Gene MAP3K2 (Human)

MAP3K2

Species: Human
Alias: MAP3K2, LOC51777, MEKK2, MEKK2B
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 2q21.1,

Classification

Group: STE
Family: STE11
Subfamily: MEKK2

Sequence

Name Sequence Type Origin Length Description Download
MAP3K2.NA RNA Sugen Kinome 4973 None Fasta, JSON
MAP3K2.AA Protein Sugen Kinome 619 None Fasta, JSON
MAP3K2.kin_dom Protein Kinase Domain Sugen Kinome 261 None Fasta, JSON

Protein domain

Protein domains of MAP3K2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PB1 MAP3K2.AA PB1 43-122 23 3.1e-22 81.12 SMART 1-95 (95) Show / Hide 
Range on Protein: 43-122
Range on HMM: 1-95/95
Sequence Identity: 23% (22 aa)

DVRVKFEH-RGEKRILQFPRPVKLEDLRSKAKIAFGQ----SMDLHYT--NNEL--VIPLTTQDDLDKAVELLDR------SIHMKSLKILLVIN
.|.||. . .|. |....||.....||.|| .  .|.    ...|.|   ....  ....|...||....|..|.      |...|.|..... .
PVDVKCRYVGGDTRRFSVPRDWSFDDLMSKVAQRCGHDNDQPFTLKYQLPDEDGDAWVTITCDEDLQEMMEMYDSLESQNKSSCWKTLRLHVFPF
PB1 MAP3K2.AA PB1 43-122 20 9.1e-20 72.8 Pfam 1-86 (86) Show / Hide 
Range on Protein: 43-122
Range on HMM: 1-86/86
Sequence Identity: 20% (18 aa)

DVRVKFEHRGEKRI--LQFPRPVKLEDLRSKAKIAFGQ--SMDLHYTNNEL--VIPLTTQDDLDKAVELLDRS-IHMKSLKILLVIN
.||.|....|..|.  ....|....|||..| .  ...  . ...| ....  ....|...||....|  ..|  .| .|..... .
TVRIKCRYGGDIRRFIIHVRRNISFEDLMHKVEQRCKCDHTFKYQYPDEDGDDWVTITCDEDLQEMMEEYRSSEKSM-TLRLHVFPS
Kinase MAP3K2.AA MEKK2 356-616 87 9.69999999999e-218 729.65 In-house 1-262 (262) Show / Hide 
Range on Protein: 356-616
Range on HMM: 1-262/262
Sequence Identity: 87% (230 aa)

WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGAL
||.|||||||||||||.||||||||||||||||||||.|||.|||.||||||||||||.|||||||||||||.||||||||||||||||.||||||||||
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGAL

TENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEML
||.||||||||||||.||||..||||||||||||||||.||||||||||||||||||...||||||||||||||||||.|||||||||.||..|||||||
TETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVINGEGYGRKADVWSIGCTVVEML

TEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKL-RPSADELLRHMFV
||||||||.||||||||||||||||.||.|||...||||||.|||.|. ||||.|||||.||
TEKPPWAEYEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MAP3K2.AA STE11 356-616 46 3.9e-166 558.22 In-house 1-303 (303) Show / Hide 
Range on Protein: 356-616
Range on HMM: 1-303/303
Sequence Identity: 46% (142 aa)

WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDS---PETSKEVNA------LECEIQLLKNLLHERIVQYYG-CLRDPQEKTLSIFMEYMPGGSI
|..|...|.||||.||.|..||||...||||.......   ....||...      ...||.|.|.| |..||.||| ||.|.|.....|||||.||||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

KDQLK-AYGA--LTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGN-VKLGDFGASKRLQTICLSGTG-------MKSVTGTPY--------
.. |.  .|.  ..|.|.||||.|||||..||||..|.||||||||||.||.|| .||.|||..|||..||.....       .||.|||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMSPEVISGEG---YGRKADIWSVACTVVEMLTEKPPWAEFEA--MAAIFKIATQ-PTNPKLPPHVS------DYTRDFLKRIFVEAKL-RPSADELLRH
||.||||..||   |||||||||. |||.||.| ||||.....  |||.|||...  . | .| |.|      . .||||.. |.  .  ||.|..||.|
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

MFV
 |.
PFI
Kinase MAP3K2.AA STE11-Unclassified 356-616 41 1.3e-110 373.79 In-house 1-308 (308) Show / Hide 
Range on Protein: 356-616
Range on HMM: 1-308/308
Sequence Identity: 41% (128 aa)

WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDS---PETSKE-VNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKA
|  |...|.|.||.||.| ...||  .||||.    ..   ..  || ..... |...||.| |. |||||||  . .|. ..|||||||||||   |. 
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

YGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQ------------------TICLSG----TGMKSVTGTPY---
||.. |.|..|||.|||||. ||||. |.|||||||||| |. |..|| |||..|                     .||..        ||  ||||   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

WMSPEVIS---GEGYGRKADIWSVACTVVEMLTEKPPWAEFEA---MAAIFKIATQPTNPKLPPHVS-----------DYTRDFLKRIF-VEAKLRPSAD
||.||||.    .|..||.||||. |||.|| | |.||. ...   |.||.||.   . | .| | |           . ..||| . | .  | ||.|.
WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTAN

ELLRHMFV
.|| | | 
QLLQHPFI
Kinase MAP3K2.AA STE 356-616 28 3.3e-105 355.82 In-house 1-359 (359) Show / Hide 
Range on Protein: 356-616
Range on HMM: 1-359/359
Sequence Identity: 28% (106 aa)

WRLGKLLGQGAFGRVYLCYDVD---------------TGRELAVKQVQFDPDSPETSK-------------EVNALECEIQLLKNLL--HERIVQYYGCL
|.. . .|.|||| ||......               ||.  |.||. .......  .             |.. .. ||...|..   |. ||.|||| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

R-----DPQEKTLSIFMEYMPGGSIKDQLK-AYGALT-------------ENVTRKYTRQILEG-VHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGAS
      . .. .| |.||||.|||. | .|  || .              |.. ....||||.|  .||||. |.|||||.||||      ||| ||| .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

KRLQTICL-------------SGTGMKSVTGTPYWMSPEVISG------EGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQ----------
..|. ..              ..   ....||| ||.||||..       ||..|.||||. ||..||.| ||||...  | |.| |..           
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----PTNPKLPP-------------------HVSDYTRDFLKRIFVEAKL-RPSADELLR--HMFV
    .. |.||.                   ..|.  .||... ..     ||.|..||.  | |.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP3K2.AA MEKK15 356-616 46 4.2e-98 332.22 In-house 1-264 (264) Show / Hide 
Range on Protein: 356-616
Range on HMM: 1-264/264
Sequence Identity: 46% (125 aa)

WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDP-DSPETSKEVNALECEIQLLKNLLHERIVQYYG-CLRDPQEKTLSIFMEYMPGGSIKDQLKAYG
|. |..||.||.| || |   .||  .|||||. |  |  .. ..   |  |..||| | |  || | | ||   .. ...|||...|||||   .  .|
WKKGNILGKGAYGTVY-CGLTNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCL---EDNVVNIFMQFVPGGSISSIINRFG

ALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTG---MKSVTGTPYWMSPEVISGEGYGRKADIWSVACT
.| | |  |||.|||.|| ||| | .|||||||.|..  .|| .|| |||  |||    ...|    .||. |||||| ||||   |||||.||||. ||
PLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCT

VVEMLTEKPPWAEFEAMAAIFKIATQ-PTNPKLPPHVSDYTRDFLKRIFV-EAKLRPSADELLRHMFV
| || | |||||. . |||.| | ..    |.|| . |.  |.| .     . . ||.| .||.| |.
VFEMATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MAP3K2.AA S_TKc 356-616 30 1.3e-94 321.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 356-616
Range on HMM: 1-231/231
Sequence Identity: 30% (86 aa)

WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPG--GSIKDQLKAYG
.......|.||||.||.|....|||. |.|..             . .. |||.||.  |. ||..|.. .|   . | ..|||..|  |. .| .| .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRG

A------LTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR-KADIWS
       ..| ..|.|..||.... |.||. |.|||.| .||| |.  ..|..||| ...|          ... |||..|.|||.   |||. |.|.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWS

VACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFV-EAKLRPSADELLR-------HMFV
. |.. |||. .||.     |...||.             |.  .||...... . . ||.| |.|.       | ..
CGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP3K2.AA Pkinase 356-616 30 7.2e-82 283.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 356-616
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGG----SIKDQLK-
...|. .|.|.||.||.|....||.. |||..  . ....  ..   |  |||..|.| |. ||..|.. .|  .. . . |||..||    . .| .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

-AYGAL--TENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNV----KLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVIS-GEGYGRKA
 ..|..  .|.. ..| .|||.|. |.||. |.|||.| .||| |..|..    |..||| .| ..    ... |....|||..|.||||  |..||.|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSVACTVVEMLTEKPPWAEF------EAMAAIFKIATQPTNPKLPPHVS-------------------DYTRDFLKRIF-VEAKLRPSADELLRHMFV
|.||. |.. |||. .||. .       . |. |..|   |.    |   |                   .  .||.|... .  | ||.|...| | ..
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MAP3K2.AA ASK 361-616 42 3e-71 236.19 In-house 1-254 (254) Show / Hide 
Range on Protein: 361-616
Range on HMM: 1-254/254
Sequence Identity: 42% (111 aa)

LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKA-YGALT--E
 ||.|..| ||   | .| . .|.| ..        |..|  |  ||.| |.| |. |||| ||  . ... . |||| .||||. . |.. .| .   |
VLGKGTYGIVYAGRDMHTQVRIAIKEIPE-----RDSRYVQPLHEEIALHKQLRHRNIVQYLGC--CSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNE

NVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDS-TGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI--SGEGYGRKADIWSVACTVVEM
|  . ||.|||||..||| | |||||||| |.|     | ||. ||| .|||  |       .. |||  .| ||||     |||. |||||. ||.|||
NTMNFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPC---TETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEM

LTEKPPWAEF-EAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIF-VEAKLRPSADELLRHMFV
 | |||. |. |. ||.||.    . |..|  .|. ...|..| | .... |.||..||.  |.
ATGKPPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MAP3K2.AA STE20 356-616 34 4.6e-69 235.75 In-house 1-288 (288) Show / Hide 
Range on Protein: 356-616
Range on HMM: 1-288/288
Sequence Identity: 34% (100 aa)

WRLGKLLGQGAFGRVYLCYDVDTGRE----LAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGC-LRDPQE-KTLSIFMEYMPGGSIKDQL
. | . .|||..| ||..|...||..     |.|..  .....|  .|.. .. ||. .|.. |. ||.|||. |.|  .   | | |||. |||. | .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

K---AYG------ALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQT--ICLSGT-GMKSVTGTPYWMSPEVISG--
|     |       ..|      .|..|.| .||||| |.|||||..||| .. |.||| ||| .  |..     .     ... ||||||.||||..  
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRD-TMQFKRNTFVGTPYWMAPEVIQCME

---EGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIA--TQPTNPKL---PPHVSDYTRDFLKRIFV-EAKLRPSADELLRHMFV
    ||. |.||||.  |  ||.. .|| ... .| |.|.|.  . |. .     | . |.  .||...  . . . ||.|..||.| |.
GPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP3K2.AA CAMK 361-616 20 2.6e-66 212.41 In-house 1-425 (425) Show / Hide 
Range on Protein: 361-616
Range on HMM: 1-425/425
Sequence Identity: 20% (88 aa)

LLGQGAFGRVYLCYDVDTG------------RELAVKQVQFD--PDSPE---------------------TSKEVNALECEIQLLKN-------LLHERI
 ||.|.|| |.||..  |.            .. |.| .  .  .|.                       . |    .. ||...|.       | |. |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYYGCLRDPQ-----------------EKTLSIFM---EYMPGG----SIKDQLKAY---------------GALTENVTRKYTRQILEGVHYLHSNMI
.. |    ||.                 .| . ..|   ||..||     . | ...                | .||  .|.| |||...|||.||. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKGANILRDST-----------------GNVKLGDFGASKRLQTICLS--------------------GTGMKSVTGTPYWMS-PEVISG------
||||.|  ||| |.                  .|.|. ||| .....    .                    |  || . |||. |. |||..|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------EGYGRKADIWSVACTVVEMLTEKPPWAEF---EAM---------AAIFKIATQPTNPKLPPH---------------VSDY--------TRD
        ..||.|.|.||. .    ||. .||. .    | .           .|.  ..      ||.               .||          .|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FLKRIFV-EAKLRPSADELLRHMFV
..... . . . |..... |.| ..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MAP3K2.AA MEKK4 356-616 35 6.4e-59 200.66 In-house 1-271 (271) Show / Hide 
Range on Protein: 356-616
Range on HMM: 1-271/271
Sequence Identity: 35% (98 aa)

WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALEC---EIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAY
| .|   |.| || || | ..||.. .|.| . | ..      .  |..    ||  .  . |.  | |||      |  . |||||   |  .   .  
WQRGDHIGEGQFGKVYTCMNMDTHEVMAMKEMRFQRN------DHKAIKNIADEIKIFEGIKHPNLVRYYGVEVHREE--MYIFMEYCSQGTLERVCHLG

GALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTIC-LSGTGMKSVTGTPYWMSPEVIS---GE-------GYGRK
| . | ..|.|| |.| .| |||.  |||||||.|||  |. . .|||||| | .||         . |  ||. .| |||..   ..       |.|| 
GNMQEHMIRQYTKQLLRAVNYLHQHGIVHRDIKPANIFLDKCTVLKLGDFGCSVKLQNHSQTMPGEFQSTMGTAAYMAPEVYTYTEKDETTGSYSGHGRA

ADIWSVACTVVEMLTEKPPWA---EFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIF-VEAKLRPSADELLRHMFV
|||||. |.|||| | | ||.   ...   .|      .. |  |   |   .||.   .    | |. | ||| | |.
ADIWSLGCVVVEMMTGKRPWHGQTQYDHNFQIMYKVGMGHYPHIPDKMSPEGKDFFDHCLEHDPKDRWTANELLDHTFC
Kinase MAP3K2.AA STE-Unique 432-616 26 5e-50 172.53 In-house 368-616 (616) Show / Hide 
Range on Protein: 432-616
Range on HMM: 368-616/616
Sequence Identity: 26% (67 aa)

TLSIFMEYMPGGSIKDQLKAYGA---------LTENVTRKYTRQILEGVHYLHSNM--IVHRDIKGANILRDSTG-----NVKLGDFGASKRLQTICLSG
.. ||||| ..|. .. .|. |.         . |    .||.|||||  ||||    |.|||.| .||. .. |     .||..||| ....| . .. 
WVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEK

-----------------------------------TGMKSVTGTPYWMSPEVISGE-----GYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIAT
                                    .||.  ||| .|.||||...     .|..|.|||| .|.. .|..  ||| ..  | | . .. 
DNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCI

QPTNPKL-------PPHVSDYTRDFLKRIFV-EAKLRPSADELLRHMFV
  . . .       ||  .  ...|.   .  .   |||| .||.| . 
HIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase MAP3K2.AA Pkinase_Tyr 356-503 32 2.5e-23 79.65 Pfam 1-156 (270) Show / Hide 
Range on Protein: 356-503
Range on HMM: 1-156/270
Sequence Identity: 32% (52 aa)

WRLGKLLGQGAFGRVYLCYDV----DTGRELAVKQVQFDPDSPETSKE---VNALECEIQLLKNL-LHERIVQYYGCLRDPQEK-TLSIFMEYMPGGSIK
 ..|| ||.||||.||...      .|. . ||| .      . ...|     ..  |....|.|  |. ||..||.  | .|   . | |||||.|. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

DQLKAY----GALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFG
| |..     ..||     .. .|| .|  ||.|. ..|||.   |.| .... || .|||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase MAP3K2.AA TyrKc 356-614 25 6.9e-18 66.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 356-614
Range on HMM: 1-280/280
Sequence Identity: 25% (74 aa)

WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNL--LHERIVQYYGCLRDPQE-----KTLSIFMEYMPGGSIKDQ
 .||| || ||||.||..      .. ||| .. |         . ..  |......|   |. ||. ||. .....     . | | |||||.|. || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKAYGA-LTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTI---CLSGTGMKSVT---GTP-----YWMSPEVISGE
|....  |.     ..  || .|  ||||. ..|||.   |.| .. . || .||| |. .          . .....   |.       ||.||.|   
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYG

GYGRKADIWSVACTVVEMLTE-KPPWAE----FEAMAAIFKIATQPTNPKLPPH--------VSDYTRDFLKRIFVE-AKLRPSADELLRHM
 .  | |.||   .  |..|  ..|. .    .   . ...   |   .. ||.         .|   .  |.   | .. ||.  |. . .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MAP3K2.AA STE-Unique 357-423 29 2.4e-10 32.41 In-house 1-68 (616) Show / Hide 
Range on Protein: 357-423
Range on HMM: 1-68/616
Sequence Identity: 29% (20 aa)

RLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPE-TSKEVNALECEIQLLKNLLHERIVQYYG
.    .|.|.|| |..| .  ... .|.| .  .  ...     || .  ||...| | |..|| |||
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYG
Kinase MAP3K2.AA Pkinase_Tyr 527-546 45 0.193455 5.5 Pfam 180-199 (270) Show / Hide 
Range on Protein: 527-546
Range on HMM: 180-199/270
Sequence Identity: 45% (9 aa)

WMSPEVISGEGYGRKADIWS
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WMAPECINYGKFTTKSDVWS