Gene KHS1 (Human)

KHS1

Species: Human
Alias: GCKR, KHS, MAP4K5, KHS1, MAPKKKK5
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 14q22.1,

Classification

Group: STE
Family: STE20
Subfamily: KHS

Sequence

Name Sequence Type Origin Length Description Download
KHS1.NA RNA Sugen Kinome 4373 None Fasta, JSON
KHS1.AA Protein Sugen Kinome 846 None Fasta, JSON
KHS1.kin_dom Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON

Protein domain

Protein domains of KHS1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase KHS1.AA KHS 20-277 86 1.2e-204 686.21 In-house 1-258 (258) Show / Hide 
Range on Protein: 20-277
Range on HMM: 1-258/258
Sequence Identity: 86% (224 aa)

YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAY
|||.|||||||||||||||.....||||||.||.||||||..|||||.|.|.|.|.||||||||||.|.|||||||||||||||||||||||||||||||
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAY

VCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMF
|||||||||.|||..||||||||||||||||.||||||||||.|.||||||||||||||||||||||||||..|||||||||||||||||||.|||||||
VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF

DLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV
|||||||||||.||||||||||||.|||.|||.|||.|||||||||||||.||.|.||
DLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase KHS1.AA STE20 20-277 51 1e-165 556.87 In-house 1-288 (288) Show / Hide 
Range on Protein: 20-277
Range on HMM: 1-288/288
Sequence Identity: 51% (149 aa)

YELVQRVGSGTYGDVYKARNVHTGEL----AAVKIIKLEPG----DDFSLIQQEIFMVKECKHCNIVAYFGSYLSR----EKLWICMEYCGGGSLQDIYH
|||....|.|.||.||||....|||.    .|.|...||.     |.. .||.|| . |.||| |||.|.||||      ..|||.|||||||||.||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---VTG------PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA----TIA-KRKSFIGTPYWMAPEVAAVEKN-
   ..|      |..| ||||.|||.||||.||| ....|||||..|||||..|.||||||||.|..|     |.. ||..|.|||||||||| . ... 
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD--KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV
 .||.. ||||..||||||. | .||.||.|||||.|.. |.. .||.|||  ..|||. ||.||.  |.|.|.|||||. ||.| |.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase KHS1.AA STE 20-277 34 3.9e-132 445.27 In-house 1-359 (359) Show / Hide 
Range on Protein: 20-277
Range on HMM: 1-359/359
Sequence Identity: 34% (126 aa)

YELVQRVGSGTYGDVYKARNVH---------------TGELAAVKIIKLEPG-----------------DDFSLIQQEIFMVKECK--HCNIVAYFGSYL
.|.....|.|..| ||||.|..               |||. |.|...||.                  ...  |..|| . |.|.  | ||| |.|.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-------SREKLWICMEYCGGGSLQDIYH---VT-----------GPLSELQIAYVCRETLQG-LAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA
       ....|||||||..|||| ||..    .           ....| ||||.||..|.| |.||| ....|||||.|||||     |||.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KITATIA----------------KRKSFIGTPYWMAPEVAAVEKNG---GYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSN----------
..| ..|                ||..|.||| ||||||   ...|   ||.  |||| .|.|.||. . .||..|.|||||.|.. ...          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---FQPPKLKD-----------------KTKWSSTFHNFVKIALTKNPKKRPTAERLLT--HTFV
   ..||.|.|                 ..|||. |..|..  |.|.|.|||||. ||   | |.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase KHS1.AA YSK 20-277 48 4.2e-127 384.88 In-house 1-257 (257) Show / Hide 
Range on Protein: 20-277
Range on HMM: 1-257/257
Sequence Identity: 48% (126 aa)

YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPG-DDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVT--GPLSELQ
.    ..| | .|.|||. ...|..  |.||| ||   |.  .|||||.   .|.  .|  |.||||   |||| ||||||||. |       |.. | .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKN-GGYNQLCDIWAVGITAIELGELQ
|| . || |.|| |||   | ||||| ||.||. ||||||.|||||..|| |  ||  |.||||||||||  . ..  .|.   ||| .||||.|.   .
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEV--ICQEVSYYDFKADIWSLGITAYEMAKGE

PPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV
||  |.||||..||  |.|  ||||... ..|  | .|| . | |.|..||.|. || | |.
PPYCDYHPMRVMFLIPKNN--PPKLEGR-SYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase KHS1.AA MST 20-277 47 1.2e-120 385.2 In-house 1-254 (254) Show / Hide 
Range on Protein: 20-277
Range on HMM: 1-254/254
Sequence Identity: 47% (125 aa)

YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYL--SREKLWICMEYCGGGSLQDIYHVTG-PLSELQ
...| . | | || |||| .  ||.. |.|... .   |.. |  || . ..||  .|| |.|||.    . .||.|||||.||. ||   |. .|.| |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVN--EDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQP
|| ... |||||.|||   |.||||| .||||   |  |||||||..  | | ||| ..|||||||||||     . .|.   |||. ||||||. |  |
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVI---QEIKYDCKADIWSLGITAIEMAEGMP

PMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV
| .|.|||||.|.  ..   ||..|| ..||. | .||.  |.||| .|.|||.|| |.|.
PYSDIHPMRAMFMIPQKP--PPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase KHS1.AA PAKA 20-277 41 2.5e-99 336.29 In-house 1-260 (260) Show / Hide 
Range on Protein: 20-277
Range on HMM: 1-260/260
Sequence Identity: 41% (111 aa)

YELVQRVGSGTYGDVYKARNVHTGEL--AAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTG-----PL
|. .. .| |  | ||.| |..|..    |.| ....  .   ||  || . ||||| ||| |  |||  ..||. ||| .||.| |.   .      ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELG
.| ||||||||.|||| ..| |.  |||||  ||||   |.||..||| .| .|    ||..  ||||||||||  . ..  |..  |||  || |||. 
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEV--IRRK-QYDEKVDIWSLGIMAIEMI

ELQPPMFDLHPMRALFLMSKSNFQ-PPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV
| .||  .  | ||..| ..   .  |..||..|||..|..|..  | .....|..|. ||.| | 
EGEPPYLNEPPLRAMYLIAT---NGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase KHS1.AA MSN 20-277 49 1.4e-95 316.05 In-house 1-265 (265) Show / Hide 
Range on Protein: 20-277
Range on HMM: 1-265/265
Sequence Identity: 49% (134 aa)

YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKE-CKHCNIVAYFGSYL------SREKLWICMEYCGGGSLQDIYHVT--G
.|||. || |||| ||| | | ||.|||.|.....  |.   |.||| |.|    | ||..|.| ..       ...||. ||.|| ||. |. . |   
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVR-EDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQ

PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITA
 | |  |||.||| |.|||.||..  .|||||| |.|||.  .||| ||||.|..  |. .| .|||||||||||| | . |    | .  |.|.|||||
SLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITA

IELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV
||. | |||. |.||||||||. .    |||||   |||  ||||.   | || ..||..|..| | |.
IEMAEGQPPLCDMHPMRALFLIPRN--PPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase KHS1.AA SLK 20-277 42 7.3e-92 310.2 In-house 1-259 (259) Show / Hide 
Range on Protein: 20-277
Range on HMM: 1-259/259
Sequence Identity: 42% (110 aa)

YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIY-HVTGPLSELQIA
.|..  .| | .| ||||..  .. .|| |.|... ... .    || .. |||| |||  ...|   .|||. .|.|.|| .  |   .  || | ||.
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

YVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVE--KNGGYNQLCDIWAVGITAIELGELQP
|||......| .|| .  .|||.|  |||.|  |||.||||||.|| . |. || .|||||||||||| . |  |   |    |||..||| ||. .. |
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV
|  .. ||| |. . ||  .||.|.   .||. |..|.|..| |.|..|.|...|. | .|
PHHEMNPMRVLLKIQKS--EPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase KHS1.AA S_TKc 20-277 29 2.1e-90 307.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-277
Range on HMM: 1-231/231
Sequence Identity: 29% (82 aa)

YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG--GSLQDIYHVTGP------
||... .|.|..| |||.|...||.. |.||||         |..|| . |. .| ||| ..... . ..|...||||.|  |.| |. .  |.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQ-LCDIWAVGITAIE
..| ............|.|.| .| .|||.| .||||..   .|..|||.|...       ..|.|||..|||||       ||.   ||.|..|.. .|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYE

LGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLT-------HTFV
.   .||    .... . ..                |. . .|..  |.|.|.|||||  .|.       | ..
MLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase KHS1.AA PAKL 20-277 40 1.4e-81 277.34 In-house 1-256 (256) Show / Hide 
Range on Protein: 20-277
Range on HMM: 1-256/256
Sequence Identity: 40% (107 aa)

YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSR-EKLWICMEYCGGGSLQDIYHVTG-PLSELQI
.|.    | | || ||||    |.   |.| | . .  .   |. || . | ||  ||| ||||  .   ..|| |.||  ||  |.  ...  | | ||
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

AYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA-KRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQP
. . . || || ||| |.  ||||| |||||.  ..||.|||||  ..  .     .. ||||||||||.    .   ||  ||||  ||||||. .  |
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEII---NKQNYNNKCDIWSLGITAIEMADGFP

PMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV
|  |. ||||.      |  ||....  .||  | .|.   ..| | ||. .  ||.| | 
PHYDMPPMRAMYMI--PNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase KHS1.AA NinaC 20-277 40 1.7e-77 263.79 In-house 1-267 (267) Show / Hide 
Range on Protein: 20-277
Range on HMM: 1-267/267
Sequence Identity: 40% (110 aa)

YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKE-CKHCNIVAYFGSYLSREK-----LWICMEYCGGGSLQDI----YHVT
.| .  .| |||| |.|. |   |..|||||       | . |  |    .. | | |.| ..| |   .|     ||. |||| |||  |.      . 
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEE-IEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKCG

GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEK--NGGYNQLCDIWAVGIT
  ..|  |||. .|.. ||  ||    .|||.|| |||||  | ||| |||| | .. |  .|   .|||.|||||| | ..  .  |   ||.|. |||
RRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGIT

AIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV
|||||   ||..|.|||||.|        ||.|   ..|.  |  |.   |.|.  |||.   .| | |.
AIELGDGDPPFADMHPMRAMFKIPRNP--PPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase KHS1.AA Pkinase 20-277 29 5e-73 253.71 Pfam 1-293 (293) Show / Hide 
Range on Protein: 20-277
Range on HMM: 1-293/293
Sequence Identity: 29% (89 aa)

YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQ-----EIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGG----SLQDIYH--V
|......|||..| |||.... ||.. ||||||.. ... .  |.     || . |...|.||| ..... .. .....||||.||    .| |. .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

TGPL--SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDV----KLADFGVAAKI-TATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDI
 |..  || ..  .....|.||.|.| .| .|||.| .|||. ..|..    |..|||.|... .      ..| |||..|||||  . .. .| . .|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV--IRGGQYYGPKVDM

WAVGITAIELGELQPPMFDL---HPMRALFLMSKSNFQPPKLKDKTKWS--------------------STFHNFVKIALTKNPKKRPTAERLLTHTFV
|..|.. .|.   .||  .    .. .    | . . .||   |  .|.                    ...  |.|  |.|.|||||||| .| | ..
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase KHS1.AA Pkinase_Tyr 20-207 26 2.6e-17 59.23 Pfam 1-203 (270) Show / Hide 
Range on Protein: 20-207
Range on HMM: 1-203/270
Sequence Identity: 26% (55 aa)

YELVQRVGSGTYGDVYKARNV----HTGELAAVKIIKLEPGDD---FSLIQQEIFMVKEC-KHCNIVAYFGSYL-SREK--LWICMEYCGGGSLQDIYHV
 .. .  |.| .|.|||..       |.   |||..|    ..        .|. . |.  .| ||| . |  .  .|   ..| |||. .|.| |  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI-----TATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLC
     .||.  ..   |..  .|..||. |.  |||.   |.|.|. . || .||| |  |       . .. ..      |||||. .  |   ..   
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGK-LPIKWMAPECINYGK---FTTKS

DIWAVGIT
|.|. |..
DVWSFGVL
Kinase KHS1.AA TyrKc 20-276 23 1.4e-16 45.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-276
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKEC--KHCNIVAYFGSYLSR-------EKLWICMEYCGGGSLQDIYHVTG
 .| .  |.| .| |||..     .  ||| .| .       . .|. . ..   .| |||. .|  ..        | |.| |||. .|.|.|  . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

P-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITAT-------IAKRKSF-IGTP-----YWMAPEVAAVEKNGGYN
| |.  .  . |    .| .||| |.  |||.   |.|... . || .||| . .|.           .||.   |.       |||||.    . | ..
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFT

QLCDIWAVGIT---AIELGELQPPM-----FDLHPMRALFLMSKSNFQPPK-----LKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF
   |.|. |..      .|.  .|       .   ....    .   |||             ..  ..  |     .|..||| . .  . |
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
CNH KHS1.AA CNH 511-826 34 2.2e-145 490.19 SMART 1-375 (375) Show / Hide 
Range on Protein: 511-826
Range on HMM: 1-375/375
Sequence Identity: 34% (129 aa)

CATSWIHPDTKDQ----YIIFGTEDGIYTLNLNEL----HEATMEQLFPRK---CTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAKKPGLAAHIQTH
|...|.|| |.||    ....|||.|||.||.|..    ||.|.|....|.   |.|.|..||.||..| ||...||||.|..||......|...|||.|
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMIS-GKKPHLYSHPLVWLFQKYRTQGMTPHIQDH

RFPDRILPRKFALTTKIPDTKG-CHKCCI-VRNPYTGHKYLCGALQSGIVLL-QWYEPMQKFMLIK--------------HFDFPLPSPLNVFEMLVIPE
.......|||...||||||||| ||.||. .....||...||.|.|. .... |||.||.|||..|              ||.||...|..||.......
MCNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDS

QEYPMVCVAISK---GTESNQVVQFE-------------TINLNSASSWFTEIGAGSQQL--DSIHVTQLER------DTVLVCLDKFVKIVNLQGKLKS
.|.|..|....|   |......||..             |.|.|..|.||... . .||.  ....|.|...      |..|.| |.|...||..| ...
FERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYG-SEW

SKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEV-TQEISDE----TRVFRLLG----SDRVVVLESRP
.......|...|..|..........|||..|.|. ..|..|. ||.| |.    .| ||||.    .||.....|.|
RRWRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
CNH KHS1.AA CNH 516-816 28 1.3e-106 365.27 Pfam 1-336 (336) Show / Hide 
Range on Protein: 516-816
Range on HMM: 1-336/336
Sequence Identity: 28% (99 aa)

IHPDTKDQYIIFG-TEDGIYTLNL----NELHEATMEQLFPRKCTWLYVIN--NTLMSL--SVGKTFQLYSHNLIALFEHA--K-KPGLAAHIQTHRFPD
..|.| .|....| |..|.|..|.    ...|.....|.|.|..|..|||.  | |...  . .|. .||.|.| .|..    . ..   .|..|||. .
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGC-DKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRI-E

RILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQS-----GIVLLQWYEPMQKF-------------MLIKH-FDFPLPSPL-NVFEMLVIPEQ
||.|||||...|.||||.||..|..||.|.....||.|. .     .|....||.||.||             ..... |..||| |. ..|.|.. | |
RIMPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLP-PMTECFSMHWLP-Q

EYPMVCVAISKGTESNQVVQFETINLN--SASSWFTEIGAGSQQLDS---------IHVTQLERD-TVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFR
|.|..||.          ..|. .||.  ....|.   .  |.|.|          |.......| ..|.| | ....||.||...|.| . .|. ... 
EKPKLCVGC--------QKGFHIVNLDGTGQPWWLHDPADHSVQQDFMARRENCKPICMHRINDDEEFLLCYDECCVYVNKQGWPRSRK-HDWEIMWEGM

IESVVCLQDSVLAFWKHGMQGKSFKSD-EV---TQEISDETRVFRLLGS
..|..|.....|||....... ....  |.   .|.|..... |...||
PQSFACCYPYLLAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS