Gene LKB1 (Human)

LKB1

Species: Human
Alias: LKB1, STK11, PJS
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19p13.3,

Classification

Group: CAMK
Family: CAMKL
Subfamily: LKB

Sequence

Name Sequence Type Origin Length Description Download
LKB1.NA RNA Sugen Kinome 3286 None Fasta, JSON
LKB1.AA Protein Sugen Kinome 433 None Fasta, JSON
LKB1.kin_dom Protein Kinase Domain Sugen Kinome 261 None Fasta, JSON

Protein domain

Protein domains of LKB1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LKB1.AA LKB 49-309 73 3.5e-246 738.61 In-house 1-265 (265) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-265/265
Sequence Identity: 73% (196 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKR
|.|||.|||||||||||..||.|||||||||.|||||||||||..|||||||.|.|..|..||||.||.|||||||||||||||||| ||||||..|.||
YMMGDVLGEGSYGKVKECMDSYTLCRRAVKIMKKKKLRRIPNGWQNVKKEIQILKRMHHRHVIQLIDVFYNEEKQKMYMVMEYCVCGTMQEMLDMQPCKR

FPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANG-LDTFSGFKVDIWSAGVTLY
.|..|||.|||||.||.||||||..|||||||||||||...||||.|.||||.||.|..||.|.||||||||||||.||| .||||||||||||.|||||
MPIWQAHFYFCQLCDGCEYLHSQRVVHKDIKPGNLLLTHDNTLKICDFGVAEQLHHFQRDDCCTTSQGSPAFQPPECANGNHDTFSGFKVDIWSMGVTLY

NITTGLYPFEGDNIYKLFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWF
|.|||.|||||||.|||||||||.....|.  ||...|..|.||||.|...||||..||..|.||
NMTTGKYPFEGDNMYKLFENIGKCQWEMPCWYDCDKDLQNLIKGMLQYDHNKRFSCHQIMHHPWF
Kinase LKB1.AA CAMKL 49-309 33 1.1e-120 386.89 In-house 1-297 (297) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-297/297
Sequence Identity: 33% (101 aa)

YLMGDLLGEGSYGKVKEVLD-SETLCRRAVKILKKKKLRRIPNGEAN-----------VKKEIQLLRRLR---HKNVIQLVDVLYNEEK----QKMYMVM
| .|. ||.||.||||  .. . | .. |.||..|||.. .|. ..|           ...|||....|.   |.|.|.| .|....|.    .|.|.||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCVCG---MQEMLDSVPEKR--FPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGG--TLKISDLGVAEALHP--FAADDTCRTSQGSPAFQ
|||  |   ....... ...|  .|  .|. ||.|......|.||.|||| |||| |.||.  |  ..||.| | .    |  |  .....|. |||...
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

PPEIANG-LDTFSGFKVDIWSAGVTLYNITTGLYPFEGDN---------IYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWF
.||| .|  . . |.||||||.||.||.. .| .||..|.          ... ...| . . |. .   .. ||...||.  | ||..| ||..| |.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase LKB1.AA CAMK 54-309 24 1.1e-96 312.02 In-house 1-425 (425) Show / Hide 
Range on Protein: 54-309
Range on HMM: 1-425/425
Sequence Identity: 24% (103 aa)

LLGEGSYGKVKEVLDSETL------------CRRAVKILKKKKLRR------------------------IPNGEANVKKEIQLLRR-------LRHKNV
 ||.||.||||.. . .|              . |.||..||||.                          |. ..||..||.....       |.|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQLVDVLYNEE-----------------KQKMYMVM---EYCVCG-----MQEMLDSVPE-------------KRFPVCQAHGYFCQLIDGLEYLHSQGI
|.| .|  ...                 ...|||||   |||  |     . ... . .              .||.  .|. || |......|.||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHKDIKPGNLLLTTG-----------------GTLKISDLGVAEALHP---------------------FAADDTCRTSQGSPAFQP-PEIANGL-----
|| |.|| |.||..                  ...||.| | |  . |                     .. .. ..|. |.|.. . ||. ||      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------DTFSGFKVDIWSAGVTLYNITTGLYPFEGD-------------NIYKLFENIGKGSYAIPGDCGPP------------------------LSD
        .  |.|.|.||.|| ||   .| .||.||             |.|.|||.| || |  | .  .|                          |
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLKGMLEYEPAKRFSIRQIRQHSWF
|...||...| ||..| |. .| |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase LKB1.AA S_TKc 49-309 29 3.8e-83 283.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVC---GMQEMLDSVPE
| .....|.|..|||. . . .|  . |.||.|            ....|||.|.. .|.|...| || ..   ...|||||||      . ..... . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

KR----FPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSA
..    ||  .|  |..|....|||.||.||.| |.|| |.||..  ..||.| |.|  |         .|  |.| . .||.      ....|.|.|| 
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQ-------HSWF
|..||   .|  ||.  .....|..||           |.. |.....|...|.|| .. .. |       | ||
GCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LKB1.AA AMPK 49-309 38 1.8e-70 208.48 In-house 1-254 (254) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-254/254
Sequence Identity: 38% (100 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKR
|..|. .|||..||||      |    |.||| |.|..        ...||..|. .|| ..||| .|.  | .. ..|||||   |  |  |  |  .|
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQ-DMVERIQREIHILKLFRHPHIIQLYEVII-ETPTDIFMVMEYVSGG--ELFDYIVKHGR

FPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYN
 .  .|  .| | | |.||.|  .||| | || ||||     .|| | |           .. .|. |||    ||.  |     | .||||| || || 
LQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNM---MKDGEFLKTACGSPCYAAPEMISGK-LYCGPEVDIWSCGVILYA

ITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWF
   |  ||. .|. .|. .| .| | || .  |  .||.|.||.  | ||..| .||.|.||
MLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase LKB1.AA Pkinase 49-309 28 2.1e-65 228.37 Pfam 1-293 (293) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVK-KEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCG--MQEMLDSVP-
|  |  .|.||.|.|..  .  | .. ||||.||.  ..    .....  |||...||.|.|...| |. ..  |...||||||| .|   ..  | .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

--EKRF--PVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTL----KISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGL-DTFSGFK
  ...|  .  ..  |. |.. ||||.||.||.| |.|| |.|.   |..    ||.| |.|. .     .  . |  |.| . .||.   . ..  | |
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV--IRGGQYYGPK

VDIWSAGVTLYNITTGLYPFEGD------NIYKLFENIGKGSYAIPGDCG---------------------PPLSDLLKGMLEYEPAKRFSIRQIRQHSW
||.||.|..||   .|  || |.      . ......|... .  . .                       ... |..|..|.. |.|| ...|| || |
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase LKB1.AA Ciliate-E2 49-309 21 3.5e-59 201.79 In-house 1-365 (365) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-365/365
Sequence Identity: 21% (80 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRA----------------VKILKKKKLRRIPNGEANVKKEIQLLRRLR----------------HKNVIQLVDV
|    ..|.|..|.|... . .. .. |                ||| .. . . ..|.  ..|.||...|...                |.|.|.....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRFPV---------CQAHGYFCQLID---------------GLEYLHSQG-IVHKDIKPGNLLLTTGGTL
 ... ....|.|||||  | ... . . . ||.            ..  .. |...               .||||||.. |.| |||| |.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KISDLGVAEALHPF-----------------------------AADDTCRTSQGSPAFQPPEIANGLD-------TFSGFKVDIWSAGVTLYNITTGLYP
||.|.| .  ....                               ... .|  |.| ...||| || .       .  ..|.||||.||.||   .| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEGDNIYKLFENIGKGSYAIPGDC----------------GPPLS--DLLKG----MLEYEPAKRFS-IRQIRQHSWF
|        ...| .. . .|  .                  ...  ||.|     ||...| ||.. . || .| ||
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase LKB1.AA ULK 49-309 26 4e-53 182.79 In-house 1-324 (324) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-324/324
Sequence Identity: 26% (87 aa)

YLMGDLLGEGSYG-KVKEVLDSET---LCRRAVKILKKKKLRRIPNG------EANVKKEIQLLRRLR---HKN--VIQLVDVLYNEEKQKMYMVMEYCV
| . . ||.||.| || .  . .|       |.|.  |||.. ..|         . |.|||... |    |.|  ...| |....      |..|||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

CG-----MQEM-LDSVPE---KRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTG------------GTLKISDLGVAEALHPF-AADDTCR
.|     ...    .. .   ||..  .| ..| |.. |. .||...|.| |||| |.|.. |            |.|||.| | |  .     ... | 
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TSQ------GSPAFQPPEIANGL--DTFSG-FKVDIWSAGVTLYNITTGLYPFEGDNIYKLF----ENIGKG--------SYAIPGD-------CGPPLS
|        |.| .  |.| .|.      . .|.|||| |. .| . .| |||... .....    . | .|           |. .       . | . 
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

DLLKGMLEYEPAKRFSIRQIRQHSWF
||...||.|.. .|.|. .| .| ||
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase LKB1.AA MELK 49-309 33 9.8e-52 174.94 In-house 1-254 (254) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-254/254
Sequence Identity: 33% (88 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKR
| . | .| | ..|||      |  . |.||. |..| .       || |.. |. |||... ||  ..  | ..|..||||||  |  ||.|  . ..|
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGH---DLPRVKTEMDALKNLRHQHICQLYHYI--ETEDKIFMVMEYCPGG--EMFDYIIRQDR

FPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYN
.   ..  .| |..  . |.||||  |.|.|| |||..    ||. |.|.              |  ||||.  ||. .|.. . |   |.|| |. || 
LEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQ-YIGSEADVWSMGILLYV

ITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWF
.  |  ||. ||.  ..  | .| |  |    |   .||. ||  .| || |.... .| | 
LMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase LKB1.AA ULK 49-309 24 4.1e-51 176.14 In-house 1-329 (329) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-329/329
Sequence Identity: 24% (80 aa)

YLMGDLLGEGSYGKVKEVLDSET----LCRRAVKILKKKKLRRIPNG------EANVKKEIQLLRRLR----HKN----VIQLVDVLYNEEKQKMYMVME
| . . ||.||.||| .  . .|        |.|.. |.|.....|          .|.||.....|     |||    ...| |....      |..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCVCG-----MQEM-LDSVPE---KRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTG------------GTLKISDLGVAEALHPF--AAD
||  |     ...    . ..   ||..  .|  .|.|.. |. .||...|.| |||| | |.. |            |.|||.| | |  .  .   ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

DTCRTS-----QGSPAFQPPEIANGL--DTFSG-FKVDIWSAGVTLYNITTGLYPFEGDNIYKLF-----ENIGKG--------SYAIPGD-------CG
... ..      |.| .  |.| .|.      . .|.|||| |. .| . .| .||..  .....     ..| ..        .  .  .       . 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

PPLSDLLKGMLEYEPAKRFSIRQIRQHSWF
| . ||...||.|.. .|.|. .. .| ||
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase LKB1.AA CAMKK 156-309 28 4.3e-47 147.24 In-house 181-396 (396) Show / Hide 
Range on Protein: 156-309
Range on HMM: 181-396/396
Sequence Identity: 28% (63 aa)

YFCQLIDGLEYLH-SQG-------------------IVHKDIKPGNLLLTTGG---TLKISDLGVAEALHPFAADDTCRT-----------SQGSPAFQP
|| . | |||||| .|.                   |.|.|||| |.|..  |   ..||.| ||.  .     |.|               .| |||..
YFRDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFE--GQDQTLSNCESCFQRELNKTAGTPAFMA

PEIANGLDT--------------FSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFE---NIGKGSYAIPG-------------DCGPPLSDLLKGMLE
||     .               ..|...|||..||||| ...|  || ..|. .|..    | . .   |              .. . | ||.|.|||
PELCSKENQKENYNGYKYRFRFIYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKRMLE

YEPAKRFSIRQIRQHSWF
 .| || .| ||  | |.
KNPTKRITIPQIKVHPWV
Kinase LKB1.AA MARK 49-194 36 4.4e-32 102.28 In-house 1-149 (262) Show / Hide 
Range on Protein: 49-194
Range on HMM: 1-149/262
Sequence Identity: 36% (54 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQK-MYMVMEYCVCG-MQEMLDSVPEK
| |.  .|.|||.||| ...  |  . |.||..|.|| . |.   ||. ||.....| |.|.|.| .|   ...|.  |..|||.  | . . . ..|  
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLND-PQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNG

RFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGG--TLKISD
| .   |. .| |.. ...|.||..||| |||| |.|.   |    ||.|
RLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIID
Kinase LKB1.AA MARK 215-309 36 1e-24 77.83 In-house 167-262 (262) Show / Hide 
Range on Protein: 215-309
Range on HMM: 167-262/262
Sequence Identity: 36% (35 aa)

GSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDN--IYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWF
|.|.. .||| .. .   |.|||||| || || ...| .||.||.  . .|...| .|.| ||    . . .|.. .|   | .| .| .| .|.|.
GTPPYMAPEIFLKKPYD-GPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase LKB1.AA CAMKK 49-132 26 1.2e-23 71.49 In-house 1-112 (396) Show / Hide 
Range on Protein: 49-132
Range on HMM: 1-112/396
Sequence Identity: 26% (30 aa)

YLMGDLLGEGSYGKVKEVLDSET-LCRRAVKILKK----KKLRR----------------------IPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEE
|  .. .|.|..|||| . ....     |.||..|    ||| .                      ..|.. .|..||  .....|.|...|. |. ...
YELMKEIGQGQFGKVKLAYNEYDTQKHYAIKIFNKKYVFKKLKKKQQFYRDPPKRMTNMNQNGEMQMMNPFDCVYQEIAIMKKCNHPNIVKLYEVIDDPQ

KQKMYMV-MEYC
 .| ||| ||||
NDKIYMVQMEYC
Kinase LKB1.AA TyrKc 49-309 22 6.8e-16 34.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

YLMGDLLGEGSYGKVKE-VLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL--RHKNVIQLVDVLYNEEK-----QKMYMVMEYCVCGMQEML
  .|. |||| .|.| . ...       ||| ||. .       ..   .|......|  .|.|...|. |   ..      . ...||||.  |    .
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG--DLK

DSVPEKR--FPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPF----AADDTCRTSQ--GSP-----AFQPPEIANG
|   ..|  ... . . .  |  .| |||||....| |.   | |.. ..| |||| | . ...      ...|. |...  |.         .||    
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

LDTFSGFKVDIWSAGVTLYNITT-GLYPFEG-----DNIYKLFENIGKG-SYAIPGD--------CGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWF
 .    .| |.|| ||... | | |  | .|      . . ..|.. .|    .| .        | . . .. |   ...|..| . ..|  |. |
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase LKB1.AA Pkinase_Tyr 49-198 25 1e-09 33.55 Pfam 1-158 (270) Show / Hide 
Range on Protein: 49-198
Range on HMM: 1-158/270
Sequence Identity: 25% (42 aa)

YLMGDLLGEGSYGKVKE-VLD-----SETLCRRAVKILKKKKLRRIPNGE---ANVKKEIQLLRRL-RHKNVIQLVDVLYNEEKQ-KMYMVMEYCVCGMQ
  .|  ||||..|.|.. ...      .. .  |||.||          .   .   .|..... | .|.|...|. | . .... ..|.||||. .|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV--AVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG--

EMLDSVPEK-----RFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVA
 .||   ..     .... .  ..  |  .|.|||.|....| |.   | |.| ... ||.| | |
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA