Gene IRR (Human)

IRR

Species: Human
Alias: IRR, INSRR
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1q21-q23.1,

Classification

Group: TK
Family: InsR

Sequence

Name Sequence Type Origin Length Description Download
IRR.NA RNA Sugen Kinome 4235 None Fasta, JSON
IRR.AA Protein Sugen Kinome 1297 None Fasta, JSON
IRR.kin_dom Protein Kinase Domain Sugen Kinome 270 None Fasta, JSON

Protein domain

Protein domains of IRR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain IRR.AA Recep_L_domain 47-159 30 4.6e-38 129.71 Pfam 1-121 (121) Show / Hide 
Range on Protein: 47-159
Range on HMM: 1-121/121
Sequence Identity: 30% (38 aa)

NCSVVEGHLQILLMFTATGEDFRGL---SFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFL--GYALVIFEMPH--LRDVALPALGAVLR--G
||.|..|.|.|..... .    .     .|| .. .|.|||..|. ..... ..|||| .|||. ||    |||.|...|.  |..  .. |  ..|  |
NCTVIYGNLEITWRDEHNE---LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNG

AVRVEKNQ--ELCHLST-IDWGLLQ
 |....|   .||.. | |.| .. 
GVYIHNNPHPKLCYTHTEIMWWMIY
Furin-like IRR.AA Furin-like 173-329 44 3.6e-84 276.6 Pfam 1-182 (182) Show / Hide 
Range on Protein: 173-329
Range on HMM: 1-182/182
Sequence Identity: 44% (82 aa)

GEECADVCPGVLGAAGEPCAKTTFSGHTDYRCWTSS--HCQ----RVCP--CPHGMACT--ARGECCHTECLGGCSQPEDPRACVACRHLYFQGACLWAC
..||.||||| . . ..|| |||..||..||||...  |||    .|||  |.| ..||  . |||||..|||||..| ....||||||.|..|.|...|
NRECPDVCPGTC-EPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKH-RRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQC

PP----------------GTYQYESWRCVTAERCASLHSVPGRASTFGIHQGSCLAQCPSGFTRN--SSSIFCHKCEGLCPKECK
||                ||||.| |||||.. |..| | ... . . ||.|.|.  ||||.|.|  ... .|..|||.|||.|.
PPMMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKL-SHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU IRR.AA FU 225-268 42 1e-13 52.85 SMART 1-48 (48) Show / Hide 
Range on Protein: 225-268
Range on HMM: 1-48/48
Sequence Identity: 42% (21 aa)

RGEC--CHTECLGGCSQPEDPRACVACRHLYFQ---GACLWACPPGTYQ
.|.|  || ||..||. |  | .|..|.| |..   |.|.  ||||.| 
DGVCKPCHPECATGCWGPG-PDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain IRR.AA Recep_L_domain 346-461 32 6.5e-40 135.92 Pfam 1-121 (121) Show / Hide 
Range on Protein: 346-461
Range on HMM: 1-121/121
Sequence Identity: 32% (40 aa)

GCTHVEGSLILNLRQGYNLEPQLQH---SLGLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDG-NYTLYVLDNQN--LQQLGSWVAAGLTIPVGK
.||...|.|....| ..|    |.    .......|||.|.|... .|..| ||.||. |||.   .. ||.||..||.|  ||.|. |    .|.  |.
NCTVIYGNLEITWRDEHNE---LEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNGG

IYFAFNP--RLCLEHIYRLEEVTG
.|. .||  .||. |.. ......
VYIHNNPHPKLCYTHTEIMWWMIY
FN3 IRR.AA FN3 479-586 16 0.004395 17.49 SMART 1-69 (69) Show / Hide 
Range on Protein: 479-586
Range on HMM: 1-69/69
Sequence Identity: 16% (19 aa)

RAACQTRTLRFVSNVTEA-----DRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRTQEPGVTLASLKPW----T
  . .  |   |..||.      . . |.|.  .|         ||.|.                                     .|.  |||.    |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK--PP---------IVGYR-------------------------------------YTVTGLKPGQYPWT

QYAVFVRAITLTTEEDS
.| . |||.. .    .
EYEFRVRAVNGNDAGEG
FN3 IRR.AA FN3 605-798 8 4.4e-07 30.77 SMART 1-69 (69) Show / Hide 
Range on Protein: 605-798
Range on HMM: 1-69/69
Sequence Identity: 8% (17 aa)

PTVPQD---VISTSNSSS------HLLVRWKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRGLRLPTSNNDPRFDGEDGDPEAEMESDCCPCQHPPP
|  |..   .  |. .|.      .. ..||||       ..|                                                         
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------------------------------------------

GQVLPPLEAQEASFQKKFENFLHNAITIPISPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQEDKVPRERAVLSGLRHF----TEYRIDIHACN
                                                                            ....||.      |||.. . | |
----------------------------------------------------------------------------YTVTGLKPGQYPWTEYEFRVRAVN

HAAHTVG
. ..  |
GNDAGEG
FN3 IRR.AA FN3 816-899 20 2e-06 28.74 SMART 1-69 (69) Show / Hide 
Range on Protein: 816-899
Range on HMM: 1-69/69
Sequence Identity: 20% (20 aa)

DGIPGK---VAWEASSKN------SVLLRWLEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPPG-----NYSARVRATSL--AGNG
 | |.    . ... ...      || |.| .|      |. |.                         . .  | ||     .|. |||| .   || |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase IRR.AA InsR 979-1248 70 9.1e-226 756.31 In-house 1-278 (278) Show / Hide 
Range on Protein: 979-1248
Range on HMM: 1-278/278
Sequence Identity: 70% (196 aa)

ISIIRELGQGSFGMVYEGLARGLEAGEEST--PVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRP
| .|||.|||||||||||.|.|....||..  ..|.||||| || ||.||||.||||||.|.||||||||||.|.|||..|.||.||.|||||.|||.||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

EAE-NNPGLP----QPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTT
|.| ||||..    .|.|..|.|||.||.||||||||.||||||||.|||||..||||||||||||||.||.|||||||||.||||||||||||||.|||
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTT

HSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFV-MDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQE
|||||||||||||.|||.||||||||||||||.. |||.||...|.|| ..|||| .||| .|..||.|..|......
HSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase IRR.AA Pkinase_Tyr 979-1246 42 5e-144 488.4 Pfam 1-270 (270) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-270/270
Sequence Identity: 42% (118 aa)

ISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRE--CIEFLKEASVMKAF-KCHHVVRLLGVVS-QGQP--TLVIMELMTRGDLKSHLR
|.....||.|.||.||.| ..| . ... .||| |...| |....    .|..||..|| . .....|||.||.. ||.|   ...||.|  |||...||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYY-RKGGKGLLPVRWMAPESLKDGIFTT
. |      .. ... . ...||. .||.||.||......|||||||||.|. ...|||.|||..||.|..||| ||.|.| ||..|||||....|.|||
KHR------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

HSDVWSFGVVLWEIVTLAEQP-YQGLSNEQVLKFV-MDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSI
 ||||||||..|||.|. ||| |.|.|||.|....  ||. ..  |.||  . .|| .||...|  ||.|. |.  .
KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase IRR.AA TyrKc 979-1246 37 6.5e-130 438.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-280/280
Sequence Identity: 37% (113 aa)

ISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAF--KCHHVVRLLGVVSQG-------QPTLVIMELMTRGDLKS
|. ...|| | || ||.| ..        ..|| |...| |      .|..||..|. .  .  ..|||.||..|.       .| ...||.|  ||||.
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

HLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYET-------DYYRK----GGKGLLPVRW
.||. ||.           . ......  ||.||.||. ....|||||||||.|. ..||||.|||..||.|.        |||||    |||..||.||
YLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQG-----LSNEQVLKFVMDGGVLEELEG--------CPLQLQELMSRCWQPNPRLRPSFTHILDS
||||....|.||| ||||||||..||| |. .||| |     .||..|...|..|. ..  .         ||  . ..|..||. .|  ||.|. | . 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

I
.
F
Kinase IRR.AA TK 979-1246 24 5.2e-117 393.99 In-house 1-486 (486) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-486/486
Sequence Identity: 24% (118 aa)

ISIIRELGQGSFG---MVYEGLARGLE--------------------AGEESTPVALKTVNEL--ASPRECIE-----------FLKEASVMKAFK----
| ....||.| ||   .||.|..||.                      ... |||| |.. |   .|..| ..           ||.||..|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-CHHVVRLLGVVSQG------------QPTLVIMELMTRGD----LKSHLRSLRPEAENNPGLPQ-----------------------------------
 . ..|||.||..||            .| ...||.|  ||    |...||. ||.. ...  |.                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------PALGEMIQMAGEIADGMAYLAAN------KFVHRDLAARNCMVSQDFT-----------VKIGDFGMT-
                               . . ... |.  ||.||.||...      .|||||||||||.|... .           .||.|||.. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RDVYETDYYRKGG------------------------KGLLPVRWMAPESLKDGI---------FTTHSDVWSFGVVLWEIVTLAEQPYQG-L
       ||.|. |.|.. .                        .| ||.||||||.|.|..         ||| ||||||||..|||.|....|| | .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------EQVLKFVMDGGVL--------------EELEGCP--------------LQLQELMSRCWQPNPRLRPSFTHILDSI
||         ..|.... .|| |              .  ..||                ...|| .||...|. ||.|. ... .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRR.AA UTK 979-1246 37 1.1e-104 354.06 In-house 1-296 (296) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-296/296
Sequence Identity: 37% (112 aa)

ISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVN-ELASPRECI---EFLKEAS---VMKAFK-CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSH
. . |.|||| ||.|... ..     ..   ||.|. . . ....|     .|..||    .||.|. . .|.||.||..|..|.....|.| .||| | 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQD-------FTVKIGDFG---MTRDVY---------ETDYYRKGGK
||. ||...  .   .  | ....||  ||.||.||.  .||||||||||| | ..        ..||.|||   |.|.|.         |..||.. . 
LRRHRPTPP--ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

GLLPVRWMAPESLKDG-IFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGG--VLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSI
. .|.||||||.| ..  |||.|||||||||.|||.| . .|| |.||.||...|..||   ..  ..||... .|| |||...|. ||.|  ... .
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase IRR.AA ALK 979-1248 42 2.2e-100 339.8 In-house 1-273 (273) Show / Hide 
Range on Protein: 979-1248
Range on HMM: 1-273/273
Sequence Identity: 42% (116 aa)

ISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEA
|  .| ||.| || ||.|. ....      .||.||  |..|. .   |..|| .|  |.   |||..|.  | || ... |.|  ||.|| ||  ||. 
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

E--NNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFT---VKIGDFGMTRDV-YETDYYRKGGKGLLPVRWMAPESLKDGIFTTH
|  .   |   .    .| .  .| |  ||  |.|.||| |||||  .       .||.|||| ||. | .|||||||. ..|| || || . |||||. 
ESLQPSQL---TMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSK

SDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQE
.||||||| .|||  |   || | .|..|..||  || ..   .||     .|. |||. | .||.|. || .||.
TDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase IRR.AA Sev 979-1246 46 3.3e-96 321.04 In-house 1-277 (277) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-277/277
Sequence Identity: 46% (130 aa)

ISIIRELGQGSFGMVYEGLARGLE-AGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPE
 .  | || | || |||| |      |||   || ||    .   | .|||||| .|  ||   .| ..||   . |  .|||.|  ||| . ||  |  
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAARMT

AENNPG----LPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQ-------DFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKD
.  ||     |    | ... |   |. |  ||    |||||||.||| ||          .|||||||  ||.|  ||||| | ||||||||||||| |
TFQNPQPTAGL---TLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLMD

GIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSI
|.||| ||||.||.  ||| ||  |||   ||  ||..|  || |.  . ||  |  .|..||.  |  ||||  . . .
GYFTTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML
Kinase IRR.AA Musk 979-1246 41 3.2e-94 311.78 In-house 1-282 (282) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-282/282
Sequence Identity: 41% (116 aa)

ISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEA
|  .|..|.| || |.   | || ..|| | || |   . ||      |  ||  |  |    .|.||||   |.|    .| |  |||   |.|  | .
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

ENN--------------PGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESL
 .               || ||    .  .|| .|| |||||   .||||||| |||..     ||| |||. | .|  |||.  .    |.|||.|||.
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

KDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSI
 .  ||. ||||..||.||||   |.||| |.. | |.... .| .|  .| ||... .|| |||| ||  ||.|. | ..|
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase IRR.AA Trk 979-1246 40 9e-93 314.52 In-house 1-275 (275) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-275/275
Sequence Identity: 40% (111 aa)

ISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEA
| ...||| | || |. .    |   .. . ||.||  . .      .| .|| ..   . .|.|.. ||   ..| | . | |  |||.  ||.  | |
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASE-NARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

----ENNP--GLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYE-TDYYRKGGKGLLPVRWMAPESLKDGIFTT
    ...|   .    ...|   | .|| || |.|   |||||.|.|||.| |.  |||||||| ||||. ||||| |... ||.||| |||     ||.
MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTY

HSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGV-LEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSI
 |||||||||.||. |   ||. .|||  |  ... | . ||  ..||  . ..|  |||  |  | .   | | |
ESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase IRR.AA TK-Unique 979-1246 36 3.1e-90 306.1 In-house 1-294 (294) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-294/294
Sequence Identity: 36% (107 aa)

ISIIRELGQGSFGMVYEGLARGLEAGEEST-PVALKTVNELASPRECIEFLKEASVMKAFKCH-HVVRLLGVVSQGQ-PTLVIMELMTRGDLKSHLRSLR
. . ...|.|.|| |. | ..|. .... .  ||.|.... |.. .  .||||...||. ..| ..|..||.    . |.. ||| . .|.| ..||. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PE-------------AENNPGLPQPA-LG--EMIQMAGEIADGMAYLAA--NKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVY-ETDYYRKGGKGLLPV
|.             ....|  |... .    ... | .|| ||.|||    |.|||||.|||.... |...||.||||.|||| ...| .....| .|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMAPESLK--DGIF-TTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGC-PLQLQELMSRCWQPNPRLRPSFTHILDSI
|||||||||  .|.. || ||||||||..|||.|| ..|| |........ . ||  ..  |.| . .. .||..||| .|  ||||. |.. .
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase IRR.AA CTKB 979-1248 40 1.5e-86 293.82 In-house 1-269 (269) Show / Hide 
Range on Protein: 979-1248
Range on HMM: 1-269/269
Sequence Identity: 40% (111 aa)

ISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKC-HHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPE
| .   || | ||.|| | |. .      ||||.| . . .|     .|.||  .|.       .|||||.     | |...||| .||||  ||  || 
IVLKQKLGEGHFGVVYAGEAKKIMPDQAVTPVAIKMLQDSSS-EATNDFMKEVKIMQTIDGDQKIVRLLGICTRETPFLMVLELMAKGDLKTLLRNSRPK

AENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWS
      |   .   .  ||  .||||||.|  . ||||||||||.| |.. | |||||. ||||   ||   .   ||.|||.|||. ||..|| |||||
TSKPSAL---SPRRLALMAADVADGMAYIASKRIVHRDLAARNCLVHQNWRVCIGDFGISRDVYMREYYKMQASNPLPIRWMSPESINDGVYTTQSDVWS

FGVVLWEIVTLAEQPYQG-LSNEQVLKFVMDG-GVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQE
.|.|.|||.| |  || . ..|  |   . |.   .   ..||  . .|| .||   |  |.||     ..  
YGIVIWEIMTFAKMPYPEYETNMEVVERICDEDYRMWQPKECPDEFYDLMMQCWDEEPDDRISFKELHEKTLL
Kinase IRR.AA FGFR 979-1246 33 1.2e-79 270.86 In-house 1-293 (293) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-293/293
Sequence Identity: 33% (99 aa)

ISIIRELGQGSFGMVYEGLARGLEAG--EESTPVALKTVNELASPRECIEFLKEASVMKAFKCHH-VVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLR
 ..   || | || |  . | |..    |. . || | . . .. .. .    |  .||    |  ...|||. .|. |  || |.  .| |.  ||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PEA---ENNPG-----LPQPALGE-------------MIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLL
| .   . ..      .|... ..              ...|  .| || |||  | .||||||||  |. |.  || |||  ||. ..||||| . | |
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLS-NEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSI
|. |||||.| | ..|. |||||.|| |||| |. .||| .    |.  |. . |  .|  . |.. .  .|  ||  .|  ||.|. . ...
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase IRR.AA S_TKc 979-1254 20 1.9e-37 131.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 979-1254
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)

ISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTR--GDLKSHLRSLRP
  |.|..|.|.|| || .  ..         ||.| ..        . ...| ...|  .. ..|.|..|    .   ..||..    |||...... ..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

EAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTT-HSDV
.  . |        .   .. .|.....|.  ....||||   | ....  ..||.|||. | .                 .|||| |    ...  .|.
HGLRFPF----PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW

WSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEEL-RPSF
||.|..|.| ..  . |..    ....| ..           . .. .....|.| .|. ||.   .| . ..    | |
WSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRR.AA Pkinase 979-1246 19 1.7e-34 123.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 979-1246
Range on HMM: 1-293/293
Sequence Identity: 19% (61 aa)

ISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVN-ELASPRECIEFLK--EASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRG----DLKSHL
. |.| .|.|||| ||..  .| .       ||.|... . ... .... ..  |...|| ... ..|||....  ..   ..||..  |    ||....
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTV----KIGDFGMTRDV-YETDYYRKGGKGLLPVRWMAPESLK-
.      ... ..      | . .. .|. |..|. .....||||   |...... ..    ||.|||  . . |  .   ..  | .  ..|||| .. 
ST-----WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP--WYMAPEVIRG

DGIFTTHSDVWSFGVVLWEIVTLAEQPYQGL------SNEQVLKFVMDGGVLEE-LEGCP-------------------LQLQELMSRCWQPNPRLRPSF
.   .. .|.||.|..|.| ..  . |..|       .  |... .|.. . ..  . |.                     .......|....|  ||..
GQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

THILDS--I
..|| .  .
EQILQHPWF