Gene KSR1 (Human)

KSR1

Species: Human
Alias: RSU2, KSR1, KSR
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 17q11.1,

Classification

Group: TKL
Family: RAF
Subfamily: KSR

Sequence

Name Sequence Type Origin Length Description Download
KSR1.NA RNA Sugen Kinome 5979 None Fasta, JSON
KSR1.AA Protein Sugen Kinome 923 None Fasta, JSON
KSR1.kin_dom Protein Kinase Domain Sugen Kinome 264 None Fasta, JSON

Protein domain

Protein domains of KSR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C1 KSR1.AA C1 348-391 22 9.6e-10 39.61 SMART 1-61 (61) Show / Hide 
Range on Protein: 348-391
Range on HMM: 1-61/61
Sequence Identity: 22% (14 aa)

HRFSTKSWLSQVCHVCQKSMIF---------GVKCKHCRLKCHNKCTKEAP--------AC
|....... .  |..|.|....         |..| .|..|||.|| . .|        .|
HHWHWWRFKPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase KSR1.AA KSR 613-877 59 6.8e-207 693.62 In-house 1-272 (272) Show / Hide 
Range on Protein: 613-877
Range on HMM: 1-272/272
Sequence Identity: 59% (162 aa)

VELGEPIGQGRWGRVHRGRWHGEVAIRLLEMD-GHNQDH-LKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKG-RTLHSFVRDPKTSLDINK
...||.|||||.|.||||.|||||||.|..|| .|...| |..||.|||.|..|||||.|||||||||||||||..|.||| .||..........||.|.
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

TRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDN-GKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQ---LPFSKAADVY
|.||||.|..||||||||||.||||||||.||.| |||||||||||.|........||..|...|.||||||||..|.|.|..||.|   ||||...|||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

AFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDML
||||.|||.....||.|.|.||. |||...||||..||..|..|.|..|||..||....||||.|. .|.||
AFGTIWYEMICGEWPFKYQCAESIIWQMCQGEGMRQVLRNVQCGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase KSR1.AA RAF 613-877 51 2.1e-173 582.4 In-house 1-275 (275) Show / Hide 
Range on Protein: 613-877
Range on HMM: 1-275/275
Sequence Identity: 51% (142 aa)

VELGEPIGQGRWGRVHRGRWHGEVAIRLLEMD-GHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNP--PHLAIITSFCKGRTLHSFVRDPKT-SLDIN
|..||.|||||.|.|.||.|||.||...|.|. ......|. ||.|||.|..|||||.|||||.||.|  ||.||.|..|||.||.......|| ..|.|
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

KTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKV-VITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQ---LPFSKAADV
.|.||||.|..||.|||||.|.|.||||||.|..|||| |||||||| .... ...||..||...|.|.|..|||..|.|.|..||.|   .|||...||
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YAFGTVWYELQARDWPLK-NQAAEASIWQIGSGE-GMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDML
||||||||||.|..||.. .| .|. ||....|. .|.|....|...||..|.|..||... .|||||. .|.|.
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase KSR1.AA RAF 613-879 32 6.3e-73 235.72 In-house 1-282 (282) Show / Hide 
Range on Protein: 613-879
Range on HMM: 1-282/282
Sequence Identity: 32% (93 aa)

VELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKL---FKKEVMNYRQTRHENVVLFMGACMNPPH---LAIITSFCKGRTL--HSFVRDPKTS
|.... ||.|. | | ||.|||.||.. | .    .. ..    || ||  |..||| |..|||| .|  |.   .||.| .| . .|  |  | ...  
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMG-YMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREK

LDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNG-KVVITDFGLFGISGVVREG-RRENQLKLSHDWLCYLAPEIVR-EMTPGKDE----DQLP
.|.... .|.. . .|| ||||| |.| ||||.|.| ... .|.|.||||  .    |.  |.. |..    |  ..|||..|  |   . .    |..|
FDMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVK--TRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENP

FSKAADVYAFGTVWYELQARDWPL--KNQAAEASIWQIGSGEGMKRVLTSVS-LGKEVSEILSACWAFDLQERPSFSLLMDMLEK
.|   |||.||.| ||| .|  |     .  .  |. .| |    .     .   |   . .. ||.|. .|||.|  .. ... 
YSFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase KSR1.AA TKL 619-877 20 1.1e-70 241.11 In-house 1-364 (364) Show / Hide 
Range on Protein: 619-877
Range on HMM: 1-364/364
Sequence Identity: 20% (75 aa)

IGQGRWGRVHRGRWHG-----------EVAIRLLEMDG-------------------------HNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPH-
||.|. | |..|.|.|           .||.  . ..                          ...   . ...|.|  ...||.|.|.|||.|..||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHA--------KGIVHKDLKSKNVFYD-NGK--------------V
            |.|.. .|.| .|....        .... ..|..| .|| |||.        ..|.| ||||||.. | |..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

VITDFGLFGISGVVR---------------EGRRENQLKLSHDWLCYLAPEIVREMTPGK-----DEDQ---LPFSKAADVYAFGTVWYELQARDWPLKN
 |.||||                         ......     .....|||. |.... .     || .   ...|...|||.|| |..|. .| .| ..
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

QAAEASI-------WQIGSGEGMKRVLTS------------VSLGKEVSEILSACWAFDLQERPSFSLLMDML
.  .  |       .... ..  .| .               .  .......  ||. | ..||||. ... |
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase KSR1.AA TKL-Unique 615-877 26 1.3e-35 123.13 In-house 1-290 (290) Show / Hide 
Range on Protein: 615-877
Range on HMM: 1-290/290
Sequence Identity: 26% (79 aa)

LGEPIGQGRWGRVHRGRWHGE-VAIRLLEM-DGHNQDHLKLFKKEVMNYRQTR-HENVVLFMGACM----NPPHLAIITSFCKGRTLHSFVR--------
 .. ||.|  |.| .| |.|. |||  ..   . . . .. |..||      . |.|.|..||.||     ||.. |....| | .|..           
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-DPKTSLDINKTRQIAQEIIKGMGYLHAKG--IVHKDLKSKNVFYDNG------KVVITDFGLFGISGVVREGRRENQLKLS-H-----DWLC----YLA
  ... |. ..  ..|. | .|| ||| ..  | | ||||.|.  ||.      .. | ||||      ..   ..|. ... |     .  |    ..|
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGL------SKFNSKINKMTNNEHKGTRNQTRCGSFRWMA

PEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDW------PLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLM
||. |            .|. .|||.||.| .|.  |.       | .. . |. .  . . |  .|.  . .. || .... .||. | ..||||.   
PEVLRMNF-------CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEII

DML
  |
HRL
Kinase KSR1.AA Pkinase_Tyr 613-753 27 5.5e-34 115.72 Pfam 1-157 (270) Show / Hide 
Range on Protein: 613-753
Range on HMM: 1-157/270
Sequence Identity: 27% (44 aa)

VELGEPIGQGRWGRVHRGRWH-------GEVAIRLLEMDGHNQDH--LKLFKKEVMNYRQT-RHENVVLFMGACM--NPP-HLAIITSFCKGRTLHSFVR
...|. .|.|  |.|..|.|.        .||.  |  .|. ...  .. | .|.   .|  .|.|.| ..|.|.    | .. |.. ....  |... |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

DP---KTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYD-NGKVVITDFGL
..   | .|..    |....| ||| ||..|...| ||  .|.  . |..| |.||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL
Kinase KSR1.AA Pkinase 613-753 22 1.9e-29 105.24 Pfam 1-158 (293) Show / Hide 
Range on Protein: 613-753
Range on HMM: 1-158/293
Sequence Identity: 22% (36 aa)

VELGEPIGQGRWGRVHRGRWHGE---VAIRLLEMDGHNQDHLKLFKK--EVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGR----TLHSFVR-DPK
 ..|..||.|  |.| .....|.   ||.  .. .. . . ..   .  |.   .  .|.|.| . .......|. ... .| |      |..... . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TSL--DINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYD-NGKV----VITDFGL
...  . .  . .. .|..|. |.|..||.| |||. |...| || .     |.||||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGL
Kinase KSR1.AA S_TKc 613-877 17 8.3e-29 102.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 613-877
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)

VELGEPIGQGRWGRVHRGRWHG---EVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKG--RTLHSFVRDPKTS---
 |....||.|  |.|...|...   .|||  .          . ...|.   .. .|.|.| . ... .  || ... .| |   .|... .. ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSK-A
  ..   .| ....|.... |.| .||.| |||  |.. |.  . |.||||  .          . .  .   . |.|||..            ...| .
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------TTFCGT---PWYMAPEVL------------GYGKCK

ADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMD---------ML
.|....| . ||. ..  |      .. ....                .|. .... |. .| ..||.   ..           .
CDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase KSR1.AA TK 613-814 13 8.9e-29 92.99 In-house 1-387 (486) Show / Hide 
Range on Protein: 613-814
Range on HMM: 1-387/486
Sequence Identity: 13% (52 aa)

VELGEPIGQGR---WGRVHRGRWHG----------------------------EVAIRLLEMD-GHNQDHLKL--------------FKKEVMNYRQ--T
..||. .|.|    .|.|..|.|.|                            .||.  |  . ...|.  ..              .  | .  ..   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHENVVLFMGACMNP------------PHLAIITSFCKGRT----LHSFVR--DPKTSLDINKTRQ----------------------------------
.|.|.| . |.|. .            ... |.. ....      |... |  .||..   ..                                     
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------IAQEIIKGMGYLHAK------GIVHKDLKSKNVFYDNGK------------VVITDFG----
                                      ... | .|| |||.|      ..|| ||   |.  ....            . |.|||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LFGISGVVREGRRENQLKLSHDWLC----------------------YLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYEL
    |    .   . .| .. . . .                         ..||| ... ..   |    |. . ||..|| . .|.
GSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase KSR1.AA Dicty4 613-753 34 1.7e-27 88.89 In-house 1-160 (277) Show / Hide 
Range on Protein: 613-753
Range on HMM: 1-160/277
Sequence Identity: 34% (55 aa)

VELGEPIGQGRWGRVHRGRWHG-EVAIRLLEMDGHN--QDHLKLFKKEVMNYRQTRHENVVLFMGACM----NPPHLAIITSFC-KGRTLHSFVRD----
   .. ||.|  | |..|.| | |||. .|  .  |  .. |. |.|||    . || |..||||||     .|. . | | .. || .|.|  .|    
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKG-NLYSLLHDKPSE

--PKTSLDINKTRQ---IAQEIIKGMGYLHAKG--IVHKDLKSKNVFYDNGKVV-ITDFGL
  ....||    ..   .|  . .|| .||.    |.| |||| |   |  ..| ..||||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGL
Kinase KSR1.AA DRK 613-753 35 4.2e-25 81.98 In-house 1-146 (258) Show / Hide 
Range on Protein: 613-753
Range on HMM: 1-146/258
Sequence Identity: 35% (52 aa)

VELGEPIGQGRWGRVHRGRWHG-EVAIRLLEMDGHN-QDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKT
.  |  || | .| | || | | .||.  |  .  |  . |. |..|.    | || |...|||.| |||   |.. .     | .   |.. ..|    
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLM

RQIAQEIIKGMGYLHAKG--IVHKDLKSKNVFYDNG-KVVITDFGL
 |..  . ||| |||     |.| |||| |   |   .| . ||||
KQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGL
Kinase KSR1.AA MLK 613-754 25 1.8e-21 71.36 In-house 1-180 (291) Show / Hide 
Range on Protein: 613-754
Range on HMM: 1-180/291
Sequence Identity: 25% (46 aa)

VELGEPIGQGRWGRVHRGRWHG-E-----VAIRLLEMDGHNQDHL-----KLFKKEVMNYRQTRHEN----VVLFMGACMNPPH-LAIITSFCKGRTLHS
 .. | || |  | |..|||.. .     ||..  . .            . |..|..  |  .|.|    .. |.|.| .||. ..|.. .| |  |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

FVRD--PKTS-----------LDINKTRQIAQEIIKGMGYLHAKG---IVHKDLKSKNVFYD-------NGKVVITDFGLF
. ..  .| .            |     ..|  . .|| |||..    |.| ||||.|.  |       .|...|.|||..
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTS
Kinase KSR1.AA UTK 613-753 22 2e-18 59.65 In-house 1-174 (296) Show / Hide 
Range on Protein: 613-753
Range on HMM: 1-174/296
Sequence Identity: 22% (40 aa)

VELGEPIGQGRWGRVHRGRWH------GEVAIRLLEMDGHNQDHLKLFKKE-------------VMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRT
|.||...|||. | ||..|.       .|.. .. . .    .. . ...|             .| . .  |.||. . | |..   ..|.| ....  
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---HHADAQQEPEPYPDFMEEARELQMMKQFH-WHPNVLRLVGVCTQEEPWMIVTEYMENGD

LHSFVRDPKTSLD-------INKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNG--------KVVITDFG---L
| |..|. . ...         .  . |  |  || ||| .|.|| ||  .|.. .          ...| |||   .
LRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGM
Kinase KSR1.AA TyrKc 613-877 21 1.4e-16 45.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 613-877
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

VELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQT--RHENVVLFMGACMNP-------PHLAIITSFCKGRTLHSFVRDPKT
..||. .| |  |.|..|.|  .||.  |  |      .. | .|    ..   .|.|.| . |.|. .       . | |.. ....  |... |... 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

SLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGRRE-------NQLKLS---HDW----LCYLAPEIVREMT
 |   .  ...  | .|| ||| |...| ||   |. ..... | |.||||       |..  .          . .   .      .  .|||  .. .
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL------SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

PGKDEDQLPFSKAADVYAFGTVWYELQ---ARDWP------LKNQAAEASIWQIGSGEGMKRVLT-----SVSLGKEVSEILSACWAFDLQERPSFSLLM
         |. . ||..|| . .|.    .  .|      ..|| . .   .. .|. |..        .|   .|. .| . ||..|  .||.|| . 
---------FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIE---YVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

DML
. .
ECF
Kinase KSR1.AA TK 850-877 35 1e-06 17.16 In-house 459-486 (486) Show / Hide 
Range on Protein: 850-877
Range on HMM: 459-486/486
Sequence Identity: 35% (10 aa)

KEVSEILSACWAFDLQERPSFSLLMDML
.|. ...  ||..| ..||.|| | ..|
EEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase KSR1.AA MLK 797-877 23 1.1e-05 15.8 In-house 212-291 (291) Show / Hide 
Range on Protein: 797-877
Range on HMM: 212-291/291
Sequence Identity: 23% (19 aa)

PFSKAADVYAFGTVWYELQARDWPLK-NQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDML
..|...||. .| | .|. .|  | |  . . | .|...  . .  .  .    .  .. .. ||  |  .||||.  .  |
KYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST--CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase KSR1.AA Pkinase_Tyr 850-877 32 3.3e-05 18.26 Pfam 243-270 (270) Show / Hide 
Range on Protein: 850-877
Range on HMM: 243-270/270
Sequence Identity: 32% (9 aa)

KEVSEILSACWAFDLQERPSFSLLMDML
.|. ...  ||..| ..||.|| .  .|
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase KSR1.AA Pkinase 778-877 14 3.9e-05 19.24 Pfam 177-293 (293) Show / Hide 
Range on Protein: 778-877
Range on HMM: 177-293/293
Sequence Identity: 14% (18 aa)

YLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQ------AAEASIWQIGSGEGMKRVLTSVSLG-----------------KEVSE
|.|||..|        .. . ....|....| . ||.  .  | ...         . | .|.... .    .. |                   .|  .
YMAPEVIR--------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKD

ILSACWAFDLQERPSFSLLMDM--L
... |...| ..||..  ..    .
FIKWCLCKDPKKRPTAEQILQHPWF
Kinase KSR1.AA UTK 854-877 37 0.000448 9.84 In-house 273-296 (296) Show / Hide 
Range on Protein: 854-877
Range on HMM: 273-296/296
Sequence Identity: 37% (9 aa)

EILSACWAFDLQERPSFSLLMDML
... .||. | ||||.|  | . .
RLMHRCWHYDPQERPDFEDLVQQM
Kinase KSR1.AA UTK 780-814 31 0.000632 9.32 In-house 207-233 (296) Show / Hide 
Range on Protein: 780-814
Range on HMM: 207-233/296
Sequence Identity: 31% (11 aa)

APEIVREMTPGKDEDQLPFSKAADVYAFGTVWYEL
|||.. ..|         |. . ||..|| |..|.
APEALTHHT--------RFTTKSDVWSFGVVCWEI
Kinase KSR1.AA DRK 856-879 37 0.038022 3.11 In-house 235-258 (258) Show / Hide 
Range on Protein: 856-879
Range on HMM: 235-258/258
Sequence Identity: 37% (9 aa)

LSACWAFDLQERPSFSLLMDMLEK
.  ||  | | |||.   .  || 
MNDCWNEDPQHRPSMQECLERLEA
Kinase KSR1.AA Pkinase_Tyr 779-814 25 0.051034 7.46 Pfam 181-207 (270) Show / Hide 
Range on Protein: 779-814
Range on HMM: 181-207/270
Sequence Identity: 25% (9 aa)

LAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYEL
.|||  ...          |. . ||..|| ...|.
MAPECINYGK---------FTTKSDVWSFGVLMWEI