Gene IKKb (Human)

IKKb

Species: Human
Alias: IKBKB, MGC131801, IKK2, FLJ40509, IKK-beta, Hs.226573, NFKBIKB, Hs.166208, IKKB, IKKb
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 8p11.1-p11.2,

Classification

Group: Other
Family: IKK

Sequence

Name Sequence Type Origin Length Description Download
IKKb.NA RNA Sugen Kinome 4137 None Fasta, JSON
IKKb.AA Protein Sugen Kinome 756 None Fasta, JSON
IKKb.kin_dom Protein Kinase Domain Sugen Kinome 275 None Fasta, JSON

Protein domain

Protein domains of IKKb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IKKb.AA IKK 15-289 41 7e-167 560.7 In-house 1-297 (297) Show / Hide 
Range on Protein: 15-289
Range on HMM: 1-297/297
Sequence Identity: 41% (123 aa)

WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHP-------NVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKY
|||..|||.|.||||..|....||...|.|.|......|.|..||.|...|.||.|.       |.....|..|.|| ......|...||||.||||.||
WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMRCRWVWCREFEWMKRLNHQRQFVWFPNIWCLCDIEEDMQ-WQICKQPVIVMEYCTGGDLYKY

LNQFENCCGLRE-GAILTLLSDIASALRYLH-ENRIIHRDLKPENIVLQ-QGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLE--------Q
||...|||||.| ...|....|.......|| .|.|.|||.||.||..| ..... |.||.|.|||.|.|......||.||..||.|...|        |
LNSPWNCCGLKEGHEFLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGYAREWDDDEMFMSFYGTEEYLHPDMYERAVLRKPHQ

QKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE-----VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRG
..|..||||||||.....|.||..||.|.|||..||.|......     |.|.|.|..||.|..||.||....|.....|..|.|...||.||..|..
KPYCATVDYWSFGVTFYHCATGELPFMPHWQPRRWHEKMKHITTEKPSGVCIGVQEEMNGPVEWSSHLPQYCHLCQIIHEQMEPWCIMMLEWHQDQCW
Kinase IKKb.AA S_TKc 15-312 27 7.3e-63 216.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-312
Range on HMM: 1-231/231
Sequence Identity: 27% (84 aa)

WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQG--GDLRKYLNQFE
.|. . .| |.|| | . .. .||.. |||. .        |. . ||||...  |||.|   || .        |   . |||| |  |||..|. .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRG

N---CCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTV-TVDYWSF
    .... |  .  ..  |..|| |.|...||||||||||| | .       ||.| | |..|      |.|.||. |.|||.|   .|.   .| ||.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALD---D
| . .|...|  ||    |. .   |..                                  . .   .. .| . |..| |        . .||    |
GCILYEMLCGYPPFP---QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPT--------A-EALQDEWD

ILNLKLV
| .   .
IKCHPWF
Kinase IKKb.AA Pkinase 15-222 33 1.3e-49 175.96 Pfam 1-212 (293) Show / Hide 
Range on Protein: 15-222
Range on HMM: 1-212/293
Sequence Identity: 33% (77 aa)

WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL-------EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGG----D
.. ....| |.|| | . |.. ||.. |.|    ... |... |..       |||||.|| |||.|  .|. |       .| . . ||||.||    |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK----IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMD

LRKYLNQFENCCGL--REGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQR---LIHKIIDLGYAKE--LDQGSLCTSFVGTLQYLAPELLE-
|  |.   .. ...   |  .   .  |...| |.|...||||||||||| . .  .    .  ||.| | ||   .  .| .|.|.||. |.|||..  
LFDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV--KICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG

QQKYTVTVDYWSFGTLAFECITGFRPF
.|.|.  || ||.| . .| ..|  ||
GQYYGPKVDMWSCGCILYEMLCGRPPF
Kinase IKKb.AA Ciliate-E2 15-257 21 4.1e-47 159.76 In-house 1-309 (365) Show / Hide 
Range on Protein: 15-257
Range on HMM: 1-309/365
Sequence Identity: 21% (74 aa)

WEMKERLGTGGFGNVIRWHNQETGEQIAIK-------------------QCRQELSPRNRERWCLEIQIMR----------------RLTHPNVVAARDV
 .  . .|.|.|| | .  . ....|.|||                        ..... | .  ||.|||                .| |||..   ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

PE--GMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCC--------GLREGAILTLLSDIAS---------------ALRYLHENR-IIHRDLKPENIVL
 .    .|.       | |||||||||..|....  ..         . |  |...   |..               ||.|||..  |||||.|||||..
FQEKDDNNIY------LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF

QQGEQRLIHKIIDLGYAKELDQG--------------------------------SLCTSFVGTLQYLAPELLEQQK---------YTVTVDYWSFGTLA
         ||||.|..|..|.                                  .  ...||. |.||| |. .|         |.  .|.||.| . 
--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

FECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSS
.|...| .||                        . ... ..|..
YEMLFGKPPF----------------------QQQIKQCKIDFPC
Kinase IKKb.AA Ciliate-E2-Unclassified 15-222 22 6.2e-43 146.76 In-house 1-270 (352) Show / Hide 
Range on Protein: 15-222
Range on HMM: 1-270/352
Sequence Identity: 22% (62 aa)

WEMKERLGTGGFGNVIRWHNQETGEQI--------AIKQCRQELSPRNRERWCLEIQIMRR----------------LTHPNVVAARDVPEGMQNLAPND
 .. . .|.|||| | .  . ... |.        .... ..     . | .  .......                | ||. .  ... .  |.    .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMF-YCFQD---KQ

LPLLAMEYCQGGDLRKYLNQFEN--------------CCGLREGAIL-----TLLSDIASALRYLHEN-RIIHRDLKPENIVLQQGEQRLIHKIIDLGYA
 . . ||||.||||..|......               . . | ...     ...  | ..| |||..  |||||.|||||..... ...  ||||.| .
NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS

KELDQG----------------SLCTSFVGTLQYL----APELLEQQKYT----VTVDYWSFGTLAFECITGFRPF
|...|                  ....|.||..|.    |||.|..|.|       .|.||.| ...|...| .||
KKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPF
Kinase IKKb.AA CAMK 20-222 21 1.1e-42 134.97 In-house 1-334 (425) Show / Hide 
Range on Protein: 20-222
Range on HMM: 1-334/425
Sequence Identity: 21% (73 aa)

RLGTGGFGNVIRWHNQETG------------EQIAIKQ--CRQELS-------------------------PRNRERWCLEIQIMRR-------LTHPNV
 ||.|.|| | .  . .|.            .. |||    ..  .                         |..|..   ||.||..       | |||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VAARDVPEGMQNLAPNDLPL-----------------LAM---EYCQGG----DLRKYLNQFENC------------CGLREGAILTLLSDIASALRYLH
.   .| | ... . |                     . |   |||.||    ||  |. . ...              . |    ..   |.||..|.|
IKLYEVYEDPHYFK-N---TNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH

ENRIIHRDLKPENIVLQQGE--------------QRLIHKIIDLGYAKELDQ------------------------GSLCTSFVGTLQYLA-PELLEQ--
.. |.||||||||| |.. .              ..   |||| | |...|.                        | ... |.||. | | ||.|..  
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG

------------QKYTVTVDYWSFGTLAFECITGFRPF
            . |.  .| || | . . . .|. ||
HCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF
Kinase IKKb.AA CAMK-Unique 15-225 21 8e-41 132.37 In-house 1-296 (363) Show / Hide 
Range on Protein: 15-225
Range on HMM: 1-296/363
Sequence Identity: 21% (64 aa)

WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERW-------------------CLEIQIMRRLTHPNVVAARDV----PEGMQN------
..| . .|.|.|| |.. ...|||   |.|  . .   ...                        |.||.... ||| .   |.     .  ..      
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

-LAPNDLP--LLAMEYCQGGDLRKYLNQ-FE----------------NCCGLRE--GAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQ-----
   |  ||   . ||||||||| ..... .|                  . . |    ....   ..||. |.|.. |.|||||.|||...  ..     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------RLIHKIIDLGYAKELDQGSLCT---SFVGTLQYLAP--------------ELLEQQKYTVTV----DYWSFGTLAFECITGFRPFLPN
        ..  |..| | ......   |.   ...||. |.||              |....|.|   .    | || | .... ..|  || ..
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCE
Kinase IKKb.AA ULK 94-222 30 1.8e-38 134.14 In-house 94-252 (324) Show / Hide 
Range on Protein: 94-222
Range on HMM: 94-252/324
Sequence Identity: 30% (49 aa)

LAMEYCQGGDLRKYLNQFENC------CGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQR---------LIHKIIDLGYAKELDQG--
. ||||.||||..|...  ..        | |  ..  . .|......||.. |||||.||.|| .  | .           . || | | || .| .  
IIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNM

--SLCTSFV------GTLQYLAPELLE----QQKYT-VTVDYWSFGTLAFECITGFRPF
   .|...|      ||  | ||..|.    |..|.   .| ||.|.. .|...|  ||
EQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPF
Kinase IKKb.AA ULK 96-222 30 4.8e-38 130.42 In-house 99-256 (329) Show / Hide 
Range on Protein: 96-222
Range on HMM: 99-256/329
Sequence Identity: 30% (48 aa)

MEYCQGGDLRKYLNQFENC-------CGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQR---------LIHKIIDLGYAKELDQG---
||||.||||..|...  ..         | |  ..  . .|......||...|||||.||.|| .  | .           . || | | || .| .   
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

-SLCTSFV------GTLQYLAPELLE----QQKYT-VTVDYWSFGTLAFECITGFRPF
  . ...|      ||  | ||..|.    |..|.  ..| ||.|.. .|...|  ||
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPF
Kinase IKKb.AA RSK 96-222 37 1.9e-34 120.77 In-house 80-212 (278) Show / Hide 
Range on Protein: 96-222
Range on HMM: 80-212/278
Sequence Identity: 37% (50 aa)

MEYCQGGDLRKYLNQFEN-CCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGE-QRLIHKIIDLGYAKE--LDQGSLCTSFVGTLQYLAP
|||| ||.| . | . .   | . |      .. |..|...||.  |||||||||||.. . . .. | |..| | .|.  .|....  .|..|..|.||
MEYCRGGELFTHLQKEKHFGC-FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHI-KLTDFGFCKQFRCDHNQWTMTFCYTIEYMAP

ELLE---QQK-YTVTVDYWSFGTLAFECITGFRPF
|.|    ||. ..  .|.||.| | .|  ||..||
EMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPF
Kinase IKKb.AA CAMKL 94-222 33 3.3e-32 99.95 In-house 98-236 (297) Show / Hide 
Range on Protein: 94-222
Range on HMM: 98-236/297
Sequence Identity: 33% (47 aa)

LAMEYCQGGD--LRKYLNQFENCC-GLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQ-QGEQRLIHKIIDLGYAKELD-Q----GSLCTSFVG
| ||||.||.  |  |. . ...   . |.    .   | ||. |.|...|.|||.||||| |  .| .    |||| | . . . .    | ... | |
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCG

TLQYLAPELLEQ--QKYT-VTVDYWSFGTLAFECITGFRPF
.. | |||...   ..|    || || | . .  ..|  ||
SPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPF
Kinase IKKb.AA STE 94-222 28 1e-28 98.6 In-house 114-268 (359) Show / Hide 
Range on Protein: 94-222
Range on HMM: 114-268/359
Sequence Identity: 28% (46 aa)

LAMEYCQGGDLRKYLNQFENC-CGLR----------EGAILTLLSDIASA-LRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQ------
..|||. || |.. ...   | ..|           |  | . . .|  . | |||...|||||.|| || |         |..| | .. |..      
ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQ

-----------GSLCTSFVGTLQYLAPELLEQ------QKYTVTVDYWSFGTLAFECITGFRPF
           .. ...||||  . ||| ..|      ..|.. .| ||.| .. | .||  |.
SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase IKKb.AA Pkinase_Tyr 15-146 27 2.6e-16 55.85 Pfam 1-137 (270) Show / Hide 
Range on Protein: 15-146
Range on HMM: 1-137/270
Sequence Identity: 27% (40 aa)

WEMKERLGTGGFGNVIR--WH--NQETGEQIAIKQCRQELSPRN--RERWCLEIQIMRRL-THPNVVAARDVPE-GMQ-NLAPNDLPLLAMEYCQGGDLR
 .. . || | ||.| .  |.   ..|. . |.| ...  ....  ||    |..||. |  |||.|    |     . |      ... |||...|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHGDLL

KYLNQF---ENCCGLREGAILTLLSDIASALRYLHENRIIHRDL
.|| .    ..   . .  .|    .||... ||.....|||||
DYLRKHREDKQPLTMKD--LLQMCWQIAKGMEYLESKNCIHRDL
Kinase IKKb.AA TyrKc 15-307 20 5.7e-14 3.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-307
Range on HMM: 1-280/280
Sequence Identity: 20% (67 aa)

WEMKERLGTGGFGNVIR--WHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRL--THPNVVAARDVPEGMQNLAPN---DLPLLAMEYCQGGDLRKY
 .... || | || | .  |      .| |.| .. .     ||  . |..||..|   |||.|.   |    .        . ... |||. .|||..|
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDY

L-NQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQG-------SLCTS-------FVGTLQYLAPE
| .  ..   |     |    .||.  .|||....|||||   |. .  .    . || | | ..... .       .  ..       ..  .  .|||
LRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

LLEQQKYTVTVDYWSFGTLAFECITGFRPFLPN-----WQPVQWHSKVRQKSEVDIVVS----EDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLM-
 .   |.|   | |||| . .|  |   .  |.       . . . .|.|    ..  .                        .   .  ..  |.|.. 
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------F--VCCPDEMYQIMKQC

--WHPRQRGTDPTYGPNGCFKALDDIL
    | .| |         |... ...
WHEDPEDRPT---------FSEIHECF
Kinase IKKb.AA CAMKL 15-74 26 5.5e-11 31.14 In-house 1-78 (297) Show / Hide 
Range on Protein: 15-74
Range on HMM: 1-78/297
Sequence Identity: 26% (21 aa)

WEMKERLGTGGFGNVIRWHN-QETGEQIAIKQCRQELSPRNRERWCL--------------EIQIMRRLT---HPNVV
... . ||.|.|| |   .. . |||. |||    .    .   ..               |||||..|    |||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNII
Kinase IKKb.AA ULK 15-74 28 6.1e-11 34.51 In-house 1-81 (329) Show / Hide 
Range on Protein: 15-74
Range on HMM: 1-81/329
Sequence Identity: 28% (23 aa)

WEMKERLGTGGFGNVIRWHNQET----GEQIAIKQ-CRQELSPRNRER--------WCLEIQIMRRLT--------HPNVV
......|| | || | .  |..|    .|..|.|. ..|...  | |.         . ||.||..|         |||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIV
Kinase IKKb.AA ULK 15-74 26 7.4e-10 31.22 In-house 1-78 (324) Show / Hide 
Range on Protein: 15-74
Range on HMM: 1-78/324
Sequence Identity: 26% (21 aa)

WEMKERLGTGGFG-NVIRWHNQET---GEQIAIKQCR---QELSPRNRE------RWCLEIQIMRRLT---HPN--VV
......|| | ||  | .  |..|   ....|.|.     .  .. ..|        . |||||. |    |||  .|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIV
Kinase IKKb.AA STE 15-74 25 1.2e-08 26.84 In-house 1-93 (359) Show / Hide 
Range on Protein: 15-74
Range on HMM: 1-93/359
Sequence Identity: 25% (24 aa)

WEMKERLGTGGFGNVIRWHNQ------ETGEQ---------IAIKQCR--QELS--------------PRNRERWCLEIQIMRRLT--HPNVV
||  |..| |.|| | .  |       .|||.         .|||| .  .. .              . ....   ||.||...   |||.|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIV
Kinase IKKb.AA RSK 18-74 28 0.002608 8.39 In-house 1-64 (278) Show / Hide 
Range on Protein: 18-74
Range on HMM: 1-64/278
Sequence Identity: 28% (18 aa)

KERLGTGGFGNVIRWHNQ---ETGEQIAIKQCRQ-ELSPRNR-ERWCL-EIQIMRRLT-HPNVV
 . ||.||.| |   .      || . | |. .. .. .|..  | .. |..|. | . ||..|
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIV
Kinase IKKb.AA Pkinase_Tyr 189-211 47 0.136772 6.01 Pfam 181-203 (270) Show / Hide 
Range on Protein: 189-211
Range on HMM: 181-203/270
Sequence Identity: 47% (11 aa)

LAPELLEQQKYTVTVDYWSFGTL
.||| .   |.|.  | |||| |
MAPECINYGKFTTKSDVWSFGVL
Ubiquitin IKKb.AA ubiquitin 316-354 34 0.00022 19.38 Pfam 1-41 (73) Show / Hide 
Range on Protein: 316-354
Range on HMM: 1-41/73
Sequence Identity: 34% (14 aa)

NMVTGT--IHTYPVTEDESLQSLKARIQQDTGIPEEDQELL
 . .|   ..|. | .|..   ||..||| .||| . | |.
KTLDGKGSTFTFEVDPDDTVEQLKQKIQQKQGIPPDQQRLI
Kinase IKKb.AA IKKbetaNEMObind 705-742 63 9.2e-34 81.24 Pfam 1-38 (38) Show / Hide 
Range on Protein: 705-742
Range on HMM: 1-38/38
Sequence Identity: 63% (24 aa)

SEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWL
||.|..|.||.|| ||...|||..|||||...||||||
SEDLIEENHNYCTQLESMMQDTMKEQDQSLMSLDWSWL
Kinase IKKb.AA IKK 695-728 17 0.103472 1.78 In-house 264-297 (297) Show / Hide 
Range on Protein: 695-728
Range on HMM: 264-297/297
Sequence Identity: 17% (6 aa)

SNSLPEPAKKSEELVAEAHNLCTLLENAIQDTVR
| .||....... ....  ..| .. .. ||  .
SSHLPQYCHLCQIIHEQMEPWCIMMLEWHQDQCW