Gene HSER (Human)

HSER

Species: Human
Alias: HSER, GUCY2C, STAR, GC-C, GUC2C
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 12p12-13.1,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
HSER.NA RNA Sugen Kinome 3850 None Fasta, JSON
HSER.AA Protein Sugen Kinome 1073 None Fasta, JSON
HSER.kin_dom Protein Kinase Domain Sugen Kinome 273 None Fasta, JSON

Protein domain

Protein domains of HSER.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor HSER.AA ANF_receptor 53-386 15 1.9e-33 119.12 Pfam 1-364 (364) Show / Hide 
Range on Protein: 53-386
Range on HMM: 1-364/364
Sequence Identity: 15% (64 aa)

NLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTY-STFQMYLDTELSYPMISAGSFGLSC
... |..  .| .  .  . . ..|... . ....         .|.| .   .   . . .. ...|||||.| ..    . ...  ||||.|..  ..
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCY---------CSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCL

DY--KE---TLTRLMSPARKL-MYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYF--SHEL--------------GFKVVLR--
..  |.   ...|.. ..... ....|.. ..                       .. |   |. .. ...  . ..              | ..|..  
TDKAKNRYPYFFRTVPSDTYQYGWAMVDIIQH-----------------------HFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAY

------QDKEFQDILMDHN----RKSNVIIMCGGPEFLYKLKGDRAVAED---------IVIILVDLFNDQYF--------EDNVTAPDYMKNVLVLTLS
      .|..|.|.|   .     |. ||.||. |. .. |   . . .           |.|..|.... |.        .|| .. ..||.||..|. 
VSMVIPWDDDFMDYLKKIKDIIKMKARVIVMCCYPDDMG-LLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQWWYDDDMDNDKFREAMKGVLGFTMH

PGNSLLNSSFSRNL---SPTKRDFALAYLNGILLFGHMLKIFLENGENITTPK----------FAHAFRN-LTFEGYDGPVTLDD-WGDVDSTMVLLYTS
   |  .. | ...   .     .|.   ....|..|.|. .| ...|.....          ..|...|  .|||  |.|..||  |.. ..|. ... 
-P-SPEFQEFMQRWKKTDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNW

V
.
D
Kinase HSER.AA RGC 509-747 35 4.4e-104 352.08 In-house 1-300 (300) Show / Hide 
Range on Protein: 509-747
Range on HMM: 1-300/300
Sequence Identity: 35% (107 aa)

DKKRVILKDLKHN----DGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDT------MIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIA
.. .|..|.....    . .||.... ||... |... ||.||.| .  ..      ... | |||.|||| ..| .     |   ||| || | ..||.
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILEN-----DDIKMDWMFKYSFIRDIV

KGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCN----------------------SILPP------KKDLWTAPEHLR----QANIS--------
||| |||.|   .||.|||.|||||||.||||||||.|                      .. ..      || |||||||||    .. ..        
KGMQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRG

-QKGDVYSYGIIAQEIILRKE-----TFYTL------SCRDRNEKIFRVENSNGMKPFRPDLFLETA---EEKELEVYLLVKNCWEEDPEKRPD-FKKIE
 |||||||.|||..|||.||.     .|. .      |... .|.. ......| |||||..  ...   .|   ... |...||.||||.||| |..| 
TQKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIR

TTLAK
..|..
KQLKT
Kinase HSER.AA RGC 509-747 35 4.4e-104 352.08 In-house 1-300 (300) Show / Hide 
Range on Protein: 509-747
Range on HMM: 1-300/300
Sequence Identity: 35% (107 aa)

DKKRVILKDLKHN----DGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDT------MIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIA
.. .|..|.....    . .||.... ||... |... ||.||.| .  ..      ... | |||.|||| ..| .     |   ||| || | ..||.
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILEN-----DDIKMDWMFKYSFIRDIV

KGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCN----------------------SILPP------KKDLWTAPEHLR----QANIS--------
||| |||.|   .||.|||.|||||||.||||||||.|                      .. ..      || |||||||||    .. ..        
KGMQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRG

-QKGDVYSYGIIAQEIILRKE-----TFYTL------SCRDRNEKIFRVENSNGMKPFRPDLFLETA---EEKELEVYLLVKNCWEEDPEKRPD-FKKIE
 |||||||.|||..|||.||.     .|. .      |... .|.. ......| |||||..  ...   .|   ... |...||.||||.||| |..| 
TQKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIR

TTLAK
..|..
KQLKT
Kinase HSER.AA TKL 521-745 22 3.6e-44 153.06 In-house 50-364 (364) Show / Hide 
Range on Protein: 521-745
Range on HMM: 50-364/364
Sequence Identity: 22% (73 aa)

NDGN---------------FTEKQKIELNKLLQIDYYNLTKFYGTVKLDTM-------------IFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKIS
|| |               | .. . |.. .....  |. .|.| ..  .              .. | |||..|||...|.            |. ...
ND-NNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCR

VLYDIAKGMSYLHSSKT-------EVHGRLKSTNCVVDSRMV--------------VKITDFGCNSILPPKKD---------------------------
  .|||.||.||||...        .|  ||| |. ||. .               .||.|||    . ....                           
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

-LWTAPEHLRQA----------------NISQKGDVYSYGIIAQEIILRKETFYTLSCRDRN-----EKIFRVENSNGMKPFRPDLFLE----TAEEKEL
  | ||| ||..                  |.| ||||.||.  ||. |.. .| . ....      | .| .  ..|..| .|.  ..      ..  .
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCP

E-VYLLVKNCWEEDPEKRPDFKKIETTL
. .  | . ||..|||||| |..|  .|
PSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase HSER.AA TKL-Unique 560-669 30 4.3e-23 78.4 In-house 78-217 (290) Show / Hide 
Range on Protein: 560-669
Range on HMM: 78-217/290
Sequence Identity: 30% (43 aa)

VIEYCERGSLREVLND----TISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKT-EVHGRLKSTNCVVDSR-----MVVKITDFGCNSILP-----PKKD
| |||..|||..||..        .. . .... ...   |||.|| |||....   |. |||.|  ||..     . .|| |||   ..      ... 
VMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNE

L-------------WTAPEHLRQ--ANISQKGDVYSYGII
.             | ||| ||.  . .|.| ||||.||.
HKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIV
Kinase HSER.AA TK 543-668 15 1.3e-16 51.43 In-house 104-382 (486) Show / Hide 
Range on Protein: 543-668
Range on HMM: 104-382/486
Sequence Identity: 15% (43 aa)

NLTKFYG-TVKLDTM-----------IFGVIEYCERGS----LREVLNDTI------------------------------------SYPDGTF------
|. ..||  .. ...           .  | ||.. |.    ||. | .                                      ..|. ..      
NIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQDYDD

-----------------------------MDWEFKISVLYDIAKGMSYLHSSKTE-----VHGRLKSTNCVVDSRMV-----------VKITDFG-----
                             .. . ..   ..||.||.|||| . |     ||. |   || |....|           .||.|||     
DLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQG

---CNSILPPKKDL-----------------------------------WTAPEHLR---------QANISQKGDVYSYGI
       .....|                                    |.||| |.             . | ||.|.|.
SGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV
Kinase HSER.AA Dicty4 562-669 31 4.1e-16 50.39 In-house 82-206 (277) Show / Hide 
Range on Protein: 562-669
Range on HMM: 82-206/277
Sequence Identity: 31% (39 aa)

EYCERGSLREVLND-TISYPDGTFMDWEFKIS---VLYDIAKGMSYLHSSKTE-VHGRLKSTNCVVDSRMVVKITDFGCNS-ILPPK--KD---------
||. .|.| ..|.|      . . .||.  ..      |.|.|| .||.. .  .|  ||| |  ||  ..||..|||    . . .  ||         
EYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTP

LWTAPEHLRQANISQKGDVYSYGII
.|.||| ..     .| ||||.||.
CWMAPEVMMHQPYNEKADVYSFGIV
Kinase HSER.AA Dicty5 543-634 34 1.7e-14 46.32 In-house 59-149 (260) Show / Hide 
Range on Protein: 543-634
Range on HMM: 59-149/260
Sequence Identity: 34% (32 aa)

NLTKFYGTVKLDTMI-FGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFG
|....||  . ..   | | ||| .|||.. ||| .    |  . .  ...   |||..| .|| |.  .|  ||| |  .  .  .|| |||
NFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLND-QRKTTGQPIAYFQQLHMAIDIAQSMRHLH-SMNIIHRDLKSMNFLITENWKIKIIDFG
Kinase HSER.AA MLK 560-634 32 2.1e-14 46.47 In-house 88-178 (291) Show / Hide 
Range on Protein: 560-634
Range on HMM: 88-178/291
Sequence Identity: 32% (30 aa)

VIEYCERGSLREVLNDTISYPDGTF--------MDWEFKISVLYDIAKGMSYLHSSKTE--VHGRLKSTNCVVDS------RMVVKITDFG
| |||| ||| .||..  | ...          .| .....  ...|.||.|||| .    .|  ||| | ..|        ...||.|||
VMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFG
TyrKc HSER.AA TyrKc 494-745 21 2.5e-13 -7.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 494-745
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

DKRRDTIQR-----LRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQI--DYYNLTKFYGTVKLD-------TMIFGVIEYCERGSLREVLNDTISY
 .  ... .      ......   |  | ||..     |    |.. . ..  .  |. ..|| .  .         .. | ||.. |.|.. | ..   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

PDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFG-------C-------NSILP----PKKDL----WTAPEHLRQANI
       .. ..|  ..||.||.|||| .  .|  |   || |... .|||.|||                 . .     .|..    |.||| ..    
-----LCMKDLLSFCWQIACGMEYLHSKNC-IHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SQKGDVYSYGIIAQEIILRKETFYTLSCR--DRNEKIFRVENSNGMKPFRPDLFLETAEE-----KELEVYLLVKNCWEEDPEKRPDFKKIETTL
. | ||.|.|.   ||  . .. |         |. ...   . .. |  |.       .        |.| . | ||.||||.|| |. |   .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-----PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
S_TKc HSER.AA S_TKc 500-752 20 3.4e-12 2.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 500-752
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)

IQRLR-------------QCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCER--GSLREVLNDTISYPDGTF
 . ||             . | ....| .| .|       |. . |.. | . .  |. |.|..    . .. | |||.   |.|.... .  . . .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDL-----WTAPEHLRQANISQ-KGDVYSYGIIAQEIILRKE
..     ...| |.... |.||    .|  ||  |  .|.  ..||.|||   .|   . .     . ||| |     .  | |..| |.|  | . .. 
FPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP

TFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIET--TLAKIFGLF
 |.        ...|..                       |.  ....|.. ||||||   .. .   ..|.   |
PFP------QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HSER.AA Pkinase 543-741 21 9.3e-12 42.65 Pfam 61-287 (293) Show / Hide 
Range on Protein: 543-741
Range on HMM: 61-287/293
Sequence Identity: 21% (51 aa)

NLTKFYGTVKLDTMIFGVIEYCERG----SLREVLNDTISYPDGTFM--DWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVV----KITD
|  ..|...  .. |  | |||| |    .| ...       ... .  ...  ....| |..|. |.|| .  .|  ||. |. .|.....    ||.|
NIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST----WRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICD

FGC-----NSILPPKKDL-----WTAPEHLR-QANISQKGDVYSYGIIAQEIILRKETFYTL----SCRDRNEKIFRVENSNGMKPFRPDLFLETAEE--
||.     .   .  ...     . ||| .| .  ...| |..|.|.|  | ....  |.      . .| ...|.|.    ...|.. | . .  .   
FGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRI----MGPPLHFDWPWWCSISYF

-------------KELEVYLLVKNCWEEDPEKRPDFKKI
              . |   ..|.|.. ||.||| .. |
FFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI
Kinase HSER.AA DRK 560-634 40 1.3e-11 35.68 In-house 75-145 (258) Show / Hide 
Range on Protein: 560-634
Range on HMM: 75-145/258
Sequence Identity: 40% (31 aa)

VIEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEV-HGRLKSTNCVVDSRMVVKITDFG
. ||  ||||  .| .. |.      |||   ..   |.|||| |||..   . |  ||| |  ||    ||. |||
CMEYMPRGSLYNILHDESIE------MDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFG
Kinase HSER.AA UTK 542-634 32 1.6e-09 28.79 In-house 70-170 (296) Show / Hide 
Range on Protein: 542-634
Range on HMM: 70-170/296
Sequence Identity: 32% (33 aa)

YNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPD--GTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSR-------MVVKITD
.|. ...|..  .  .  |.||.|.|.|| .| .    |.  ... . . ...  .||| ||.|||| .  ||. |   || |..        ||.|| |
PNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGF-VHRDLAARNCLVHMHRMMWHCMMVCKIAD

FG
||
FG
Kinase HSER.AA MLK 723-745 52 6.3e-09 27.23 In-house 269-291 (291) Show / Hide 
Range on Protein: 723-745
Range on HMM: 269-291/291
Sequence Identity: 52% (12 aa)

LVKNCWEEDPEKRPDFKKIETTL
| |.||..||.|||.|. | . |
LMKQCWNQDPHKRPSFRQIVQHL
Kinase HSER.AA TK 714-745 37 7.4e-09 25.02 In-house 455-486 (486) Show / Hide 
Range on Protein: 714-745
Range on HMM: 455-486/486
Sequence Identity: 37% (12 aa)

EEKELEVYLLVKNCWEEDPEKRPDFKKIETTL
.... |.|.| . ||..|||.||.|. .   |
HCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase HSER.AA Pkinase_Tyr 560-634 36 3.6e-08 28.28 Pfam 85-156 (270) Show / Hide 
Range on Protein: 560-634
Range on HMM: 85-156/270
Sequence Identity: 36% (27 aa)

VIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFG
| ||.. |.|.. | .    .|.   . . ...  ..|||||.||.| .  .|  |   || |.. .||||.|||
VMEYMPHGDLLDYLRKHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFG
Kinase HSER.AA UTK 718-745 39 6.5e-08 23.17 In-house 269-296 (296) Show / Hide 
Range on Protein: 718-745
Range on HMM: 269-296/296
Sequence Identity: 39% (11 aa)

LEVYLLVKNCWEEDPEKRPDFKKIETTL
..|| |.. ||. ||..||||. .. ..
HPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase HSER.AA Dicty5 723-749 40 8.5e-08 22.92 In-house 234-260 (260) Show / Hide 
Range on Protein: 723-749
Range on HMM: 234-260/260
Sequence Identity: 40% (11 aa)

LVKNCWEEDPEKRPDFKKIETTLAKIF
|.| || . | .|| ||.|  .. .| 
LIKKCWQQKPHNRPSFKEICKYFESII
Kinase HSER.AA Pkinase_Tyr 719-745 51 2.3e-07 25.59 Pfam 244-270 (270) Show / Hide 
Range on Protein: 719-745
Range on HMM: 244-270/270
Sequence Identity: 51% (14 aa)

EVYLLVKNCWEEDPEKRPDFKKIETTL
|.| | | ||..|||.|| |. |   |
EIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase HSER.AA DRK 646-677 46 7e-06 16.01 In-house 168-199 (258) Show / Hide 
Range on Protein: 646-677
Range on HMM: 168-199/258
Sequence Identity: 46% (15 aa)

WTAPEHLRQANISQKGDVYSYGIIAQEIILRK
||||| ||      | ||||..|.  |.. |.
WTAPEVLRNQRYTEKADVYSFAIVLWECVTRQ
Kinase HSER.AA Dicty4 723-747 37 2.3e-05 14.02 In-house 251-277 (277) Show / Hide 
Range on Protein: 723-747
Range on HMM: 251-277/277
Sequence Identity: 37% (10 aa)

LVKNCWEEDPEKRPDFKKIETT--LAK
|.. ||..||..|| |. |     |  
LIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase HSER.AA DRK 723-747 36 4e-05 13.34 In-house 234-258 (258) Show / Hide 
Range on Protein: 723-747
Range on HMM: 234-258/258
Sequence Identity: 36% (9 aa)

LVKNCWEEDPEKRPDFKKIETTLAK
| . ||.|||  || .  .   |  
LMNDCWNEDPQHRPSMQECLERLEA
Kinase HSER.AA TKL-Unique 723-745 43 6.8e-05 13.41 In-house 268-290 (290) Show / Hide 
Range on Protein: 723-745
Range on HMM: 268-290/290
Sequence Identity: 43% (10 aa)

LVKNCWEEDPEKRPDFKKIETTL
| . ||  ||..|| |  | . |
LIQQCWHHDPSQRPSFDEIIHRL
Kinase HSER.AA Dicty5 659-678 60 0.000709 9.22 In-house 182-201 (260) Show / Hide 
Range on Protein: 659-678
Range on HMM: 182-201/260
Sequence Identity: 60% (12 aa)

QKGDVYSYGIIAQEIILRKE
|| ||||.||.  |.. |||
QKCDVYSFGIVLWEMFTRKE
Kinase HSER.AA UTK 646-668 41 0.001722 7.81 In-house 205-228 (296) Show / Hide 
Range on Protein: 646-668
Range on HMM: 205-228/296
Sequence Identity: 41% (10 aa)

WTAPEHLRQA-NISQKGDVYSYGI
|.||| | ..   ..| ||.|.|.
WMAPEALTHHTRFTTKSDVWSFGV
Kinase HSER.AA MLK 646-669 40 0.015822 4.74 In-house 199-225 (291) Show / Hide 
Range on Protein: 646-669
Range on HMM: 199-225/291
Sequence Identity: 40% (11 aa)

WTAPEHL---RQANISQKGDVYSYGII
| ||| .   |    | | ||.|.|..
WMAPEVIQQFRCEKYSEKCDVWSWGVV
Kinase HSER.AA Pkinase_Tyr 646-668 39 1.037232 3.03 Pfam 180-202 (270) Show / Hide 
Range on Protein: 646-668
Range on HMM: 180-202/270
Sequence Identity: 39% (9 aa)

WTAPEHLRQANISQKGDVYSYGI
|.||| ..    . | ||.|.|.
WMAPECINYGKFTTKSDVWSFGV
CYCc HSER.AA CYCc 788-983 47 3.5e-107 363.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 788-983
Range on HMM: 1-231/231
Sequence Identity: 47% (109 aa)

AERDRADRLNFMLLPRLVVKSLKEKG-FVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHD-----VYKVETIGDAYMVASGL
.|....|||  ..||| | ..||...  |.|..|..|||.|.||||||..|. .|||.||.||||.|. || |.|.|.     .||||||||||||.||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PKRNG-------------------NRHAIDIAKMALEILSFMGTFELEHL----PGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGL
| ||.                    .|| .|| .||.....|.||...|     |. |...|||.|.||...|||||.|||||.||||||.||||||||.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PLRIHVSGSTIAIL------KRTECQFLYEV
| .|||| .|. .|      .|  .||  |.
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc HSER.AA Guanylate_cyc 815-1002 44 2.2e-104 357.88 Pfam 1-214 (214) Show / Hide 
Range on Protein: 815-1002
Range on HMM: 1-214/214
Sequence Identity: 44% (96 aa)

VEPELYEEVTIYFSDIVGFTTICKYST----PMEVVDMLNDIYKSFDHIVDHH--DVYKVETIGDAYMVASGLPKR-----NGNRHAIDIAKMALEILSF
|... |..|||.|.|||||| .| ...    ||..|.||||.|..||...|.|  ..|||.||||.||..||||..     ..  || ..| |||... .
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

MGTFELEHLPGLP-----IWIRIGVHSGPCAAGVVG--IKMPRYCLFGDTVNTASRMESTGLPL--RIHVSGSTIAILKRTEC-QFLY--EVRGETYLKG
....  .|... |     |..|||.|.||. |||.|  ..|||||..|||||.||||||||.|.  .|||| .| ..||. |. || .  . ||| ..||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

RGNE---TTYWLTG
 |..   .||.|.|
KGKMGEMETYFLHG