Gene KDR (Human)

KDR

Species: Human
Alias: FLK1, VEGFR, FLK-1, Hs.12337, VEGFR2, VEGFR-2, Hs.KDR, CD309, KDR
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 4q11-q12,

Classification

Group: TK
Family: VEGFR

Sequence

Name Sequence Type Origin Length Description Download
KDR.NA RNA Sugen Kinome 6055 None Fasta, JSON
KDR.AA Protein Sugen Kinome 1356 None Fasta, JSON
KDR.kin_dom Protein Kinase Domain Sugen Kinome 327 None Fasta, JSON

Protein domain

Protein domains of KDR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG KDR.AA IG 38-119 19 0.000228 21.76 SMART 1-58 (58) Show / Hide 
Range on Protein: 38-119
Range on HMM: 1-58/58
Sequence Identity: 19% (17 aa)

KDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDT---GAYKCFYRETDLAS--VIYVYVQ
   .| |.  |...||  .  . |.                         ||| .|  .|.   | | |  .  .  |   ....||
PP-VTVKEGETVTLTC-VS-QIWWY-------------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set KDR.AA I-set 87-103 52 0.378238 6.41 Pfam 59-75 (92) Show / Hide 
Range on Protein: 87-103
Range on HMM: 59-75/92
Sequence Identity: 52% (9 aa)

TLTIPKVIGNDTGAYKC
|||| .|   |.| |.|
TLTISNVQPDDEGKYTC
IG KDR.AA IG 135-218 14 0.078641 6.85 SMART 1-58 (58) Show / Hide 
Range on Protein: 135-218
Range on HMM: 1-58/58
Sequence Identity: 14% (13 aa)

VVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYA---GMVFCEAKINDESYQS--IMYIVVV
   .| .   ||...|  |    ....                       .|| .   . .   |  .|.|.    .|.|    .. | 
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IG KDR.AA IG 231-325 16 1.9e-13 51.95 SMART 1-58 (58) Show / Hide 
Range on Protein: 231-325
Range on HMM: 1-58/58
Sequence Identity: 16% (16 aa)

SHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQ---GLYTCAASSGLMTKK-NSTFVRVH
.  .. ..|| ..|.| .         . |                               ||| .|...|.   | |.|.|. . .... ..| ..|.
PP-VTVKEGETVTLTC-VS-------QIWWY------------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
V-set KDR.AA V-set 225-324 13 1.1e-09 35.23 Pfam 1-128 (128) Show / Hide 
Range on Protein: 225-324
Range on HMM: 1-128/128
Sequence Identity: 13% (17 aa)

DVVLSP--SH----GIELSVGEKLVLNCTAR--TELNVGI-DFNWEY-PSSKHQHKKLV-------NRDLKTQSGSEMK----------KFLSTLTIDGV
......  ..     .. ..|... |.|. .  .. . .. ...| .  .. .... ..       ...  . .... |          |   .|||  .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TRSDQGLYTCAASSG-LMTKKNSTFVRV
..|| | |.||....  ..  ..| ..|
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
IGc2 KDR.AA IGc2 237-314 21 0.000142 18.73 SMART 1-56 (56) Show / Hide 
Range on Protein: 237-314
Range on HMM: 1-56/56
Sequence Identity: 21% (17 aa)

SVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLM
  |. ..|.|    . | . .. | . ... .                     .||||  ||..| |.||| |..   
HEGQSVTLTCP--ATGNPDPNIHWYK-GQPLP-------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set KDR.AA I-set 290-310 52 0.000826 15.44 Pfam 58-78 (92) Show / Hide 
Range on Protein: 290-310
Range on HMM: 58-78/92
Sequence Identity: 52% (11 aa)

STLTIDGVTRSDQGLYTCAAS
.||||..|...| | ||| |.
YTLTISNVQPDDEGKYTCVAT
I-set KDR.AA I-set 340-417 31 4.9e-13 46.74 Pfam 10-92 (92) Show / Hide 
Range on Protein: 340-417
Range on HMM: 10-92/92
Sequence Identity: 31% (27 aa)

VEATVGERVRIPAKYLGYPPPEIKWYKNGIPLES---NHTIKAGH----VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVV
||...||..|   .  |.|||.. |.|.| || .    | ... .     ||| .|  .|.| ||.. ||.    ...  ..| |
VEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSF--GEAECTAELTV
IG KDR.AA IG 337-418 20 2.5e-10 41.55 SMART 1-58 (58) Show / Hide 
Range on Protein: 337-418
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

ESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDT---GNYTVILTNPISKEKQS-HVVSLVVY
 . |.. .||.|...  .      .|.||                 ||| .|.. |.   |.|.   |   .....| . . | |.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ
IGc2 KDR.AA IGc2 343-405 34 8.2e-07 29.87 SMART 1-56 (56) Show / Hide 
Range on Protein: 343-405
Range on HMM: 1-56/56
Sequence Identity: 34% (22 aa)

TVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPIS
  |. |... .  |.| |.|.||| | ||.       .  ||| .|.. | |.|| . .||..
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set KDR.AA V-set 333-417 16 0.001452 14.12 Pfam 1-128 (128) Show / Hide 
Range on Protein: 333-417
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

GSGMES--------LVEATVGERVRIPAKYL-GY----PPPEIKWYK-NGI-------------------------PLESNHTIKAGHV-----LTIMEV
 | ..         .|.. .|..|..| .|  .|    ..  | ||.                             .   . |. .        |||. .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

SERDTGNYTVILTNPISKEKQSHVVSLVV
.. |.| |.   .|. ..    | . |.|
QPSDSGTYYCAVWNC-NEDYFGHGTRLTV
C2-set_2 KDR.AA C2-set_2 356-371 68 0.743729 5.51 Pfam 32-47 (101) Show / Hide 
Range on Protein: 356-371
Range on HMM: 32-47/101
Sequence Identity: 68% (11 aa)

GYPPPEIKWYKNGIPL
||||| | ||.|| |.
GYPPPQITWYLNGQPM
IG KDR.AA IG 556-662 15 9.1e-07 29.73 SMART 1-58 (58) Show / Hide 
Range on Protein: 556-662
Range on HMM: 1-58/58
Sequence Identity: 15% (17 aa)

QPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQ---GDYVCLAQDRKTKKR
.| .   | |.|.| | .      ...||                                          ... |....|.   |.|.| |.    .. 
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------------------------LTI-NVQPEDSQQHGTYYCQAT---HGQY

HC-VVRQLTVL
..    .|||.
WSIQGTTLTVQ
IGc2 KDR.AA IGc2 562-649 23 3.7e-05 24.27 SMART 1-56 (56) Show / Hide 
Range on Protein: 562-649
Range on HMM: 1-56/56
Sequence Identity: 23% (21 aa)

TEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKT
 | .||.| | |. .   | .|||   ||||                              .    ..||... | | |.|.|. .. 
HEGQSVTLTCPATGNPDPNIHWYK--GQPLP------------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG KDR.AA IG 430-548 14 0.000223 21.79 SMART 1-58 (58) Show / Hide 
Range on Protein: 430-548
Range on HMM: 1-58/58
Sequence Identity: 14% (18 aa)

SPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVS----
.|  . . | | |||| |       .|.||                                                         |.|  . ..    
PP-VTVKEGETVTLTC-VS------QIWWY---------------------------------------------------------LTI-NVQPEDSQQ

-ALYKCEAVNKVGRGER--VISFHVT
 . | |.|    | ..    .  .|.
HGTYYCQAT--HGQYWSIQGTTLTVQ
IGv KDR.AA IGv 566-644 19 0.001322 7.06 SMART 1-76 (76) Show / Hide 
Range on Protein: 566-644
Range on HMM: 1-76/76
Sequence Identity: 19% (17 aa)

SVSLWCTADRSTFENLTWYKLGP-----QPLPIHVGELPTPVCKNLDTLWKLNATMFSNS----TNDILIMELKNASLQDQGDYVCLA
||.| |..  .|| ...||.  |        . ..|.             |   |.  ..     .    ....|    |.| | |  
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY-----------SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
I-set KDR.AA I-set 528-547 35 1.469323 4.41 Pfam 73-92 (92) Show / Hide 
Range on Protein: 528-547
Range on HMM: 73-92/92
Sequence Identity: 35% (7 aa)

YKCEAVNKVGRGERVISFHV
|.| |.|..|  |  ..  |
YTCVATNSFGEAECTAELTV
V-set KDR.AA V-set 525-557 18 14.758903 0.3 Pfam 105-128 (128) Show / Hide 
Range on Protein: 525-557
Range on HMM: 105-128/128
Sequence Identity: 18% (6 aa)

SALYKCEAVNKVGRGERVISFHVTRGPEITLQP
|. | | . |           ... |....|. 
SGTYYCAVWNC---------NEDYFGHGTRLTV
I-set KDR.AA I-set 667-739 35 7.9e-22 76.59 Pfam 1-77 (92) Show / Hide 
Range on Protein: 667-739
Range on HMM: 1-77/92
Sequence Identity: 35% (27 aa)

PTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVE---DSGIVLKD-GNRNLTIRRVRKEDEGLYTCQA
|..|  . ... ..||... .|...|.||||. ||||.. | .      .. .. |.  |||..| ..||| |||.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
IGc2 KDR.AA IGc2 679-744 37 8.2e-21 76.39 SMART 1-56 (56) Show / Hide 
Range on Protein: 679-744
Range on HMM: 1-56/56
Sequence Identity: 37% (25 aa)

SIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLG
 .|.|..  | |.||| |.|.|.| .. |          .|  |||..|..||.|.|||.|..  |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG KDR.AA IG 673-755 22 6.1e-15 56.89 SMART 1-58 (58) Show / Hide 
Range on Protein: 673-755
Range on HMM: 1-58/58
Sequence Identity: 22% (20 aa)

LENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDE---GLYTCQACSVLGCAKV--EAFFIIE
 . .| . ||... .| .|     || |.                    ||| .|..||.   | |.|||    |...   ..  ...
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set KDR.AA V-set 666-739 14 2.3e-05 20.34 Pfam 1-112 (128) Show / Hide 
Range on Protein: 666-739
Range on HMM: 1-112/128
Sequence Identity: 14% (16 aa)

APTITG-NLE----NQTTSIGESIEVSCTASGNP----PP-QIMWFK-DNE------------TLVED----SGIVLKDGNRN-----------LTIRRV
. ..|. . .      | . |.|.. .|. | ..    .. .| |..  .              .. .         . |..            |||. .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

RKEDEGLYTCQA
. .|.| |.|..
QPSDSGTYYCAV
C2-set_2 KDR.AA C2-set_2 667-736 24 2.3e-05 21.63 Pfam 1-70 (101) Show / Hide 
Range on Protein: 667-736
Range on HMM: 1-70/101
Sequence Identity: 24% (19 aa)

PTITGN---LENQTTSIGESIEVSC----TASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYT
|.|...   ||.|  . ..  .. |    ...|.||||| | ......|      .  ...  |    . ...||||
PEIEPPPTQLEWQY-QENMEVVATCVFPWSCGGYPPPQITWYLNGQPMV------PNEKTEAITTTSEQDPETGLYT
IGv KDR.AA IGv 683-739 20 0.000341 12.96 SMART 1-76 (76) Show / Hide 
Range on Protein: 683-739
Range on HMM: 1-76/76
Sequence Identity: 20% (16 aa)

SIEVSCTASGNPPPQIMWFKDN------ETLVE------DSGIVLKDGN--------RNLTIRRVRKEDEGLYTCQA
|...||..||.   .. |..           .|       . . ..  |          ||....| ||.| |.|. 
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
Kinase KDR.AA VEGFR 834-1160 74 4.3e-271 906.89 In-house 1-332 (332) Show / Hide 
Range on Protein: 834-1160
Range on HMM: 1-332/332
Sequence Identity: 74% (247 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLSTYLRSK
|||||.|||||||||.||.||||.|..||.||||||||||||.|||||||||||.||||||||||||.||.|||  ..||||||||.|.|||||.|||.|
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RNEFVPYKTKGARFRQGKDYVG-AIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLA
|..||||..|....||.|...| .. .|.|||.||..|.|||..|.|...||..|||..|. ||..||.||.|.|||||||||.||||||||||||||||
RMYFVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLA

ARNILLSEKNVVKICDFGLARD-IYKDPDYVRKGD-ARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAP
||||||.|.||||||||||||. |||||||||||| .|||.||||||.|||.|||..|||||.||.||||||||.||||||.||||||.|||.|.|||||
ARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAP

DYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL
||.|||.|..||||||.|| .||.||||||||
DYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase KDR.AA Pkinase_Tyr 834-1160 40 4.1e-154 522.58 Pfam 1-270 (270) Show / Hide 
Range on Protein: 834-1160
Range on HMM: 1-270/270
Sequence Identity: 40% (136 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE--HRALMSELKILIHIGHHLNVVNLLGACTKPGGP--LMVIVEFCKFGNLSTYLR
...|| ||.||||.| .. ..| |.  |. .||||||||||.|..  ....|.|.||. ..||| |.|.|.|.||. |.|  .....|... |.| .|||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDL
..|                                                                |. ||...|.....|.|||||.|.|..||||||
KHR--------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL

AARNILLSEKNVVKICDFGLARDIYKDPDY-VRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASP-YPGVKIDEEFCRRL-KEGTRMR
||||.|..|.|||||||||||||||.|  | . .|...|| |||||| |.....|..|||||||||.||||..|..| |||.  .||..... ..| || 
AARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMP

APDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL
.|.....|.|. |..||| .|..||||||..|.|
CPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase KDR.AA TyrKc 834-1160 35 4.3e-140 472.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 834-1160
Range on HMM: 1-280/280
Sequence Identity: 35% (127 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIG-HHLNVVNLLGACTKPG------GPLMVIVEFCKFGNLST
..||| ||.||||.| .. .         ..||||||||.|    ....|.|..|. ..| || |.|.|.|.||..|      .|||...|... |.|  
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIH
|||..|..                                                                 |....|. ...|.|.|||.|.|..|||
YLRKHRPK-----------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIH

RDLAARNILLSEKNVVKICDFGLARDIYKD------PDYVRKG---DAR--LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGV----KI
|||||||.|..|...|||.||||.|||| |       || ||    ...  ||..|||||.|.....|..||||||||..||||..|..||||.    . 
RDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMS

DEEFCRRLKEGTRMRAPDY--------TTPEMYQTMLDCWHGEPSQRPTFSELVEHL
..|  ...|.| ||. |..         ..|||| |..||| .|..||||||..| .
NQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase KDR.AA TK 834-1160 26 4.3e-131 441.8 In-house 1-486 (486) Show / Hide 
Range on Protein: 834-1160
Range on HMM: 1-486/486
Sequence Identity: 26% (136 aa)

LKLGKPLGRGAFG---QVIEADAFGID--------------------KTATCRTVAVKMLKEGATHSEHRALM----------------SELKILIH-IG
..||| ||.|.||   .| .. ..|..                    |. .. .|||||||||...|. . ..                .|.|.. | .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHLNVVNLLGACTKPG-----------GPLMVIVEFCKFGN----LSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFV
|| |.|.|.|.||...           .|.|...|... |.    | .|||..|..| ..  ......... .   .   ..                . 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LH--HC----------------M-

EEK-----SLSDVEEEEAPEDLYKD----------------------------FLTLEHLICYSFQVAKGMEFLASRKC------IHRDLAARNILLSEK
  |     |....... ..|. |.|                            .||...|. ...|.|.|||.|.|..|      .||||||||.|..|.
--KGDITYSHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGEN

NV-----------VKICDFG--------LARDIYKDPDYVRKG------------------------DARLPLKWMAPETIFDRV---------YTIQSD
||           .||.|||        ||||||.| ||.||.                        ...||..|||||...|||         .|..||
NVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSD

VWSFGVLLWEIFSLGASPYPGVKID---------EEFCRRLKEG--------------TRMRAPDYTT--------------PEMYQTMLDCWHGEPSQR
|||||||.||||..|. ||.|   .         .|....|..|               || .|.. .              .|.|. |..||| .|..|
VWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDR

PTFSELVEHL
||||.|.| |
PTFSQLHEQL
Kinase KDR.AA TK-Unique 834-1160 36 2.9e-113 382.58 In-house 1-294 (294) Show / Hide 
Range on Protein: 834-1160
Range on HMM: 1-294/294
Sequence Identity: 36% (121 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCR-TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKR
|..|. .|.||||||. ....||.|.   .  |||||||..||  .......|.... ..| | |.|..||.|||...| | | |.|  ||| .|||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

NEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLAS--RKCIHRDLA
 . ..   ...  .                                          . .|..  ....... |. . .|.|.|||.|||  .|..||||.
PAMRQHQ-TYGNLK---------------------------------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLC

ARNILLSEKNVVKICDFGLARDIYKDPDYVRK-GDARLPLKWMAPETIF--DRVY-TIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMR
|||.||.|..|.||||||.|||.|.. .|... .  |.|..||||| .   ...| |..|||||||||.||||.||| ||||.. .. . .....| || 
ARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMP

APDYT-TPEMYQTMLDCWHGEPSQRPTFSELVEHL
 |..  ..|||. |  ||. ||..||.|....  |
QPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase KDR.AA PDGFR 984-1160 59 1.2e-105 340.17 In-house 184-358 (358) Show / Hide 
Range on Protein: 984-1160
Range on HMM: 184-358/358
Sequence Identity: 59% (105 aa)

SDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYT
.||..|.  .|.    ||.. |.|.|.|||||||||||  |.||||||||.|| .  ||||||||||||| .|  || || ||||.|||||| ||| |||
QDVKNELMEDDS--NVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYT

IQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL
.||||||.|.||||||||| .||||. .|..| .  ||| ||  |.. . |.|. |  ||  .| .||||..|.. |
TQSDVWSYGILLWEIFSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase KDR.AA FGFR 1000-1160 60 5.5e-93 315.22 In-house 133-293 (293) Show / Hide 
Range on Protein: 1000-1160
Range on HMM: 133-293/293
Sequence Identity: 60% (98 aa)

LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRK-GDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEI
||  .|.   .|||.|||.|||||||||||||||.| .. .| ||||||||||| .. || || .. ||| ||||||  |||||| ||||||.|||||||
LTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDI-HCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEI

FSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL
. .| .|||..   ||    |||| ||  |  .. |.|  | .||| .|.||||| .||| |
MTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase KDR.AA Src 834-1160 33 9.6e-78 263.71 In-house 1-255 (255) Show / Hide 
Range on Protein: 834-1160
Range on HMM: 1-255/255
Sequence Identity: 33% (111 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRN
.|| . ||.| || | .    |. .  |   |||| ||.|    .  |.  | .|.     | ..|.|.  |..   |   . |. . |.| .||.    
IKLCRKLGQGQFGEVWM----GYWNGNT--KVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEE-PIYIVTEYMSHGSLLDYLKK---

EFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARN
                                                            |     | |..||  . |||.||..| |.. |||||||||
------------------------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARN

ILLSEKNVVKICDFGLARDIYK--DPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYT
.| .|.||.|..|||||| . |  |  |. . .|..| ||.||| |  ...|| |||||||.||.||.. |  |||| .  .|  .... | ||  |.  
VLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMT-NHEVLQQVERGYRMPCPHNC

TPEMYQ-TMLDCWHGEPSQRPTFSELVEHL
 .|.|.  || ||| .| |||||  | . |
PDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase KDR.AA UTK 998-1160 35 9.9e-69 234.25 In-house 113-296 (296) Show / Hide 
Range on Protein: 998-1160
Range on HMM: 113-296/296
Sequence Identity: 35% (65 aa)

DFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEK-------NVVKICDFG---LARDIY---------KDPDYVRKGDARLPLKWMAPETIF
..|||....|.. ..| ||..|.|....||||||||.|. .        .|.||.|||   ..|...          .. | . .. |.|..||||| . 
HWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALT

DR-VYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEG--TRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL
..  .|..||||||||..|||.. |. ||||   ... . .. .|   ||..|.    ..|. |..||| .|. ||.| .||. .
HHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGM-SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase KDR.AA Ret 997-1162 45 1.3e-68 233.42 In-house 124-293 (293) Show / Hide 
Range on Protein: 997-1162
Range on HMM: 124-293/293
Sequence Identity: 45% (78 aa)

KDFLT-----LEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSF
|| ..     .  .| .  |. ||| .|.. | .||||||||.|. |  . || |||| ||.| |  ||..   |.| ||||.|  .| ||| .||||||
KDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSF

GVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGN
|||.|||  .||.||||.   |  .  || | ||  |.    |||  |. ||  ||  || |  .   .  
GVLCWEIVTMGANPYPGIPP-ERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase KDR.AA RTKB 1000-1160 43 6e-59 197.35 In-house 106-264 (264) Show / Hide 
Range on Protein: 1000-1160
Range on HMM: 106-264/264
Sequence Identity: 43% (70 aa)

LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQS-DVWSFGVLLWEI
|  . |. .. |.|.|| || ... |||||.|||.|.. .   ||||||.|| |  | . .... .||| |||||| . .| ||..| |||||||  |||
LKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREI--DHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWEI

FSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL
||||. ||.  .   .    |  | |.  |    ....  | .||  |...||.|.|||. .
FSLGGTPYQQYRN-GDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase KDR.AA Tie 1000-1160 46 6.9e-57 171.36 In-house 111-267 (267) Show / Hide 
Range on Protein: 1000-1160
Range on HMM: 111-267/267
Sequence Identity: 46% (75 aa)

LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIF
|. . .. .   ||.||..|. ..||||||||||||  |  | || ||||.|    |  ||.|   ||| .||| | .   ||| .|||||.||||||| 
LSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRG---DEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEIV

SLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL
|||  || |.    |.  .| .| ||  |     |.|. |  ||   | .||.|.... .|
SLGGTPYCGMTC-AELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase KDR.AA PDGFR 834-936 56 9.7e-55 173.99 In-house 1-102 (358) Show / Hide 
Range on Protein: 834-936
Range on HMM: 1-102/358
Sequence Identity: 56% (58 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRN
|..|| || ||||.|.|| |.|. |.    .|||||||. |  ||  ||||||||. | |.|.|.||||||||. |||  .| |.| .| |  ||..|| 
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTH-GGPIYIITEYCCYGDLLNYLHRKRH

EFV
 |.
SFH
Kinase KDR.AA Pkinase 834-1160 18 1.4e-42 151.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 834-1160
Range on HMM: 1-293/293
Sequence Identity: 18% (69 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKML-KEGATHSEHRALMS--ELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFG----NLST
...|...|.|.||.|     .   .  |...|||| . |... .......    |..|. .. .| |.| |.....  .. . .. |.|  |     |..
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFD

YLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFL--TLEHLICYSFQVAKGMEFLASRKC
|..                                                                  ..  .  . .....|  |...|.|.. |...
YIST----------------------------------------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGI

IHRDLAARNILLSEKNVV----KICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASPYPGV----KIDEEF
|||||   |||.......    ||||||||. ..    ..   .    . .|||| |  .. |.  .|.||.|..|.| .. |  |.||     ..|. .
IHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQ

CRRLKEGTRMRAPDYTT---------------------PEMYQTMLDCWHGEPSQRPTFSELVEH--L
. ... |.. . . ...                     .|. . . .|..  |..|||. ....|  .
MICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase KDR.AA FGFR 834-932 51 6.9e-40 133.61 In-house 1-100 (293) Show / Hide 
Range on Protein: 834-932
Range on HMM: 1-100/293
Sequence Identity: 51% (52 aa)

LKLGKPLGRGAFGQVIEADAFGIDKT--ATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSK
| |||.|| |.||||. | |.|||.   .   ||||||||...|  .   | ||. ..  || | |..||||.||  .||| ||||.|. |||  .||..
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQ-EGPLYVIVEYCHHGNLRDFLRAR

R
|
R
Kinase KDR.AA Ret 834-932 44 1e-32 109.0 In-house 1-100 (293) Show / Hide 
Range on Protein: 834-932
Range on HMM: 1-100/293
Sequence Identity: 44% (45 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEG-ATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPG-GPLMVIVEFCKFGNLSTYLRSK
| |.. || | ||||. | || |   .   ||||||||.. |. || ..| ||. .|  .  | .|. |.|||.  .  |...|||.||.| |  .||  
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

R
|
R
Kinase KDR.AA S_TKc 834-1160 21 5.8e-30 106.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 834-1160
Range on HMM: 1-231/231
Sequence Identity: 21% (73 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKF--GNLSTYLRSK
 ......|.||||.|  .   .     | | ||.|..|        . ...|..|| .  || |.|.|....    . | .. |.|    |.| .|....
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR

RNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAA
. .  ...                                                            ..  |  .|  |.....|.. |.. |||||  
GRHGLRFP------------------------------------------------------------FPE-HARFYMYQICCALEYCHSHGIIHRDLKP

RNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTI-QSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDY
 ||||.|  ..||||||||| .               . .|||| .    |.   .|.||.|..|.| .. |  |.|    ...  ....          
ENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------

TTPEMYQTMLDCWHGEPSQRPTFSELVE-------H--L
 .||. . .  |.. .|..|||  |. .       |  .
-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase KDR.AA Tie 843-932 43 4.5e-27 78.88 In-house 2-87 (267) Show / Hide 
Range on Protein: 843-932
Range on HMM: 2-87/267
Sequence Identity: 43% (39 aa)

GAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKR
| ||||. |    | |      ||.||.||.| . .||  | || ..  .||| |..||.||| .  | | | .|. ..|||  .||. |
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEH-RGYLYVAIEYAPYGNLLDFLRKSR
Kinase KDR.AA RTKB 834-932 37 4.6e-19 60.91 In-house 1-97 (264) Show / Hide 
Range on Protein: 834-932
Range on HMM: 1-97/264
Sequence Identity: 37% (37 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKR
..||. || ||||.|  |  .    . | . .|.| || ||   |. .  ||. ..  .| | ||. ..| | .   |... ||.| .|||  |||  |
VWLGEKLGNGAFGEVFQA-WVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQ-DEPYILLVELCELGNLRDYLRMCR
Kinase KDR.AA UTK 834-932 30 1.4e-18 60.18 In-house 1-105 (296) Show / Hide 
Range on Protein: 834-932
Range on HMM: 1-105/296
Sequence Identity: 30% (32 aa)

LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EGATHSEHR---ALMSELK---ILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLST
..||..||.||||.| .|..  ..  ..   |||| .. ....  |..    .| | .   .. .  .| ||..|.| ||. .. .|...|... |.|..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

YLRSKR
|||. |
YLRRHR