Gene KIT (Human)

KIT

Species: Human
Alias: PBT, CD117, C-Kit, SCFR, KIT
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 4q11-q12,

Classification

Group: TK
Family: PDGFR

Sequence

Name Sequence Type Origin Length Description Download
KIT.NA RNA Sugen Kinome 5190 None Fasta, JSON
KIT.AA Protein Sugen Kinome 976 None Fasta, JSON
KIT.kin_dom Protein Kinase Domain Sugen Kinome 336 None Fasta, JSON

Protein domain

Protein domains of KIT.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG KIT.AA IG 43-112 12 0.015858 12.88 SMART 1-58 (58) Show / Hide 
Range on Protein: 43-112
Range on HMM: 1-58/58
Sequence Identity: 12% (10 aa)

KSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNT---GKYTC--TNKHGLSN--SIYVFVR
 . . |..|. ..| |  .  ..|.               .  .... ..   | |.|  | ..  .   .... |.
PP-VTVKEGETVTLTC-VS-QIWWY--------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
IG KIT.AA IG 218-308 20 2.4e-12 48.24 SMART 1-58 (58) Show / Hide 
Range on Protein: 218-308
Range on HMM: 1-58/58
Sequence Identity: 20% (20 aa)

KASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDS---GVFMCYANNTFGSANV--TTTLEVV
   .. .|||  | || ..      . .|.                           ||| .....||   |.. | |.   |..    .|||.| 
PP-VTVKEGETVTLTC-VS------QIWWY---------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set KIT.AA I-set 273-307 45 3.4e-07 26.93 Pfam 58-92 (92) Show / Hide 
Range on Protein: 273-307
Range on HMM: 58-92/92
Sequence Identity: 45% (16 aa)

ATLTISSARVNDSGVFMCYANNTFGSANVTTTLEV
.||||| .   |.|.  |.| | ||.| .| .|.|
YTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 KIT.AA IGc2 224-297 25 2e-06 28.9 SMART 1-56 (56) Show / Hide 
Range on Protein: 224-297
Range on HMM: 1-56/56
Sequence Identity: 25% (19 aa)

REGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFG
.||. .| ||   . .     .|..    ..|.                 ||||......|||.  ||| |  |
HEGQSVTLTCP-ATGNPDPNIHWYK---GQPLP--------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG KIT.AA IG 320-410 12 0.005036 17.2 SMART 1-58 (58) Show / Hide 
Range on Protein: 320-410
Range on HMM: 1-58/58
Sequence Identity: 12% (12 aa)

NTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEG---GTYTFLVSNSDVNAAI--AFNVYVN
   | |. ||.| |   ..      . .|                            |.. ...       |||.  ..    ..     ....| 
PP-VTVKEGETVTLTC-VS------QIWWY---------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set KIT.AA I-set 426-441 31 0.208183 7.29 Pfam 20-35 (92) Show / Hide 
Range on Protein: 426-441
Range on HMM: 20-35/92
Sequence Identity: 31% (5 aa)

LQCVAAGFPEPTIDWY
..| . | |.|.. |.
FECQVTGDPPPQVSWF
Kinase KIT.AA PDGFR 589-924 65 1.9e-279 907.69 In-house 1-358 (358) Show / Hide 
Range on Protein: 589-924
Range on HMM: 1-358/358
Sequence Identity: 65% (236 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDS
|.||||||.||||||||||||||.||.|.|.||||||||.||..|.||||||||..|.||.||||||||||||.|||...||||||||||||.|.|||.|
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKRHS

FI-----------CSKQEDHAEAALYKNLLHSKE--------SSCSDSTNEYMDMKPGVSYVVPTKAD---KRRSVRIGSYIERDVTPAIMEDDELALDL
|.           .|.|.|......|||..|.||        |||.||....|.|..||...|.....   ...| .. ||||.||....||||...|..
FHQHHPEKPKKETWSNQQDPHNFSFYKNVHHHKENDGDYMDMSSCEDSQYVPMLMHKGVDKYVDMQRNNYMSPHSNYEDSYIEQDVKNELMEDDSNVLTY

EDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLG
.|||.|||||||||.|||||||.||||||||.||.||...|||||||||||.||||||||||||||||||||||||.||||..||||||||.|||.||||
WDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLG

SSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI
..||||||||||||||||||.|| .|.|||.|.|.||..|||.||.|||||.|..|..
GNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase KIT.AA Pkinase_Tyr 589-924 38 2.1e-154 523.54 Pfam 1-270 (270) Show / Hide 
Range on Protein: 589-924
Range on HMM: 1-270/270
Sequence Identity: 38% (134 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTE--REALMSELKVLSYLGNHMNIVNLLGACT-IGGP--TLVITEYCCYGDLLNFLR
..|||.||.||||.|...|..|  ...  ..|||||||..|.  .  ||..|.|.|... ||.| |||.|.|.||  |.|   ....||...||||..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFL
..|                                                                        .|. .|...|||....|.||||..|
KHR------------------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYL

ASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNY-VVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSP-YPGMPVDSKFYK
.|||||||||||||.|.|.... ||||||||||| ||..| ...|...||.||||||.|.....| .|||||.|. .||.|..| .| ||||  .. .|.
ESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYE

MI-KEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI
.| ..| ||  ||..|.|.||.|| ||..|| .||||..|.. .
YIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase KIT.AA TyrKc 589-924 33 8.3e-143 481.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 589-924
Range on HMM: 1-280/280
Sequence Identity: 33% (123 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG-NHMNIVNLLGACTIG-------GPTLVITEYCCYGDLLN
...||.|| ||||.|...|..        ..|||||||..|    ||..|.|..... || .| |||.|.|.|| .       .| ....||...|||..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
.||..|.                                                                            | ..|||||..|.|.||
YLRKHRPK---------------------------------------------------------------------------LCMKDLLSFCWQIACGM

AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND-------SNYVVKG--NAR--LPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSP
..|.|||||||||||||.|...... ||.||||.|||..|       . |..|.  ...  ||..|||||.|. ...|..|||||.|. .||.|..| .|
EYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQP

YPGM----PVDSKFYKMIKEGFRMLSPEH--------APAEMYDIMKTCWDADPLKRPTFKQIVQLI
||||      ..  .. .|.|.||  |..        .|.|||.|||.||..|| .||||..|....
YPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase KIT.AA TK 589-924 24 9.60000000001e-128 430.61 In-house 1-486 (486) Show / Hide 
Range on Protein: 589-924
Range on HMM: 1-486/486
Sequence Identity: 24% (125 aa)

LSFGKTLGAGAFG---KVVEATAYGLI--------------------KSDAAMTVAVKMLKP--SAHLTEREA--------------LMSELKVLSY-LG
. .||.||.|.||   .| .....|..                    |... ..|||||||.  ... .|...              ...|.|.... ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHMNIVNLLGACTIG------------GPTLVITEYCCYGD----LLNFLRRKRDSFIC---SKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVS
.| |||.|.|.|| |            .| ....||...||    |...||..|. |..   .... |.    .| |.|.              |  |..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LHHC--------------M-KGDI

YVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLS-------------------FSYQVAKGMAFLASK------NCIHRDLAARNILLTHGR
     .  ...|.    . |.|. . ...|....|.. |||.                   ...|.|.||..|.||      |..||||||||.|.... 
-----TY-SHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENN

I-----------TKICDFG--------LARDIKNDSNYVVKG------------------------NARLPVKWMAPESIF---------NCVYTFESDV
.            ||.|||        ||||| .|..|..|.                        ...||..|||||...         . ..| .|||
VCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDV

WSYGIFLWELFSLG-SSPYPGMPV--------DSKFYKMIKEG--------------FRMLSPEHAP--------------AEMYDIMKTCWDADPLKRP
||.|...||.|..|   .|.||.         .  .......|              .||  |.|.|              .|.||.|. ||..|| .||
WSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRP

TFKQIVQLI
||.|... .
TFSQLHEQL
Kinase KIT.AA TK-Unique 589-924 33 7.69999999999e-110 371.22 In-house 1-294 (294) Show / Hide 
Range on Protein: 589-924
Range on HMM: 1-294/294
Sequence Identity: 33% (120 aa)

LSFGKTLGAGAFGKVVEATAYGLI-KSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGG-PTLVITEYCCYGDLLNFLRRKR
| .|...| |||| |  ... |.. ..|.   ||||||| .|..|.. ....|......|| | |||..||.||  . |.. | ||| .|.|...||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

------------DSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDEL--ALDLEDLLSF
            .                                                                 ... |.|. .  .....||..|
PAMRQHQTYGNLK----------------------------------------------------------------FDFHHMPDKPRTEPISPKDLYHF

SYQVAKGMAFLAS--KNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVK-GNARLPVKWMAPESIF--NCVY-TFESDVWSYGIFLWELFSLG
 .|.|.||..|||  |...||||.|||.|||.. . ||||||.|||. ..  |. . .  |.|..||||||.     .| | .|||||.|...||.|.||
AWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLG

SSPYPGMPVDSKFYKMIKEGFRMLSPEHA-PAEMYDIMKTCWDADPLKRPTFKQIVQLI
. |||||| .. . ..|..|.||. |||  . ||| .||.||  .| .||.| ||.. .
ACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase KIT.AA VEGFR 764-924 58 1.7e-97 330.24 In-house 170-332 (332) Show / Hide 
Range on Protein: 764-924
Range on HMM: 170-332/332
Sequence Identity: 58% (95 aa)

LDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARD-IKNDSNYVVKGN-ARLPVKWMAPESIFNCVYTFESDVWSYGIFLWE
|..|||...|.|||.|| ||||..|||||||||||||.   . |||||||||. |  | .|| ||. .||| |||||||||  |||  |||||||.||||
LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWE

LFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI
 |||| |||||  .| .|.. .|.| ||  |. .. |.|.||  ||  .|  ||.|   |   
IFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase KIT.AA UTK 589-924 27 3e-88 299.49 In-house 1-296 (296) Show / Hide 
Range on Protein: 589-924
Range on HMM: 1-296/296
Sequence Identity: 27% (100 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAH-LTERE---ALMSELK---VLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNF
. .|..||.|||| | .|..         | |||| ....|   .|.|    .| | .   .....  |.|...|.| || ..|....|||.. |||...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMA
||| |...                                                                     .....|.|...|......| ||.
LRRHRPTPP--------------------------------------------------------------------ACPHWLTLHQRLCMAWDIARGMQ

FLASKNCIHRDLAARNILLTHGR-------ITKICDFG---LARDIKN--------DSNYVVK-GNARLPVKWMAPESIFNC-VYTFESDVWSYGIFLWE
.|.|....||||||||.|... |       . ||.|||   ..|....        .|.|. . .. |.|..|||||.. .   .|. |||||.|...||
YLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWE

LFSLGSSPYPGMPVDSKFYKMIKEG--FRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI
... |. |||||  . .  . . .|   || .|.. |...|..|. || .|| .||.|...|| .
IWTWGRLPYPGM-SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase KIT.AA Src 589-924 31 1.9e-85 290.21 In-house 1-255 (255) Show / Hide 
Range on Protein: 589-924
Range on HMM: 1-255/255
Sequence Identity: 31% (105 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDS
. . . ||.| || | ...  | .|      |||| |||     . ||.  | ...  |  | ..|.|.  |. . | . .||| . | || .|..    
IKLCRKLGQGQFGEVWMGYWNGNTK------VAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----

FICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNC
                                                                     .... .| |..|.... |||.|||.| |.| 
---------------------------------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNY

IHRDLAARNILLTHGRITKICDFGLARDIK-NDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGF
|||||||||.|  .. . |..|||||| || .| .|. .  |..|.||.||| |   ..|  |||||.|| |.|... |  |||||       .... |.
IHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGM-TNHEVLQQVERGY

RMLSPEHAPAEMYD-IMKTCWDADPLKRPTFKQIVQLI
||  |.. |.|.|. ||. ||..|| .||||. . .  
RMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase KIT.AA FGFR 768-924 55 6.1e-82 278.54 In-house 137-293 (293) Show / Hide 
Range on Protein: 768-924
Range on HMM: 137-293/293
Sequence Identity: 55% (87 aa)

DLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGS
|| |. ||||.|| .|||. ||||||||||.| | . . |||||||||||..   |  ..| |||.||||||. |  ||| .|||||||. ||| . .| 
DLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGG

SPYPGMP-VDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI
.|||. | |    ||  ||| ||  |.. . |.| .|  || . |  ||||||.|  .
QPYPHIPSVE-ELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase KIT.AA Ret 768-926 49 2.4e-67 229.1 In-house 136-293 (293) Show / Hide 
Range on Protein: 768-926
Range on HMM: 136-293/293
Sequence Identity: 49% (78 aa)

DLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGS
...||  |. |||..|..   .||||||||.|.  ||| || |||| ||.  |  || .   |.||||||.|| .  |||  |||||.|. .||.  .| 
MIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGA

SPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK
.|||| | . . .   | |.||  ||    ||| ||..||   | ||| || | . .||
NPYPGIPPE-RLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase KIT.AA RTKB 758-924 41 1.3e-62 209.93 In-house 100-264 (264) Show / Hide 
Range on Protein: 758-924
Range on HMM: 100-264/264
Sequence Identity: 41% (69 aa)

EDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFES-DVWSYG
. . . |  . |..|. |.|.||||| ..| |||||.|||.|.. ..  ||||||.|| |...   . .. .|||.|||||||.    ||  | ||||.|
QHNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHEC--YETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFG

IFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI
.  || ||||. ||.  ..   ||     |.|. .|. .|.....||. || ... .||.|. .|.. 
VTMWEIFSLGGTPYQQYRNGDIFY-WLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase KIT.AA Tie 763-924 48 1.7e-61 185.69 In-house 110-267 (267) Show / Hide 
Range on Protein: 763-924
Range on HMM: 110-267/267
Sequence Identity: 48% (78 aa)

ALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL
.|  . .| |   ||.|| .|. |.||||||||||||     ..|| ||||.|    |  || |   ||||.||| ||.   ||| .|||||||..|||.
TLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEI

FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI
 |||  || ||   ...|. . .|.||  |     |.||.|. ||   | .||.| ||.  .
VSLGGTPYCGMTC-AELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase KIT.AA VEGFR 589-693 53 1e-51 178.11 In-house 1-108 (332) Show / Hide 
Range on Protein: 589-693
Range on HMM: 1-108/332
Sequence Identity: 53% (58 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTI---GGPTLVITEYCCYGDLLNFLRRK
|  || ||.||||.|.||.| |. |.    ||||||||. |   |  |||||||.|  .|.| | ||.||.||.   .|| .|| ||||.| |.|.|| |
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RDSFICSK
|. |   .
RMYFVPYP
Kinase KIT.AA Pkinase 589-924 20 1.4e-42 151.61 Pfam 1-293 (293) Show / Hide 
Range on Protein: 589-924
Range on HMM: 1-293/293
Sequence Identity: 20% (78 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLT--EREALM-SELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYG----DLLNF
. .|...|.|.||.|     |  .. .   .|||| .| .      .....  ||....  | || ||| |..... ..   ...|||  |    ||  .
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELAL--DLEDLLSFSYQVAKG
...                                                                          ... ..  . ... .. ||...|
IST--------------------------------------------------------------------------WRHGCFYFSEWECKFYMYQILRG

MAFLASKNCIHRDLAARNILLTHGRIT----KICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIF-NCVYTFESDVWSYGIFLWELFSLGSSPYPGM-
.... |...|||||   |||. .   .    ||||||||. ..   |..          .|||| |  .  |. ..|.||.|. |.|... |  |.||  
LEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHC

-----PVDSKFYKMIKEGFRMLSPEHAP-------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I
       . ....  .  ..  .|.  .                    |. |..| |.. || ||||..||.|   .
WHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase KIT.AA FGFR 589-686 46 4.9e-37 123.74 In-house 1-100 (293) Show / Hide 
Range on Protein: 589-686
Range on HMM: 1-100/293
Sequence Identity: 46% (46 aa)

LSFGKTLGAGAFGKVVEATAYGLIKS--DAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKR
|. ||.|| |.||.|. |.| |. ..  ....|||||||| ... ..   | ||. ..   | | ||.||||.|| .||  || |||  | |  ||| .|
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR
Kinase KIT.AA Ret 589-686 43 9.2e-29 95.34 In-house 1-100 (293) Show / Hide 
Range on Protein: 589-686
Range on HMM: 1-100/293
Sequence Identity: 43% (44 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPS-AHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGG--PTLVITEYCCYGDLLNFLRRK
| ...||| | ||.|| |.|  .       ||||||||   |   |  .| ||. .|  . || ... |.|||.  .  ||..| ||| || |  |||  
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

R
|
R
Kinase KIT.AA Tie 598-686 42 7.2e-26 75.16 In-house 2-87 (267) Show / Hide 
Range on Protein: 598-686
Range on HMM: 2-87/267
Sequence Identity: 42% (38 aa)

GAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKR
| ||.|. |.   . |    | ||.||.|  |   ..   | || |.  .| | ||.||.|||   |   | .||  || ||.|||. |
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSR
Kinase KIT.AA S_TKc 589-928 20 3.2e-24 87.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 589-928
Range on HMM: 1-231/231
Sequence Identity: 20% (72 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCY--GDLLNFLRRKR
  .....| ||||||  ..  .         ||.|..|        | ...|...|.   .| |||.|....   .   ...|||    |||. ......
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

DSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK
    .                                                                        ..  .  .. ||........ |.
RHGLR----------------------------------------------------------------------FPFPE-HARFYMYQICCALEYCHSH

NCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTF-ESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKE
. |||||   ||||..    ||||||||| .                 .|||| .    |.. ..|.|| |. |.|... |  |.|    . . .|.|. 
GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-

GFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ-----LIEKQI
          . |. |... |.. || ||||  .. |      .   .
----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase KIT.AA RTKB 589-688 35 2.2e-18 58.6 In-house 1-99 (264) Show / Hide 
Range on Protein: 589-688
Range on HMM: 1-99/264
Sequence Identity: 35% (35 aa)

LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDS
.. |. || |||| |  |  . .  .. .  .|.| |||.| ..|| .  ||. |.  || | |.. ..| |    | ..  |.| .| |  .||  | |
VWLGEKLGNGAFGEVFQA-WVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRAS