Gene LRRK1 (Human)

LRRK1

Species: Human
Alias: FLJ23119, LRRK1, Roco1, FLJ27465, RIPK6, KIAA1790
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 15q26.3,

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
LRRK1.NA RNA Sugen Kinome 7647 None Fasta, JSON
LRRK1.AA Protein Sugen Kinome 2015 None Fasta, JSON
LRRK1.kin_dom Protein Kinase Domain Sugen Kinome 284 None Fasta, JSON

Protein domain

Protein domains of LRRK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 LRRK1.AA LRR_1 303-323 33 0.005422 14.78 Pfam 1-26 (26) Show / Hide 
Range on Protein: 303-323
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLRKLNLSD-N--HL-GELPG--VQSS
||..|.||. |  .| |..|     . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK1.AA LRR_TYP 301-324 45 0.012702 15.39 SMART 1-24 (24) Show / Hide 
Range on Protein: 301-324
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

LINLRKLNLSDNHLGELPGVQSSD
| |||.|.||.|.| .||    ..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_BAC LRRK1.AA LRR_BAC 301-320 45 0.285562 5.38 SMART 1-20 (20) Show / Hide 
Range on Protein: 301-320
Range on HMM: 1-20/20
Sequence Identity: 45% (9 aa)

LINLRKLNLSDNHLGELPGV
  .|..|| |.|.| |||  
PPHLKWLNVSNNQLTELPEL
LRR_TYP LRRK1.AA LRR_TYP 278-300 43 0.300665 4.13 SMART 2-24 (24) Show / Hide 
Range on Protein: 278-300
Range on HMM: 2-24/24
Sequence Identity: 43% (10 aa)

CQITELDLSANCLATLPSVIPWG
 . .||||| | | .||. . .|
PNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRRK1.AA LRR_1 279-301 29 0.374108 8.26 Pfam 1-26 (26) Show / Hide 
Range on Protein: 279-301
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

QITELDLSA-N--CLA-TLPSVIPWGL
....||||  |  .|  ..|. .  .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC LRRK1.AA LRR_BAC 277-296 30 0.835495 1.82 SMART 1-20 (20) Show / Hide 
Range on Protein: 277-296
Range on HMM: 1-20/20
Sequence Identity: 30% (6 aa)

SCQITELDLSANCLATLPSV
  ....|. | | | .||  
PPHLKWLNVSNNQLTELPEL
LRR_1 LRRK1.AA LRR_1 330-351 37 0.001642 16.62 Pfam 1-26 (26) Show / Hide 
Range on Protein: 330-351
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLLEIDISS-N--KLS-HLPPG-FLHL
.| ..|.|. |  .|. |.||. | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK1.AA LRR_TYP 328-351 45 0.086831 8.55 SMART 1-24 (24) Show / Hide 
Range on Protein: 328-351
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

CSRLLEIDISSNKLSHLPPGFLHL
 . | | | |.|.|.||||| .. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_BAC LRRK1.AA LRR_BAC 328-347 30 0.666396 2.57 SMART 1-20 (20) Show / Hide 
Range on Protein: 328-347
Range on HMM: 1-20/20
Sequence Identity: 30% (6 aa)

CSRLLEIDISSNKLSHLPPG
 ..| ....|.|.|. ||  
PPHLKWLNVSNNQLTELPEL
LRR_TYP LRRK1.AA LRR_TYP 379-401 50 6.9e-05 23.49 SMART 1-24 (24) Show / Hide 
Range on Protein: 379-401
Range on HMM: 1-24/24
Sequence Identity: 50% (12 aa)

LRKLQELDISDNKLTELP-ALFLH
|..|.||| |.|.||.||  .| .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_BAC LRRK1.AA LRR_BAC 379-398 50 0.000201 21.94 SMART 1-20 (20) Show / Hide 
Range on Protein: 379-398
Range on HMM: 1-20/20
Sequence Identity: 50% (10 aa)

LRKLQELDISDNKLTELPAL
  .|..|..|.|.|||||.|
PPHLKWLNVSNNQLTELPEL
LRR_1 LRRK1.AA LRR_1 381-403 33 0.001002 17.38 Pfam 1-26 (26) Show / Hide 
Range on Protein: 381-403
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

KLQELDISD-N--KLT-ELPALFLHSF
.||.||.|. |  .|| ..|   . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC LRRK1.AA LRR_BAC 403-422 40 0.026351 13.28 SMART 1-20 (20) Show / Hide 
Range on Protein: 403-422
Range on HMM: 1-20/20
Sequence Identity: 40% (8 aa)

FKSLNSLNVSRNNLKVFPDP
  .| .||||.|.|. .|. 
PPHLKWLNVSNNQLTELPEL
LRR_1 LRRK1.AA LRR_1 405-425 25 0.260054 8.82 Pfam 1-26 (26) Show / Hide 
Range on Protein: 405-425
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLNSLNVSR-N--NL-KVFPD--PWAC
.| .|..|. |  || . .|.    ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK1.AA LRR_TYP 403-427 32 0.289067 4.27 SMART 1-24 (24) Show / Hide 
Range on Protein: 403-427
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

FKSLNSLNVSRNNLKVFPDPWACPL
  .| .|. |.|.|.  | | |.  
LPNLRELDLSNNQLTHLP-PGAFQG
LRR_TYP LRRK1.AA LRR_TYP 472-493 41 0.066861 9.48 SMART 1-24 (24) Show / Hide 
Range on Protein: 472-493
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LDALMFLRLQGNQLAALPPQ--EK
| .|  |.|..||| .|||.  . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_BAC LRRK1.AA LRR_BAC 472-491 35 1.069813 1.0 SMART 1-20 (20) Show / Hide 
Range on Protein: 472-491
Range on HMM: 1-20/20
Sequence Identity: 35% (7 aa)

LDALMFLRLQGNQLAALPPQ
 ..| .|. ..|||  ||  
PPHLKWLNVSNNQLTELPEL
LRR_1 LRRK1.AA LRR_1 451-472 25 3.027428 5.04 Pfam 1-26 (26) Show / Hide 
Range on Protein: 451-472
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

HLKDVDFSE-N--AL-KEVPLG-LFQL
.|.  |.|  |   | ...| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRK1.AA LRR_1 474-490 38 37.315592 1.17 Pfam 1-21 (26) Show / Hide 
Range on Protein: 474-490
Range on HMM: 1-21/26
Sequence Identity: 38% (8 aa)

ALMFLRLQG-N--QLA-ALPP
 |  | |.| |  .|   .||
NLQHLDLSGCNCCNLTGHIPP
LRR_1 LRRK1.AA LRR_1 498-511 44 0.386454 8.21 Pfam 1-18 (26) Show / Hide 
Range on Protein: 498-511
Range on HMM: 1-18/26
Sequence Identity: 44% (8 aa)

QLKTLDLSR-N--QL-GK
.|..||||. |  .| |.
NLQHLDLSGCNCCNLTGH
LRR_1 LRRK1.AA LRR_1 572-594 29 0.004022 15.24 Pfam 1-26 (26) Show / Hide 
Range on Protein: 572-594
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLSELYLGN-N-PGL-RELPPE-LGQL
.| .|.|.. | . | ...||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK1.AA LRR_TYP 570-594 48 0.016589 14.44 SMART 1-24 (24) Show / Hide 
Range on Protein: 570-594
Range on HMM: 1-24/24
Sequence Identity: 48% (12 aa)

LKSLSELYLGNNPGLRELPPELGQL
| .| ||.|.||  |..|||.. | 
LPNLRELDLSNNQ-LTHLPPGAFQG
LRR_1 LRRK1.AA LRR_1 549-570 33 0.116997 10.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 549-570
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLEVLCLND-N--HL-DTVPPS-VCLL
.|..| |.. |  .| ...|||    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC LRRK1.AA LRR_BAC 547-566 25 0.426485 4.05 SMART 1-20 (20) Show / Hide 
Range on Protein: 547-566
Range on HMM: 1-20/20
Sequence Identity: 25% (5 aa)

SESLEVLCLNDNHLDTVPPS
 ..|. |. ..|.| . |  
PPHLKWLNVSNNQLTELPEL
LRR_TYP LRRK1.AA LRR_TYP 548-569 30 0.63482 1.47 SMART 2-24 (24) Show / Hide 
Range on Protein: 548-569
Range on HMM: 2-24/24
Sequence Identity: 30% (7 aa)

ESLEVLCLNDNHLDTVPPSV-CL
 .|..| |..|.| ..|| .   
PNLRELDLSNNQLTHLPPGAFQG
LRR_BAC LRRK1.AA LRR_BAC 570-591 45 0.754089 2.16 SMART 1-20 (20) Show / Hide 
Range on Protein: 570-591
Range on HMM: 1-20/20
Sequence Identity: 45% (10 aa)

LKSLSELYLGNNPGLRELPPEL
  .| .|. .||  |.|| |||
PPHLKWLNVSNNQ-LTEL-PEL
ROC LRRK1.AA ROC 636-818 19 4.8e-26 84.52 In-house 1-215 (215) Show / Hide 
Range on Protein: 636-818
Range on HMM: 1-215/215
Sequence Identity: 19% (46 aa)

CKLMKMIIVGPPRQGKSTLLEILQTGRAP---------QVVHGEATIR-TTKWELQRP---AGSRAKVESVEFNVWDIGGPASMATVNQCFFTD-KALYV
|. || ...| .. ||..|.. |  .  .         .  .  . |     |.|. .      |.| . . ||||| ||   .    | |.|  ...|.
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMF--RKKEDEIKFNVWDFGGQEIYHATHQFFLTNHRSVYL

VVWNLAL----GEEA----VAN--LQFWLLNIEAKAPN--------AVVLVVGTHLDLIEAKFR-----------VERIATLRAYVLALCRSPSGSRATG
.||....    |..       |  |..|| .|.. .|.        . |..||||.| .. .             ....                     
LVWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCCRMWQKL------------------RNK

FPDITF--------KHLHEISCKSL-EGQEGLRQL
||.|..        .  . ..|..  .| ..||. 
FPNICHSWMQIEHYQGFFHVDCETGCKGIDKLRHH
Miro LRRK1.AA Miro 640-760 17 6.8e-08 30.39 Pfam 1-140 (140) Show / Hide 
Range on Protein: 640-760
Range on HMM: 1-140/140
Sequence Identity: 17% (25 aa)

KMIIVGPPRQGKSTLLEILQTGRAP----------QVVHGEATIRTTKWELQRPAGSRA----KVESVEFNVWDIGGPASMATVNQCF--FTDKALYVVV
|  ..| .. |||.... . ..  |           .     .... . ..| .   .     .|    |..||.||.  ..  .. |  ...   ...|
KVVVCGDKGCGKSSFIHQYCGEEFPPNIPRVLPDKTMPREMHGHTYYVDTMQVDWDTQSENVDRVKMCYFHIWDCGGREYWKFEHMHFACMKWADAICFV

WNLALGE--EAVANLQFWLLNIEAKAPN-AVVLVVGTHLD
  .  .|  . | |.  || ...... .  .| |||...|
YDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
COR LRRK1.AA COR 829-1194 15 1.7e-32 102.43 In-house 1-386 (434) Show / Hide 
Range on Protein: 829-1194
Range on HMM: 1-386/434
Sequence Identity: 15% (66 aa)

VGSTIGCQRL-------AGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTP-------DNDIKDYEDLQSAISFLIETGTLLHFP--DT
.. |.  .         ... .|.|.. . ... ..   ..|  . ....  .. |..           .| |.| . |. .. .| ..|...||   | 
IRKTAKKIKHKQMFEDYMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWDH

SHGLRNLYFLDPIWLSECLQRIFNIKGSRSV---AKNGV-IRAEDLRMLLVGT----------GFTQQTEEQYFQFLAKFEIALPVAN----------DS
  .|.....||| |... . .|||.| ||..   ...|. .. .||  .. .            ...   |...... |||...|...          . 
DPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQETTT

YLLPHLLP-SKPGLD-THGM-----RHPTANTIQRVFKM------SFVPVGFWQRFIARML-ISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCS
|| | ||| ..|. . .. .      .   ....|....       | | |||.||..|.. ... ...                               
YLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKC------------------------------

TFRVKRNQTI----YWQEGLLVTFDGG---YLSVESSDVNWKKKKSGGMKIVCQSEVR-----DFSAMAFITDHVNSLIDQWF--PALTATESDGTPLME
     .. .     ||. |..  . |.   . .|...       .  . .|. ... .         .. |..|. .. ..|.  | |.  .  .  ...
----FYERSCCEWMYWRNGMVLKWEGHNKNEALVKCDN------HDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHW--VCR

QYVPCPVCETAWAQHTDPSEKSE-DVQ--YFDMEDCV
 ..||| |           .... . .  |. ...|.
EWIPCPHC---------IQDHWDTCCDICYYQYDWCI
LRR_1 LRRK1.AA LRR_1 1184-1205 25 12.546949 2.85 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1184-1205
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

DVQYFDMEDC---VLT-AIERD-FISC
  |. |. .|    ||  |  . | ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase LRRK1.AA LRRK 1242-1522 33 2.6e-152 512.32 In-house 1-351 (351) Show / Hide 
Range on Protein: 1242-1522
Range on HMM: 1-351/351
Sequence Identity: 33% (117 aa)

EDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKN------------FANVPADTMLRH-----------------------------LRATDAMKN
  ... .|.||.||..|||...||||.|.|.|.|....            ...|......|.                             ....|....
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FSEFRQEASMLHALQHPCIVALIGISIHPLCFALELAPLSSLNTVLSENARDS-SFIP--LGHMLTQKIAYQIASGLAYLHKKN--IIFCDLKSDNILVW
|.|||.|..... |.||.|| |.|..|||||...|.||. .|...|.....|. .|..  ...||..|||.|||.|..|||..|  ||..||||.|||.|
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLW

SLD-------VKEHINIKLSDYGISR--QSFHEG-ALGVEGTPGYQAPEIRP---RIVYDEKVDMFSYGMVLYELLSGQRPALGHH--------QLQIAK
|..       ...|...|..|.||||  |.||.| | |..|.||..||||..   ...|.||||..|.||.|.|||..|... ..|        . || .
SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIED

KLSKGIRPVLG---QPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKD
| ..|.||..    .|........|.|...||...|.||| . ..|.....
KIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase LRRK1.AA TKL 1248-1520 22 3.3e-79 269.44 In-house 1-364 (364) Show / Hide 
Range on Protein: 1248-1520
Range on HMM: 1-364/364
Sequence Identity: 22% (87 aa)

LGQGGSGTVIYRARYQG----------QPVAVKRFHIKKFKNFA------------NVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIG-
.|.||.| ..|.....|          ..||||.|...  ..|             .   | |   |....|.... ....|. |.. |.|| || ..| 
IGSGGFG-EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYS---D-M--QLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGY

--------ISIHP------LCFALELAPLSS-LNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHK--------KNIIFCDLKSDNILVWSL----
        ...||      ||.  |..|  | |....             . .. ..|..||.|..|||         ..|| .||||.||||..     
CCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNV

-----DVKEHINIKLSDYGISRQSFHEG--------------------ALGVEG-TPGYQAPEIR----------------PRIVYDEKVDMFSYGMVLY
     ........|..|.|.||  ...|                    ... .. ||.. |||.                 .   |.||.|..|.|.||.
SNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW

ELLSGQRPALGHHQ----------LQIAKKLSKGIRPVLG---------QPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQM
|.|...||  ...           . ...  .|| || .          .|..   ...  ||..|||..||||| .. .....
EILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRRK1.AA Pkinase 1242-1520 21 2.2e-40 143.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1242-1520
Range on HMM: 1-293/293
Sequence Identity: 21% (71 aa)

EDEGSVLGQGGSGTVIYRARYQGQP--VAVKRFHIKKFKNFAN-----VPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHP--LCF
   |...|.|..|.| |... .| .  ||||..  .. |   .                            .|..... |.||.|| |...   .  ...
YHIGRKIGSGSFGCV-YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----------------------SEIQIMKRLNHPNIVRLYDWFEDKDHIYM

ALELAPLS----SLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVW-SLDVKEHINIKLSDYGISR---QSFHEGALGV
 .|...      .| ...|   |. .|. .     ....|||..||.|.|...|| .|||..|||.    ....   .|..| |...       . . ..
VMEYCEGGLYVMDLFDYIST-WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS-MTTF

EGTPGYQAPEIRP-RIVYDEKVDMFSYGMVLYELLSGQRPALGH---HQLQIAKKLSKGIRPVLGQPEEVQF---------------------RRLQALM
 |||.| |||.   .  |. ||||.|.| .|||.|.|. |  ||   .     ... . |..     .. .                      . .. ..
CGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFI

MECWDTKPEKRPLALSVVSQ--M
  |.. .|.||| |  ..    .
KWCLCKDPKKRPTAEQILQHPWF
Kinase LRRK1.AA S_TKc 1242-1525 24 8.8e-38 132.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 1242-1525
Range on HMM: 1-231/231
Sequence Identity: 24% (71 aa)

EDEGSVLGQGGSGTVIYRARYQG--QPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISI-HPLCFALELAP
 . . ..|.|. |.| |..|  .  . ||.|. .                              .|.| ..|.  .|| || |...   . |.. .|...
YEILRKIGKGAFGKV-YKCRHKKTGRIVAIKIIK----------------------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCD

L--SSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIR
    .| ... .. |     |.    .....|||...|.|.|...|| .||| .|||. .       .||..| |..||        . ||| | |||. 
GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL

PRIVYDE-KVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVS----QMKDPTF
    |.  |.|. | | .|||.|.|. |    .. .. ||.                . .  ... |..  ||||| |  .       ...| |
---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRRK1.AA TKL-Unique 1303-1520 26 5.3e-37 128.06 In-house 41-290 (290) Show / Hide 
Range on Protein: 1303-1520
Range on HMM: 41-290/290
Sequence Identity: 26% (67 aa)

EFRQEASMLHALQ-HPCIVALIGISI----HPL--CFALELAPLSSLNTVLS------ENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKN--IIFCDL
||. | . .  |. || || ..|...    .|   |. .|  |..||. ||.       | .... ...  ..  |.| .||.|. ||| ..  || .||
EFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRV--KMAIDIAQGMYYLHHCEPPIIHRDL

KSDNILVWSLDVKEHINIKLSDYGISRQSF--HEGALG---------VEGTPGYQAPEIRPR--IVYDEKVDMFSYGMVLYELLSGQR------PALGHH
|| |.|| .      .|||..| |.|. .    .. ..         ..|.. . |||.  .    |.||.| .|.|.||.|......      |  |  
KSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMD

QLQIAKKLSK---GIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQM
| |..... .   . || ...  . ..|    |. .||.  |..||   ....  
QEQWCEMVHYMEENYRPPIPNHCPKEYR---DLIQQCWHHDPSQRPSFDEIIHRL
Kinase LRRK1.AA Dicty4-Unclassified 1303-1520 31 9.5e-34 112.93 In-house 44-263 (263) Show / Hide 
Range on Protein: 1303-1520
Range on HMM: 44-263/263
Sequence Identity: 31% (71 aa)

EFRQEASMLHALQHPCIVALIGISIHP------LCFALELAPLSSLNTVLS-ENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVW
.|. |  .|  .|||  | . | .| |      .|   |. .   |  |     .     | |   |  |.|  || |...|| .|.|  |.|| |||  
DFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNIL--

SLDVKEHINIKLSDYGISRQ-SFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHH-QLQIAKKL-SKGIRPVLGQPEEVQF
   .  | |||  | ||||  .|      . |||   .||.     |  | | .||.|.||||. |  | ..    . .|    .|. || .  |. .  
---MDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKI--PDNCD-

RRLQALMMECWDTKPEKRPLALSVVSQM
  .. |   ||   | |||    ..  .
NFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase LRRK1.AA TK 1288-1520 15 6.8e-32 103.61 In-house 59-486 (486) Show / Hide 
Range on Protein: 1288-1520
Range on HMM: 59-486/486
Sequence Identity: 15% (65 aa)

MLRHLRATDAMKNFS-------------EFRQEASMLH--ALQHPCIVALIGISIHP--------------LCFALELAPLSS----LNTVLSENARDSS
||.   |....  |              |. .|..|..  ...|| || |.|.. ..              ..  .|..|. .    | . | .. .. .
MLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQ

F----------------------------------------------------IPLGHMLTQK-----------------IAYQIASGLAYLHKK-----
                                                     ... ..| .                  ...|||.|..|||.|     
HEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFI

-NIIFCDLKSDNILVWSLDV-KEHIN------IKLSDYGIS--------RQSFHEGALGVEGTPG----------------------------YQAPEIR
 |..  ||   |.|| . .| | | .      .|..|.| |        |   ...   . ...|                            . |||  
QNFVHRDLAARNCLVGENNVCKWH-FDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECL

P---------RIVYDEKVDMFSYGMVLYELLS-G-QRPALGHHQ---------LQIAKKLSK------------GIRPVLGQPEEVQF------------
            .. .| |..|.| ...|... | . .. |..           .. ..| .            | |  . ||.                
NDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCP

-RRLQALMMECWDTKPEKRPLALSVVSQM
   .. ||..||. .||.||    ...|.
PEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LRRK1.AA MLK 1303-1520 27 8.3e-32 107.67 In-house 51-291 (291) Show / Hide 
Range on Protein: 1303-1520
Range on HMM: 51-291/291
Sequence Identity: 27% (69 aa)

EFRQEASMLHALQHPC----IVALIGISIHP---LCFALELAPLSSLNTVLSENARDSS----------FIPLGHMLTQKIAYQIASGLAYLHKKN---I
.|..|.  |  |.||     |... |... |   .|  .| .. .||..|| ..   ..           ....|...  .|.|.|.|..|||..    |
DFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMN--WALQCARGMHYLHSMAPKPI

IFCDLKSDNILVW---SLDVKEHINIKLSDYGISRQSFHEG---ALGVEGTPGYQAPEIR---PRIVYDEKVDMFSYGMVLYELLSGQRPAL-GHHQLQI
|  |||| |||.    . | .. .  | .| |.|| ..|.      .  ||. . |||..   .   |.||.|..|.|.||.|.|... |   .. ...|
IHRDLKSHNILIDEICH-DMHHGT-LKICDFGTSR-DWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAI

A-KKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQM
| .   .|.|| ...      ...  ||..||...|.|||   ..|.. 
AWWVAYNGLRPPIPST---CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase LRRK1.AA Dicty4 1302-1463 29 7.7e-29 93.44 In-house 43-216 (277) Show / Hide 
Range on Protein: 1302-1463
Range on HMM: 43-216/277
Sequence Identity: 29% (53 aa)

SEFRQEASMLHALQHPCIVALIGISI----HP--LCFALELAPLSSLNTVLSE---NARDSSFIPLGHMLT-QKIAYQIASGLAYLHKKN--IIFCDLKS
.|||.|.. .  ..|| |. . | ..    ||  .|   |. |  .| ..|        .|  .... ..   ..|  .| |...||  |  ||  ||||
NEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKS

DNILVWSLDVKEHINIKLSDYGISR-----QSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRP
.|.|     | .. ..| .| |.|.      ..  .. .. |||.. |||.     |.||.| .|.|.||.|.| .| |
HNLL-----VDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEP
Kinase LRRK1.AA STE 1242-1511 16 1.2e-27 94.79 In-house 1-346 (359) Show / Hide 
Range on Protein: 1242-1511
Range on HMM: 1-346/359
Sequence Identity: 16% (63 aa)

EDEGSVLGQGGSGTVIYRARY----------------QGQPVAVKRFHIKKFK----NFANVPADTMLRHLRATDAM------KNFSEFRQEASMLHALQ
 .  ...|.|..||| . ..                 .|. .|.|. .... .    |              .   .      ... .. .| .... ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDEN-----------Q-EN-Q-ELENKNHEEMQQILKEIKIMKKCN

--HPCIVALIGISIHP---------LCFALELAPLSSLNTVLSEN-ARDSSFI-------PLGHMLTQKIAYQIASG-LAYLHKKNIIFCDLKSDNILVW
  || ||  .|  ..          |. ..|. .  ||  .. ..  .  ..        ..   .  .|..||  | |.|||...||  |.|..|||. 
HMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-

SLDVKEHINIKLSDYGISRQSFHEGA-------------LGVE-----GTPGYQAPEI-RP-----RIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQ
         .||.| |.. |  ...|              . .     ||| . |||. ..     .  ||.|.|. | | .. |.. |. |    | ..
---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMR

IAKKLSKGIRPVL---------GQPEEVQF----------------------RRLQALMMECWDTKPEKRP
      ......          |.|   .                         ..  .  | .  |.|||
AMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP
Kinase LRRK1.AA Ciliate-E2 1364-1463 26 4e-25 83.19 In-house 148-295 (365) Show / Hide 
Range on Protein: 1364-1463
Range on HMM: 148-295/365
Sequence Identity: 26% (42 aa)

QKIAYQIAS---------------GLAYLHKKN-IIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQ-----------SFHEGALGVE-----------
..| .||..               .| |||.|| ||  |.| .|||.          ||..| |.|..           . ..  .              
KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD

------------GTPGYQAPEIRP---------RIVYDEKVDMFSYGMVLYELLSGQRP
            |||||.||||           .  ||.|.|..| |..|||.|.|..|
QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP
Kinase LRRK1.AA MLK 1305-1473 31 1e-24 78.42 In-house 49-235 (280) Show / Hide 
Range on Protein: 1305-1473
Range on HMM: 49-235/280
Sequence Identity: 31% (61 aa)

RQEASMLHALQHPCIVALIGISIH--PLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKN---IIFCDLKSDNILVWSLDV
|||| .. .|.|| |.|| |. ..   ||  .|..  .||| |..        ||. | |    | ||| |. |||.     ||  ||||.|||.    .
RQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK-----RIPP-HVLVN-WAVQIARGMNYLHNEAPVPIIHRDLKSSNILILE-KI

K---------------------EHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIA
                      ..   |  |.|. |.  ..  .   ||    |||.    .. .  |  ||| .| ||| |  |  |.  | .|
CLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMSAAGTYAWMAPEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVA
Kinase LRRK1.AA TyrKc 1242-1520 22 1e-20 76.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 1242-1520
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)

EDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHAL--QHPCIVALIGISI---------HPL
   | .|| |  |.| |....  ..||||  .  .                          .|..||.... |  .||.||.|.|. .         .||
ITLGKKLGEGAFGEV-YKGTWK-IQVAVKMLKEDA------------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPL

CFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHE------GALGV
.  .|..|. .|.  | .. ..   ... ..|  ....|||.| .|||.||.|  ||   |.|| .        .| || | ||   ..      .   .
MIVMEYMPHGDLKDYLRKHRPK---LCMKDLL--SFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYR

E----GTPG-----YQAPEIRPRIVYDEKVDMFSYGMVLYELLS-GQRPALG-----HHQLQIAKKLSKGIRPVLGQPEEV-------QFRRLQALMMEC
     |. .       |||     .. .| | .|.| ...|... || |  |         .. ... .| |  . ||...           .  .| .|
KKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR--MPQPPNDYPMSFVCCPDEMYQIMKQC

WDTKPEKRPLALSVVSQM
|. .||.||    .....
WHEDPEDRPTFSEIHECF
Kinase LRRK1.AA Pkinase_Tyr 1296-1414 28 2.3e-16 56.07 Pfam 39-159 (270) Show / Hide 
Range on Protein: 1296-1414
Range on HMM: 39-159/270
Sequence Identity: 28% (37 aa)

DAMKN---FSEFRQEASMLHAL-QHPCIVALIGISI---HP--LCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCD
.||.      .| .||.... | .|| || |.|. .    |  ..  .|..|. .| . | ..   ..  || .    ....|||.|..||. ||.|  |
GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRD

LKSDNILVWSLDVKEHINIKLSDYGISR
|   |.|| .        .| .| | .|
LAARNCLVTE-----NNVVKICDFGLAR
Kinase LRRK1.AA Pkinase_Tyr 1440-1520 25 4.7e-07 24.52 Pfam 190-270 (270) Show / Hide 
Range on Protein: 1440-1520
Range on HMM: 190-270/270
Sequence Identity: 25% (21 aa)

VYDEKVDMFSYGMVLYELLS-GQRP-ALGHHQLQIAKKL-SKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQM
.. .| |  |.| ...|... |. |   |    .. ...  .| |  . .||      .  ||..||. .||.||    ...|.
KFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR--MPCPENCP-DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase LRRK1.AA MLK 1242-1282 18 2e-06 18.81 In-house 1-57 (291) Show / Hide 
Range on Protein: 1242-1282
Range on HMM: 1-57/291
Sequence Identity: 18% (11 aa)

EDEGSVLGQGGSGTVIYRARYQGQP-----VAVKRFH------------IKKFKNFAN
 ..  ..| |..| | ...|....      |||||..            ...|. ...
IQFHEWIGSGSFGKV-WKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECR
Kinase LRRK1.AA MLK 1496-1520 36 1.9e-05 13.69 In-house 256-280 (280) Show / Hide 
Range on Protein: 1496-1520
Range on HMM: 256-280/280
Sequence Identity: 36% (9 aa)

QALMMECWDTKPEKRPLALSVVSQM
..|| .||.. | |||   ... |.
AKLMQDCWNQDPHKRPKFSEILQQL
Kinase LRRK1.AA TKL-Unique 1245-1274 40 4.5e-05 14.03 In-house 2-30 (290) Show / Hide 
Range on Protein: 1245-1274
Range on HMM: 2-30/290
Sequence Identity: 40% (12 aa)

GSVLGQGGSGTVIYRARYQGQPVAVKRFHI
....|.||.| ..|.. . | |||.|.||.
WNKIGEGGYG-QVYKGKWRGYPVAIKQFHP
Kinase LRRK1.AA Dicty4 1494-1511 38 0.000716 8.99 In-house 247-264 (277) Show / Hide 
Range on Protein: 1494-1511
Range on HMM: 247-264/277
Sequence Identity: 38% (7 aa)

RLQALMMECWDTKPEKRP
.. .|. .|||. |..||
SWKHLIQWCWDHDPQHRP
Kinase LRRK1.AA MLK 1243-1273 41 0.008773 4.77 In-house 2-31 (280) Show / Hide 
Range on Protein: 1243-1273
Range on HMM: 2-31/280
Sequence Identity: 41% (13 aa)

DEGSVLGQGGSGTVIYRARYQGQPVAVKRFH
.   ..| || | | ||| ..|. ||||. .
KIKEIIGNGGFGKV-YRAQWKGEEVAVKAHR
Kinase LRRK1.AA Dicty4 1243-1270 35 0.196668 0.74 In-house 2-28 (277) Show / Hide 
Range on Protein: 1243-1270
Range on HMM: 2-28/277
Sequence Identity: 35% (10 aa)

DEGSVLGQGGSGTVIYRARYQGQPVAVK
. .. .|.|. |.| |...  |. ||||
NIEQRIGKGSFGEV-YKGTWRGKEVAVK