Gene IRAK4 (Human)

IRAK4

Species: Human
Alias: REN64, NY-REN-64, LOC51135, IRAK4
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 12q11-q12,

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
IRAK4.NA RNA Sugen Kinome 4303 None Fasta, JSON
IRAK4.AA Protein Sugen Kinome 460 None Fasta, JSON
IRAK4.kin_dom Protein Kinase Domain Sugen Kinome 269 None Fasta, JSON

Protein domain

Protein domains of IRAK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Death IRAK4.AA Death 20-88 22 0.000544 15.66 Pfam 1-71 (87) Show / Hide 
Range on Protein: 20-88
Range on HMM: 1-71/87
Sequence Identity: 22% (18 aa)

RKLSDFI----DPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGK---SPTSELLFDWGTT---NCTVGDLVDLL
.||....    .| . |..||  .        . . .|...|   | ..   |.| ..| .|      | ||..|...|
QKLCRLLDPDHHPGKDWRRLARKL-------GMSDNEIDQIEHD-QNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEAL
Kinase IRAK4.AA IRAK 186-454 44 1.1e-165 556.73 In-house 1-317 (317) Show / Hide 
Range on Protein: 186-454
Range on HMM: 1-317/317
Sequence Identity: 44% (141 aa)

SVGGNKMGEGGFGVVYKGYVNNTT--VAVKKLAAMVDITTEELKQQFDQ---EIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDG-
. ..|..||||||.||.|  .|||  .||||| .|.|....|..|.|.|   |.||...|.|.|.|.|.|........|||| ||||||| |||.|.|| 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-TP-PLSWHMRCKIAQGAANGINFLHENH----HIHRDIKSANILLDEAFTAKISDFGLAR----ASEKFAQTV---MTSRIVGTTAYMAPEALR---GE
 .| |||||.||.|..|.|.||.|||.||    .||.||||||||||. ||.||.||||.|    ||.|..||.   |||...|||.||.||..|   |.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

ITPKSDIYSFGVVLLEIITGL-PAVDEHREPQLLLDIKEEIEDEEK-------------------------TIEDYIDKKMNDADSTSVEAMYSVASQCL
.|.|.|.||||.||||..||. ...|...|...|.|..|||..|..                         ..|..||..|..........|...|..|.
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG

HEKKNKRPDIKKVQQLL
|...|.|.|...|.|.|
HHRANRRCDMAWVMQQL
Kinase IRAK4.AA TKL 192-454 24 8.9e-85 287.95 In-house 1-364 (364) Show / Hide 
Range on Protein: 192-454
Range on HMM: 1-364/364
Sequence Identity: 24% (92 aa)

MGEGGFGVVYKGYVNN----------TTVAVKKLAAMVDITTEE-----------------------LKQQFDQEIKVMAKCQHENLVELLGFSSDGDD-
 |.||||.||||. ..          ..|||||.  . |  ...                       ..... .||..| ...|.|.| ..|.. .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENH--------HIHRDIKSANILLDEAFT-------------
            ||.|. |.|.||||..|          || ||..|...| |.|.|| ..         ||||.||.|||.|| .|             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-AKISDFGLAR-ASEKFAQTVM----------------TSRIVGTTAYMAPEALR-----------------GEITPKSDIYSFGVVLLEIITGLPAVDE
 .||.||||.|  |... .. .                |....||...||||.||                 .| ..|.|.||||.|| ||.|. .  ..
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

HREPQLLLD-------IKEEIEDEEKTIE-----DYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLL
. ... ..        ..   . .  .|       .  | |    ..  . | . . .| ... .|||  ... . |
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK4.AA S_TKc 186-458 25 2.3e-52 181.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 186-458
Range on HMM: 1-231/231
Sequence Identity: 25% (72 aa)

SVGGNKMGEGGFGVVYKGYVNN--TTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPN--GSLLDRLSCLDGTP
   ..| |.|.||.|||.. ..    ||.|..            ... .||... | .|.|.| |...  | |.|..|  |...  |.|.|..    . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

P---LSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITP-KSDIYSFGVVL
.   ..  . .....  .......|... ||||.| .||||||  . ||.||||||           . ..||  ||||| |    .. |.|..|.|..|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCIL

LEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQ-----LLQEMT
 | ..| |  .   ..|.....                         | ||     ..||.   .||| . .. |      . .  
YEMLCGYPPFP---QMQMMFKKIG-----------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase_Tyr IRAK4.AA Pkinase_Tyr 185-382 34 1.4e-47 161.74 Pfam 1-209 (270) Show / Hide 
Range on Protein: 185-382
Range on HMM: 1-209/270
Sequence Identity: 34% (73 aa)

ISVGGNKMGEGGFGVVYKGYVN------NTTVAVKKLAAMVDITTEEL--KQQFDQEIKVMAKC-QHENLVELLGFSS-DGDD--LCLVYVYMPNGSLLD
|. |  | ||| ||.||||. .      ...||||.|      ...|   .. | .|.|.| .  .|.|.| |.|  . .|.   ...|  |||.|.|||
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

RLSCL-DGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQT-VMTSRIVGTTAYMAPEALR-GEITPKSD
 |    .. .||. .. .....  |.| ..|.... ||||.   |.|..| ...||.||||||. ..  .  ....        ||||... |. | |||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

IYSFGVVLLEIIT
..||||.. ||.|
VWSFGVLMWEIFT
Kinase IRAK4.AA STE 186-385 26 5.8e-47 162.35 In-house 1-266 (359) Show / Hide 
Range on Protein: 186-385
Range on HMM: 1-266/359
Sequence Identity: 26% (71 aa)

SVGGNKMGEGGFGVVYKGYVNNTT-----------------VAVKKLA---AM----------VDITTEELKQQFDQEIKVMAKCQ--HENLVELLGFSS
  |  | |.|.||.|||.. ....                 .|.|..                .... .| .||. .|||.| ||.  |.| |. .|   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DG-------DDLCLVYVYMPNGSLLDRLS--CLDGTP---------PLSWHMRCKIAQGAANG-INFLHENHHIHRDIKSANILLDEAFTAKISDFGLAR
..       |.|...  ||..||| | .   .  | |         ... .  ..|..    |  ..||..| ||||||.|||||     .|..|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

-ASEKFA------------QTV-MTSRIVGTTAYMAPEALRGE-------ITPKSDIYSFGVVLLEIITGLP
  ... |             .. ..  .|||  .|||| ....        . |.||.|.| ...| .|| |
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKP
Kinase IRAK4.AA TK 186-454 16 9e-47 154.38 In-house 1-486 (486) Show / Hide 
Range on Protein: 186-454
Range on HMM: 1-486/486
Sequence Identity: 16% (84 aa)

SVGGNKMGEGGFG---VVYKGYVNN---------------------------TTVAVKKLAAMVDITTEELKQ-------------QFDQEIKVMA--KC
 . |.| ||| ||   .|||| ...                           |.|||| | .  . . || ..             .. .|.|.|   ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHENLVELLGFSSDGDD------------LCLVYVYMPNGS----LLDRLS-CLDGTPP-----------------------------------------
.|.|.| |.| ...|.             ...|  |||.|.    |.| |  | ... .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSWHMRCKIAQGAANGINFLHEN------HHIHRDIKSANILLDEAFT-----------AKISDFGLA-
                               |. | .. ... .|.|  .||..      . .|||.   |.|..|  .           .||.||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----RASEKFAQTVMTSRIVGTTAY--------------------------MAPEALR----------GEITPKSDIYSFGVVLLEIIT---GLPA--V
     .| .    .  ...  ..|.                           ||||.|.          |  |.|||..||||.. || |   . ..  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DE------HREPQLLLDIKEEI-------EDEEKTIEDYIDKKMNDA--DSTSV-------------EAMYSVASQCLHEKKNKRPDIKKVQQLL
.       . ..| ...  ..          .       .  .|  .  .  .              |..| .  || |.. ..||. . ... |
SNQDVWKDG-DNQEVMEYLRRGGRLCRSGL-N------EVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK4.AA TKL-Unique 189-383 33 5.7e-46 159.03 In-house 2-224 (290) Show / Hide 
Range on Protein: 189-383
Range on HMM: 2-224/290
Sequence Identity: 33% (76 aa)

GNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQ-HENLVELLGFSS----DGDDLCLVYVYMPNGSLLDRLS---CLD--
.|| ||||.|.||||  . . ||.|...        |..| |  |...| | . |.|.| . |..     .  ..|.|  |.| ||| | |.    .   
WNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

--GTPPLSWHMRCKIAQGAANGINFLHENH--HIHRDIKSANILLDEA-----FTAKISDFGLARASEKFAQTVMT-------SRIVGTTAYMAPEALRG
     .|.. .| |.|. .| | ..|| .    ||||.|| |.|.|..     . .||.||||.. . |  ..  .       .  .|.. .|||| ||.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

---EITPKSDIYSFGVVLLEIITG
    .. |||.||||.|| ||.|.
NFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK4.AA Pkinase 186-454 25 1.2e-45 162.44 Pfam 1-293 (293) Show / Hide 
Range on Protein: 186-454
Range on HMM: 1-293/293
Sequence Identity: 25% (76 aa)

SVGGNKMGEGGFGVVYKGYVNNTT--VAVKKLAAMVDITTEELKQQFD-QEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNG----SLLDRLSCLD
 . | | |.|.||.|||..  .|   ||||..    ..  ..... .  .||..|....|.| |.|...  |.|....|  |...|    .| |..|  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-W

GTPPL--SWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTA----KISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR--GEITPKSDI
   ..  |..  ....   . |....|..  ||||.|..|||.|.  .     ||.|||||.  .     . .. ..||  ||||| .|   ...||.|.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSFGVVLLEIITGLPAVDEH------REPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSV---------EAMYSVASQCLHEKKNKRPDIKKVQQL--
.|.|..| | ..| |  ..|      .. |..  |.. . ...   .. |   . . . .           |.. .. . ||. . .||| .. . |   
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

L
.
F
Kinase IRAK4.AA LRRK 186-403 25 3.1e-45 156.6 In-house 1-302 (351) Show / Hide 
Range on Protein: 186-403
Range on HMM: 1-302/351
Sequence Identity: 25% (78 aa)

SVGGNKMGEGGFG-VVYKGYVNN----------------------------TTVAVKKLAA------------------------------MVDITTEEL
 . ... |.|||| .||.. ...                            ..||.||.                                 ... . . 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

KQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTP------PLSWHMRCKIAQGAANGINFLHENH--HIHRDIKSANIL
 . | .|. .| . .| |.| |.||.   . ||.|  |.|.|.| ..|.    ..       .||... |||   | |...|| ..   |||| || |||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

L---D---------EAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRG----EITPKSDIYSFGVVLLEIITGL-PAVDEHR---EPQLLLD
|   .         .. .|||.|||. |   .  ..  ... ||.  .|||| .|.    | | |.|.||||..| |..|.. .. |||      |.   
LWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQ

IKEEI
|...|
IEDKI
Kinase IRAK4.AA MLK 193-383 29 4.7e-45 154.25 In-house 8-232 (291) Show / Hide 
Range on Protein: 193-383
Range on HMM: 8-232/291
Sequence Identity: 29% (68 aa)

GEGGFGVVYKGYVNNTT-----VAVKKLAAMV--DITTEELKQQFDQEIKVMAKCQHEN----LVELLGF-SSDGDDLCLVYVYMPNGSLLDRLSCLDGT
|.|.||.|.||.  |..     ||||. .|.      |.. ...|..|..  .. .|.|     ....|  .... ..|.|  |...||| . |   .. 
GSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSK

PP-----------LSWHMRCKIAQGAANGINFLHENHH---IHRDIKSANILLDE------AFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
.             . .   ..|   |.|...||..     ||||.|| |||.||        |.||.|||..|   .   | |.|.. || |.||||..
WMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTYAWMAPEVI

----RGEITPKSDIYSFGVVLLEIITG
     .  . |.|..|.|||| |..|.
QQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAK4.AA TyrKc 186-454 28 1.9e-44 154.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 186-454
Range on HMM: 1-280/280
Sequence Identity: 28% (83 aa)

SVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC--QHENLVELLGFSSDG-------DDLCLVYVYMPNGSLLDRLSC
 . | | ||| ||.||||  . ..||||.| .         .. | .|...| |   .|.|.| |.|  ...       . |..|  |||.|.|.|.|  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

LDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKF------AQTVMT-----SRIVGTTAYMAPEAL-RGEI
  ..  |..   ....  .|.| ..||... ||||.   |.|..| .|.|||||||.|. .         .. ..     .. .     ||||..  |. 
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TPKSDIYSFGVVLLEIITGLPAVDEH------REPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLL
|.|||..||||.. || | . .           ..| ..   .. .  ..  .||    |     .  ..||.. .|| ||. ..||  . . ...
TTKSDVWSFGVCMWEIFT-YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK4.AA Dicty4 187-383 34 5.6e-42 137.88 In-house 2-213 (277) Show / Hide 
Range on Protein: 187-383
Range on HMM: 2-213/277
Sequence Identity: 34% (75 aa)

VGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSS----DGDDLCLVYVYMPNGSLLDRLSCLD----
. ... |.|.|| |||| .  . |||||| .  .   |.. . | .|.. |.| .| |.. ..| .        ..| |  ||| |.|.  |  .|    
NIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLL--HDKPSE

--GTPPLSWHMRCK---IAQGAANGINFLHE-N-HHIHRDIKSANILLDEAFTAKISDFGLAR---ASEKFAQTVMTSRIVGTTAYMAPEALRGEI-TPK
     .|.|  . .   .|  || |.| ||. |   ||||.||.|.| |. ...|..||||..     | . .  ||   .||...|||| ....  . |
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMT--ACGTPCWMAPEVMMHQPYNEK

SDIYSFGVVLLEIITG
.| |||| || || |.
ADVYSFGIVLWEILTR
Kinase IRAK4.AA RIPK 192-383 31 4.8e-41 137.6 In-house 1-224 (290) Show / Hide 
Range on Protein: 192-383
Range on HMM: 1-224/290
Sequence Identity: 31% (70 aa)

MGEGGFGVVYKGY-VNNTTVAVKKLAAMVDITTE---ELKQQFDQEIKVMAKCQHENLVELLGFSSDGDD------LCLVYVYMPNGSLLDRLSCLD--G
 | |||| |.| . .   ....|| .    . |.   . ...  .| | |.| ..|. | ..||  . ..      . .|  ||.|||| . |.      
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

TPPLSWHMRCKIAQGAANGINFLHENH--HIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTV----------MTSRIV-GTTAYMAPEALR----G
 .|. |  || . .  . | ..|| .    |||| | .|||.|  | .||.|||||   .   ..           |.|.   || .||.||..|     
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKK

EI---TPKSDIYSFGVVLLEIITG
 |   |||.|.|||..|. |. |.
PIKVVTPKYDVYSFAIVMWEVLTQ
Kinase IRAK4.AA Dicty4-Unclassified 190-383 34 1.9e-37 125.79 In-house 5-204 (263) Show / Hide 
Range on Protein: 190-383
Range on HMM: 5-204/263
Sequence Identity: 34% (71 aa)

NKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDG----DDLCLVYVYMPNGSLLDRLS--CLDGTPPL
  .|.| |  |.||      |||||.    .   ||. | |  |. ..   || ||| . | .         .| |   |. | |.        .   |.
QFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPI

SWHM--RCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI-TPKSDIYSFGVVLLEI
.       |.|   | |. .||    |||||||.|||.|  | .|| |||..|  . | .. ||  | || .  .|| |..|  . |||.||....| | 
KLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVID-FNFN-MTT-IAGTPKWESPECLMHESYNQKSDVYSYAMMLYEL

ITG
.||
ATG
Kinase IRAK4.AA Dicty4-Unclassified 436-454 42 0.00664 5.74 In-house 245-263 (263) Show / Hide 
Range on Protein: 436-454
Range on HMM: 245-263/263
Sequence Identity: 42% (8 aa)

CLHEKKNKRPDIKKVQQLL
|.|.  |||| . .. | |
CWHNDPNKRPTMNQIIQYL
Kinase IRAK4.AA Pkinase_Tyr 427-454 25 0.064745 7.11 Pfam 243-270 (270) Show / Hide 
Range on Protein: 427-454
Range on HMM: 243-270/270
Sequence Identity: 25% (7 aa)

EAMYSVASQCLHEKKNKRPDIKKVQQLL
. .|..  || |.. ..||  . ... |
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase IRAK4.AA MLK 434-454 33 0.343614 0.04 In-house 271-291 (291) Show / Hide 
Range on Protein: 434-454
Range on HMM: 271-291/291
Sequence Identity: 33% (7 aa)

SQCLHEKKNKRPDIKKVQQLL
.|| ... .|||. . ..| |
KQCWNQDPHKRPSFRQIVQHL