Gene IRAK1 (Human)

IRAK1

Species: Human
Alias: IRAK, IRAK1, pelle
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: Xq28,

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
IRAK1.NA RNA Sugen Kinome 3590 None Fasta, JSON
IRAK1.AA Protein Sugen Kinome 712 None Fasta, JSON
IRAK1.kin_dom Protein Kinase Domain Sugen Kinome 310 None Fasta, JSON

Protein domain

Protein domains of IRAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Death IRAK1.AA Death 28-103 20 1.7e-14 50.94 Pfam 1-87 (87) Show / Hide 
Range on Protein: 28-103
Range on HMM: 1-87/87
Sequence Identity: 20% (18 aa)

CRFYKVM--DALEPADWCQFAALIVRDQTELRLCER-SG-----QRTASVLWPWINR---NARVADLVHILTHLQLLRARDIITAWH
.......  |.. ..||...| ..  ...|.. .|.         .| . || |..|   || |..|. .|..... .....|..| 
QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHDQNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKIQSWL
Kinase IRAK1.AA IRAK 212-518 51 1.2e-202 679.53 In-house 1-317 (317) Show / Hide 
Range on Protein: 212-518
Range on HMM: 1-317/317
Sequence Identity: 51% (165 aa)

FSEELKIGEGGFGCVYRAVMRNTV--YAVKRLKENADLEWTAVKQSFLT---EVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQA
|.....|||||||||||....||   ||||.|||.||..|. ..|.|..   |.....|.||||||...|||......||||...|||||||||.||...
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

CPP--LSWPQRLDILLGTARAIQFLHQDSP--SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIK--TGR
|||  |||.||..|..|||..||||||..|  ..|||||||.|.|||...|||..||||.||...|... .|......|..||||..|.|.|.|.  .|.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCC
|...||..|||.|.||.|.|.|||........|||||.||..||.|. |.|.||||..|.|.||||||..||||.|..|.|..||||.... . |.||||
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGH-LDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCC

LHRRAKRRPPMTQVYERL
.|.||.||..|..|...|
GHHRANRRCDMAWVMQQL
Kinase IRAK1.AA TKL 218-518 22 6.6e-76 258.48 In-house 1-364 (364) Show / Hide 
Range on Protein: 218-518
Range on HMM: 1-364/364
Sequence Identity: 22% (88 aa)

IGEGGFGCVYRAVMRN----------TVYAVKRLKENADLEWTA-----------------------VKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGF-
||.||||.||... |.          .. |||..|.. | |.|                         .. .  |. ..||.|||||| | ||| .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDS------PSLIHGDIKSSNVLLDERLT------------
            .|.|. . |.|||...||          |.||... |..||....||..       | .|| |.||.|.|.|| .|            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PKLGDFGLARFSRFAGSSPSQSSMVA----------RTQTVRGTLAYLPEEYIK----------------TGRLAVDTDTFSFGVVVLETLAGQRAVK
  .|..||||.||    |..  .....           .| |..||..... | ..                 .     .| .|||.|  | |...|  .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

THGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERL
 .. .. .. | . .|.. ..|.... . ..                    |. . . ...|    .. .|. .| .  .. || .... .||
DYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQN--------------HH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK1.AA MLK 212-364 27 8.9e-37 125.15 In-house 1-182 (291) Show / Hide 
Range on Protein: 212-364
Range on HMM: 1-182/291
Sequence Identity: 27% (51 aa)

FSEELKIGEGGFGCVYRAVMRNTV-----YAVKRLKENADLEWTAV---KQSFLTEVEQLSRFRHPN----IVDFAGYCAQNGF-YCLVYGFLPNGSLED
. .. .||.|.|| |.....||.       |||| . ... .       .. | .|...|....|||    |. | | |.|..  .|.|  ....||| .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

RLHCQTQACP----------PLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDE------RLTPKLGDFGLARF
 || ..                .  . ... |  ||....||.. |  .|| |.||.|.|.||       .| |  |||..|.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRD
Kinase IRAK1.AA TKL-Unique 217-365 34 6.3e-34 117.08 In-house 4-167 (290) Show / Hide 
Range on Protein: 217-365
Range on HMM: 4-167/290
Sequence Identity: 34% (57 aa)

KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFR-HPNIVDFAGYCA----QNGFYCLVYGFLPNGSLEDRLH------CQTQ
||||||.| ||... | . .|.|....|.|.. . ..| |  ||  ..... ||||| . |||.    ... .|.|  ..| ||| | ||          
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNE-MMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

ACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDER-----LTPKLGDFGLARFS
   .|.. ||... .  |..  .||  .|  ||.|.||||.|.|..     .  |. ||||..|.
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFN
Kinase IRAK1.AA Pkinase 212-421 24 3.9e-33 118.24 Pfam 1-209 (293) Show / Hide 
Range on Protein: 212-421
Range on HMM: 1-209/293
Sequence Identity: 24% (55 aa)

FSEELKIGEGGFGCVYRAVMRNTV--YAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNG----SLEDRLHCQTQ
.  . |||.|.|||||... ..|   .|||..|   . .|  .    |.|.. . |..||||| . ...  .. ...|  ....|    .| |...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

ACPPL--SWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTP----KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIK-T
.  ..  |. .  .... ..|.....|.   . || |.|..|.|.|.. ..    |..|||||.. .              ..|. ||. |.. | |.  
RHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPEVIRGG

GRLAVDTDTFSFGVVVLETLAGQ
       | .|.|... | | |.
QYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK1.AA TK 212-366 16 1.2e-29 95.94 In-house 1-307 (486) Show / Hide 
Range on Protein: 212-366
Range on HMM: 1-307/486
Sequence Identity: 16% (51 aa)

FSEELKIGEGGFG---CVYRAVMRN---------------------------TVYAVKRLKENADLEWTAVKQ-------------SFLTEVEQLS--RF
   . |.||| ||    ||.. .|.                           |  ||| ||| .. . .. ..             ... | ....   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNIVDFAGYCAQN------------GFYCLVYGFLPNGS----LEDRLH-------------------------------------------------
.||||| . |.| |.            . ...|  . |.|.    | | |.                                                 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------CQTQACPP-----LSWPQRLDILLGTARAIQFLHQDSP----SLIHGDIKSSNVLLDERLT-----------PKLGDFGLA
                   ...|.| .     |. .|.| . .  |.. ..||.        ..|.|.   |.|..|...            |..||||.
DDDLIKDHPPPLTTKDLLQMAWQWC-LTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

R-----FSR
|      .|
RQGSGVLAR
Kinase IRAK1.AA RIPK 218-420 26 1.8e-29 97.57 In-house 1-224 (290) Show / Hide 
Range on Protein: 218-420
Range on HMM: 1-224/290
Sequence Identity: 26% (59 aa)

IGEGGFGCVYRAV--MRNTVYAVKRLK-ENADLE-WTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQN------GFYCLVYGFLPNGSLEDRLHCQTQ-A
.| |||| |..|.    ....|.|  .  . . .    ...  . |.. . . |. .||   | | .       . | .|  . .||||.. || ...  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

CPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSP---SQSSMVARTQTVR-GTLAYLPEEYIKTGRLA
 .|. || |  ..  .... ..||   | .|| | | .|.|.|  .  |. ||||| . .   |      |      .   | |||.|.| | . |.  .
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKK

V------DTDTFSFGVVVLETLAG
         |  ||..|. | |..
PIKVVTPKYDVYSFAIVMWEVLTQ
Kinase IRAK1.AA LISK 217-363 35 2.9e-29 92.07 In-house 1-153 (296) Show / Hide 
Range on Protein: 217-363
Range on HMM: 1-153/296
Sequence Identity: 35% (55 aa)

KIGEGGFGCVYRAVMR--NTVYAVKRLKE-NADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQ-NGFYCLVYGFLPNGSLEDRLHCQTQACPPLSW
.||.|.||.||.   |  ..| |.| ...   |... .    .| ||. . ..|||||| | | | . .| . .|  .   | |...|.   .   ||.|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

PQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDER----LTPKLGDFGLAR
|||..| |. |..  .||  |   || | || |.|..|.     . |..|||.||
PQRVKIALDIACGMSYLH--SMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFAR
Kinase IRAK1.AA TKL-ciliate2 212-363 33 5.1e-27 86.77 In-house 1-167 (273) Show / Hide 
Range on Protein: 212-363
Range on HMM: 1-167/273
Sequence Identity: 33% (58 aa)

FSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLS
   . || |||.| .|.|  | .| |||. |   | . . .   |. | . .   |||||| | | | .   .|..  .   |||   |  | |   .|.
LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQQQIRD--FVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLL--QNQDV-RLT

WPQRLDILLGTARAIQFLHQDSPSLIHGDIK--------------------SSNVLLDERLTPKLGDFGLAR
|  |  | |  || . .||   | .|| |.|                    | |||.|. .  || |||  |
WEDRRRIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTR
Kinase IRAK1.AA S_TKc 212-525 17 8.8e-26 92.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 212-525
Range on HMM: 1-231/231
Sequence Identity: 17% (57 aa)

FSEELKIGEGGFGCVYRAVMRN--TVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPN--GSLEDRLHCQTQAC
.    |||.|.||.||... ..   ..|.|..|           .... |.. |.. .||||| . ...   .....|  ....  |.| |... .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

PP--LSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAV-D
..  ..  .   ..  ...|....|.     || |.| .|.||||  . |..||||||.                  |. ||. |.. | .         
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL---GYGKCK

TDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRR
 |  |.|... | |.|.          . .| ..                                                      . .. . ||.. 
CDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------------------------------------------------SPEAKDFIRKCLQKD

AKRRPPMTQVYE--RLEKLQAVV
 ..||   .. .  .. |.   .
PEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK1.AA Ciliate-E2 212-422 18 2.4e-24 80.47 In-house 1-294 (365) Show / Hide 
Range on Protein: 212-422
Range on HMM: 1-294/365
Sequence Identity: 18% (55 aa)

FSEELKIGEGGFGCVYRAVMRNT-------------------------VYAVKRLKENADLEWTAVKQSFL---------TEVEQLSRFRHPNIVDFAGY
.    |||.|.||.||..  ...                          ||.|..|.|   ..  ... .           | . |..  ||||. .  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CA--QNGFYCLVYGFLPNGSLED--------RLHCQTQACPPLSWPQRLDILLGTAR---------------AIQFLHQDSPSLIHGDIKSSNVLLDERL
    ..  . ||  ..  |.|.|        |.|.....  .... ....|    ..               |...||.  .  || ||| .|.|.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF----

TPKLGDFGLARFS----------RFAGSSPSQSSMVARTQT-------------VRGTLAYLPEEYIKTGRLA---------VDTDTFSFGVVVLETLAG
 .|. ||||...           . ..  .  ...  ||..             . ||. |.. | .. .               | .|.||.  | | |
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

QR
..
KP
Kinase IRAK1.AA LRRK 212-365 24 1.5e-23 80.14 In-house 1-230 (351) Show / Hide 
Range on Protein: 212-365
Range on HMM: 1-230/351
Sequence Identity: 24% (57 aa)

FSEELKIGEGGFG-CVYRAVMRN-----TVYAVKRLKE---------NADLEWTAVKQSFLT--------------------------------------
. .| .||.||||  |||| .|.        . |.|.           .  .|.|.|.  ..                                      
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

------EVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQAC-----PPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVL
      ||  .|...|||||.  |.| .   .|.|  ..|.|.| ..||   |       . .||  .| | |  |.....||  .|..|| | || |.|
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

L---D---------ERLTPKLGDFGLAR--FS
|   .         .  . |..|||. |  ..
LWSSPQNHSPNYPNAHVCAKIADFGISRMFQC
Kinase IRAK1.AA Pkinase_Tyr 212-363 30 2.4e-22 76.31 Pfam 1-159 (270) Show / Hide 
Range on Protein: 212-363
Range on HMM: 1-159/270
Sequence Identity: 30% (50 aa)

FSEELKIGEGGFGCVYRAVMR------NTVYAVKRLKENADLE-WTAVKQSFLTEVEQLSRF-RHPNIVDFAGYCA-QNGF--YCLVYGFLPNGSLEDRL
 .   |.||| || ||.....      ..  ||| |||.|. |     ...|. |.. .. . .||||| . | |  | .   ...|  . |.|.| | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLAR
. .    .||. .. |.. .  |.. ..|..    .|| |.   |.|..| .. | .||||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLAR
Kinase IRAK1.AA TyrKc 212-518 21 1.4e-16 45.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 212-518
Range on HMM: 1-280/280
Sequence Identity: 21% (71 aa)

FSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRF--RHPNIVDFAGYCAQN-------GFYCLVYGFLPNGSLEDRLHC
 . . |.||| || ||..... .  ||| |||.|       .. |. | . ....  .||||| . |.| |        . ...|  . |.|.| |.|. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFA---GSSPSQSSMVART-QTVR--GTLAYLPEEYI
       |.... |.. .  |.  ..||.    .|| |.   |.|..|..| | .||||.|.       |   |..  .... .  .    .  .. | |
HRPK---LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--ESKDYYRKKEHKGGKTMLPIRWMAPECI

KTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLK-----DLVEEEAEEAGVALRSTQSTL----QAGLAADAWAAPIAMQIYKKHLDPRPGPCPP
..|.    .| .||||.  | .            . |          .|  |      |  |                                     .
NYGKFTTKSDVWSFGVCMWEIFT--------YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------F-V

ELGLGLGQLACCCLHRRAKRRPPMTQVYERL
.    . |.  .| |. .. || .....|..
CCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK1.AA TK 495-518 33 0.001216 7.23 In-house 463-486 (486) Show / Hide 
Range on Protein: 495-518
Range on HMM: 463-486/486
Sequence Identity: 33% (8 aa)

QLACCCLHRRAKRRPPMTQVYERL
.| ..| |. ...|| ..|..|.|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK1.AA LRRK 500-520 33 0.094151 1.96 In-house 331-351 (351) Show / Hide 
Range on Protein: 500-520
Range on HMM: 331-351/351
Sequence Identity: 33% (7 aa)

CLHRRAKRRPPMTQVYERLEK
| .   |.|| ..|. .||. 
CWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK1.AA Pkinase_Tyr 500-518 31 0.18955 5.53 Pfam 252-270 (270) Show / Hide 
Range on Protein: 500-518
Range on HMM: 252-270/270
Sequence Identity: 31% (6 aa)

CLHRRAKRRPPMTQVYERL
| |  ...|| .....|.|
CWHYDPEDRPTFSEIHEQL