Gene MAP2K4 (Human)

MAP2K4

Species: Human
Alias: SEK1, MAP2K4, PRKMK4, MAPKK4, MEK4, JNKK1, MKK4, JNKK, SERK1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 17p12-p13,

Classification

Group: STE
Family: STE7
Subfamily: MEK4

Sequence

Name Sequence Type Origin Length Description Download
MAP2K4.NA RNA Sugen Kinome 3752 None Fasta, JSON
MAP2K4.AA Protein Sugen Kinome 399 None Fasta, JSON
MAP2K4.kin_dom Protein Kinase Domain Sugen Kinome 266 None Fasta, JSON

Protein domain

Protein domains of MAP2K4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAP2K4.AA MEK4 102-367 68 2.5e-223 736.05 In-house 1-275 (275) Show / Hide 
Range on Protein: 102-367
Range on HMM: 1-275/275
Sequence Identity: 68% (187 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIR-STVD-----EKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSV
|.||||||.||.|.||||.||.||.|||||||| ..||     .||||.|||..||||.|..|||||.||||.|.|||||||||||..|.||||||||.|
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

LDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGI
 ...|||.|.|.||..||.|||.|||..||||||.|||||||||.|..|||||||.||||||||||.|||||||||||||||.....|||.|||||||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

TLYELATGRFPYPKWN--SVFDQLTQVVKGDPPQLSNSEE-REFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
|.||.|||.|||.|||  |||||...|||||||.|..... ...|.....|.|.|||||...||||..|.|.||.
TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase MAP2K4.AA STE7 102-367 55 3.3e-192 644.85 In-house 1-288 (288) Show / Hide 
Range on Protein: 102-367
Range on HMM: 1-288/288
Sequence Identity: 55% (165 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDE-KEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGD--CWICMELMS-TSFDKFYKYVYSV--
|...||.|.|.||.|.||.|||||.||||||||.|... .||||.||.|||.....|||||||||||...|||  .|||||.|. ...|||||.|. |  
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--LDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSI-AKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWS
   .. ||| |||||..|..|.|..|.|..||||||.||||||....|..|||||||.||||||. |.|...||.|||||||||.  ..|.|||||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG--NKQHYDVRSDVWS

LGITL-YELATGRFPYPKWNS-----------------VFDQLTQVVKG-DPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLK-HPFI
||||. .|.||||.|||.||.                 .|.|||..|.. .||.|      .|||.|..|||.||.||...||||..|.| ||||
LGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP-----KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase MAP2K4.AA MEK3 102-367 60 1.2e-176 593.17 In-house 1-264 (264) Show / Hide 
Range on Protein: 102-367
Range on HMM: 1-264/264
Sequence Identity: 60% (161 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIP
.  . | |||||| | || |..||.||||||||.||  .|||..|||.|. |||||||| |.||||.||||| |||||.|.|. ||||. ||   .  ||
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

EEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELA
|.||||| .  |.||....| ||.||||.||||.|. . | .|.|||||||.||||.||| ||||.||||||||||  .  ||||.|||||||||. |.|
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA

TGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
.||.|| .|   |.||.|||.. ||||   .|. ||| .  |.| || |.   ||.|.||..|||.
IGRYPYDNWHTPFQQLKQVVEEPPPQL--PMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase MAP2K4.AA MEK7 102-367 54 3.3e-143 482.06 In-house 1-269 (269) Show / Hide 
Range on Protein: 102-367
Range on HMM: 1-269/269
Sequence Identity: 54% (146 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIP
|. .|..| |  | | || || || |||||  | |    | |  ||||||.  . ||||||| .|.. .. | |||||.||| .||  | ..    | ||
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP

EEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDP-SASRQGYDVRSDVWSLGITLYEL
| |.||.. |...||. |||   |.|||.|||||||| .|||||||||||| .||| |.|| ||| .|||||||||       ||.|.|||||||||.||
EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVEL

ATGRFPYPKWNSVFDQLTQVVKG--DPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
|||..|||  .  |. .| .     .|| |   . . ||| |..||..||.||  .||||..|..||||
ATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MAP2K4.AA STE 102-367 29 2.6e-120 406.02 In-house 1-359 (359) Show / Hide 
Range on Protein: 102-367
Range on HMM: 1-359/359
Sequence Identity: 29% (109 aa)

LKDLGEIGRGAYGSVNKMVHK------PSGQI---------MAVKRIR----------------STVDEKEQKQLLMDLDVVMRSSD-CPYIVQFYGALF
......||.||.|.| | ...      ..|..         ||.|...                ......|..|.|..... ..... .|.||..||. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

REG-------DCWICMELMS-TSFDKFYKYVYSVLD---------DVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISG
.||       ..|||||.|.  |.|...| .|....         ...||.....|. ...|.| .......||||||||.||||     .||||||..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLVDSIA----------------KT-RDAGCRPYMAPERIDPSASR--QGYDVRSDVWSLGITLYELATGRFPYPKWNSV---------------FDQLT
||.||.|                |.  ..|.  .||||.|..  .   .|||...|.||||.|. |.|||. |. . .                 |.|| 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

QVVKGDPPQLSNSEE---------------REFSPSFINFVNLCLTKDESKRPKYKELLK--HPFI
..|.|.||.| .  .               ...||.|..|.|.||.|| .|||....|||  ||||
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP2K4.AA STE7-Unclassified 102-367 37 4e-98 332.3 In-house 1-301 (301) Show / Hide 
Range on Protein: 102-367
Range on HMM: 1-301/301
Sequence Identity: 37% (114 aa)

LKDLGEIGRGAYGSVNKMVHKP------SGQIMAVKRIR-STVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGD---CWICMELMST-SFD---K
|. |...|.|..|.| | .||.      .| ||| | |.    |.. .||.|. | ..   . .||||..||| . |.      ||||.|   |.|   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

FYKYVYS---VLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSI--AKTRDAGCRPYMAPERIDPS-ASR
 || .|    .    ||| .||||...  ..| .|.| ..||||||||.|||..  |..|.||||..|||....  |||  .||  ||.||||      |
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKT-WVGCQMYMSPERIQGQMPHR

QGYDVRSDVWSLGITLYELATGRFPYP------KWNSVFD-------QLTQVVKGDP-PQLSN-SEEREFSPSFINFVNLCLTKDESKRPKYKELLK-HP
 .| |.||.||||.|. |.|||..||.      . |  |.       .| . . . | |.| .  |.  .|..|..|.. |. |..  || . .||. ||
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP

FI
.|
WI
Kinase MAP2K4.AA S_TKc 102-367 28 5.5e-81 276.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 102-367
Range on HMM: 1-231/231
Sequence Identity: 28% (80 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMST---SFDKFYKYVYS-VLD
 . | .||.||.|.| | .|| .|.|.|.|.|.        ....  ... ..  ..|.||..|..    .. ...||....   .  .. |   .  |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

DVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDV-RSDVWSLGIT
 ..||    ...  ...||... .. .|||||.||.|||||.  .||.||||.. ||      |   | . ||||| .       ||.  ..|.||.|..
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCI

LYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLK-------HPFI
|||...|. |.|      ... ....              ||....|.. ||.|| .|||   |.|.       ||..
LYEMLCGYPPFP----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP2K4.AA MEK5 102-367 44 6.7e-75 255.14 In-house 1-254 (254) Show / Hide 
Range on Protein: 102-367
Range on HMM: 1-254/254
Sequence Identity: 44% (120 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIP
..    .| |  |.| |  | |||.|.||| |   .  . |||.. .|... .  | |||. |||| | |    || | |       |.         ||
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYK-CDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYR--------CIP

EEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELA
|.|||..| | || || |  ||||.|||.||||.|    |.|||||||.| |||.||..|   |   |||||||    | . | . |||||||| . |.|
EHILGRMTVAIVKGLNYLW-NLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERI----SGDQYGIHSDVWSLGIFFMEMA

TGRFPYPKWNSVF------DQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
|||||||. .           |  .|  .|| |      .||  |..|.| |. |    ||| ..|..||||
TGRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVD---KFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MAP2K4.AA MEK1 102-308 43 1.3e-65 223.13 In-house 1-197 (297) Show / Hide 
Range on Protein: 102-308
Range on HMM: 1-197/297
Sequence Identity: 43% (91 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELM-STSFDKFYKYVYSVLDDVI
.. .||.| |  | |.|..|...| ||| | |.  .    ..|.. .|  |.     |||| |||| . .|.  |||| |   | |   | .       |
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQ-VLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-----GRI

PEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
||.||||...| .. |  |... ||.|||.||||||   .| |||||||.||||.||.|     | | ||.|||.  .     | |.||.||.|. | |.
PEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTH----YTVQSDIWSMGLSLVEM

ATGRFPYP
| ||.| |
AIGRYPIP
Kinase MAP2K4.AA STE20 102-367 32 1.3e-62 214.35 In-house 1-288 (288) Show / Hide 
Range on Protein: 102-367
Range on HMM: 1-288/288
Sequence Identity: 32% (96 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQI----MAVKRIRSTVDE---KEQKQLLMDLDVVMRSSDCPYIVQFYGALFRE----GDCWICMELMST-SFDKFY
 ..| .||.|.||.| |  |||.|..     |.|..    ..   .|.. ..   ..  ..  .|.||..||. ...     . ||.||...  |    .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

KYVYSVLDD-----VIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVD----SIA-K-TRDAGCRPYMAPERIDPS
| .. ...      .. ||    |.  ....|..| .| .|||||||  ||||. .|..||.||| ..|| .    ... |     |   .|||| |   
KHCM-KCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCM

AS-RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG--DPPQLSNSEE-REFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
 . ..||| ..|.||||||. |.|.|. || . . .   . .. |.  .|| |...   . .||.| .||..||.|| .|||  ..|||||||
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPM-RAMFMIPKNQNPPPTLKDD-KPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP2K4.AA Pkinase 102-367 27 1.1e-61 216.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 102-367
Range on HMM: 1-293/293
Sequence Identity: 27% (82 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLL---MDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTS---FDKFYKYVYSV
.. .. ||.|..|.| | .|| .|.| |||.|.   ......| .   . . .  |  ..|.||..|..  ........||..      .| |  |.   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYISTW

LDDVI--PEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNI----KLCDFGISGQ--LVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVR
 . ..  .|. . .. . ....|... .. .|||||.||.|||.|. |.|    |.||||.. |  .  .   |  .| ..||||| |    ..|.|. .
RHGCFYFSEWECKFYMYQILRGLEYCHSM-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPK

SDVWSLGITLYELATGRFPYP------KWNSVFDQLTQVVKGDPPQLSNSEEREFS-----------------PSFINFVNLCLTKDESKRPKYKELLKH
.|.||.|..|||...||.|.|      . ..   |. . ..| |.  . ..... |                 .... |.. ||.|| .|||  ...|.|
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQM-QMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PFI
|..
PWF
Kinase MAP2K4.AA Ciliate-E2 213-367 24 7.4e-43 144.94 In-house 170-365 (365) Show / Hide 
Range on Protein: 213-367
Range on HMM: 170-365/365
Sequence Identity: 24% (52 aa)

VKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDS-----------IAKTRD----------------------AGCRPYMAPERIDPSA
..||..|... .||||||||.|||.     ||..|||.| .. |.           . .                         .|  .||||| .    
ILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKK

-----SRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSE--------------EREFSPSFINFVNL----CLTKDESKRP
      ..|||  .|.||||..|||. .|..|.           |  |  . .... |                . |.. ... .     .| ||..||.
YDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI

K-YKELLKHPFI
  ....|.||..
TGWEQILNHPWF
Kinase MAP2K4.AA TyrKc 102-367 21 1.6e-14 11.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 102-367
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSS--DCPYIVQFYGALFRE-------GDCWICMELMST-SFDKFYKY
.. . ..|.||.| | | . |   .  ||| ...       .. .|.   .|..   . | ||..||.   .       .  .| ||.|.  . ... ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

VYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDS-------IAKTRDA--GCRP-----YMAPERIDP
        .. . | .. .   .  ..| .. ..||||.   |.|... . .| .||| |  . |          ..     |..       |||| |  
HRPK----LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

SASRQG-YDVRSDVWSLGITLYELAT-GRFPYPKW----NSVFDQLTQVVKG---DPPQL-----SNSEEREFSPSFINFVNLCLTKDESKRPKYKELLK
   . | .   ||||| |....|. | |  |||       | .. . .| .|   ..|.      .     . ..   .    |   | ..||  .|.  
---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF----VCCPDEMYQIMKQCWHEDPEDRPTFSEI--

HPFI
| ..
HECF
Kinase MAP2K4.AA MEK1 313-367 38 1.7e-11 35.04 In-house 246-297 (297) Show / Hide 
Range on Protein: 313-367
Range on HMM: 246-297/297
Sequence Identity: 38% (21 aa)

VFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
.|. |  .|.. ||.|   ..| ||  |..||. || |  . |   |.|. |.||
IFEMLDYIVNEPPPKL---PHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MAP2K4.AA Pkinase_Tyr 221-323 28 3.6e-11 38.46 Pfam 128-232 (270) Show / Hide 
Range on Protein: 221-323
Range on HMM: 128-232/270
Sequence Identity: 28% (33 aa)

ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQL-VDSIAKTRDAG----CRPYMAPE----RIDPSASRQGYDVRSDVWSLGITLYELAT-GRFP-YPK
|. ..||||.   |.|..... .| |||| .  .  |.   .| .|      . ||||    ..        . . ||||| |....|. | |. | || 
ESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK--------FTTKSDVWSFGVLMWEIFTYGEQPTYPG

WNSVFDQLTQV-VKG
. | .. . ..  .|
M-SNEEVYEYIYEDG
Kinase MAP2K4.AA Ciliate-E2 102-167 16 3.7e-05 13.63 In-house 1-100 (365) Show / Hide 
Range on Protein: 102-167
Range on HMM: 1-100/365
Sequence Identity: 16% (16 aa)

LKDLGEIGRGAYGSVNKMVH-----------------------KPSGQIMAVKRI--RSTVDEKEQKQLLMDLD---------VVMRSSDCPYIVQFYGA
 | .  ||.|..||| |. .                       |  ..| |.|..  .     |  ..... ..          .... ..|.|...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
Kinase MAP2K4.AA Pkinase_Tyr 102-181 21 0.001508 12.64 Pfam 1-89 (270) Show / Hide 
Range on Protein: 102-181
Range on HMM: 1-89/270
Sequence Identity: 21% (19 aa)

LKDLGEIGRGAYGSVNKMVHK----PSGQIMAVKRIRSTVDEKE--QKQLLMDLDVVMRSSDCPYIVQFYGALF-REGD--CWICMELM
.. . ..|.||.|.| | . |      ..  ||| .. . ....  .. ..  . . .   ..| ||..||.   ...    .| ||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYM