.                                                                             
IVKLYDIFYHKNSDGNEYEDKHI-----------------------------------------------------------------------------

EDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVH---YLYIQMEYCEKSTLRDTIDQGL--YRD-----------
                                                  .|      .   .||. .||... .| . |..    |..           
--------------------------------------------------IS------QHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSEHEN

---------TVRLWR----LFREILDGLA--YIHEKG--MIHRDLKPVNIFLDSD--------------------DHVKIGDFGLAT--DHL--------
         ...        .. || ||.  |.| ..   ||||||| || ....                    ...||.|||||.  ..         
KHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQ

--------AFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTK--------SAYNQKVDLFSLGIIFFEM
        .               . .|. ..|  | |  | .||.  . |          |....|  |.| ||.||
PQSFKNVNK--------------DD-KPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEM
Kinase GCN2.AA STE-Unique 796-1001 25 1.4e-34 119.97 In-house 367-616 (616) Show / Hide 
Range on Protein: 796-1001
Range on HMM: 367-616/616
Sequence Identity: 25% (65 aa)

HYLYIQMEYCEKSTLRDTIDQGLY---------RDTVRLWRLFREILDGLAYIHEKG--MIHRDLKPVNIFLDSDD-----HVKIGDFGLATDHLAFSAD
. ..|.|||||..||.. |..                .  .. ..|| || |.| ..   ||||||| |||...|.     .|||.|||.||     ..|
NWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHAT---CCQPD

SKQD-----------------------DQTGDLIKSDPSGHLTGMVGTALYVSPEVQGST---KSAYNQKVDLFSLGIIFFEM-SYHPMVTASERIFVLN
.. .                        ||     ..    .....||  | .|||        . |. ||| .|||...|.| . .|  .   ..  . 
HFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYI

QLRDPTSPKFP----EDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELL
.....     |    |.  .     |   |  .|. .| .||.| .||....|
EMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase GCN2.AA PEK 797-873 39 7.2e-29 92.6 In-house 413-516 (758) Show / Hide 
Range on Protein: 797-873
Range on HMM: 413-516/758
Sequence Identity: 39% (41 aa)

YLYIQMEYCEKSTLRDTIDQG---LYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDH------------------------VKIGDFGL
|.||||..|.| ||.| .        |.      .|  |..|. ||| |||||||||| |||. .|.                         .|||||||
YMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGL

ATDH
.|||
VTDH
Kinase GCN2.AA PEK 899-1001 32 2.9e-26 83.74 In-house 646-758 (758) Show / Hide 
Range on Protein: 899-1001
Range on HMM: 646-758/758
Sequence Identity: 32% (38 aa)

TGMVGTALYVSPE-VQGS-------------TKSAYNQKVDLFSLGIIFFEMSYHP-MVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLN
|. ||| || ||| . .               |  || ||| .|||.||||. .||   |..||| ..  ||.    ..| .|.. .. ..   |.... 
TVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFEL-IHPGFSTQMERIRTMCDLRN---GQWPKWFTQ-KYPQEYEFIQQMMS

HDPAKRPTATELLKSELL
..|  ||||...... . 
MNPDERPTADQISMHDFF
Kinase GCN2.AA PEK 590-658 40 1.4e-22 71.13 In-house 1-77 (758) Show / Hide 
Range on Protein: 590-658
Range on HMM: 1-77/758
Sequence Identity: 40% (31 aa)

FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINP--------ASRQFRRIKGEVTLLSRLHHENIVRYYNAWIER
||. | ||.| || | ...||.|.. ||.|||.           ..    .   ||  |  | | |||||.||| |.
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLET
Kinase GCN2.AA STE11 830-912 40 9.4e-16 53.68 In-house 123-206 (303) Show / Hide 
Range on Protein: 830-912
Range on HMM: 123-206/303
Sequence Identity: 40% (35 aa)

REILDGLAYIHEKGMIHRDLKPVNIFLDSDDH-VKIGDFGLATDHLAFSADSKQD-DQTGDLIKSDPSGHLT-GMVGTALYVSPEV
. || ||.| |..| ||||.|. ||.|||| . .|..||| |.  || .. ...  ..| . .||.. | .  .|.||. . .|||
KQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAK-RLAWICTCTHNMNMTQNHCKSMT-GTPYNSMMGTPMWMAPEV
Kinase GCN2.AA STE-Unique 591-657 33 2e-15 50.71 In-house 1-72 (616) Show / Hide 
Range on Protein: 591-657
Range on HMM: 1-72/616
Sequence Identity: 33% (24 aa)

EELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQ-----FRRIKGEVTLLSRLHHENIVRYYNAWIE
.. | .|.|.|| | . ||| |.  .|.| |...  .          |  |......|||.|||.|| .|..
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLW
Kinase GCN2.AA STE20 590-660 24 1.5e-14 49.84 In-house 1-82 (288) Show / Hide 
Range on Protein: 590-660
Range on HMM: 1-82/288
Sequence Identity: 24% (20 aa)

FEELQLLGKGAFGAVIKVQNKLDGCC----YAVKRIPINPAS---RQFRRIKGEVTLLSRLHHENIVRYYNAWIER----HE
.| |. .|.|..|.| |. .|  | .    .|.|........    ... |. |.  .....|.|||.||.. .      .|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDE
Kinase GCN2.AA STE11 590-652 34 1.7e-14 49.06 In-house 1-76 (303) Show / Hide 
Range on Protein: 590-652
Range on HMM: 1-76/303
Sequence Identity: 34% (26 aa)

FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPAS----------RQ---FRRIKGEVTLLSRLHHENIVRYY
. . ...|||||| | |  |.  |  .||| |.|.. .          ..   .. |. |. |.. |.|.||||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYY
Kinase GCN2.AA Pkinase 590-657 29 2.2e-14 51.95 Pfam 1-71 (293) Show / Hide 
Range on Protein: 590-657
Range on HMM: 1-71/293
Sequence Identity: 29% (21 aa)

FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIK---GEVTLLSRLHHENIVRYYNAWIE
.. .. .|.|.|| | | ..| .|. .|||.|.   .. ......    |. .. ||.|.||||.| .. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED
Kinase GCN2.AA STE20 830-870 51 4.8e-13 44.3 In-house 124-164 (288) Show / Hide 
Range on Protein: 830-870
Range on HMM: 124-164/288
Sequence Identity: 51% (21 aa)

REILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLA
||.| ||.|.|....||||.|  || |..|  ||. |||..
REVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVC
Kinase GCN2.AA TyrKc 590-1001 14 2.8e-11 -40.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 590-1001
Range on HMM: 1-280/280
Sequence Identity: 14% (66 aa)

FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRL--HHENIVRYYNAWIE---------------------------RHE
 . .. || |||| | | . |      ||| .  .      . .  |  ....|  ||.|||| | . ..                           |  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSASARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDII
||                                                                                                  
RPK-------------------------------------------------------------------------------------------------

FDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDD
                                                             .  |      | .| .|.|.|. |||||   |. .... 
-----------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH

HVKIGDFGLATDHLAF-SADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEM------SYHPM----VTASERIF
.|||.||||. |.    ..        .| ...  ...  .|.      .||.    .. .. | | .| |.  .|.       |  |    ....|   
TVKISDFGLSRDIYDDDQQG-----ESKDYYRKKEHKGGKTMLPIR-WMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE---

VLNQLRDPTSPKFPED-----FDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELL
|......   .. |..     |  . ...  .....  ..||..||| .|.   |..
VIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase GCN2.AA Ciliate-E2 590-657 19 2.4e-10 31.72 In-house 1-103 (365) Show / Hide 
Range on Protein: 590-657
Range on HMM: 1-103/365
Sequence Identity: 19% (20 aa)

FEELQLLGKGAFGAVIKVQNKLDGC-----------------------CYAVKRIP------INPASRQFRRIK------GEVTLLSRLHHENIVRYYNA
.. ....|.|.|| | |........                        ||.|..       |.   ...|.|.       |  .|..| | ||...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WIE
..|
FQE
Kinase GCN2.AA Pkinase_Tyr 834-873 45 1.2e-08 29.96 Pfam 122-161 (270) Show / Hide 
Range on Protein: 834-873
Range on HMM: 122-161/270
Sequence Identity: 45% (18 aa)

DGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDH
.|..| ..|..|||||   |. .... .|||.||||| |.
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase GCN2.AA CAMK 975-1001 33 3.6e-07 18.37 In-house 399-425 (425) Show / Hide 
Range on Protein: 975-1001
Range on HMM: 399-425/425
Sequence Identity: 33% (9 aa)

KSVISWLLNHDPAKRPTATELLKSELL
|. |...|. || ||.|... |. . .
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GCN2.AA STE20 978-1001 45 1.6e-05 16.53 In-house 265-288 (288) Show / Hide 
Range on Protein: 978-1001
Range on HMM: 265-288/288
Sequence Identity: 45% (11 aa)

ISWLLNHDPAKRPTATELLKSELL
..  |. ||.|||||..||| . .
VDKCLQKDPEKRPTASQLLKHPFI
Kinase GCN2.AA Pkinase_Tyr 590-652 28 5.7e-05 17.47 Pfam 1-70 (270) Show / Hide 
Range on Protein: 590-652
Range on HMM: 1-70/270
Sequence Identity: 28% (22 aa)

FEELQLLGKGAFGAVIKVQNKLDGCCY----------AVKRIPINPASRQ--FRRIKGEVTLLSRL-HHENIVRYY
 . .. ||.|||| | |      | ..          ||| .. .  ..|   .    |. ... | ||.||||.|
ITFGKKLGEGAFGEVYK------GTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase GCN2.AA STE11 982-1001 50 0.001522 9.02 In-house 284-303 (303) Show / Hide 
Range on Protein: 982-1001
Range on HMM: 284-303/303
Sequence Identity: 50% (10 aa)

LNHDPAKRPTATELLKSELL
. ||| ||||| .||.   .
FEHDPKKRPTANQLLQHPFI
Kinase GCN2.AA CMGC 985-1001 41 0.002953 5.52 In-house 497-513 (513) Show / Hide 
Range on Protein: 985-1001
Range on HMM: 497-513/513
Sequence Identity: 41% (7 aa)

DPAKRPTATELLKSELL
||.||.|| . |. . .
DPDKRITAEQALQHPYF
Kinase GCN2.AA STE20 901-936 41 0.017554 5.24 In-house 182-220 (288) Show / Hide 
Range on Protein: 901-936
Range on HMM: 182-220/288
Sequence Identity: 41% (16 aa)

MVGTALYVSPEV-QGST--KSAYNQKVDLFSLGIIFFEM
.|||  . .||| |. .  .. |..|.|  ||||   ||
FVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEM
Kinase GCN2.AA Pkinase_Tyr 983-1000 38 2.1468 1.96 Pfam 254-270 (270) Show / Hide 
Range on Protein: 983-1000
Range on HMM: 254-270/270
Sequence Identity: 38% (7 aa)

NHDPAKRPTATELLKSEL
..||..||| .|.  ..|
HYDPEDRPTFSEI-HEQL