Gene MAP2K5 (Human)

MAP2K5

Species: Human
Alias: HsT17454, PRKMK5, MEK5, MAP2K5, MAPKK5
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 15q22.33,

Classification

Group: STE
Family: STE7
Subfamily: MEK5

Sequence

Name Sequence Type Origin Length Description Download
MAP2K5.NA RNA Sugen Kinome 2381 None Fasta, JSON
MAP2K5.AA Protein Sugen Kinome 448 None Fasta, JSON
MAP2K5.kin_dom Protein Kinase Domain Sugen Kinome 254 None Fasta, JSON

Protein domain

Protein domains of MAP2K5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PB1 MAP2K5.AA PB1 18-97 25 1.2e-15 58.2 Pfam 1-86 (86) Show / Hide 
Range on Protein: 18-97
Range on HMM: 1-86/86
Sequence Identity: 25% (22 aa)

VIRIKIPNSGAVDW-TVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDG-DRITVRSDEEMKAMLSYY----YSTVMEQQVNGQ
 .|||.   |.. .  .|. ... |.|... ..|.... .|.   |.|||| | .|. .||... |...|    .|  .  .|...
TVRIKCRYGGDIRRFIIHVRRNISFEDLMHKVEQRCKCDHTFKYQYPDEDGDDWVTITCDEDLQEMMEEYRSSEKSMTLRLHVFPS
PB1 MAP2K5.AA PB1 18-97 18 1.4e-14 55.64 SMART 1-95 (95) Show / Hide 
Range on Protein: 18-97
Range on HMM: 1-95/95
Sequence Identity: 18% (18 aa)

VIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEAT--TTAFEYE--DEDGD-RITVRSDEEMKAMLSYYYS----------TVMEQQVNGQ
 ...|   .|.. . ..  ... | |... ..|....    .. . |.  |||||  .|. .||... |...| |           ..  .|.  
PVDVKCRYVGGDTRRFSVPRDWSFDDLMSKVAQRCGHDNDQPFTLKYQLPDEDGDAWVTITCDEDLQEMMEMYDSLESQNKSSCWKTLRLHVFPF
Kinase MAP2K5.AA MEK5 166-419 85 4e-213 714.33 In-house 1-254 (254) Show / Hide 
Range on Protein: 166-419
Range on HMM: 1-254/254
Sequence Identity: 85% (218 aa)

IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAV
||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||.||..|||.|||..|
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRCIPEHILGRMTV

AVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGS
|.||||.|||.|||.|||||||||||||.||.|||||||||||||||..||.|||||||||||||.|||||||||||||.|||.|.|||||||||..||.
AIVKGLNYLWNLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYPQIQRDQGE

LMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFI
|||.|||||||||..|.|||..|||||||||.|||.||||.||.|..||.||||
LMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MAP2K5.AA STE7 166-419 49 9.20000000001e-159 533.73 In-house 1-288 (288) Show / Hide 
Range on Protein: 166-419
Range on HMM: 1-288/288
Sequence Identity: 49% (144 aa)

IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDIT-LELQKQIMSELEILYKCD-SSYIIGFYGAFFVENR--ISICTEFMDGGSLD-VY--------
..  . |||||.|.|||..|.|||||.|||.| |...  |.||||. ||..| ||. . ||..|||||. |..  |.|| |.||||.|| .|        
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----RKMPEHVLGRIAVAVVKGLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSI--AKTYVGTNAYMAPERISG--EQYGIHSDVWSLG
    ...||..||.|||||.|||.||.. .|| ||||||||.|||.||||||||||.. |||.|.  |.|.||...|||||||.|  ..|...|||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

ISF-MELALGRFPYP-----QIQKNQGSLM------PLQLLQCIVDE-DSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMG-HPFI
|.  .|.|.||.|||     .....| ..|      ....|.|||.| ..| ||  .||..|..|. .|..|.|.||| ...||  ||||
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase MAP2K5.AA STE7-Unclassified 166-419 41 5.6e-114 384.96 In-house 1-301 (301) Show / Hide 
Range on Protein: 166-419
Range on HMM: 1-301/301
Sequence Identity: 41% (126 aa)

IRYRDTLGHGNGGTVYKAYHVP------SGKILAVKVILLDIT-LELQKQIMSELEILYKCD-SSYIIGFYGAFFVENR---ISICTEFMDGGSLD----
..  . ||||..|||.|..|..      .||| | ||| ....  |..|||  ||..| ||  . ||...|||.. | .   | || |.||.||||    
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

VYRKM-----------PEHVLGRIAVAVVKGLTYLWSLK-ILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSI--AKTYVGTNAYMAPERISGE-----
.| ||           || |||.|| .| .|| ||.  . | |||.||.| ||| .||||.|||||. ||.|..  ||| ||.  ||.||||.|.     
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

QYGIHSDVWSLGISFMELALGRFPYP------QIQKN--QGSLMPLQLLQCIVDEDSPVLPV-G---EFSEPFVHFITQCMRKQPKERPAPEELMG-HPF
.|.. ||.||||..  |.|.|..||.      |...|  .  .  ..||.|||.. .| ||  .    .|. |  || .|  | |.||| . .|   ||.
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPW

I
|
I
Kinase MAP2K5.AA STE 166-419 28 1.3e-103 350.57 In-house 1-359 (359) Show / Hide 
Range on Protein: 166-419
Range on HMM: 1-359/359
Sequence Identity: 28% (106 aa)

IRYRDTLGHGNGGTVYKAYHV------PSGKI---------LAVKVILLDITL----------------ELQKQIMSELEILYKCD--SSYIIGFYGAFF
 .  . .|.|..||||||...      ..|..          |.|.. |.                   | ..||. |..|. ||.  . .|. .||..|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VE-------NRISICTEFMDGGSLDVYRK------------------MPEHVLGRIAVAVVKG-LTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVST
.|       . . || |.|||||||   |                  .||.....|.....|| | || |..| |||.||.| |.     ||||||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLVNSIA----------------K--TYVGTNAYMAPERISG------EQYGIHSDVWSLGISFMELALGRFPYPQIQKN-QGSLMP--------LQLLQ
||..|.|                |  | |||  .||||.|..       .|.. .|.||||.  .|.| |. |.   .      ..|        ...| 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

CIVDEDSPVLPVG------------------EFSEPFVHFITQCMRKQPKERPAPEELMG--HPFI
|||....| ||                    ..|..| .|| .| .| |..|| ...|.   ||||
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP2K5.AA MEK1 166-357 53 9e-88 297.91 In-house 1-197 (297) Show / Hide 
Range on Protein: 166-357
Range on HMM: 1-197/297
Sequence Identity: 53% (106 aa)

IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----MPEHVLG
.     ||||||| | |. | ..| |.| |.| |.|   ...||. ||..| .| | ||.||||||. .. |||| |.|||||||.  |    .||..||
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILG

RIAVAVVKGLTYLW-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYP
...|||..|||||    ||.||||||||.||| || .|||||||| ||. |.|  .||| .||.|||. |  | . ||.||.|.| .|.|.||.| |
KVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYPIP
Kinase MAP2K5.AA MEK3 172-419 44 7e-83 281.65 In-house 7-264 (264) Show / Hide 
Range on Protein: 172-419
Range on HMM: 7-264/264
Sequence Identity: 44% (118 aa)

LGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIGFYGAFFVENRISICTEFMDGGSLD-----VYR----KMPEHVLG
|| |  | | |  |..|| |.||| |   .    ||... .. |     |  | . |||| | |  . || | ||  .||     ||     ..|| .||
LGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMD-TCLDKFYRHVYKPHGMHIPEDILG

RIAVAVVKGLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERISGE----QYGIHSDVWSLGISFMELALGRFP
.||. .|..| |. . ||. |||||||| |.|. ||||.||||.| .||.|.|||   |   ||||||| .|    .| . ||||||||   |.| ||.|
KIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMAIGRYP

YPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGE-FSEPFVHFITQCMRKQPKERPAPEELMGHPFI
|   .       | | |. .| | .| || .. ||. .. || || .| ..|||  .||| |||.
YDNWHT------PFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase MAP2K5.AA MEK4 166-419 39 5.8e-76 247.38 In-house 1-275 (275) Show / Hide 
Range on Protein: 166-419
Range on HMM: 1-275/275
Sequence Identity: 39% (111 aa)

IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVIL-LDIT-----LELQKQIMSELEILYKC-DSSYIIGFYGAFFVENRISICTEFMDGGSLD-----VY-
 .    .| |. |||.|  | .||||.||| |    .         ||.   |..   |  .  ||. |||| | |    || | ||  |.|     || 
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMD-ISMDKFYKYVYM

---RKMPEHVLGRIAVAVVKGLTYL-WSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERISG----EQYGIHSDVWSLG
   ...|| ..|.|.|..|. | ||   .|| |||||||| |.. .| |||||||.. |||.|||||  .|   |||||||      . | | |||||||
VQKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLG

ISFMELALGRFPYPQIQ-KNQGSLMPLQLLQCIVDEDSPVLPVGEF----SEPFVHFITQCMRKQPKERPAPEELMGHPFI
|  .|.| |.|||.  .  ..     .  .. .|  |.| |   ..    |.|.. ||  |..|  ..||  ..|  .||.
ITMYEVATGKFPYRKWNDASV-----FDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase MAP2K5.AA S_TKc 166-419 28 2.1e-73 251.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 166-419
Range on HMM: 1-231/231
Sequence Identity: 28% (77 aa)

IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDG--GSLDVYRK---------
 .  ...|.|  |.|||..|. .|.| |.|.|         ..|..|..|| | .  .|. .|..|   ... ...|..||  |.|  | |         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-MPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGI-HSDVWSLGISFMELALG
 .|| .  ...  ....| |. |..|.|||.||.| |...  ..|.||||...||     .|..||  ||||| .   .||   .|.||.|. . |.. |
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

RFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMG-------HPFI
. |.|          . .... |.            |... .|| .|..| |..||   |..        ||..
YPPFP---------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP2K5.AA Pkinase 166-419 28 4.3e-70 243.98 Pfam 1-293 (293) Show / Hide 
Range on Protein: 166-419
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIM---SELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGG----SLD------VY
..   ..| |. |.|||..|. .||| |||.| .. . . ..|.    ||..|. .... .|. .|..|  ...| ...|...||    .|        .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RKM--PEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQV----KLCDFGVST---QLVNSIAKTYVGTNAYMAPERIS-GEQYGIHSDVWSL
...  .|... ...  ...|| |. | .|.|||.||.| |.. .|..    |.||||..       || ..|..||  ||||| |  |. ||  .|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GISFMELALGRFPYPQI----QKNQGSLMPLQLLQCIVDEDSPVLPVGE---------------FSEPFVHFITQCMRKQPKERPAPEELMGHPFI
|. . |...||.|.|.       .    |  . .......|.| .  .                 ||.. .||. | .| ||.|| .|... ||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MAP2K5.AA STE20 166-419 31 8.5e-69 234.87 In-house 1-288 (288) Show / Hide 
Range on Protein: 166-419
Range on HMM: 1-288/288
Sequence Identity: 31% (92 aa)

IRYRDTLGHGNGGTVYKAYHVPSGKI----LAVKVILLDITL---ELQKQIMSELEILYKCDSSYIIGFYGAFFVE----NRISICTEFMDGGSL-DVYR
    . .|.|. |.||||||.|.|..     |.|.. |.      . .. |. |  |. .|.. .|. .||.....    . . |. |...|||| |...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

------------KMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVN----SIA---KTYVGTNAYMAPERISG----
            .| |     |   |..|| || | .| |||.|  | |....|.|||.||||. || .    ...   .| |||  .|||| |..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-EQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIV--DEDSPVLP---VGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFI
  .|.  .|.|||||  .|.| |. ||         . |.. .  |   ....| |       .|  | .|. .|  | |..|| ...|. ||||
DKGYDYKCDIWSLGITAIEMAEGEPPY-------FDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP2K5.AA MEK7 166-419 36 4.8e-65 219.63 In-house 1-269 (269) Show / Hide 
Range on Protein: 166-419
Range on HMM: 1-269/269
Sequence Identity: 36% (102 aa)

IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCD-SSYIIGFYGAFFVENRISICTEFMDGGSLD-----VYRK----M
.     .|||  |.| |  |  || |.|||        |  | |   | .  .|  . ||.  .|.|  .  . || | | .  .|     ..       
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECM-STCCDKLLKRIKHPKLDFI

PEHVLGRIAVAVVKGLTYLWSL-KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKT-YVGTNAYMAPERISG-----EQYGIHSDVWSLGISFME
|| ..|.. ||... | ||     |.||||||||.|   ||..||||||.|  .| | |.|   |  ||||||||        .| | .|||||||.  |
PEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVE

LALGRFPYPQIQKNQGSLMPLQLLQCIVDE--DSPVLPVGE---FSEPFVHFITQCMRKQPKERPAPEELMGHPFI
|| |..|||  .      |    .  | ..  ..| || ..   ||  |  |. .|..| ...||  ..|| ||||
LATGQYPYPGCD------MEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MAP2K5.AA YSK 167-419 34 2.6e-56 167.9 In-house 2-257 (257) Show / Hide 
Range on Protein: 167-419
Range on HMM: 2-257/257
Sequence Identity: 34% (90 aa)

RYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGS-LDVYRK-----MPEHVL
   .  | |. | |||.. .  ... |.|.| |.   .    |  |  .|  |||.||  .||..     . |  |.  ||| ||  ..     ..|   
TKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYI

GRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISG--EQYGIHSDVWSLGISFMELALGRFPY
. |   . ||| || | . .|||.|  | |..  |.||||||||. |. ..  |  | |||  .|||| |     .|    |.|||||   |.| |  ||
AIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPY

PQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFI
         . |.  .. |. .  | |   ..| .|  |.  |  | |..||  .||  | ||
CD-------YHPMRVMFLIPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase MAP2K5.AA TyrKc 166-419 23 6.8e-17 50.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 166-419
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC--DSSYIIGFYGAFFVE-------NRISICTEFMDGGSLDVYRKMP
|.  ..||.|. |.|||.         |||..  |     .. .|.|..|. |   .   |. .||.   .         . | .|.|..|.|. | . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

EHVLG-----RIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNS-IA----KTYV-----GTN-----AYMAPERISGEQYGIH
.. |       ... . .|  || | .. |||    | ||. ...|| .||| |  . .   .    ..|.     |..       |||| |    . . 
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDVWSLGISFMELA-LGRFPYPQ-IQKNQGSLMPLQLLQCIVDEDSPVLPVG-------EFSEPFVHFITQCMRKQPKERPAPEELMGHPFI
||||| |.   |.  .|  |||  ||.    . . ...... . . .  |         . ..     ..|| . .|..||  .|.  | ..
SDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MAP2K5.AA MEK1 371-419 44 9.9e-13 39.32 In-house 249-297 (297) Show / Hide 
Range on Protein: 371-419
Range on HMM: 249-297/297
Sequence Identity: 44% (22 aa)

LLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFI
.|. ||.|  | || . ||| |. |. .|..|.|.||    .|| |.||
MLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MAP2K5.AA Pkinase_Tyr 166-252 25 4.4e-09 31.4 Pfam 1-97 (270) Show / Hide 
Range on Protein: 166-252
Range on HMM: 1-97/270
Sequence Identity: 25% (25 aa)

IRYRDTLGHGNGGTVYKAYHV----PSGKILAVKVILLDITLEL--QKQIMSELEILYKC-DSSYIIGFYGAFF-VENR--ISICTEFMDGGSLDVY
|.   .||.|. |.|||..        .   |||..  . . |   ..  |.|..|. .  .   |. .||.    .    | | .|.| .|.|. |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY
Kinase MAP2K5.AA Pkinase_Tyr 269-363 33 5.1e-05 17.63 Pfam 122-222 (270) Show / Hide 
Range on Protein: 269-363
Range on HMM: 122-222/270
Sequence Identity: 33% (34 aa)

KGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKT-YVGTNAY-----MAPERISGEQYGIHSDVWSLGISFMELAL-GRFP-YPQIQ
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KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-

KNQ
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SNE