Gene MAPKAPK5 (Human)

MAPKAPK5

Species: Human
Alias: MAPKAPK5, MAPKAP5, PRAK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 12q24,

Classification

Group: CAMK
Family: MAPKAPK
Subfamily: MK5

Sequence

Name Sequence Type Origin Length Description Download
MAPKAPK5.NA RNA Sugen Kinome 2066 None Fasta, JSON
MAPKAPK5.AA Protein Sugen Kinome 473 None Fasta, JSON
MAPKAPK5.kin_dom Protein Kinase Domain Sugen Kinome 283 None Fasta, JSON

Protein domain

Protein domains of MAPKAPK5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAPKAPK5.AA MAPKAPK 22-304 56 2.8e-192 645.07 In-house 1-268 (268) Show / Hide 
Range on Protein: 22-304
Range on HMM: 1-268/268
Sequence Identity: 56% (162 aa)

INWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQH--RH
..|.|.||.||.|.|..|..|.||..||||.|.|.||||.||.||.||..||.|||||.|..|..|||||.|||..||||||.||||||||||...  .|
QIWKQVLGIGINGKVMQCYHKRTQQKFALKVLRDSPKARREVELHWMCSGHPHIVQIIDVYENMYQFPHEPSPRKCLLIVMECMEGGELFHRIQERGDQH

FTEKQASQVTKQATLALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQG--DLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYT
|||..|.|..|| . |..||| .|||||||||||||.||.. ....||.|||||| ...  .||||..|||||||.||....                  
FTEREAAQIMKQICQAVQHCHSMNIAHRDLKPENLLYKDTQPNCVLKLTDFGFAKETTRHNTLMTPCYTPYYVAPEVLGPEK------------------

YNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
|.||||.||||||.|.|||||||||| .|...|...|...||.|..|||..|||..||.|||..||||...|.||||||....|||.
YDKSCDMWSLGVIMYIMLCGYPPFYS-NHGQAISPGMKHRIMNGQYEFPHPEWSCVSEDAKDLIRKLLRTDPTERLTIEEFMNHPWI
Kinase MAPKAPK5.AA MAPKAPK 22-304 47 2.6e-189 591.77 In-house 1-292 (292) Show / Hide 
Range on Protein: 22-304
Range on HMM: 1-292/292
Sequence Identity: 47% (149 aa)

INWTQKLGAGISGPVRVCVKKSTQERFALKILLDR-----PKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQ
..|...||.||.|.|. ||.|.|....|.|||.|.     .|||.||.||..|..||||||||..|.|..||      ......|||.|||||||..|.|
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQF------DKCFYLVMECMEGGELFQHIQQ

--HRHFTEKQASQVTKQATLALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKI-------DQG----DLMTPQFTPYYVAPQVLEAQRRHQK
  |.||||..|||..|. ..|....| .|||||||||||.|..|.. ..|||||||||||        ...    .||||..||||.||.|..|..    
RGHKHFTEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFK----

EKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKD-----------MRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEER
          ...||.||||.||||||.|.||||||||||.........|           |...|..|..|||.||||.|||.|||..||||...|..|
----------EAHTYDKSCDMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQR

LTIEGVLDHPWL
|||| |..|||.
LTIEQVMNHPWI
Kinase MAPKAPK5.AA CAMK 27-304 26 5.2e-109 352.5 In-house 1-425 (425) Show / Hide 
Range on Protein: 27-304
Range on HMM: 1-425/425
Sequence Identity: 26% (114 aa)

KLGAGISGPVRVCVKKSTQ------------ERFALKILL---------------------------------DRPKARNEVRLHMMCAT------HPNI
.|| |  | |. |. |.|.            ...| ||.                                  || . |.|.......        ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQIIEVFANSVQFP----------HESSPRARLLIVM---EMMEGGEL----FHRISQH---------------RHFTEKQASQVTKQATLALRHCHLLN
....||. .. .|.          .  ... .. .||   |...||||    | .| .|               ..|||..|... .|   |...|| .|
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IAHRDLKPENLLFKDNSLD--------------APVKLCDFGFAK-IDQGD-------------------------LMTPQFTPYYVA-PQVLEAQRRHQ
|.||||||||.|. ||. |              ...|..|||||. .|.|.                         . |.  ||.|.| | ||. .....
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

KEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTI--------PKDMRRKIMTGSFEFPEEE------------WSQISEM------
..  . . |. .   |...|| ||.||| |.|||||||||........        .... .|||.| ..||...            |. ||.       
MQ--N-A-TDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVS

--AKDVVRKLLKVKPEERLTIEGVLDHPWL
  .|| .||.|.| ||.|.||| .|.|||.
QECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MAPKAPK5.AA CAMK1 23-304 35 2.6e-99 289.33 In-house 2-276 (276) Show / Hide 
Range on Protein: 23-304
Range on HMM: 2-276/276
Sequence Identity: 35% (108 aa)

NWTQKLGAGISGPVRVCVKKST---QERFALKILL--DRPKA---------RNEVRLHMMC--ATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMME
. . ..|.|  . |. |..|.|   .. .|.|..   .  |          .||.  .  .    ||||....|..        ||     . .||| . 
EFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWY--------ES--DNHFYLVMELVT

GGELFHRISQHRHFTEKQASQVTKQATLALRHCHLLNIAHRDLKPENLLFKDNSLDAPVK--LCDFGFAKIDQGD--LMTPQF-TPYYVAPQVLEAQRRH
|||||.|| .  ..|||.|. . ||   |. ..| ..|.||||||||||..|.. |...|  ..||| .||  .|  ||. .. ||.|||| |||     
GGELFDRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLE-----

QKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKH-HSRTIPKDMRRKIMTGSFEFPEEEWSQISEM-AKDVVRKLLKVKPEERLTIEGVL
.|.        ..||   |.||.|| ||| |..||||||||..  ..      . .||. ...|||. .|  ||.  ||| ....|.| |..|.|.| .|
CKK--------DKPYD--KACDMWSIGVITYILLCGYPPFYDENVDNE-----LFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCL

DHPWL
.|||.
NHPWI
Kinase MAPKAPK5.AA S_TKc 22-304 32 1.7e-83 284.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-304
Range on HMM: 1-231/231
Sequence Identity: 32% (96 aa)

INWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEG--GELFHRISQHRH
    .|.| |  | |. |..|.|....|.||.    ..|.|......   |||||....|| .            .| .|||...|  |.||..| ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-----------DHLYMVMEYCDGDLGDLFDYIKKRGR

------FTEKQASQVTKQATLALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSP
      |.| .|  ...|  .|| .|| ..| ||||||||.|. .      .|.||||.|..     .|   ||.|.|| ||                  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL------------------

TPYTYNK-SCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD-------HPWL
    |.| .|| ||.|.|.| ||||||||.        .. | .||.              |. ||| .||.|.. ||.|.|.  .|        |||.
---GYGKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAPKAPK5.AA Pkinase 22-304 29 2.9e-78 271.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 22-304
Range on HMM: 1-293/293
Sequence Identity: 29% (96 aa)

INWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARN----------EVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGG---
.   .|.|.| .| |. |..|.|....|.||.  | ...           |.... ..  |||||.....| .          . .. .||| .|||   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED----------KDHIYMVMEYCEGGLYV

-ELFHRIS--QHRHF--TEKQASQVTKQATLALRHCHLLNIAHRDLKPENLLFK-DNSLDAPVKLCDFGFA----KIDQGDLMTPQFTPYYVAPQVLEAQ
 .||..||  .|. |  .|...  . .|   .| .||  .| ||||||||.|.. .. .||.||.||||.|       .. ..|.  ||.|.|| |.   
MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--

RRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK--HHSRTIPKDMRRKIMTGSFEFPEEEWSQIS-----------------EMAKD
               .   | ...| ||.|.|.| ||||.|||...  |..   .. | ..|| . ..|....|. ||                 | .||
---------------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKD

VVRKLLKVKPEERLTIEGVLDHPWL
.....|...|..|.|.| .| |||.
FIKWCLCKDPKKRPTAEQILQHPWF
Kinase MAPKAPK5.AA MSK 22-304 32 8.7e-73 245.38 In-house 1-277 (277) Show / Hide 
Range on Protein: 22-304
Range on HMM: 1-277/277
Sequence Identity: 32% (96 aa)

INWTQKLGAGISGPVRVCVKKSTQERFALKILL-------DRPKAR--NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFH
.    ..| |  . .| ||...|   .| |||         . ..    |..   ||  |||||.  ..|  .          . . .|||   ||||| 
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQ----------CHTYLVMEYCNGGELFT

RISQHRHFTEKQASQVTKQATLALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGD----LMTPQFTPYYVAPQVLEAQRRHQKEKSGI
.|.. .||.|. ....  .  .|..| | . | ||||||||.|| |.. ...||| |||||..   |    . .| ||  | || .|.    ..      
HIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDG-----

IPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFY----SKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
        .|...||.|||||| | || |  ||     .  || .  .. ...|..|.| || ..|...|. ||| ...|| ..|. ||. .. ..| |.
--------GYDEACDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase MAPKAPK5.AA RAD53 72-304 32 6.1e-72 213.41 In-house 63-305 (305) Show / Hide 
Range on Protein: 72-304
Range on HMM: 63-305/305
Sequence Identity: 32% (83 aa)

HPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRI-SQHRH---FTEKQASQVTKQATLALRHCHLLNIAHRDLKPENLLFKDNSLDA----
||.|..|...| .             . .|.| |.||||| .| |. |    |.| ..    .|  .|..  | ..|.|||||||| |..... .     
HPCIIRIYDIFDTP---------QKYYYMVLELMTGGELFNKIVSNKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQ

-----------PVKLCDFGFAKIDQGD--LMTPQFTPYYVAPQVLEAQRR---HQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS
            .|. ||| .|. . .  . |   || |||| |.  . .   |  | .           |.|..|.||.|.| |..|||||||      
LGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKGHNCYHENEERQVQ------VGYTKKVDCWSMGCILYICLCGYPPFSDDYTQ

RTIPKDMRRKIMT-GSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
   ....  .| . |...|| ..|. ||| ||| ....|.| ||.|.||...| |||.
EMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNHPWM
Kinase MAPKAPK5.AA Ciliate-E2 22-304 23 1.5e-65 224.02 In-house 1-365 (365) Show / Hide 
Range on Protein: 22-304
Range on HMM: 1-365/365
Sequence Identity: 23% (96 aa)

INWTQKLGAGISGPVRVCVKKSTQERFA-----------------------LKILLDRPKARNEVRLHMM----CAT--------------HPNIVQIIE
..  .|.| |  | |. | ....|..||                       .||.  . .   .  .|.|    |                ||||....|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

VFAN-SVQFPHESSPRARLLIVMEMMEGGELFHRISQHRH-----------FTEKQASQVTKQATL---------------ALRHCHLLN-IAHRDLKPE
.| . . .          . .|||  .||.||..| ....           ||||......|| .                ||...|  | | |||.|||
CFQEKDDNN---------IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPE

NLLFKDNSLDAPVKLCDFGFAKIDQGD-----------LMTPQF------------------------TPYYVAPQVLEA-----QRRHQKEKSGIIPTS
|.||        .|..|||..|. . |           ...  .                        ||.|.||..|.      |              
NILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ--------------

PTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEE--------------WSQISEMAKDVVRK----LLKVKPEERLT
 .   |...||.||||||.| ||.|.|||              ..|. . ..||..|              | ..|. .||  .|    .|...||.|.|
QKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT

-IEGVLDHPWL
 .| .|.|||.
GWEQILNHPWF
Kinase MAPKAPK5.AA CDPK 218-304 43 1.5e-36 109.76 In-house 190-271 (271) Show / Hide 
Range on Protein: 218-304
Range on HMM: 190-271/271
Sequence Identity: 43% (38 aa)

YNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
||..||.||.||| |..|||||||| |  . ..      |.. | ..|  .||. ||. ||| .||.| . |. |.. . .|.||| 
YNEKCDIWSCGVILYILLCGYPPFYGKNDQEIM-----EKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase MAPKAPK5.AA RSK 36-201 31 8.1e-36 125.32 In-house 15-189 (278) Show / Hide 
Range on Protein: 36-201
Range on HMM: 15-189/278
Sequence Identity: 31% (58 aa)

VRVCVKKSTQERFALKILLD---RPKAR------NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRH---FTEK
.| |. . |.  .| |.|     .....       |..  ..|  ||.||.  ..|               | ..|| ..||||| ......|   |.|.
CRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTE----------GKLYLIMEYCRGGELFTHLQKEKHFGCFSED

QASQVTKQATLALRHCHLLNIAHRDLKPENLLFKDNSLD-APVKLCDFGFAKI---D-QGDLMTPQFTPYYVAPQVLEA--QRR-H
 |...  . .||..| | . | |||||||| |. | | . . .||.||||.|.   |  . .||. .|  |.|| .|    |.. |
EACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGH
Kinase MAPKAPK5.AA CDPK 100-196 41 1.6e-35 106.57 In-house 78-187 (271) Show / Hide 
Range on Protein: 100-196
Range on HMM: 78-187/271
Sequence Identity: 41% (46 aa)

IVME--MMEGGELFHRISQHRHFTEKQASQVTKQATLALRHCHLLNIAHRDLKPENLLFKDNSLDA----PVKLCDFGFAKIDQG------DLMTPQF-T
||||  . .||||| .| . .|||||.|... .|   |. .||  || ||||||||.||. .. |.    ..|. |.| .|. ..      . |. .. |
IVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGT

PYYVAPQVLE
|||.|| ||.
PYYIAPEVLQ
Kinase MAPKAPK5.AA RSK 217-304 36 3.1e-32 113.43 In-house 188-278 (278) Show / Hide 
Range on Protein: 217-304
Range on HMM: 188-278/278
Sequence Identity: 36% (34 aa)

TYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLT-----IEGVLDHPWL
...|.||.|||||..| || |.|||..   .   .|.  ..|..| | .. ..|. .|. ||| .||.|.. |. ||.     .| ...|||.
GHDKACDWWSLGVLMYEMLTGCPPFQG-PND-NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MAPKAPK5.AA MNK 25-173 37 2.5e-30 101.57 In-house 4-148 (292) Show / Hide 
Range on Protein: 25-173
Range on HMM: 4-148/292
Sequence Identity: 37% (58 aa)

TQKLGAGISGPVRVCVKKSTQERFALKILLDR--PKARN----EVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHR
   || |  . |. ||. ..   .| ||.  .    .|     || .   |  |.||.| || | .  .|            |.| |.|| |  .| |..
DEHLGEGAYASVQTCVNIQSGKEYAVKIIDKQGPGHSRKRVFREVETFYHCQGHRNILQLIEWFEDDDRF----------YLVFEKMRGGPLLQHIQQRK

HFTEKQASQVTKQATLALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFA
||||. ||||.|   .||   |   |||||||||| | ..    .|||.|||. .
HFTEHEASQVIKDIASALDFMHNKGIAHRDLKPENILCEHPNHVCPVKICDFDLG
Kinase MAPKAPK5.AA MNK 258-304 48 2.1e-18 59.9 In-house 246-292 (292) Show / Hide 
Range on Protein: 258-304
Range on HMM: 246-292/292
Sequence Identity: 48% (23 aa)

IMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL
|  | .||||.||..||| ||| . .||. .. .||. . ||.||| 
IQEGHYEFPEKEWHHISEEAKDLISNLLVRDAKQRLSAAQVLNHPWV
Kinase MAPKAPK5.AA MNK 218-241 83 7.8e-14 43.98 In-house 195-218 (292) Show / Hide 
Range on Protein: 218-241
Range on HMM: 195-218/292
Sequence Identity: 83% (20 aa)

YNKSCDLWSLGVIIYVMLCGYPPF
| | |||||||||.|.||||||||
YDKRCDLWSLGVILYIMLCGYPPF
Kinase MAPKAPK5.AA TyrKc 22-304 20 2.8e-08 -88.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-304
Range on HMM: 1-280/280
Sequence Identity: 20% (66 aa)

INWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVR--LHMMCAT---HPNIVQIIEVFANSVQFPHESSPR-------ARLLIVMEMMEGGE
|   .||| |  | |. .. |   .  | | | .    | . .  . .||     |||||... |           .           |.|||| |..| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGV----------CTQQGRNFMYIEPLMIVMEYMPHGD

LFHRISQHRH-FTEKQASQVTKQATLALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGD-LMTPQFTPYYVAPQVLEAQRRHQKEKSG
| ...  ||. .. |.  .   |.    .. |  |. ||||   | | ..|     || .||| ..    |  .            . .   |....|.|
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-----------ESKDYYRKKEHKGG

I--IPT------SPTPYTYNKSCDLWSLGVIIY-VMLCGYPPFYS---KHHSRTIPKDMRRKIMTGSFEFPEEE--------WSQISEMAKDVVRKLLKV
   .|       .   ....   | || || .. ..  | .| .    .      ..........|    . ..         ..  || . . ..  . 
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPD--EMYQ-IMKQCWHE

KPEERLTIEGVLDHPWL
.||.| | . .  |  .
DPEDRPTFSEI--HECF
Kinase MAPKAPK5.AA CDPK 20-52 45 0.00184 6.72 In-house 1-33 (271) Show / Hide 
Range on Protein: 20-52
Range on HMM: 1-33/271
Sequence Identity: 45% (16 aa)

YSINWTQKLGAGISGPVRVCVKK-ST-QERFALKI
| |.   .|| |  | || ...| .| |||.| ||
YKIK--KVLGKGHFGQVRKVKHKQKTNQERVAMKI
Kinase MAPKAPK5.AA RAD53 20-53 32 0.004524 4.41 In-house 1-32 (305) Show / Hide 
Range on Protein: 20-53
Range on HMM: 1-32/305
Sequence Identity: 32% (11 aa)

YSINWTQKLGAGISGPVRVCVKKSTQERFALKIL
|...   .||.|  | |. ...|.| ...| ||.
YYMS--KELGSGNFGTVKLAYEKKTCQKVAIKII
Kinase MAPKAPK5.AA CDPK 72-82 54 0.24933 0.08 In-house 60-70 (271) Show / Hide 
Range on Protein: 72-82
Range on HMM: 60-70/271
Sequence Identity: 54% (6 aa)

HPNIVQIIEVF
||||..| |..
HPNIIKIYEFY