Gene GPRK4 (Human)

GPRK4

Species: Human
Alias: IT11, GPRK4, GRK4, GRK4B, GRK4A, HUMGPRKLG, GPRK2L
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 4p16.3,

Classification

Group: AGC
Family: GRK
Subfamily: GRK

Sequence

Name Sequence Type Origin Length Description Download
GPRK4.NA RNA Sugen Kinome 2321 None Fasta, JSON
GPRK4.AA Protein Sugen Kinome 578 None Fasta, JSON
GPRK4.kin_dom Protein Kinase Domain Sugen Kinome 263 None Fasta, JSON

Protein domain

Protein domains of GPRK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RGS GPRK4.AA RGS 52-171 24 3.5e-38 127.93 Pfam 1-124 (124) Show / Hide 
Range on Protein: 52-171
Range on HMM: 1-124/124
Sequence Identity: 24% (31 aa)

DYSSLCDKQPIGRRLFRQFCDT-KPTLKRHIEFLDAVAEYEVA---DDEDRSDC-GLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEEC
.. .||..|||||||||||... .. . ..|||..|. .....   .||..... . .| .... .. . ... |. |....|. .|....|....|.|.
SFHHLCNDQPIGRRLFRQFLESEFCEY-ENIEFWLACEDFKKMFSDSDEKMHQKDAREIYNKYIAPDSPCECHNIDHDTREHCQDNLEQAQPTPDCFDEA

TRVAHNYLRGEPFEEYQESSYFSQF
 |  ......... ....| |. .|
QRHIYTLMEKDSYPRFLKSDYYQRF
RGS GPRK4.AA RGS 52-172 25 5.1e-34 120.26 SMART 1-121 (121) Show / Hide 
Range on Protein: 52-172
Range on HMM: 1-121/121
Sequence Identity: 25% (31 aa)

DYSSLCDKQPIGRRLFRQFCDTKPTL-KRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAA-PLPEIPPDVVTECRLGLKEENPSKKAFEECTRV
.. .|||..|||||.||.|..... . |...||..|. |.....||.|. ..  | |...  . .    ..|.......|. .|..  |.. .|.|. |.
SFHHLCDNDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMEDEERRQKAREIYDKYISPNAPCEHCVNIDHHTREQCQQCLCN--PHPDCFDEAQRH

AHNYLRGEPFEEYQESSYFSQFL
 ......... .. .| |....|
VYQLMEKDSYPRFLRSDYYKRYL
Kinase GPRK4.AA GRK 187-449 75 5.6e-234 745.43 In-house 1-272 (272) Show / Hide 
Range on Protein: 187-449
Range on HMM: 1-272/272
Sequence Identity: 75% (204 aa)

FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSR---FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGN--
||.|||||||||||||||||||||||||||.|.||||||||||.||||||.|||||.||   |.|..|||||||||||||.||||||||..||||.||  
FRQYRVLGKGGFGEVCACQVRATGKMYACKCLDKKRIKKRKGETMALNEKQILEKVHSRDCPFIVCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGNNE

PGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEVVNNEK-YTFSPDWWGLGCLIYEM
|||||.|..|||||.|||||...|.||||||||||||||||.||.|||||||| |||||| ...|||||.|||||||..||. |.||||||.|||.||||
PGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIHGRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYEM

IQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGE--GAAGVKQHPVF
|.|||||...|||||.||||.|.|.|...|..||||.||.||.|||.|.|..||||||.  ||. ||.||.|
IEGHSPFRQHKEKVKREEVDRRVKEDPVKYPDKFSEEAKDICEMLLQKDPEQRLGCRGGTCGAQEVKEHPFF
Kinase GPRK4.AA GRK 187-449 83 1.1e-231 775.92 In-house 1-265 (265) Show / Hide 
Range on Protein: 187-449
Range on HMM: 1-265/265
Sequence Identity: 83% (221 aa)

FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLG-NPGFD
||.|||||||||||||||||||||||||||||.||||||||||.||||||.|||||.||||||||||||||||||||.||||||||||||||.| |||||
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEQMALNEKQILEKVHSRFVVSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGENPGFD

EQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSP
|.||.|||||.|||||.|.||||||||.|||||||||.|||||||||||.||||||..|||||||||||||||.||.||||||||||||||||||.|.||
EERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQMIRGRVGTVGYMAPEVVKNERYTFSPDWWGLGCLIYEMIEGRSP

FKKYKEKVKWEEVDQRIKNDTEEYS-EKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVF
|...|||||.||||.|.|.|.|.|| |||||.||.||||||.|.|..|||||.||.. |.|||.|
FRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREEGCDEVRQHPFF
Kinase GPRK4.AA AGC 187-449 28 3e-153 399.48 In-house 1-395 (395) Show / Hide 
Range on Protein: 187-449
Range on HMM: 1-395/395
Sequence Identity: 28% (113 aa)

FRHYRVLGKGGFGEVCACQVR------ATGKMYACKKLQKKR-IKKRK--GEAMALNE------------KRILEKVQ----------SRFVVS-LAYAY
|. ..|.|||.||.|. .. .      .|||.||.|.|.||. |...|   ......|            ..||||..          . |.|. | |..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKDA--LCLVLTIMN---------GG-DLKFHIYNL-GNPGFDEQRAVFYAAE-------LCCGLEDLQR-ERIVYRD-LKPENILLDDRGHIRISDLG
..||   |..|.  |.         || .| .|...  ..  |||.|| |||||       ....|| | .   |..|| |||||||||..|||...| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LATEIP---------------------------------------------------EGQRVRGRVG--TVGYMAPEVVNNEKYTFSPDWWG--LGCLIY
|..|..                                                   ...|    .|  |  |||||..    |... |||.  ||||.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMIQGHSPFKK------------YKEKVKWEEVDQRIKNDTEEYS----------EKFSEDAKSICRMLLTKNPSKRLGCRGE-----GAAGVKQHPVF
||. |..||               .|. .  . .....|. ...           ..||..||.....||.|.|.|||||.|.     ||  .|.|| |
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase GPRK4.AA BARK 187-449 47 2.2e-93 316.55 In-house 1-264 (264) Show / Hide 
Range on Protein: 187-449
Range on HMM: 1-264/264
Sequence Identity: 47% (128 aa)

FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSR----FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNP
|   |..|.||||||  |    |||||| | | ||||| ..|| .||||. .|. |       |.| ..||..| | || .| .|||||| .|.   |  
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV-

GFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN-EKYTFSPDWWGLGCLIYEMIQ
 | ||   |||||.  ||| . .  .||||||| |||||. ||.|||||||| .  . ..    ||| |||||||..    |  | ||. |||..| ...
-FSEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLYKLLR

GHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVF
|||||.. | | | .|.|.       |  ..||.. ...  .|| .. ||||||.|.||  ||.|| |
GHSPFRQHKTKDK-HEIDRMTLTMNVELPDSFSKEMRDLLEGLLQRDVSKRLGCMGRGAQEVKEHPFF
Kinase GPRK4.AA S_TKc 187-449 32 1.3e-85 291.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 187-449
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNG--GDLKFHIYNLGNPG-
..  |..|||.||.|. |. . ||. .|.|..            ....| .||.| .  ..| | ..... | |..|.  ..|  |||. .| . | .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTF-SPDWWGLGCLIYEM
   |.| .| ||....||.|| . . .|..|||||||||||.  || |.| |||...      .  .||  ||||||.   .|.. . ||| .||..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

IQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGA--AGVKQHPVF
. |  ||    ... .. .               |..||.. | .|.|.|.||...    .    .|.|| |
LCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GPRK4.AA RSK 190-449 36 1.1e-82 281.0 In-house 1-278 (278) Show / Hide 
Range on Protein: 190-449
Range on HMM: 1-278/278
Sequence Identity: 36% (101 aa)

YRVLGKGGFGEVCACQVR---ATGKMYACKKLQKKRIKKR-KGEAMALNEKRILEKVQ-SRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPG-
 .|||.||.|.|  |.     .||. || | |.|. |..| |  . .. | .||| .| . |.|.| ||..|.. | |..  ..||.|  |... .  | 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDD---RGHIRISDLGLATE-IPE-GQRVRGRVGTVGYMAPEVVN---NEK-YTFSPDWWGLGC
|.| .| ||.||. . .| |    |..|||||||||.||   .|||...| |.. .  .. .|.    ..|. |||||...    .. .. . ||| ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDT--EEYS--EKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVF
|.|||  |..||.   ..   .|. .||.. .   .    .. |..||.. |..|...|.|||||  ..|. .|||| |
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase GPRK4.AA SGK 187-449 35 2.2e-74 229.0 In-house 1-283 (283) Show / Hide 
Range on Protein: 187-449
Range on HMM: 1-283/283
Sequence Identity: 35% (103 aa)

FRHYRVLGKGGFGEVCACQVRAT------------------GKMYACKKLQKKRIK-------KRKGEAMALNEK-RILEKVQSRFVVSLAYAYETKDAL
|.   |.|||.||.|   .  ..                  .|.|| | |||. |        |.| .   . |.  || .. . | |.| ||  ||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLAT-EIPEGQRVRGRVGTVGYMAPEVVN
 .|.  .|||.. .|.   .   | | || |||||. | || |    |.||||||||||||. ||... | ||.  .| . .      ||. |.|||| .
YFVMDYVNGGEMFYHLQREKH--FPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLR

NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVF
 . .  . ||| |||. |||. |  ||  |   .  ..  . | |        .| ||...   ||.|.|.|||| . .... .|.|| |
KQPHDRTVDWWCLGCVLYEMMYGLPPF--YSRNK--QQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase GPRK4.AA AktR 187-449 36 1.4e-73 250.77 In-house 1-268 (268) Show / Hide 
Range on Protein: 187-449
Range on HMM: 1-268/268
Sequence Identity: 36% (100 aa)

FRHYRVLGKGGFGEVCACQVR-ATGKMYACKKLQKKRIKKRKGEAMALNEKRILE-KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGF
|. |..||||.||.|  .| .  ..|.|| | . || |..|. .  ...|. |.| ...  | | | |. .||. | ... .. ||.| .|. . .   |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK--F

DEQRAVFYAAELCCGLEDLQRE-RIVYRDLKPENILLDDRGHIRISDLGLAT-EIP--EGQRVRGRVGTVGYMAPEVVNN-EKYTFSPDWWGLGCLIYEM
.|..| ||.|. . .|| |  .  |.||||||||||||  ||..|.| ||.  ..   . .. .  .||. |||||.... . ...| ||| .|..||||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

IQGHSPFKKYKEKVKWEEVDQRIKN-DTEEYSEKFSEDAKSICR-MLLTKNPSKRLGCRGEGAAGVKQHPVF
. |. ||  | .. ...   ..||.    .|...||. .|...   || ||| ||||   .|.  .| || |
VTGCPPF--YHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase GPRK4.AA PKC 187-449 39 2.5e-73 236.97 In-house 1-262 (262) Show / Hide 
Range on Protein: 187-449
Range on HMM: 1-262/262
Sequence Identity: 39% (105 aa)

FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSR-FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFD
|.  .||||| || |     . | ..|| | | |  | .      ...|||.|.  .   | ..|     |.| |  |.   ||||| ||| . .   |.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRR--FK

EQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLA-TEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHS
|..|.||||| .|.|  | .  |.||||| .|.|||  |||.| | |.. ... .|.. .   ||  |.|||..  ..|..| ||| .| | |||  |.|
EEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQS

PFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEG---AAGVKQHPVF
||    |    .|. | | .|.  |   .|..|.|||  ..||||.|||||. ..   .  ...|| |
PFHGEDE----DELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase GPRK4.AA Pkinase 187-449 28 6.6e-68 236.7 Pfam 1-293 (293) Show / Hide 
Range on Protein: 187-449
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMAL-NEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGG----DLKFHIY---N
..  |..|.|.||.|. |. . |||..|.|.. |...|. | .. .. .| .|. .... ..| | ...|.|| ...|.  ..||    ||. .|    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

LGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHI----RISDLGLATE--IPEGQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWG
 .   |.|. . ||. ....||| . ...|..|||||||||.|..|||    .|.| |||    .  ..   ...|| .||||||.. ...|. . |.|.
GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCLIYEMIQGHSPFKKY----KEKVKWEEVDQRIKNDTEEYSEKFS--------------------EDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHP
.||..|||. |. ||.      .   . . .... . .... ... .                    |..|.... .|.|.|.||..     |. ..|||
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHP

VF
 |
WF
Kinase GPRK4.AA Ciliate-E2 187-449 22 1e-67 231.25 In-house 1-365 (365) Show / Hide 
Range on Protein: 187-449
Range on HMM: 1-365/365
Sequence Identity: 22% (87 aa)

FRHYRVLGKGGFGEVCACQVRATGKM-----------------------YACKKLQKKRIKKRKGEAMAL----------NEKRILEKVQSRFVVSLAYA
.   ...|.|.|| |. |.|. ..|.                       || | ..|. |.  | |   .          |||.|||.... ... . ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--TKDALCLVLTIMNGGDLKFHIYNL----------GNPGFDEQRAV---------------FYAAELCCGLEDLQRER-IVYRDLKPENILLDDRGH
..  ... . ||.   .||||. .|.|           .   |.|. .                ||.|.....|| |  .  |..||.||||||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IRISDLGLATEIPEG--------------------------------QRVRGRVGTVGYMAPEVVNNEK---------YTFSPDWWGLGCLIYEMIQGHS
| |.|.||.... .                                 . ..  .|| ||||||..|..|         |... |.| ||...|||. |  
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFKKYKEKVKWEEVDQRIKNDTEEYS------------------EKFSEDAKSICRM----LLTKNPSKRLGCRGEGAAGVKQHPVF
||             | ||.   ...                  .| |...| ...     .| |.|.||..    |.  ...|| |
PF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase GPRK4.AA Akt 187-386 40 2.2e-63 201.43 In-house 1-203 (264) Show / Hide 
Range on Protein: 187-386
Range on HMM: 1-203/264
Sequence Identity: 40% (83 aa)

FRHYRVLGKGGFGEVCACQVRATGKMY-ACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFD
|.  .||||| || |  ..  .|.|.| | | |.|..| ...  . .. |..||..... |.|.| |.  |.| |..|.  .|||.| .|..    . |.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQR--KRRFS

EQRAVFYAAELCCGLEDLQRERIVYRD-LKPENILLDDRGHIRISDLGLAT-E-IPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWG-LGCLIYEMIQ
|.|| ||.||. ...| |    |.||| |||||||.|  |||.. | ||.  . | ....     ||  |.|||. |.  .| . |||| |||..|||..
EDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMC

GHSPF
|  ||
GRPPF
Kinase GPRK4.AA TyrKc 187-433 20 5e-14 4.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 187-433
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV--QSRFVVSLAYAYETK-------DALCLVLTIMNGGDLKFHIY
 .  ..|| | ||||. .. .    . | |.|..        ... ..| ||. |.  .   .| |  .  ..       . |..|.  | .|||| .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEG---------QRV----RGR-VGTVGYMAPEVVNNEKY
. ..  .  .  . ..   .|| | | . ... |||   |.|........||| ||. .| ..          |.     |. .  .  ||||. |  |.
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TFSPDWWGLGCLIYEMI-QGHSPFKK---YKEKVKWEEVDQRIKND-TEEYSEK--------FSEDAKSICRMLLTKNPSKR---------L
|.  | |  | ...|.   | .|         .....|| ...|.    .  .          ...  .| ..    .|..|         .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GPRK4.AA Akt 411-449 38 2.5e-10 29.13 In-house 226-264 (264) Show / Hide 
Range on Protein: 411-449
Range on HMM: 226-264/264
Sequence Identity: 38% (15 aa)

EKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVF
...| ..|.. . ||.|.|.||||   ..|  .|.|| |
DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase GPRK4.AA S_TK_X 450-529 19 2.1e-05 23.24 SMART 1-79 (79) Show / Hide 
Range on Protein: 450-529
Range on HMM: 1-79/79
Sequence Identity: 19% (17 aa)

KDINFRRLEA--NMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESG----CFKDINKSE
..|....|..   ..|||| |....||  .  |...|      . . ..   .  . .. ... |||| .| .    .| . ... 
RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPE---FTEETPM--LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF