Gene JAK2 (Human)

JAK2

Species: Human
Alias: JAK2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 9p24.1, Secondary Group: TK, Secondary Family: JakB,

Classification

Group: TK
Family: Jak

Sequence

Name Sequence Type Origin Length Description Download
JAK2.NA RNA Sugen Kinome 5285 None Fasta, JSON
JAK2.AA Protein Sugen Kinome 1132 None Fasta, JSON
JAK2.kin_dom Protein Kinase Domain Sugen Kinome 278 None Fasta, JSON
JAK2.kin_dom2 Protein Kinase Domain Sugen Kinome 265 None Fasta, JSON

Protein domain

Protein domains of JAK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase JAK2.AA Jak 545-807 41 2.8e-149 502.23 In-house 1-299 (299) Show / Hide 
Range on Protein: 545-807
Range on HMM: 1-299/299
Sequence Identity: 41% (123 aa)

LIFNESLGQGTFTKIFKGVRREVGDY----GQLHE--TEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVC--VCGDENILVQEFVKFGSLDT
|...|.||.|.|............|.    .| ||  ..|..||....|...|..|....|.||..||||.|...|||  .|.||...|.|....|.||.
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

YLK----KNKNCINI--LWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDIL--QERIPWVPPECIEN-P
||.    ..|.|.|.   ||. .|||..|.||.||.. .|||.|||.|||. ||........||.||.||..|.........  .|||||..|||..| .
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

KNLNLATDKWSFG-TTLWEIC----------------SGGDKPLSALDSQRKLQFYEDRHQLPAPK--WAELANLINNCMDYEPDFRPSFRAIIRDLNS
..|.||.|||||| .||||||                ..|..|....|..|||.|||..|.||.|.  |.|..||...|..|.|..|||||.||||||.
FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase JAK2.AA Pkinase_Tyr 545-805 26 5.6e-84 285.04 Pfam 1-270 (270) Show / Hide 
Range on Protein: 545-805
Range on HMM: 1-270/270
Sequence Identity: 26% (76 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRN-YSESFFEAASMMSKL-SHKHLVLNYGVCVCGDEN---ILVQEFVKFGSLDTY
..|.. ||.| | ...||. .     .. ....|  |.|  .  |.. ..|.|.. |..|..| .|...|  ||||.. .|    ..| |... |.|..|
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LKKN---KNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITV-------LPKDILQERIPWVPPECIENP
|.|.   |. ... ..|. . | |..| .||.. .||  ..|.|.|. .        . ..| .| | . ..         ..     |.| .|||| . 
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYG

KNLNLATDKWSFGTTLWEICSGGDKP-LSALDSQRKLQFY-EDRHQLPAPK--WAELANLINNCMDYEPDFRPSFRAIIRDL
|  . ..| |||| ..|||.. |..|    .. .. ...  ||....|.|.  ..|. .|.  |..|.|. ||.|..|...|
K-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase JAK2.AA Jak 266-544 15 1.4e-75 257.4 In-house 1-287 (299) Show / Hide 
Range on Protein: 266-544
Range on HMM: 1-287/299
Sequence Identity: 15% (44 aa)

YTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR-GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALS
... ....|   |.........|........||.. ............. |..|||. .|.......... .....|.. ..||.. ...|.... ....
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

FVS----LIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAG--NQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNE
...    ........|.|......|...............||.......... ....  .......|.........|........|....|.....|...
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

NEEYNLSGTKKNFS--SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNED
.... |...| .|.   |....|||..|..... |......|||....|....|.|..|| ...  ......  ...|...|...|..
FYLT-LAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQR
Kinase JAK2.AA TK 545-805 15 1.3e-57 191.32 In-house 1-486 (486) Show / Hide 
Range on Protein: 545-805
Range on HMM: 1-486/486
Sequence Identity: 15% (76 aa)

LIFNESLGQGTFT---KIFKGVRREVGDY------------------GQLHETEVLLKVLDKAHRNYSESFFE--------------AASMMSKLS----
... . ||.| |    ...||  |. ...                  .   .|.|  |.| . . . .| ||.               |..|....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKHLVLNYGVCVCGDE------------NILVQEFVKFGS----LDTYLKKNKN---------------------------------------------
 |...|  ||||. |..             ..| |... |.    |..||.|...                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------CINILWKLEVAKQLAWAMHFLEENTL------IHGNVCAKNILLIREEDRK---TGNPPFIKLSDPGIS-
                               ..  ..|  . |.| .| .|...        .|....| |.|. ..  .|   .|..|..|..| | | 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------ITVLPKDIL------------------------------QERIPWVPPECIEN--------PKNLNLATDKWSFGTTLWEICSGGDKPLSALD
         . ..|                                .  | | .|||..          .    ..| |||| ..|||.. |..|     
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SQRK----------LQFYED--------------RHQLP----APKW------------AELANLINNCMDYEPDFRPSFRAIIRDL
| ..          ... ..              |...|    .| |            .|.. |.  | .|.|. ||.|... . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
B41 JAK2.AA B41 33-270 22 1.4e-55 191.91 SMART 1-232 (232) Show / Hide 
Range on Protein: 33-270
Range on HMM: 1-232/232
Sequence Identity: 22% (58 aa)

KQIDPVLQVYLYHSLGKSEADYLTFPSG-EYVAEEICIAASKACGITPVYHNMFALMSETE---RIWY-PPNHVFHIDES----TRHNVLYRIRFYFPRW
.  . .. ||....       .|.| .. .. ....| .. . |||.|..|..|.|. | .   | |. ........|..       ....|..||.| |
SPKPRFCRVYFMDGT------TLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHEDRHWLDHWKTIMKQDVKWHKSEPWTLHFRVKFYPPDW

YCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQT-------PLAIYNSISYKTFLPKCIRA
..               ... .|. ...|...|.|||...|....|    ..||||..|.|.... ... |..       .  . . .|||.|||| .. 
HG-------------FPNQLQEDPTRYNYFYLQCRHDILQGRHPCP----HEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWID

-------KIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
       ..| .|  .||||. .....      |. |   .||||| ..... .....| |
SIKQSFMHYQMHHKEWRKRIMEWHKNH------CGMTPEEAKLKYLQICQRWPPMYGVEHF
Kinase JAK2.AA TyrKc 545-805 23 2.8e-28 101.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 545-805
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKL--SHKHLVLNYGVCVCG-------DENILVQEFVKFGSLD
. ... || | | ...||. .          ..|  |.| . .    | | . |..|.||  .|...|  ||||. .       .   .| |... |.|.
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

TYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPK-------DIL------QER--IP--W
 ||.|... ..   .|. . | |  | .|... .||    | |.|. ..          .| || | |  .  .       |        ...  .|  |
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

VPPECIENPKNL--NLATDKWSFGTTLWEICSGGDKPLSA-----LDSQRKLQFYEDRHQLPAPKW----------AELANLINNCMDYEPDFRPSFRAI
 .||||   .    . ..| |||| ..|||.. |..| .      .. |. ... .... .| |.           .|. ...  | ...|. ||.|..|
MAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

IRDL
....
HECF
Kinase JAK2.AA TKL 551-805 16 6.9e-28 97.51 In-house 1-364 (364) Show / Hide 
Range on Protein: 551-805
Range on HMM: 1-364/364
Sequence Identity: 16% (61 aa)

LGQGTFTKIFKGVRRE---VGDYGQLHE----TEVLLKVLDKAHRNYS---------------------------ESFFEAASMMSKLSHKHLVLNYGVC
.|.|.| ...||. |    ..           ..|  |.. . . . .                           . . | . |||.|.| ..|. .|.|
IGSGGFGEVYKGKWRGWGGKC------PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYC

VCGDE-------------NILVQEFVKFGS-LDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENT--------LIHGNVCAKNILLIREEDRKTGNPPF
 |..                .| |... || |....        .  ..  |.. | .|..|  ..        .|| .   ||||. .     . | ..
CCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMY

-------IKLSDPGISITVLPKD--------------------ILQERI---PWVPPECIENP---------------KNLNLATDKWSFGTTLWEICSG
       .|..| |.| .. ..                      .  ..    | .||....                .  . ..| .|||  ||||...
NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR

GDKPLSALDSQRK---------LQFYEDRHQLPAP--------------KWAELANLINNCMDYEPDFRPSFRAIIRDL
         ....          . .......| |               . ....|.  |.|..|. ||||  |.  |
CRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase JAK2.AA Fer 600-806 27 1.1e-23 77.59 In-house 61-283 (283) Show / Hide 
Range on Protein: 600-806
Range on HMM: 61-283/283
Sequence Identity: 27% (64 aa)

MMSK-LSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKN-CINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDR-KTGNPPFIK
.| . ..|.. |  |||||      .| ||.. ||||.|||||||  . .  |.. . | |. | .|...  ||  . | |.|.  ...  |       |
IMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKK------CK

LSDPGISIT--VLPKDIL----QERIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSA---------LDSQRKLQFYEDRHQLPAP--KW
.|| | | .  .  .| .    ....|  | .||....    . .|| |||| ..|||.. |..|  .         .. |.. .  .... .| |    
ISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGI-YSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMP

AELANLIN-NCMDYEPDFRPSFRAIIRDLN
 |.....  .|....|. ||..  |.. |.
PEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase JAK2.AA TK-Unique 545-805 23 2.7e-23 77.26 In-house 1-294 (294) Show / Hide 
Range on Protein: 545-805
Range on HMM: 1-294/294
Sequence Identity: 23% (71 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHET-EVLLKVLD-KAHRNYSESFFEAASMMSKLS-HKHLVLNYGVCVCGD-ENILVQEFVKFGSLDTYLKK
| .....|.| |  ...|  ...   .   ..  |..| |  .|.      |.  ..||..|  |...|  .|.|.  |    .. |..  |.|..||..
LEVGDVIGEGAFGQVWRGEVWGIW--KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

NK-------------------NCINILWKLE------VAKQLAWAMHFLEE--NTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISI-----TVLP
..                   . .. .  .        |.|.| .| .|..     .|...||.|.|| .           .|..| |..      .|. 
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE--------DKVCKICDFGMARDVYTNGVYS

KDILQERIP--WVPPECIE-NPKNL-NLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWA---ELANLINNCMDYEPDFRPSFRAI
.   |.|||  | .|| .    ..  .  .| |||| ..|||.. |  | . ... . ..  .| . .| |.     |. ||. .|  .||. |||||.|
MMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQI

IRDL
.  |
KHRL
Kinase JAK2.AA Frk 545-809 24 1.8e-21 70.86 In-house 1-260 (260) Show / Hide 
Range on Protein: 545-809
Range on HMM: 1-260/260
Sequence Identity: 24% (69 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLK---KN
. .   || | | ... |            .| | .| | |.     . |   | .| || |  |.  | ||   .  ... | .. ||| .||.   ..
IQLIRRLGSGQFGEVWEGLWNN--------TTPVAVKTL-KPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDK

KNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDI------LQERIP--WVPPECIENPKNLNLA
 . ...   ...| |.|  | .||.   ||  . |.|.|.        |.   .|. | |.   ..  ..       . |.|  |  || . | .   . 
GRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLV--------GEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAA-NYNKFTIK

TDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPK--WAELANLINNCMDYEPDFRPSFRAIIRDLNSLF
 | ||||  | ||   |  | . .  .  ||  .    .| |     .| ... .|   .|. || |  .   |.  |
SDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase JAK2.AA SH2 397-487 28 4.6e-20 73.9 SMART 1-87 (87) Show / Hide 
Range on Protein: 397-487
Range on HMM: 1-87/87
Sequence Identity: 28% (26 aa)

QSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSG-TKKNFSSLKDLLNCYQMETVR
|  .||.|| . | ..||. |.. | ...| | .. ..| |.. ..     ..||..| .|..  | . . ... |.|| .|.| ||    .
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase JAK2.AA EGFR 545-806 25 7.6e-18 55.66 In-house 1-258 (258) Show / Hide 
Range on Protein: 545-806
Range on HMM: 1-258/258
Sequence Identity: 25% (69 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL-DKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKN
|     || | | ...||.   . . |.     |  ||| ..  .. .| . . | .|  . |.|||   |||.  .   ||  .  .|.|  |....|.
LKKVKVLGSGAFGTVYKGIW--IPE-GENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKD

CINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGIS--ITVLPKDILQER----IPWVPPECIENPKNLNLATDKW
 |     |  . | |  | .|||  ..| .  | |.|.          |  .|  | |..    .  |..  .     | |.  |||.. .    . | |
NIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKS--------PNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHH-RCYTHQSDVW

SFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKW--AELANLINNCMDYEPDFRPSFRAIIRDLN
|.| |.||.   | ||   .  .   .. |.  .|| |.     .  ..  |    .| || |. ..  ..
SYGVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase JAK2.AA UTK 545-681 24 2.4e-16 52.44 In-house 1-151 (296) Show / Hide 
Range on Protein: 545-681
Range on HMM: 1-151/296
Sequence Identity: 24% (37 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLD--KAHRNYSE---SFFEAAS---MMSKLS-HKHLVLNYGVCVCGDENILVQEFVKFGSLD
... . |||| |  ..|. .... .  .  |  | .||..  .. .  .|    | | |    ||.... | ...  .|||. .   ..| |. . |.|.
VQLGRQLGQGAFGEVHKARFTQCSE--HMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

TYLKKNKN----CINILW---KLEVAKQLAWAMHFLEENTLIHGNVCAKNILL
.|| ...     |  .|    .|. | . | .|..|..  ..|....|.|.|.
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLV
Kinase JAK2.AA S_TKc 545-809 18 2.1e-15 48.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 545-809
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKF--GSLDTYLKKNK
  . . .|.|.| | .|.. ..          .| .|...       |..    ....|  |...|  |.|..  |.  .| |..    |.| .|.||..
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

N-----CINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI---PWVPPECIENPKNLNL-A
       ..  .   ...|.. |. .. ..  ||  .   |||| .           ||..| |..  .         .    ...|| .      .  .
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCK

TDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIR-----DLNSLF
 | ||.| .|.| .. |  | .    | .. |   .         |. ..|..|....|. ||.   . .      .   |
CDWWSCGCILYEMLC-GYPPFP----QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase JAK2.AA Src 545-680 29 2.4e-11 34.74 In-house 1-129 (255) Show / Hide 
Range on Protein: 545-680
Range on HMM: 1-129/255
Sequence Identity: 29% (41 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLK--KNK
. . . |||| |   ..|. .         .|.|  |.| ...    | | . |  | ||.|..||  | ||  ..    |.|. . ||| .|||  .  
IKLCRKLGQGQFGEVWMGYWNG--------NTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEG

NCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNIL
  ...   .. | | |  | .||.. .||    |.|.|
RHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVL
Kinase JAK2.AA Ack 589-699 30 2.4e-10 31.14 In-house 44-149 (266) Show / Hide 
Range on Protein: 589-699
Range on HMM: 44-149/266
Sequence Identity: 30% (35 aa)

NYSESFFEAASMMSKLSHKHLVLNYGVCVCGDEN-ILVQEFVKFGSLDTYLKKNKN----CINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIR
| ...|.  .. | .| | |||  ||| | .     .| |.   ||| . |.| .      | .|.  . . |.| .| .||   .||  . | |||| .
NCMDDFLREVAIMHSLDHPHLVRLYGV-VLDQPMLMMVTELAPCGSLLDCLRKHCRTAFFLIHTLC--DFCMQIAMGMRYLEMKRCIHRDLAARNILLFS

EEDRKTGNPPFIKLSD
 .         .| .|
DD-------RKVKICD
Kinase JAK2.AA UTK 737-805 24 1e-09 29.4 In-house 224-296 (296) Show / Hide 
Range on Protein: 737-805
Range on HMM: 224-296/296
Sequence Identity: 24% (18 aa)

WSFGTTLWEICSGGDKPLSALDSQRKLQFYEDR--HQLPAPKW--AELANLINNCMDYEPDFRPSFRAIIRDL
|||| ..|||...| .|   .  .. ... ...  ...|.|.   ... .| . |. |.|..||.|. .   .
WSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase JAK2.AA Ack 716-805 31 1.7e-09 28.19 In-house 175-266 (266) Show / Hide 
Range on Protein: 716-805
Range on HMM: 175-266/266
Sequence Identity: 31% (29 aa)

IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYE-DRHQLPAPKW--AELANLINNCMDYEPDFRPSFRAIIRDL
..| .|||. . .    | | |.|| ||||  |.| .|  ..     ||  . ..  || |.    .. ..  .| . .|  ||.| ||  .|
FAWCAPECL-RHRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase JAK2.AA Pkinase 545-645 19 5.3e-07 25.83 Pfam 1-103 (293) Show / Hide 
Range on Protein: 545-645
Range on HMM: 1-103/293
Sequence Identity: 19% (22 aa)

LIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSE---SFF--EAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFG----SLD
. . . .|.|.| . .|....  |.       .| .|...| |.. ..    .   |.. .| .|.|.. |  |...  .|.  .|.|..  |    .| 
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQ-IMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

TYLK-KNKNCI
.|.. ....|.
DYISTWRHGCF
Kinase JAK2.AA Src 734-805 30 0.021769 3.87 In-house 181-255 (255) Show / Hide 
Range on Protein: 734-805
Range on HMM: 181-255/255
Sequence Identity: 30% (23 aa)

TDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKW--AELAN-LINNCMDYEPDFRPSFRAIIRDL
.| ||||  |.|| . |  |    . .  ||  |    .| |.   .|| . ..  | . .|. || |  .   |
SDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase JAK2.AA Pkinase 737-805 17 0.06282 7.9 Pfam 196-293 (293) Show / Hide 
Range on Protein: 737-805
Range on HMM: 196-293/293
Sequence Identity: 17% (17 aa)

WSFGTTLWEICSGGDKPLSAL----DSQRKLQFYEDRHQ----LPAPKW---------------------AELANLINNCMDYEPDFRPSFRAIIRD--L
||.| .|.| .. |  | .      .  ...| .. . .     . |.|                      |.  .|..| .. |  ||... |  .  .
WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase JAK2.AA Jak 849-1125 43 2.3e-157 529.11 In-house 1-299 (299) Show / Hide 
Range on Protein: 849-1125
Range on HMM: 1-299/299
Sequence Identity: 43% (131 aa)

LKFLQQLGKGNFGSVEMCRYDPLQ------DNTGE--VVAVKKLQHS-TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRD
||....||.|.||.|..||||..|      |...|  .|.|||.||. ...| .||.|||.|.....|..||||.|||.. ........|||..||.|.|
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

YLQ----KHKERIDH--IKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENR---VKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK
||.    .||....|   ...|...|||.||.||. |||||.|...|||||..|..   |||..|.|......|||||.........|.|||||.||..|
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

FSV--ASDVWSFG-VVLYELF-TYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQ
|.   |.|.|||| |.|.|.. .|...|.||.|.|..|||...|.|| .........|..|||.|| |.||||..|..||... |||||||... ...|
FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase JAK2.AA Pkinase_Tyr 849-1123 40 1.1e-127 433.06 Pfam 1-270 (270) Show / Hide 
Range on Protein: 849-1123
Range on HMM: 1-270/270
Sequence Identity: 40% (114 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL-QHSTEEH--LRDFEREIEILKSL-QHDNIVKYKGVCYSAGRR-NLKLIMEYLPYGSLRDYLQK
..|...||.|.||.| ........|||.  ||||.| .....|.  ..|| ||..|.|.| .|.|||.. |||.. |.  .. ..||| |.|.|.|||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYY-KVKEPGESPIFWYAPESLTESKFSVASDVWS
|   |.....  |||.  ||.||||||  |..||||||.||.||...| |||.||||.. . ....|| .... |  ||.|.|||.. ..||...|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELL-KNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRV
|||...|.||| |.                   |  . ..|.. ....|.|.|..||||||..|..||. . ..||.|...  . 
FGVLMWEIFTYGEQP--------------TYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase JAK2.AA TyrKc 849-1123 37 1.5e-120 407.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 849-1123
Range on HMM: 1-280/280
Sequence Identity: 37% (112 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSL--QHDNIVKYKGVCYSAGR-----RNLKLIMEYLPYGSLRDYL
......|| |.|| |  ....       . ||||.|....   ..|| ||..|...|  .|.|||.  ||| . ||       | ..||| |.|.|.|||
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD------KEYYKVKE--PGE--SPIFWYAPESLTESKF
.||.... . .||..  ||..|||||  |..||||||.||.|| ....|||.||||.. .  |      |.||..||   |    || |.|||.. ..||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDG--------CPDEIYMIMTECWNNNVNQRPSFRDLALRV
. .||||||||...|.||| ..  . ...         |  |  ...||..|. .|.|.|.         ||||.|.||..||. . ..||.|...  . 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQ---------Q-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase JAK2.AA TK 849-1123 19 1.9e-96 323.87 In-house 1-486 (486) Show / Hide 
Range on Protein: 849-1123
Range on HMM: 1-486/486
Sequence Identity: 19% (96 aa)

LKFLQQLGKGNFG---SVEMCRYDPLQ---------------------DNTGEVVAVKKLQHSTEEHLRD-----------------FEREIEILKS--L
......||.|.||    | .... ..                      ... . |||| |   .... ..                 . .|......  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHDNIVKYKGVCYSAGR----------RNLKLIMEYLPYGS----LRDYLQKHKER--------------------------------------------
.|.|||.  |||   .           . . ..||| |.|.    |||||.|....                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IDHIKLLQYTSQICKGMEYLGTK------RYIHRDLATRNILVENENR-----------VKIGDFG---
                               ..   || .  ||..|||||  |      ...|||||.||.|| ..|.           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LTKVLPQDKEYYKVKEPG-----------------------ESPIFWYAPESLT---------ESKFSVASDVWSFGVVLYELFTYIEKSKSPPA
     |.. ...|..||.....|                         || |.|||.|.         . ||. .||||||||...|.||| ..   .  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

EF---------MRMIGNDKQGQMIVFH--LIELLKNNGRLPRP--DGCP--------------DEIYMIMTECWNNNVNQRPSFRDLALRV
             .. . ..|..  ..  | .  .  .|...|  ..||              .|.| .|..||. . ..||.|..|  . 
SNQDVWKDGDNQEVMEYLRRGGRL-CRSGL-N--EVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase JAK2.AA UTK 849-1050 30 5.2e-62 210.91 In-house 1-236 (296) Show / Hide 
Range on Protein: 849-1050
Range on HMM: 1-236/296
Sequence Identity: 30% (73 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGE-VVAVKKLQ--HSTEEHLR---DFEREIE---ILKSLQ-HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLR
.....|||.|.|| | ..|...  .  .| .||||..|  ....   .   || .|     ..| .. | |...  ||| . .   . ...|| . |.||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLR

DYLQKHKE----RIDHIK---LLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE-------NRVKIGDFG---LTKVLP--------QDKEYYKVKEP
.||..|..    . .. .   .|.. ..|  ||.|| .....||||| ||.||          . .||.|||   ... ..        .. .||.  . 
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

GESPIFWYAPESLTES-KFSVASDVWSFGVVLYELFTY
.. || |.|||.||.  .|. .|||||||||..|..|.
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase JAK2.AA Frk 849-1127 34 1.6e-61 210.71 In-house 1-260 (260) Show / Hide 
Range on Protein: 849-1127
Range on HMM: 1-260/260
Sequence Identity: 34% (97 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ---KHK
......|| | || |   ..     |    ||||.|.  | .  .|| ||  |.|.|.|  ...   ||  .    . .| | .  ||| .|||   .. 
IQLIRRLGSGQFGEVWEGLW-----NNTTPVAVKTLKPGTMDP-NDFLREAQIMKKLRHPKLIQLYAVC--TVEEPIYIITELMRHGSLQEYLQAINDKG

ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE-YYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVL
...   .|.. . |.  || ||  . ||||||| ||.||...| .|| |||| .|| .|.|  |  .     || | |||    .||.. |||||||..|
RQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILL

YELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIR
.|. ||           |   |      |   . .. .... |.|.| .|| ..| || |||. . ..|| |  |  ....  
TEIITYGR---------MPYPG------MTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase JAK2.AA EGFR 849-1050 39 4.7e-60 198.01 In-house 1-199 (258) Show / Hide 
Range on Protein: 849-1050
Range on HMM: 1-199/258
Sequence Identity: 39% (80 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST-EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER
|| .. || | || |    . |  .|    ||.| |. .| ..   .. .|  .. |..|...|.  ||| .    ...|.  |.|||.| ||...||..
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHS---QMQLVTQYMPYGCLLDYVRQHKDN

IDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYEL
|   .|| .  || |||.||  .| .|||||.||.||   |.||| |||| |.|..|.. |.... |  || | | |.. . ..  .|||||.|| . ||
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQG-GKMPIKWMALECIHHRCYTHQSDVWSYGVTCWEL

FTY
 |.
MTF
Kinase JAK2.AA TK-Unique 849-1050 33 3.1e-59 202.87 In-house 1-235 (294) Show / Hide 
Range on Protein: 849-1050
Range on HMM: 1-235/294
Sequence Identity: 33% (78 aa)

LKFLQQLGKGNFGSVEMCRYDPLQ--DNTGEVVAVKKLQ-HSTEEHLRDFEREIEILKSLQ-HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ--
|......|.|.|| |  . . ..   ..   .||||.|. ..|..  .|| .||...|.|  | |||.  |.| . .  .  .||||.|.|.|..||.  
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

--------------------KHKER---IDHIKLLQYTSQICKGMEYLGT--KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESP
                    ..| |   |.   |...  ||..|||||    |. .||||..||.|. . ...||.|||... .  ...| . .. |. |
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

IFWYAPESLT--ESKF-SVASDVWSFGVVLYELFTY
| | |||||   .  . .  ||||||||...|.||.
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTL
Kinase JAK2.AA TKL 855-1123 22 3.4e-58 199.66 In-house 1-364 (364) Show / Hide 
Range on Protein: 855-1123
Range on HMM: 1-364/364
Sequence Identity: 22% (86 aa)

LGKGNFGSVEMCRYD------PLQDNTGEVVAVKKLQH---------------------------STEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAG
.|.| || |   ..       |   .||..|||||.                              ..     .|.|| ....|.|.|||...|.| . .
IGSGGFGEVYKGKWRGWGGKCP-S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

-----------RRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKR--------YIHRDLATRNILVENENR-------------
             .| ..||| | |||..||.       . ....   .|..||.|| ...         ||||| ..|||| . ..             
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-VKIGDFGLTKVLPQDKE---------------YYKVKEPGES-PIFWYAPESLTES----------------KFSVASDVWSFGVVLYELFTYIEKSKS
 .||.|||| ... |...                .. .   .   . | ||| | ..                ..| ..||.|||.||.|..|  .    
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----

PPA--EFMRMIGNDKQGQMIVFHLIELLKNNGRLP----------RPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRV
| .   .| ||..| .   . | .. . ..   .|           .. ||...  .|..||. . ..|||| ..  | 
PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase JAK2.AA Ack 849-1050 38 3.2e-57 191.57 In-house 1-207 (266) Show / Hide 
Range on Protein: 849-1050
Range on HMM: 1-207/266
Sequence Identity: 38% (82 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS---TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK
.. . .|| | ||.|     .    ..   |||| |        . . || ||  |. ||.| ..|.  ||  .     |....|  | ||| | | |  
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPM--LMMVTELAPCGSLLDCLRK-H

ERIDHI---KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE-NRVKIGDFGLTKVLPQDKEYYKVKEPG--ESPIFWYAPESLTESKFSVASDVWS
 |  .     |...  ||..|| ||. || ||||||.||||.    . |||.||||   |.| . ||. ...     |. | |||.|.  .|| |||||.
CRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWM

FGVVLYELFTY
||| | | |.|
FGVTLWEMFSY
Kinase JAK2.AA Src 849-1050 38 4.1e-57 192.55 In-house 1-196 (255) Show / Hide 
Range on Protein: 849-1050
Range on HMM: 1-196/255
Sequence Identity: 38% (78 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ-KHKER
.|....||.|.|| | |  .   ..||   |||| |   |  .  .| .|..|.|.|.|...|.   || | .      . ||   ||| |||. . ..|
IKLCRKLGQGQFGEVWMGYW---NGNT--KVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVC-SQEE-PIYIVTEYMSHGSLLDYLKKDGEGR

-IDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYE
 .   .|.  . |. .||.||. ..||||||| ||.|| ..| .|..|||| ... .|.. |  ..    || | ||| ... .|.. |||||||. |.|
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

LFTY
..||
IVTY
Kinase JAK2.AA S_TKc 849-1126 24 3.1e-56 194.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 849-1126
Range on HMM: 1-231/231
Sequence Identity: 24% (73 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPY--GSLRDYLQKHKE
 ..|...||| ||.|  ||       ||..||.|..        ....|||.|||. .|.||||...|...    .| ..|||..   |.|.||..|.. 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

R-----IDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSV-ASDVWSF
.     ..      |. |||...||.  .. |||||   |||. .  ..||.|||| ..|                 .. ||| |   ...  ..|.||.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVVLYELFT----YIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLAL------RVDQI
|..|||...    .       ... ...||                            ..|   ..  |.. . ..||.  ..            .
GCILYEMLCGYPPFP-----QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase JAK2.AA Fer 849-1049 32 2.9e-53 179.77 In-house 1-213 (283) Show / Hide 
Range on Protein: 849-1049
Range on HMM: 1-213/283
Sequence Identity: 32% (70 aa)

LKFLQQLGKGNFGSVEMCR-----YDPLQDN-TGEVVAVKKL--QHSTEEHLRDFEREIEILKS-LQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRD
 ..  .||.|.|| |   |     ... . . .   |.|||.   ..|.| ...| .|  |... ..|.|.||. |  ... .  . ..||. . |||..
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYG--VCVDEQPIMIVMEFCNGGSLDS

YLQKHKER-IDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN-ENRVK--IGDFGLTKVLPQDKEYYKVK-EPGESPIFWYAPESLTESKFSVA
||.| |.. .   ...... |...|||||  |  ||||.| ||.|. . .. .|  | |||. . .  ... || | .    || | |||...   .| .
YLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPK

SDVWSFGVVLYELFT
.|||||||...| ||
TDVWSFGVMCWEIFT
Kinase JAK2.AA Pkinase 849-1119 22 8.1e-42 148.95 Pfam 1-287 (293) Show / Hide 
Range on Protein: 849-1119
Range on HMM: 1-287/293
Sequence Identity: 22% (70 aa)

LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRD--FER--EIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYG----SLRDY
.......|.|.||.|  |.      .||..||||..  ..|..  |    |  ||.|.|.|.|.|||........  .... ..|||.. |    .| ||
YHIGRKIGSGSFGCVYKCH----HKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDY

LQ-KHKERI--DHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV----KIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLT-ESKFS
.. . . ..  .   .  |  ||..|.||.  .. |||||   |||. |.. .    ||.|||| |..      .         ... ||| .   .. .
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

VASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHL--------IELLKNNGR----LPRPDGCP-------------------DEIYMI
 ..|.||.|..|||...                     |. .  .         .........     ..|  |.                   .|   .
PKVDMWSCGCILYEMLC---------------------GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF

MTECWNNNVNQRPSFRDL
.. |.. . ..||.....
IKWCLCKDPKKRPTAEQI
Kinase JAK2.AA UTK 1085-1123 38 8.7e-17 53.96 In-house 255-296 (296) Show / Hide 
Range on Protein: 1085-1123
Range on HMM: 255-296/296
Sequence Identity: 38% (16 aa)

NG---RLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRV
||   |.|.|..||...|..|..||. ..  ||.|.||  ..
NGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase JAK2.AA Src 1087-1123 44 3.7e-14 44.46 In-house 218-255 (255) Show / Hide 
Range on Protein: 1087-1123
Range on HMM: 218-255/255
Sequence Identity: 44% (17 aa)

RLPRPDGCPDEIYM-IMTECWNNNVNQRPSFRDLALRV
|.|.|..||||.|. ||..||..   ||| |  |    
RMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase JAK2.AA TK-Unique 1078-1123 34 7.5e-14 44.25 In-house 248-294 (294) Show / Hide 
Range on Protein: 1078-1123
Range on HMM: 248-294/294
Sequence Identity: 34% (16 aa)

LIELLKNNGRLPRPDGC-PDEIYMIMTECWNNNVNQRPSFRDLALRV
..|....  |.|.|..| ..|.| .| .||. .  .|||||... | 
IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase JAK2.AA Ack 1083-1123 41 3.2e-13 40.95 In-house 226-266 (266) Show / Hide 
Range on Protein: 1083-1123
Range on HMM: 226-266/266
Sequence Identity: 41% (17 aa)

KNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRV
|.  |||||| || .|| .| .||  ..  ||.| ..    
KEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase JAK2.AA EGFR 1080-1124 35 8.2e-11 31.94 In-house 214-258 (258) Show / Hide 
Range on Protein: 1080-1124
Range on HMM: 214-258/258
Sequence Identity: 35% (16 aa)

ELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVD
.||..  ||| |. |   .||.|  ||    . || |. |. . .
DLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase JAK2.AA Fer 1083-1124 27 1.9e-10 31.93 In-house 241-283 (283) Show / Hide 
Range on Protein: 1083-1124
Range on HMM: 241-283/283
Sequence Identity: 27% (12 aa)

KNNGRLPRPDGCPDEIYMIMT-ECWNNNVNQRPSFRDLALRVD
|.. ..| |...|.||. ||.  ||. . ..||.. ..  .. 
KKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK