Gene HH498 (Human)

HH498

Species: Human
Alias: HH498, MGC33828, MGC142099, CARK, TNNI3K, LOC51086
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 1p31.1,

Classification

Group: TKL
Family: MLK
Subfamily: HH498

Sequence

Name Sequence Type Origin Length Description Download
HH498.NA RNA Sugen Kinome 3269 None Fasta, JSON
HH498.AA Protein Sugen Kinome 936 None Fasta, JSON
HH498.kin_dom Protein Kinase Domain Sugen Kinome 261 None Fasta, JSON

Protein domain

Protein domains of HH498.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank HH498.AA Ank 234-266 54 1.3e-09 38.97 Pfam 1-33 (33) Show / Hide 
Range on Protein: 234-266
Range on HMM: 1-33/33
Sequence Identity: 54% (18 aa)

GGLTALHIATIAGHLEAADVLLQHGANVNIQDA
 | |.||.| . ||.| .  ||||||.||.|| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 201-233 39 6.5e-08 32.81 Pfam 1-33 (33) Show / Hide 
Range on Protein: 201-233
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

NGFTALHLAVYKDNAELITSLLHSGADIQQVGY
.|||.||||......| .. ||  |||.  .  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 167-200 26 1.085234 6.75 Pfam 1-33 (33) Show / Hide 
Range on Protein: 167-200
Range on HMM: 1-33/33
Sequence Identity: 26% (9 aa)

NGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTR
.| . ||| |.||  .. .. |. .|  .   ..
DGFTPLHLACRCG-HTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 269-299 51 1.3e-08 35.28 Pfam 3-33 (33) Show / Hide 
Range on Protein: 269-299
Range on HMM: 3-33/33
Sequence Identity: 51% (16 aa)

FTPLHIAAYYGHEQVTRLLLKFGADVNVSGE
|||||.|...||..| ..||. |||||.   
FTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 300-334 45 3.9e-07 29.99 Pfam 1-33 (33) Show / Hide 
Range on Protein: 300-334
Range on HMM: 1-33/33
Sequence Identity: 45% (16 aa)

VGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDN
 |. |||||. .| ....|.|..    |||||||.
DGFTPLHLACRCGHTEVVKMLLQ--HGADVNAQDD
Ank HH498.AA Ank 335-365 39 0.006084 14.87 Pfam 1-33 (33) Show / Hide 
Range on Protein: 335-365
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

EDHVPLHFCSRFGHHDIVKYLLQ--SDLEVQPH
.   |||  .| ||...||.|||   |. .|  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 370-392 56 6.3e-05 22.04 Pfam 1-23 (33) Show / Hide 
Range on Protein: 370-392
Range on HMM: 1-23/33
Sequence Identity: 56% (13 aa)

YGDTPLHLACYNGKFEVAKEIIQ
.|.|||||||..|  ||.|. .|
DGFTPLHLACRCGHTEVVKMLLQ
Ank HH498.AA Ank 440-472 48 4.2e-08 33.5 Pfam 1-33 (33) Show / Hide 
Range on Protein: 440-472
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

DGHTGLHSACYHGHIRLVQFLLDNGADMNLVAC
|| | || ||..||.. |..||..||| |..  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 405-439 31 0.042099 11.84 Pfam 1-33 (33) Show / Hide 
Range on Protein: 405-439
Range on HMM: 1-33/33
Sequence Identity: 31% (11 aa)

FSETAFHSACTYGKSIDLVKFLLDQNVININHQGR
  .|. | || .| ... ||.||. .  ..|.| .
DGFTPLHLACRCG-HTEVVKMLLQ-HGADVNAQDD
Ank HH498.AA Ank 482-502 38 0.024004 12.72 Pfam 1-21 (33) Show / Hide 
Range on Protein: 482-502
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

DEQTCLMWAYEKGHDAIVTLL
| .|.|..| ..||  .|..|
DGFTPLHLACRCGHTEVVKML
Kinase HH498.AA HH498 564-820 66 8.60000000001e-222 710.57 In-house 1-284 (284) Show / Hide 
Range on Protein: 564-820
Range on HMM: 1-284/284
Sequence Identity: 66% (188 aa)

IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-----VDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLL------
|||||.||||||||||||..||||||.|||||...|.|||     ||||||||||.|.||||||.|||.||..|||||||||||...|||||.|      
IEFHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIG

--------HEQK---RILDLQSKLIIAVDVAKGMEYLHN-LTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQC
        |.||   ||.|||||..|.||||.||.|||| |..|||||||||||||..|||||||||||||||......||||||||||||||||||.||
GAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQC

TRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS----IPKPISSLLIRGWNACPEGRPEFSEVVMKL
..|.||.||||||.|.||..|.|.||.|.|||||||.||||||||||...    ||...|.|....|..|||.||.|...|..|
QKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase HH498.AA MLK 564-820 42 8.20000000001e-142 477.43 In-house 1-291 (291) Show / Hide 
Range on Protein: 564-820
Range on HMM: 1-291/291
Sequence Identity: 42% (124 aa)

IEFHEIIGSGSFGKVYKGRCRNKI-----VAIKRYRANTYCSKSD-------VDMFCREVSILCQLN-HPCVIQFVGACLNDPSQFAIVTQYISGGSLFS
|.|||.|||||||||.|||.|||.     ||.||.||... .|||       ..|.||...||...| |||.|||.|.||..|..|.||..|..||||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLHEQK-------------RILDLQSKLIIAVDVAKGMEYLHNLTQ-PIIHRDLNSHNILLYE------DGHAVVADFGESRFLQSLDEDNMTKQPGNLR
.||...             |. |..... .|...|.||.|||.. . |||||||.|||||..|      .|.....|||.||.... . .||....|...
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

WMAPEVF--TQCTRYTIKADVFSYALCLWEILTGEIPFA-HLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKL
||||||.   .|..|..|.||.|....|||.||.|.|.. |..|.|.|. .||...||||....|.....|. . ||..|. || |...|..|
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase HH498.AA TKL 570-820 26 9.5e-96 324.4 In-house 1-364 (364) Show / Hide 
Range on Protein: 570-820
Range on HMM: 1-364/364
Sequence Identity: 26% (99 aa)

IGSGSFGKVYKGRCRN----------KIVAIKRYRA--NTYCSKSDVD--------------------MFCREVSILCQLN--HPCVIQFVGACLNDPS-
||||.||.||||..|.          | ||.|...   .  ..|.. .                    .|..|. |.. ..  || ..||.|.|.. |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------QFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLT------QPIIHRDLNSHNILLYEDGH--------------A
           |..||..|..||||...||       .. .. .| |.|.||.|||. .       |||||||.|.|||. |...              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

VVADFGESRFLQSLDEDNMTK------------------QPGNLRWMAPEVFTQCT---------------RYTIKADVFSYALCLWEILTGEIPFAHLK
 ..||| |||..   ..|.|.                  | |..|||||||. . .                |. |.||.|....||||||...|.....
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

PA---------AAAADMAYHHIRPPIG------------YSIPKPISSLLIRGWNACPEGRPEFSEVVMKL
.          . ..  ...  ||||              ..|.....|. . |.. || || |.|.. .|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase HH498.AA Dicty4 564-822 36 8e-75 248.99 In-house 1-277 (277) Show / Hide 
Range on Protein: 564-822
Range on HMM: 1-277/277
Sequence Identity: 36% (102 aa)

IEFHEIIGSGSFGKVYKGRCRNKIVAIKRY-RANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACL---NDPSQFAIVTQYISGGSLFSLLHE-----
| . ..||.||||.||||..| |.||.|     |.  . .    | .||.|.|.. || ...| |||.     |. . ||| | . |.|.||||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-QKRILD--LQSK-LIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLD--EDNMTKQPGNLRWMAPEVFTQCTRYTIKAD
 |.  ||  |  . . .| |.|.|| .||. .  |||||| |||.|  ..  . |.||| |.  .      ||.. . |   ||||||  .  .|. |||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM-MHQPYNEKAD

VFSYALCLWEILTGEIPFA--HLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMK--LEE
|.|... ||||||...|..  |  .  ...  . .. ||||  . |.....|. . |.  |. || |.|.. .  ||.
VYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase HH498.AA TKL-Unique 566-820 32 8.6e-74 251.46 In-house 1-290 (290) Show / Hide 
Range on Protein: 566-820
Range on HMM: 1-290/290
Sequence Identity: 32% (94 aa)

FHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN-HPCVIQFVGACLN---DPSQFAIVTQYISGGSLFSLLH--------
| . ||.|..|.||||  | ..||||.   |   |.. .. | .||...  |. || . ...|.|     .|... ||. |..|||| ..||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-EQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYED-----GHAVVADFGESRFLQSLDEDNMT--------KQPGNLRWMAPEVFTQ
 ...  |..| .. .| |.|.||.|||..  ||||||| | |.|. ..       . ..||| |.|. . .. . .           |..|||||||...
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

C-TRYTIKADVFSYALCLWEILTGEI------PFAHLKPAAAAADMAY--HHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKL
  . |..|.||.|.. .||||.|..|      |. .. . . ..  .|     ||||. ..|| .. |. ..|.  |. || |.|.. .|
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase HH498.AA Pkinase_Tyr 564-820 30 2e-64 218.79 Pfam 1-270 (270) Show / Hide 
Range on Protein: 564-820
Range on HMM: 1-270/270
Sequence Identity: 30% (86 aa)

IEFHEIIGSGSFGKVYKGRCR------NKIVAIKRYRANTYCSKSD--VDMFCREVSILCQL-NHPCVIQFVGACL--NDPSQFAIVTQYISGGSLFSLL
|.| . .|.|.||.||||...      .  ||.|  .   ......   ..| ||..|..|| .|| .....|.|.   .|.|  ||. |  .|.| . |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HEQ---KRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNM-TKQP---GNLRWMAPEVFTQCTRYTI
...   |. |... .| .....|||||||..    .|||||   |.|. |.... ..||| .| .   ..|.  .|.       .|||||..  .  .|.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGK-FTT

KADVFSYALCLWEILT-GEIP-FAHLKPAAAAADMA-YHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKL
| || |.  ..|||.| ||.| .. . . .   ..   .  | |.    |..| .|. . |.. || || |||.. .|
KSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase HH498.AA CZAK 564-820 35 1e-63 218.02 In-house 1-279 (279) Show / Hide 
Range on Protein: 564-820
Range on HMM: 1-279/279
Sequence Identity: 35% (100 aa)

IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD---VDMFCREVSILCQLNHPCVIQFVGACLNDP-SQFAIVTQYISGGSLFSLLHEQKRIL
 .|   || | ||.|||.. | | ||||    | .  |.      || .||||.  | || ..||.|||  |      ||. .  ||||  || .    .
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

DL--QSKLIIAVDVAKGMEYLHN-LTQ-PIIHRDLNSHNILLYEDGH-------------AVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTR
      .. .|.|.|.|| |||   .  ||.|||| | |||| .                . ..||| || .       ||   | | |||||.|     
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSR-EMMEQPFEMTQTMGCLCWMAPECF-KGEN

YTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPIS---SLLIRGWNACPEGRPEFSEVVMKL
|| |.||.|... ||.|.|.. |   ..|   |   ||   |||.   ..        |. . ||  |. || |....  |
YTEKVDVYSFGMILWCIITCDQPYQNMQPMKMAHLAAYENYRPPMPQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL
Kinase HH498.AA TK 564-820 16 2.5e-62 207.45 In-house 1-486 (486) Show / Hide 
Range on Protein: 564-820
Range on HMM: 1-486/486
Sequence Identity: 16% (79 aa)

IEFHEIIGSGSFG---KVYKGRCRNK---------------------------IVAIKRYRANTYCSKSDVDM-----------FCREVSILCQLN----
|.. . .|.| ||   .||||. |..                            ||.|  .. .  |. .  .           |..|........    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPCVIQFVGACLNDP-----------SQFAIVTQYISGGS----LFSLLHEQKR---------------------------------------------
 || .....|.|. .              . ||. | ..|.    | . |.. ..                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------ILDLQSKLIIAVDVAKGMEYLHNLT----QPIIHRDLNSHNILLYEDGH-----------AVVADFG---
                              .|... .| .....|.|||||| .     | ..||||  .|.|. |...           . .||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----ESRFLQSLDEDNMTKQPGN-------------------------LRWMAPEVFTQCT--------RYTIKADVFSYALCLWEILT-GEIPFAHLK
      .| ..| |.   ....|                          .||||||...  .        ..|.| ||.|.  ..|||.| |. |..   
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PA------------AAAADM------------AYHHIRPPIGYSIP-------------KPISSLLIRGWNACPEGRPEFSEVVMKL
.                  .             | . .|.  .  .             . .  |. . |.. || || ||... .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase HH498.AA TyrKc 564-820 27 2.3e-57 197.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 564-820
Range on HMM: 1-280/280
Sequence Identity: 27% (80 aa)

IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQL--NHPCVIQFVGACLNDP------SQFAIVTQYISGGSLFSLLHEQ
|.. ...|.| ||.||||. .   ||.|  ....      . .|.|| .|.|.|  .||......|.|. .        .  ||. | ..|.| . |.. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSL-------DEDNM-----TKQPGNLRWMAPEVFTQCTRY
.. | .. .| .....|.||||||    ..|||||   |.|. |.... ..||| ||.. .        |   .     .| .  .||||||.. .  ..
RPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF

TIKADVFSYALCLWEILT-GEIPFAH-----LKPAAAAADMAYHHIRPPIGY-------SIPKPISSLLIRGWNACPEGRPEFSEVVMKL
|.| ||.|.  |.|||.| |. |        .... . ..    . .|.  .         |. . ..  . |.. || || |||.. ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase HH498.AA DRK 564-822 36 1e-56 190.59 In-house 1-258 (258) Show / Hide 
Range on Protein: 564-822
Range on HMM: 1-258/258
Sequence Identity: 36% (94 aa)

IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQS
|     || |..| |. |  |  .||.|.  .        .  | ||. ..||| || ..|| |.|.| |.   |.. |.. ||| . ||...  .|   
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNN-PPDICICMEYMPRGSLYNILHDESIEMDWPL

KLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGES-RFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTG
 . .. |.|||| |||. .  |||||| ||| |  |     ||||| | || . ..        |   | ||||     ||| ||||.|.|  |||..| 
MKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRN-QRYTEKADVYSFAIVLWECVTR

EIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE
..|..   .         |  |||.    | .   |... ||  |  || . |..  || 
QDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase HH498.AA Dicty4-Unclassified 564-820 32 6.6e-54 183.0 In-house 1-263 (263) Show / Hide 
Range on Protein: 564-820
Range on HMM: 1-263/263
Sequence Identity: 32% (87 aa)

IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSK-SDVDMFCREVSILCQLNHPCVIQFVGACLNDP----SQFAIVTQYISGGSLFSLLH----E
|     || | | ||.||  . | ||.|    | .      .. | .|| ||  . ||  ..  |.|.| |    | . ||.  .  | || . |    |
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCIN-PRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

QKRILDLQS--KLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSY
|.. . | .   . .| |.|.|| .||  |  .||||. | |||.  .  . .|||| ||        |||   |  .| .||.      |. |.||.||
QQQPIKLDDTLIIKYAFDIAQGMQHLH--TRNFIHRDIKSSNILMDKHFNIKIADFGISRVID--FNFNMTTIAGTPKWESPECLMHES-YNQKSDVYSY

ALCLWEILTGEIPFAHLK-PAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKL
|. |.| .||. |.     .  ||   .    || |  ...  ...|    |   |  || . ... .|
AMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase HH498.AA LRRK 609-822 33 5.9e-49 168.96 In-house 106-351 (351) Show / Hide 
Range on Protein: 609-822
Range on HMM: 106-351/351
Sequence Identity: 33% (84 aa)

REVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKR--I------LDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILL---
.||.|.. ||||.... .| |.. |  ...|. |.. |.| ..||. |.  .      .. . || ||...||||||||. . ||||||| |.||||   
HEVWIMSHLNHPNIVSLKGFCIH-P--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSS

---Y------EDGHAVVADFGESR-FLQSLDEDNMTKQPGNLRWMAPEVFTQC--TRYTIKADVFSYALCLWEILTGE-IPFAHLK-P-----AAAAADM
   .      .. .| .|||| || | |.. .    .  || .|||||.        || |.|..|... |||.||.. .|| ... .          | 
PQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDK

AYHHIRPPIG--YSIPK-----PISSLLIRGWNACPEGRPEFSEVVMKLEE
    .||.|   |  |        ..|.   |.. |. || ||..| .|..
IIEGLRPTIPQHY-CPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase HH498.AA S_TKc 564-824 26 7.3e-47 162.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 564-824
Range on HMM: 1-231/231
Sequence Identity: 26% (74 aa)

IEFHEIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISG--GSLFSLLHEQKRI-
 |....||.|.||||||.| ..  .|||||. .          ....||..|| . .|| .... ... .  . . .|. |..|  |.||.......|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTI-KADVFSYA
    ..      ..  .....||.|..   ||||||   |||| |  |  ..||| .|.|        | . | . .|||||.     |.  |.|. |  
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG

LCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVM-----KLEECL
 .|.| |.|. ||          .| ...|.       ...  ... . ..  || ||   |.       |. . .
CILYEMLCGYPPFP-------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HH498.AA Pkinase 564-768 27 1.2e-38 137.75 Pfam 1-214 (293) Show / Hide 
Range on Protein: 564-768
Range on HMM: 1-214/293
Sequence Identity: 27% (63 aa)

IEFHEIIGSGSFGKVYKGRCRNK--IVAIKRYRANTYCSKSDVDMFCR-------EVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGG----SLFS
......|||||||.|||.. ..   |||.|. .      |.. .. ..       |..|.  ||||..... ... . ..   .|. |  ||    .||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK------KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFD

LLH-EQKRIL--DLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHA----VVADFGESRFL-QSLDEDNMTKQPGNLRWMAPEVFTQCTR
... .... .  . .    ..  ...|.||.|.    |||||| . |||. ..||      ..||| ....    ..  ||   | ...|||||   .. 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQY

YTIKADVFSYALCLWEILTGEIPFAH
|. |.|..|. . |.| |.|. || .
YGPKVDMWSCGCILYEMLCGRPPFPG
Kinase HH498.AA LRRK 564-605 23 4.6e-09 28.2 In-house 1-55 (351) Show / Hide 
Range on Protein: 564-605
Range on HMM: 1-55/351
Sequence Identity: 23% (13 aa)

IEFHEIIGSGSFG-KVYKGRCRN-----KIVAIKRYRA-------NTYCSKSDVD
... | ||.|.|| .||....|.     . ...|.          |.| . ..|.
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVA