Gene MARK3 (Human)

MARK3

Species: Human
Alias: KP78, PAR1A, CTAK1, MARK3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 14q32,

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MARK3.NA RNA Sugen Kinome 3615 None Fasta, JSON
MARK3.AA Protein Sugen Kinome 776 None Fasta, JSON
MARK3.kin_dom Protein Kinase Domain Sugen Kinome 275 None Fasta, JSON

Protein domain

Protein domains of MARK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MARK3.AA MARK 56-330 54 2e-175 577.67 In-house 1-262 (262) Show / Hide 
Range on Protein: 56-330
Range on HMM: 1-262/262
Sequence Identity: 54% (154 aa)

YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP-TSLQKLFREVRIMKILNHPNIVKLFEVIE--TEKT-LYLIMEYASGGEVFDYLVAH--GR
|..|||||.|..||||||.|..|||.|||||..|..||.  ......||..||| |.||||.|||.|||  ||.. .|||||||||||..||..||  ||
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

MKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADM--NIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELF
..|.|||  |||                       |||||.|||.|.|||||.|.||.|.|...  ||||.|||||.... | ||.||||.|||.|||.|
LHEEEARRIFRQ-----------------------IVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIF

QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN--LKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI
..|.||||.||.|||||.||..|.|..||||..  .|||....|||||.||...|..|.||..|.|..|| .| |.|.|||..|.
LKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MARK3.AA CAMKL 56-330 45 2.6e-166 534.88 In-house 1-297 (297) Show / Hide 
Range on Protein: 56-330
Range on HMM: 1-297/297
Sequence Identity: 45% (148 aa)

YRLLKTIGKGNFAKVKLARH-ILTGREVAIKIID--KTQLNPTSLQK-----------LFREVRIMKILN---HPNIVKLFEVIETEKT------LYLIM
||..||.|||.|.|||||.| ..||..|||||||  |....| ....           ..||..||| ||   ||||.||.|||||...      .||.|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYASGGE--VFDYLVAH----GRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADM--NIKIADFGFSN
||.||||   |||.|.|    |||.|.|||  |||                       |||||.|||...|||||.|.||.||| ..  ||||.||||||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQ-----------------------IVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSN

EFT-V----GGKLDTFCGSPPYAAPELFQG--KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK---------ELRERVLRGKYRIPFYMSTDCENLLK
... .    | ||.||||||||.|||.|||  |.||||.||.||.|||||..| | ||||.....         ....... ....|....| ||..|..
MYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIR

RFLVLNPIKRGTLEQIMKDRWI
. |. || || |..|||...| 
KMLQVNPEKRPTIHQIMNHPWM
Kinase MARK3.AA CAMK 61-330 29 1.9e-139 452.38 In-house 1-425 (425) Show / Hide 
Range on Protein: 61-330
Range on HMM: 1-425/425
Sequence Identity: 29% (134 aa)

TIGKGNFAKVKLARHILTG------------REVAIKIIDKTQLN--------------------------PTSLQKLFREVRIMKI-------LNHPNI
|.|.|.|.||||..|..|.            ..||||||||..|                           | ......||..|||        |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLFEVIE------------TEKT--------LYLIM---EYASGG----EVFDYLVAH---------------GRMKEKEARSKFRQGCQAGQTIKVQV
.||.||.|            | ..        .|..|   ||.|||    ..|||.|.|               ||..|.|||  |||            
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQ------------

SFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADM-----------------NIKIADFGFSNEFTVGG------------------------KL
           |.|||.|||.. ||||||| ||.||| ..                 ||||.||||.|.|. |                         |.
-----------ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKM

DTFCGSPPYAA-PELFQG-------------KKYDGPEVDVWSLGVILYTLVSGSLPFDGQ-------------NLKELRERVLRGKYR-IPFYMST---
 ||||.|.|.| ||...|             |.|.||..|.||.|||||....| .||.|              |..|| |....|||. .|.|.|.   
KTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISC

--------------------DCENLLKRFLVLNPIKRGTLEQIMKDRWI
                    .| .|... |. .| || |.||.... |.
NYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MARK3.AA S_TKc 56-330 33 3.2e-99 336.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 56-330
Range on HMM: 1-231/231
Sequence Identity: 33% (97 aa)

YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASG--GEVFDYLVAHGR----
|..|..|||| |.||...||. |||.||||||.         ... ||..|.|  .|||||||..|... . ||..|||..|  |..|||.. .||    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELF
  . | .||. ..|                       |..|..|||...|.||||| ||.|||   .|||.|||.. ..      .||||.| | |||..
FPFPE-HARFYMYQ-----------------------ICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL

QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMK-------DRWI
   .|.....|.||.|.||| ...|  ||.  ..... ....          | .. ..... |. .| || |  ....       . |.
---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MARK3.AA QIK 181-330 64 1.1e-98 334.1 In-house 123-272 (272) Show / Hide 
Range on Protein: 181-330
Range on HMM: 123-272/272
Sequence Identity: 64% (97 aa)

MFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN
.|. |.|||.|||.. ||||||||||.|||..|||||||||||| |. |  | |.||||||||||.|.||.||||.||.||.||.|| ||.|.|||||..
WFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKT

LKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI
|..||.||| ||.||||.||.||| | .. ||..| .| | .||.. ||.
LQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MARK3.AA NuaK 181-330 51 3.7e-87 229.1 In-house 104-252 (252) Show / Hide 
Range on Protein: 181-330
Range on HMM: 104-252/252
Sequence Identity: 51% (77 aa)

MFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN
.|  ||||| |||. ||.||||| || |||.. |.|||||| || .  .  | |||||| || ||   |. | ||||| |||||.|||.| |..||||..
FFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFDGHD

LKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI
 |.|   . .|.|. |   |. |. |    |  || .| |...| .  |.
FKHLVKQISQGAYYEPCKPSDACM-LIRWMLMVNPRRRATIYDICHHWWV
Kinase MARK3.AA AMPK 185-330 52 5.5e-82 243.19 In-house 109-254 (254) Show / Hide 
Range on Protein: 185-330
Range on HMM: 109-254/254
Sequence Identity: 52% (76 aa)

IVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKEL
|.|.| |||.  ||||||| ||||||...||||.||| ||  . | .| | |||| |||||. .||.| |||||.|| ||||| .. | |||| .|  .|
IISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTL

RERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI
  ... |.| || ..|.....|.|. |  .|.|| | ..|... | 
YKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MARK3.AA NIM1 180-330 43 9.5e-67 195.11 In-house 104-258 (258) Show / Hide 
Range on Protein: 180-330
Range on HMM: 104-258/258
Sequence Identity: 43% (67 aa)

LMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTV----GGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLP
..|  |||||.  | . |||||.|||| .. .   .|..|||||         . .|.|||||||||||||||   | |. |||| ||..||  . |  |
PIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDFGFSCYCKMGTGANQMLNTFCGSPPYAAPELFQDEHYIGEYVDVWALGILLYFMMTGVMP

FDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI
|      ..   .| |.| || | |  |  | .. |   |  | | .|.|.. |.
FRAETVPKMKKCILKGQYQIPDYVSLPCHRLIRGMLKHIPTQRYTIDQMMNHQWM
Kinase MARK3.AA TSSK 185-330 38 1.1e-63 207.82 In-house 132-289 (289) Show / Hide 
Range on Protein: 185-330
Range on HMM: 132-289/289
Sequence Identity: 38% (61 aa)

IVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGG------KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG
.||||.||| . .|||||| ||.||| . |||..||||..... .       .. |||||  ||||| ..|..||.  .||||.|||||..| |..||| 
MVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRCCHLSKTFCGSYAYAAPEILRGIPYDPKWYDVWSMGVILYIMVCGCMPFDD

--QNLKELRERVL-RG-KYRI--PFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI
  .|.. . ...  .. ....      |..| .|... | ..| .| ....|... |.
DKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM
Kinase MARK3.AA BRSK 182-330 50 2.1e-59 201.03 In-house 106-254 (254) Show / Hide 
Range on Protein: 182-330
Range on HMM: 106-254/254
Sequence Identity: 50% (75 aa)

FTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNL
|  |.||. .|| . | ||||| |||||| . ||||||||       .  |.| |||| || ||  .| ||||   |||| ||||| |  | ||||  ||
FRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNL

KELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI
 .| |.| || . .| .   || .||.  .  .| || .|..| |  | 
RQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase MARK3.AA QIK 56-165 50 8.7e-59 201.61 In-house 1-130 (272) Show / Hide 
Range on Protein: 56-165
Range on HMM: 1-130/272
Sequence Identity: 50% (66 aa)

YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR------
| . .|||||||| ||||||. |  .||||||||.||. . |||..||| ||| |.||.|.||..|.||.. .|...||.|.|| ||||..|||      
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------MKEKEARSKFRQGCQA
              |.|.||| .| | | |
NSPDIGDQVLMGVPMAENEARRWFWQICSA
Kinase MARK3.AA SNRK 182-330 46 8e-58 187.81 In-house 105-254 (254) Show / Hide 
Range on Protein: 182-330
Range on HMM: 105-254/254
Sequence Identity: 46% (70 aa)

FTFIVSAVQYCHQKRIVHRDLKAENLLLDADMN-IKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN
|  |. |..||||...|||||| || .    .  .|. ||||||.|  | ||.|.|||  |.|||.  | .|| | ||.|||||||| || | .||.  |
FCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPFQEAN

LKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI
  |   ...  || .|  .|..| .|... || .| || .||.|    |.
DSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase MARK3.AA Pkinase 185-330 32 1.2e-56 199.25 Pfam 117-293 (293) Show / Hide 
Range on Protein: 185-330
Range on HMM: 117-293/293
Sequence Identity: 32% (58 aa)

IVSAVQYCHQKRIVHRDLKAENLLLDADMNI----KIADFGFSNE--FTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG
|.....|||...|.||||| ||.|.| ...|    ||.|||..       .. ..||||.|.|.|||. .| .|.||.||.||.|.||| ...| .||.|
ILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPG

Q------NLKELRERVLRGKYRIPFY---------------------MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI
.      . ... .|....... ...                     .| .|  ..|. | ..| || | |||... |.
HCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MARK3.AA AMPK 56-161 49 9.3e-56 164.04 In-house 1-108 (254) Show / Hide 
Range on Protein: 56-161
Range on HMM: 1-108/254
Sequence Identity: 49% (53 aa)

YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILNHPNIVKLFEVI-ETEKTLYLIMEYASGGEVFDYLVAHGRMKEK
| . ||||.| | |||.. ||||| .|||||..|. .   . . .. ||..|.|...||.|..|.||| ||.. ....|||.|||| ||| | |||..|.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EARSKFRQ
||.  | |
EACRFFQQ
Kinase MARK3.AA NuaK 56-161 46 7.5e-47 120.87 In-house 1-107 (252) Show / Hide 
Range on Protein: 56-161
Range on HMM: 1-107/252
Sequence Identity: 46% (50 aa)

YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKE
|...|| ||| . |||||. . |||||||| | |     .  . .  ||..||  ||||.|.. .|| |    . ..|||||||| .||.   ... |.|
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

ARSKFRQ
||  |||
ARHFFRQ
Kinase MARK3.AA NIM1 56-161 44 4.6e-45 130.34 In-house 1-108 (258) Show / Hide 
Range on Protein: 56-161
Range on HMM: 1-108/258
Sequence Identity: 44% (48 aa)

YRLLKTIGKGNFAKVKLARHILTGREVAIKIID--KTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEK
||. . || ||| ||||. | ||   |||||.|  || .    .  | ||.  |  ..|||||.|.||.||   ..|.||||.||| . .    | . | 
YRFCGEIGRGNFSKVKLGVHQLTKEKVAIKIMDLDKTKMDQKTQRMLSREIQCMECMHHPNIVRLYEVVETLTRVHLVMEYARGGELYTHIHQEGKLREI

EARSKFRQ
..   | |
HCKPIFAQ
Kinase MARK3.AA BRSK 56-161 53 2.5e-43 145.45 In-house 1-108 (254) Show / Hide 
Range on Protein: 56-161
Range on HMM: 1-108/254
Sequence Identity: 53% (58 aa)

YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEK
||| || |||   .|||  |  ||. |||||| |  |   .  |.|  ||. |||  .||.. |...| |. | ||||.|. |||| |||||  ||.. |
YRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPK

EARSKFRQ
|||  |||
EARKFFRQ
Kinase MARK3.AA SNRK 56-165 50 2.3e-42 136.37 In-house 1-111 (254) Show / Hide 
Range on Protein: 56-165
Range on HMM: 1-111/254
Sequence Identity: 50% (56 aa)

YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKE
| | ||.|.| || ||||||. ||  ||.|.||||..   |  .||.||| ||.  |||||.|.|||.|   ||||.|   |....||.. | . ..|. 
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL

ARSKFRQGCQA
||  |.|  .|
ARKYFCQIMHA
Kinase MARK3.AA Pkinase 56-161 37 3.7e-37 132.48 Pfam 1-116 (293) Show / Hide 
Range on Protein: 56-161
Range on HMM: 1-116/293
Sequence Identity: 37% (44 aa)

YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFR--EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGG----EVFDYLV--AH
|.....||.|.|..|....|. ||..||.|||.|   ..  .| ..|  |..||| |||||||.|... |... .|..|||. ||    . |||.   .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRM--KEKEARSKFRQ
|..   |.|... ..|
GCFYFSEWECKFYMYQ
Kinase MARK3.AA TSSK 56-161 34 9.1e-35 111.53 In-house 1-131 (289) Show / Hide 
Range on Protein: 56-161
Range on HMM: 1-131/289
Sequence Identity: 34% (45 aa)

YRLLKTIGKGNFAKVKLARHILTGRE----------------VAIKIIDKTQLNPTSLQK-LFREVRIMKI-LNHPNIVKLFEVIETEK-TLYLIMEYAS
| . |.||.|..|||..|..  . ..                |||||||..   .  |.| | ||  ||.. |.||||....| .||.    |..||||.
YNVGKKIGHGSYAKVYCAYSKKHKCKHNPRLRDDLRIKRHTHVAIKIIDRKKAPTDYLNKFLPREIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAE

GGEVFDYLVAH------GRMKEKEARSKFRQ
.| ...|  ..      |...|..||  |||
HGDLLEYIQRRTQERCCGALHEEQARKWFRQ
Kinase MARK3.AA Pkinase_Tyr 56-296 26 7e-30 101.83 Pfam 1-236 (270) Show / Hide 
Range on Protein: 56-296
Range on HMM: 1-236/270
Sequence Identity: 26% (69 aa)

YRLLKTIGKGNFAKVKLARHI----LTGREVAIKIIDKTQLNPTS--LQKLFREVRIMKIL-NHPNIVKLFEVIE-TEKT--LYLIMEYASGGEVFDYLV
 ...|..|.|.| .|....       |. .||.|.. | .  .    .....||..||| | .|||||.|  |.   ..   .|..|||. .|   ||| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEF-------TVGGKLDTFCGS
.|                    . | ...   |  | . | .. .| ..|...|||| | | |.. .. .||.||| .          ...|. .     
KHR-------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK---LP

PPYAAPELFQGKKYDGPEVDVWSLGVILYTLVS-GSLP-FDGQNLKELRERVLRGKYRIP
 .  ||| .. .|.   . |||| || .. ... |  | . |    |. |.. .  || |
IKWMAPECINYGKFT-TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMP
Kinase MARK3.AA TyrKc 56-329 23 1.5e-27 98.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 56-329
Range on HMM: 1-280/280
Sequence Identity: 23% (74 aa)

YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKIL--NHPNIVKLFEVIETE-------KTLYLIMEYASGGEVFDYLVA
 .|.|..| |.| .| ... .   ..||.| . .       .. . || |||. |  .|||||.|. |. ..       . |...|||...|   ||| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVG------GKLDTF----C
|..                       .. . |  . . | .  .| |.|...|||| | | |....  .||.||| | . . .      ..  .     .
HRPK----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

GS--PPYA--APELFQGKKYDGPEVDVWSLGVILYTLVS-GSLPFDG-----QNLKELRERVLRG-KYRIPFY--------MSTDCENLLKRFLVLNPIK
|    |.   ||| .. .|.  .. |||| || .. . . |  |  |      . .|..|.| .|   ..| .        ....  .. |.    .| .
GKTMLPIRWMAPECINYGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED

RGTLEQIMKDRW
| | ..| ....
RPTFSEI-HECF
UBA_CAMKL MARK3.AA UBA_CAMKL 351-388 48 1.3e-16 57.61 In-house 1-41 (41) Show / Hide 
Range on Protein: 351-388
Range on HMM: 1-41/41
Sequence Identity: 48% (20 aa)

DQKRIDIMVGM--GYSQEEIQESLSKMKY-DEITATYLLLG
|...|..|. |  |.. ||| |||.. || ..|||||.||.
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL
UBA MARK3.AA UBA 351-388 23 4.2e-11 44.13 SMART 1-38 (38) Show / Hide 
Range on Protein: 351-388
Range on HMM: 1-38/38
Sequence Identity: 23% (9 aa)

DQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLG
....|| ...||...||....|.. .... .|...|. 
YEEKIDQLMEMGFDREECVQALRACNWNVEMAMNWLFS
UBA MARK3.AA UBA 350-386 18 9e-06 24.7 Pfam 1-38 (38) Show / Hide 
Range on Protein: 350-386
Range on HMM: 1-38/38
Sequence Identity: 18% (7 aa)

SDQKRIDIMVGM-GYSQEEIQESLSKMKYDEITATYLL
.|.. .. .. | |.| .. .. | . .... .|.. |
IDEEMVKQLMEMTGFSMMQCKKALRACNNNVERAVEWL
KA1 MARK3.AA KA1 730-776 43 1.3e-23 82.42 Pfam 1-48 (48) Show / Hide 
Range on Protein: 730-776
Range on HMM: 1-48/48
Sequence Identity: 43% (21 aa)

AENLVQWEMEVCKLP-RLSLNGVRFKRISGTSIAFKNIASKIANELKL
 .. |..|..|||.| ||.|.||.|||.|| . ..|....|| .|..|
EPEVVKFEIQVCKVPGRLGLYGVDFKRVSGNQWQYKDLCTKILKEMRL