Gene IRAK3 (Human)

IRAK3

Species: Human
Alias: IRAK3, IRAK-M
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 12q13.3,

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
IRAK3.NA RNA Sugen Kinome 8351 None Fasta, JSON
IRAK3.AA Protein Sugen Kinome 596 None Fasta, JSON
IRAK3.kin_dom Protein Kinase Domain Sugen Kinome 279 None Fasta, JSON

Protein domain

Protein domains of IRAK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Death IRAK3.AA Death 26-106 28 6.5e-20 69.1 Pfam 1-87 (87) Show / Hide 
Range on Protein: 26-106
Range on HMM: 1-87/87
Sequence Identity: 28% (25 aa)

GELCAVL-DSCDGALGWRGLAERLSSSWLDVRHIEKYVDQGK---SGTRELLWSWAQK---NKTIGDLLQVLQEMGHRRAIHLITNYG
 .||..| ....    || ||..|  |. ....|| . ....   | |...|| | |.   | |...|...|..||.|.....|... 
QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHD-QNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKIQSWL
Kinase IRAK3.AA IRAK 165-443 44 1.4e-173 582.92 In-house 1-317 (317) Show / Hide 
Range on Protein: 165-443
Range on HMM: 1-317/317
Sequence Identity: 44% (142 aa)

FHKDFLIGEGEIFEVYRVEIQNLT--YAVKLFKQEKKMQCKKHWKRFLS---ELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVG-D
||||..||||....|||....|.|  ||||..|....|....||.||..   ||.|.....||||..|..|.||....||.||||.||.|.|||.| . .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

TAP--LPWHIRIGILIGISKAIHYLHNVQPC-SVICGSISSANILLDDQFQPKLTDFAMAHFR---SHLEHQSCTINMTSSSSKHLWYMPEEYIR--QGK
..|  |.||.|. |..|....|..||...|| ..|.| |.|||||||..|.||..||....|.   ||.|.|..|..|||   ...||||.|.||  ||.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LSIKTDVYSFGIVIMEVLTGCRVVLDD-PKHIQLRDLLRELMEKRG-LDSCLS----------------------FLDKKVPPCPRNFSAKLFCLAGRCA
|..||||||||||..|||||||.|.|| |.|..|.||..|.||..| ||||.|                      |.|...||||.|........|..|.
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG

ATRAKLRPSMDEVLNTL
..||..|..|..|...|
HHRANRRCDMAWVMQQL
Kinase IRAK3.AA TKL 171-443 20 8.1e-62 211.69 In-house 1-364 (364) Show / Hide 
Range on Protein: 171-443
Range on HMM: 1-364/364
Sequence Identity: 20% (76 aa)

IGEGEIFEVYRVEIQN----------LTYAVKLFKQ------EKKMQC-----------------KKHWKRFLSELEVLLLFHHPNILELAAYFTETEK-
||.|   |||. . ..           . ||| ||.      .|..|.                 ..  ...  |. ... ..||||. . .| .. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQP-----CSVICGSISSANILLDDQFQ-------------
            .|... |. .|.|...|.         || |. . ..|.....|||. .|     . .|   . |.|||.|. ..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKLTDFAMAHFRSHLEHQSCTINM------------TSSSSK-HLWYMPEEYIR----------------QGKLSIKTDVYSFGIVIMEVLTGCRVVLD
 .|..||  . | |. .....| ..            |...   .. .|. | .|                ... | |.||||||||. |.||.||.  |
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

DP-KHIQLR---DLLRELMEKRGLDSCLS------FLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTL
.|   ....   ..  ..  ..||   .       .  | . ... ..   .  |. .| .. .. |||..|.| .|
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK3.AA TK 165-443 13 1.9e-26 85.03 In-house 1-486 (486) Show / Hide 
Range on Protein: 165-443
Range on HMM: 1-486/486
Sequence Identity: 13% (67 aa)

FHKDFLIGEGE---IFEVYRVEIQNL---------------------------TYAVKLFKQEKKMQCKKHWK-------------RFLSELEVLL--LF
 .    .|||.     |||. | ...                           . |||  | .  |. . .               ....|.....  |.
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPNILELAAYFTET------------EKFCLIYPYMRNGT----LFDRLQ-CVGDTAP-----------------------------------------
|||||. | .. |.             | ....  || .|     | | |. | ... .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LPWHIRIGILIGISKAIHYLHNVQPC----SVICGSISSANILLDDQFQ-----------PKLTDFAMA
                               |. | .. .   |...  |||  ..|     .. . .   |.|.... .            |..|| ..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHS-KNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------HFRSHLEHQSCTINMTSSSSKHLW----------------------YMPEEYIR---------QGKLSIKTDVYSFGIVIMEVLTGCRVVLDDP
      . | . ...  .   . . .. .|                      .|. | ..          || ..|.||.|||... |..| ...     
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

KHIQL----RDLLRELMEKRGLDSCLSF-------LDKKVPPCPRNFS--------------AKLFCLAGRCAATRAKLRPSMDEVLNTL
 . |        ..|.||.    . | .        ..  .|.| . .              . .. |  .| .  .. ||....... |
MSNQDVWKDG-DNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK3.AA TKL-Unique 170-372 25 9e-22 73.67 In-house 4-226 (290) Show / Hide 
Range on Protein: 170-372
Range on HMM: 4-226/290
Sequence Identity: 25% (58 aa)

LIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFH-HPNILELAAYFT----ETEKFCLIYPYMRNGTLFDRLQ-------CVG
.||||.  .||...     .|.| |.  .  . ..  . | .|. ..  .| ||||. . .| .       ..|..  |.  |.| | |.          
KIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

DTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQ-----FQPKLTDFAMAHFRSHLEHQSCTINMT-----SSSSKHLWYMPEEYIR
.  .|..  |. . | |... .|||. .|  .| . . | |.|.|       .. |. ||  . |.|       |.|.      ..  . . .|. | .|
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKM--TNNEHKGTRNQTRCGSFRWMAPEVLR

Q--GKLSIKTDVYSFGIVIMEVLTGCR
.   . |.| ||||||||  | .|...
MNFCQYSEKSDVYSFGIVLWEIATRKI
Kinase IRAK3.AA TK-Unique 209-369 21 1.2e-18 60.99 In-house 50-234 (294) Show / Hide 
Range on Protein: 209-369
Range on HMM: 50-234/294
Sequence Identity: 21% (40 aa)

FLSELEVLLLFH-HPNILELAAYFTET-EKFCLIYPYMRNGTLFDRLQCVGDT-----------------------APLPWHIRIGILIGISKAIHYLHN
||.|....     ||||. .  . |.. | ...|..|...|.| . |.  ...                       .|.  .  . ....| ..  ||. 
FLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLAS

VQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIR--QGKL-SIKTDVYSFGIVIMEVLT
 |.. .. . ... |.|| . .. |..|| ||    ....   ...|.|..  .. .|. |...  .|   ..|.||.|||... |..|
-QRKKIVHRDLCARNVLLTEDKVCKICDFGMA---RDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK3.AA Pkinase 165-370 22 1.8e-15 55.8 Pfam 1-208 (293) Show / Hide 
Range on Protein: 165-370
Range on HMM: 1-208/293
Sequence Identity: 22% (50 aa)

FHKDFLIGEGEIFEVYRVEIQNLT--YAVKLFKQEKKMQCKKHWKRFL-SELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNG----TLFDRLQCVG
.|.   ||.|   .||.   ..    .||| .| . .  ..|.  ... ||..... ..||||..|  .|..  . ... .|...|     |||...   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-W

DTAPL--PWHIRIGILIGISKAIHYLHNVQPCSVICGSIS-----SANILLDDQFQP----KLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYI
.  ..  ...  . ..  | ... |.|.         .|      ..|||.|.. ..    |..||  | . . . ..| .   . .    .|||. | |
RHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGT----PWYMAPEVI

R-QGKLSIKTDVYSFGIVIMEVLTG
| . . . | |..|.|... |.|.|
RGGQYYGPKVDMWSCGCILYEMLCG
Kinase IRAK3.AA TyrKc 165-443 18 1.2e-14 14.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 165-443
Range on HMM: 1-280/280
Sequence Identity: 18% (58 aa)

FHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLF--HHPNILELAAYFTET-------EKFCLIYPYMRNGTLFDRLQC
 ...  .|||.  |||. .   .. |||  | ..        . |..|....  .  |||||. | .. |.        |  ...  || .| | |.|. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

VGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSC------TINMTSSSSKHLW------YMPE
 ...  |..   . . . |..   |||      .|   .   |.|...... | .|| ..      .. .       .   .....|.         |. 
HRPK--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLS-----RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKH--IQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRN--------FSAKLFCLAGRCAATRAKLR
| |. || ..|.||.|||... |..| .     ..    .  ..... ... . .            |.| |         ..... .  .| .  .. |
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM------------PQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR

PSMDEVLNTL
|.. |.   .
PTFSEIHECF
Kinase IRAK3.AA S_TKc 165-452 19 1.1e-13 23.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 165-452
Range on HMM: 1-231/231
Sequence Identity: 19% (57 aa)

FHKDFLIGEGEIFEVYRVEIQN--LTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRN--GTLFDRLQCVGDTA
...  .||.|   .||..   .    .|.|  |           .....|...|   |||||  |  .| . ......  |. .  |.|||...  |   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

P---LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSI-KTD
.   .|      ..  | .|. |.|. .   .|   .  .|||||.  . |..|| .| .              ..    .|||. | .   . .  | |
LRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCD

VYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYF
..|.|... | |.|.          |.  ... ..                       |  .  .  .|     . ||.  |.|.  .   .  .|
WWSCGCILYEMLCGYPPFP------QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK3.AA Ciliate-E2-Unclassified 165-370 15 1.7e-12 39.71 In-house 1-266 (352) Show / Hide 
Range on Protein: 165-370
Range on HMM: 1-266/352
Sequence Identity: 15% (43 aa)

FHKDFLIGEGEIFEVYRVEI--QNLT----YAVKLFKQEKKMQCKKHWKRFLSELEVLLL------------------FHHPNILELAAYFTETEKFCLI
...   ||.|   .||...   |..     |. |  .. .| . .|.    ....|.  .                  . ||.|. .  .|. .......
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

YPYMRNGTLFDRLQ---------------------------CVGDTAPLPWHIRI---GILIGISKAIHYLHNVQPCSVICGSISSANILLDDQ---FQP
. |...|.|.. ..                           ..           .    ..  | ... |||  .   .|   |   |||.|..   ...
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKY-----------KKAKFYFAQILQGLEYLHHKN--NIIHRDIKPENILFDNNGKNYYI

KLTDFAMAHFRSHLEHQSCT----------INMTSSSSKHLWYM----PEEYIRQGKLS----IKTDVYSFGIVIMEVLTG
|..||  . .    . .  |           .|... .  . ||    . |.... . .    .| |..|.|... | |.|
KIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFG
Kinase IRAK3.AA RIPK 243-370 35 2e-12 38.6 In-house 83-224 (290) Show / Hide 
Range on Protein: 243-370
Range on HMM: 83-224/290
Sequence Identity: 35% (51 aa)

YMRNGTLFDRLQCVG--DTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFR--SHLEHQSC-TINMTSSSSKH
|| || | . |.        |.||  |  ..  || . .|||. .|  .|      .|||.|  |  |. ||  | ..  ||.    |      |. || 
YMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMNPP-IIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKN

----LWYMPEEYIR--QGKL----SIKTDVYSFGIVIMEVLTG
    | ||| | .|  . |     . | |||||.||. ||||.
RWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQ
Kinase IRAK3.AA TKL-ciliate2 165-286 28 3.7e-10 29.52 In-house 1-118 (273) Show / Hide 
Range on Protein: 165-286
Range on HMM: 1-118/273
Sequence Identity: 28% (35 aa)

FHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPW
   .  | ||    .|.     .. ||| || .   |  .  . |..| . .    ||||       |.   ||.|  |   | |.  ||   .  .| |
LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQ--QQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQN--QDVRLTW

HIRIGILIGISKAIHYLHNVQP
  |  | . | . .||||  .|
EDRRRIALDIARGVHYLHSSNP
Kinase IRAK3.AA UTK 208-285 29 1.1e-08 25.81 In-house 52-138 (296) Show / Hide 
Range on Protein: 208-285
Range on HMM: 52-138/296
Sequence Identity: 29% (26 aa)

RFLSELE---VLLLFH-HPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAP-----LPWHIRIGILIGISKAIHYLHNVQ
.|. |     ..  || |||.| | .. |  | ..... ||.|| | . |.  ..|.|     |  | |..    |. . .|||. .
DFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG
Kinase IRAK3.AA Pkinase_Tyr 203-283 26 1.3e-08 29.84 Pfam 42-129 (270) Show / Hide 
Range on Protein: 203-283
Range on HMM: 42-129/270
Sequence Identity: 26% (23 aa)

KKH--WKRFLSELEVLLLF-HHPNILELAAYFT-ETEK--FCLIYPYMRNGTLFDRLQCV-GDTAPLPWHIRIGILIGISKAIHYLHN
...  .. |..|....  . |||||. | .  | . |    ... .|| .| | | |.    |  ||. .  ... . |.|.  ||..
HEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase IRAK3.AA MLK 171-312 20 3e-08 24.85 In-house 7-177 (291) Show / Hide 
Range on Protein: 171-312
Range on HMM: 7-177/291
Sequence Identity: 20% (36 aa)

IGEGEIFEVYRVEIQNLT-----YAVKLFKQEKKMQCKKH---WKRFLSELEVLLLFHHPN----ILELAAYFTETEK-FCLIYPYMRNGTLFDRL---Q
||.|   .|.. . .| .      ||| .....     .     . |  | . |  . |||    | .. .  ..... ||..  |...| |.. |   .
IGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGAR

CVGDTA--------PLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDD------QFQPKLTDF
  .. |          . .  . .   .....||||. .|  .|   . | |||.|.      . . | .||
SKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDF
Kinase IRAK3.AA MLK 346-370 48 1.1e-05 15.86 In-house 208-232 (291) Show / Hide 
Range on Protein: 346-370
Range on HMM: 208-232/291
Sequence Identity: 48% (12 aa)

IRQGKLSIKTDVYSFGIVIMEVLTG
.| .| |.| ||.|.|.|. |.||.
FRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAK3.AA UTK 339-370 37 1.3e-05 15.16 In-house 205-236 (296) Show / Hide 
Range on Protein: 339-370
Range on HMM: 205-236/296
Sequence Identity: 37% (12 aa)

WYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTG
|. || .. . . ..|.||.|||.| .|..|.
WMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase IRAK3.AA Pkinase_Tyr 346-372 40 2.4e-05 18.73 Pfam 186-212 (270) Show / Hide 
Range on Protein: 346-372
Range on HMM: 186-212/270
Sequence Identity: 40% (11 aa)

IRQGKLSIKTDVYSFGIVIMEVLTGCR
|. || ..|.||.|||... |..| ..
INYGKFTTKSDVWSFGVLMWEIFTYGE
Kinase IRAK3.AA TKL-ciliate2 294-367 32 0.00036 9.17 In-house 145-211 (273) Show / Hide 
Range on Protein: 294-367
Range on HMM: 145-211/273
Sequence Identity: 32% (24 aa)

ISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEV
| | |.|.|| |  |||||     .           ||       |  | | |.      | ||.|..|.. |.
INSLNVLVDDNFRCKLTDFGWTRVKPQDNY------MTNKIGTYQWMAP-EVIKAFYYTEKADVFSYSIILWEI
Kinase IRAK3.AA TKL-ciliate2 408-444 35 0.000385 9.07 In-house 237-273 (273) Show / Hide 
Range on Protein: 408-444
Range on HMM: 237-273/273
Sequence Identity: 35% (13 aa)

PPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLE
|  |.|   ..  |  ||      ||||..|..  ||
PTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase IRAK3.AA TKL-Unique 433-443 54 0.187671 1.11 In-house 280-290 (290) Show / Hide 
Range on Protein: 433-443
Range on HMM: 280-290/290
Sequence Identity: 54% (6 aa)

RPSMDEVLNTL
||| ||... |
RPSFDEIIHRL
Kinase IRAK3.AA MLK 433-443 36 0.286055 0.32 In-house 281-291 (291) Show / Hide 
Range on Protein: 433-443
Range on HMM: 281-291/291
Sequence Identity: 36% (4 aa)

RPSMDEVLNTL
|||.....  |
RPSFRQIVQHL
Kinase IRAK3.AA Pkinase_Tyr 409-443 28 6.074057 0.43 Pfam 236-270 (270) Show / Hide 
Range on Protein: 409-443
Range on HMM: 236-270/270
Sequence Identity: 28% (10 aa)

PCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTL
|||.| ....  |  .| .  .. ||.. |... |
PCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL