Gene MAST4 (Human)

MAST4

Species: Human
Alias: MAST4, LOC375449
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 5q11.2-q12.3,

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
MAST4.NA RNA Sugen Kinome 10452 None Fasta, JSON
MAST4.AA Protein Sugen Kinome 2635 None Fasta, JSON
MAST4.kin_dom Protein Kinase Domain Sugen Kinome 238 None Fasta, JSON

Protein domain

Protein domains of MAST4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF1908 MAST4.AA DUF1908 270-349 66 1.3e-45 162.69 Pfam 1-93 (369) Show / Hide 
Range on Protein: 270-349
Range on HMM: 1-93/369
Sequence Identity: 66% (62 aa)

PQDSPRNFSPSASAHFSF--AR-------RTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKL----HQLPYQPTPDELHFLSKHFCTTES
| ||||||| |....| |  .|       | ||||||.|||||||||||.|||.|||.|||||.|    ||||.||| |.||||||||| |||
PIDSPRNFSTSSMMNFPFVPIRRITNCRDRADGRRWSVASLPSSGYGTNPPSSNVSSQCSSQERLNQLPHQLPFQPTQDDLHFLSKHFCCTES
DUF1908 MAST4.AA DUF1908 356-544 68 1.2e-131 448.48 Pfam 178-369 (369) Show / Hide 
Range on Protein: 356-544
Range on HMM: 178-369/369
Sequence Identity: 68% (131 aa)

CRNTPMRPRSRSL-SPGRSPACCDHEIIMMNHVYKERFPKATAQMEERLKEIITSYS--PDNVLPLADGVLSFTHHQIIELARDCLDKSHQGLITSRYFL
||  ..||||||| ||.||.   | ||.||||||||||||||.||||||...|. ..  |.. |.|||.|. | |||..|.|||||.|||..|||||||.
CRSPHHRPRSRSLSSPSRSCITFDNEIVMMNHVYKERFPKATQQMEERLQHFIHHFKNIPCDSLRLADPVVRFIHHQVVEMARDCLHKSHAKLITSRYFY

ELQHKLDKLLQEAHDRSESGELAFIKQLVRKILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKTDIPRYIISQLGLNKDPLEEM
|.| || .||.|||.|||| | .|| ....|.||.|.||||||||||||||||| |||||||.||..||||||||||||.|||||.||.|||
EMQEKLERLLHEAHERSESEEVPFITHVIKKLLIIISRPARLLECLEFDPEEFYHLLEAAEGQAKVMQGIKTDIPRYIIHQLGLNRDPIEEM
Kinase MAST4.AA MAST 582-855 54 1e-230 713.06 In-house 1-337 (337) Show / Hide 
Range on Protein: 582-855
Range on HMM: 1-337/337
Sequence Identity: 54% (185 aa)

FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFET--RRHLCMVMEYVEGGDCATLMKNMG-PLP
||.||.||.||||||| |.||....|||||.||.|..|..||..|.||||.|||...|||||.|..||.|  ...|||||||.||||||.|....| ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

VDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEG---------------HIEKDAREFL------------
..||.||.|||||.|||||.||||||||||||.| .|.||||||||||||||.|..|||.|||               ||.|....|             
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

------------------------DKQVCGTPEYIAPEVILRQG-YGKPVDWWAMGIILYEFLVGCVPFFGDTPEE-LFGQVIS--DEINWPEK-----D
                        .||.||||.||||||||.|| ||||||||.||||.|||||||.||.|||||| .|...|.  .||.|||.     |
QIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDD

EAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFF
.. .|.|||||  ||..||..|||..||.|.|||.||
DCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase MAST4.AA MAST 582-855 51 2.1e-211 688.24 In-house 1-334 (334) Show / Hide 
Range on Protein: 582-855
Range on HMM: 1-334/334
Sequence Identity: 51% (171 aa)

FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDM
||.||.||.||||.|| |.||....|||||.|.|...|..|...| .|||.||....|||||.|..||.|...|||||||.||||||.|....|.....|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEG---------------HIEKDAREFL---------------
|.||.|||||.|||||..|||||||||||.| .|.||||||||||||||.|......|||               ....|...|                
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

--------------------DKQVCGTPEYIAPEVILRQG-YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE---INWPEK-----DEAPP
                    .||.||||.||||||||.|| .|||||||.||||.|||||||.||..|||||.|.......   | |||.     |||..
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

PDAQDLITLLLRQNPLERLGTG-GAYEVKQHRFF
|.|||||  || ..|..|||.. ||.|||||.||
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase MAST4.AA AGC 582-855 28 9.20000000001e-168 437.89 In-house 1-395 (395) Show / Hide 
Range on Protein: 582-855
Range on HMM: 1-395/395
Sequence Identity: 28% (116 aa)

FETIKLISNGAYGAVYFVRHK------ESRQRFAMKKINKQN-LILRN--QIQQAFVE------------RDILTFAE----------NPFVVS-MYCSF
|| .|.|. |..| || ||.|       . . .|||...|.   ....  ..... .|            |.||. .           .||.|. ...||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETRRH--LCMVMEYVE--------GGDCATLMKNMG-----PLPVDMARMYFAE-------TVLALEYLHN-YGIVHRD-LKPDNLLVTSMGHIKLTDFG
.. .|  |..||||..        ||.| ... ..|      .. ..|| |.||       .||||||||.  ||.||| |||.|.| .. |||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKVGLMSM-----------TTNLYEG---------------HIEKDA----------REFLDKQVCG--TPEYIAPEVILRQGYGKPVDWWA--MGIIL
|.|.| ...           ... ...               .. ...           ... .  ||  ||||.|||..    |||..|||.  .|...
LCKEGMNDGEKGQQSQSNMKFHW-HNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YEFLVGCVPFFGDTPE----------ELFGQVI------SDEINWP-------EKDEAPPPDAQDLITLLLRQNPLERLGTG-------GAYEVKQHRFF
||.|.|. ||.||.|.          |.| ...      .... .|       ..|.   |.|.|||. ||  .| .|||.|       || |.|.| .|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MAST4.AA S_TKc 582-855 33 3.7e-101 343.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 582-855
Range on HMM: 1-231/231
Sequence Identity: 33% (95 aa)

FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEG--GDCATLMKNMGP---
.| ...|  ||.| || .|||.. ...|.|.|.          ...  |..||     |..| .| .|..  ||.|||||..|  ||  ...|..|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYG
   .|  .|| |......||||.|. ||.||||||.|.|...  |||..||||...                       . .||||.|.||||.   |||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL---GYG

K-PVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYE----VKQHRFF
| ..|||. |.||||.|.|. ||   .....| ..              .|.| |.|  .|. .| .|..   | .    .|.| .|
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAST4.AA RSK-Unclassified 582-855 37 9.8e-92 288.4 In-house 1-283 (283) Show / Hide 
Range on Protein: 582-855
Range on HMM: 1-283/283
Sequence Identity: 37% (106 aa)

FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMK--NMGPLPV
|. ..||  |  | || || |.. | .|||  .|. .| .| |. .  |..|.   . ||.| .| || |.  | ..|||  |||    .       .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

DMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVG------LMS--MTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQG
| .|.| .|...||||||  ... ||||||| .    ||..||||.||. .       |       . .  |  .   |  .  ||| ||.|||.| | |
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHG--FRTNSFCGTEEYLAPEMIRRCG

YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTG-G-AYEVKQHRFF
 .| |||| .||..|| |.|| |. |.  .|.|  .   ..  |.  .    ...|||  || .||  ||| . | | ..|.| ||
HTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYI-SNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase MAST4.AA AktR 582-855 37 1e-86 294.4 In-house 1-268 (268) Show / Hide 
Range on Protein: 582-855
Range on HMM: 1-268/268
Sequence Identity: 37% (105 aa)

FETIKLISNGAYGAVYFVRHK-ESRQRFAMKKINKQNLILRNQIQQAFVERDILT-FAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPV
|. .|.. .||.| || |..| .. . .||| | |...| |||....  ||.|.   . .|| | .. .|.|...|  .|||..||.  .  |. . .  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DMARMYFAETVLALEYLHNY-GIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDA-REFLDKQVCGTPEYIAPEVILR-QGYGKPV
..|| |||. .|||||||.   |. |||||.|.|  . ||.|.|||||||              ....  .. . . .||||||.|||.|.. .|..|.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSV

DWWAMGIILYEFLVGCVPFFG-DTPEELFGQVISDEINWPEKDEAPPPDAQDLIT-LLLRQNPLERLG--TGGAYEVKQHRFF
|||| || .|| ..|| ||.  .. .... . |.. .| ... . . . ..|||.  || .|| .|||  . |. |.| | .|
DWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase MAST4.AA RSK 585-855 33 3.5e-79 269.38 In-house 1-278 (278) Show / Hide 
Range on Protein: 585-855
Range on HMM: 1-278/278
Sequence Identity: 33% (97 aa)

IKLISNGAYGAVYFVRHK---ESRQRFAMKKINKQNLILRNQ-IQQAFVERDILTFAE-NPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGP---
.|.   |.||.|. .| .    ..| .||| ..|  .. |.  .  .. ||.||   .  ||.|. . .|.|  .| ..|||..||.  |  .. .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTS---MGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVIL----R
.  | |..|.|| |||.|.||  ||.||||||.| | ..    |||||||||..| .  ...  ..                |.| ||.|||..     .
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT--------------FCYTIEYMAPEMLKRANQQ

QGYGKPVDWWAMGIILYEFLVGCVPFFG---DTPEELFGQVISDE--INWPEKDEAPPPDAQDLITLLLRQNPLERLG--TGGAYEVKQHRFF
 |..| .|||  |...|| |.||.|| |   ....|.. .. . .   . |. ..   ..|.|||. .|  .|  |||   ..| |.||| .|
GGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYL-SQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MAST4.AA Pkinase 582-855 29 4.2e-79 273.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 582-855
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFV--ERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGG----DCATLMK--N
..... |  |..| ||  .|| .....|.|.|.|.  .  .. |...   |  |.     |..| .|..||...|..|||||.|||    | .....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

MGPL--PVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHI----KLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVI
 |..  . . ...|. ... .|||.|. ||.||||||.|.|. . |||    |..||||.|.              .   . .  . .||||.|.|||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------Y-NNS-M--TTFCGTPWYMAPEVI

L-RQGYGKPVDWWAMGIILYEFLVGCVPFFGD------TPEELFGQVIS--DEINWPEKDE----------------APPPDAQDLITLLLRQNPLERLG
. .|.||..||.|..|.||||.| |  || |.      .. ... .. .   . .||....                . .....|.|. .|...| .|..
RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

TGGAYEVKQHRFF
   | ...|| .|
---AEQILQHPWF
Kinase MAST4.AA NDR 582-731 45 1.4e-75 232.38 In-house 1-155 (350) Show / Hide 
Range on Protein: 582-731
Range on HMM: 1-155/350
Sequence Identity: 45% (71 aa)

FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAE--NPFVVSMYCSFETRRHLCMVMEYVEGGDCAT---LMKNMGP
|| ||.|. ||.| |. ||.|.... .|||...|.  . .||. .   ||||.. |   ||.||..|.||    .|. ||||. |||  |   | ..|. 
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGL
.. |.|| | ||.|.|.|..|..|..|||.||||.|. . ||||||||||.. |.
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGM
Kinase MAST4.AA Akt 582-733 38 9.5e-52 163.66 In-house 1-154 (264) Show / Hide 
Range on Protein: 582-733
Range on HMM: 1-154/264
Sequence Identity: 38% (59 aa)

FETIKLISNGAYGAVYFVRHKESRQRF-AMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVD
|. .|..  |..| |. |. | . . . ||| . |. .| .||..... || ||    .||.|... || |  .|..||.|. ||.  ....  .  . |
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

MARMYFAETVLALEYLHNYGIVHRD-LKPDNLLVTSMGHIKLTDFGLSKVGLMS
 || | || .||.|.||. .|. || ||| |.|. . |||.||||||.| ....
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIK
Kinase MAST4.AA PKA 582-728 42 1.2e-51 177.94 In-house 1-149 (263) Show / Hide 
Range on Protein: 582-728
Range on HMM: 1-149/263
Sequence Identity: 42% (64 aa)

FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVV-SMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVD
||.|... .| .| |. .|||.| . .||| ..||  . ..|..    |. ||.  ..||.| .|| .| ..|.| ||||||.||.  . . . | .. .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

MARMYFA-ETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSK
.|. | | . ||||||||.  |..||||| |.|  . ||||.|||| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase MAST4.AA SGK 582-728 36 5.5e-50 152.3 In-house 1-173 (283) Show / Hide 
Range on Protein: 582-728
Range on HMM: 1-173/283
Sequence Identity: 36% (63 aa)

FETIKLISNGAYGAVYFVRHKES------------------RQRFAMKKINKQNLI-------LRNQIQQAFVER-DILTFAENPFVVSMYCSFETRRHL
|. .|.|  | .| || |.||.                    . .||| ..||  |        ...      || .||     || |.   .| |   |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSK
 .||.||.||.    ..  . .| | || | || |.||||||   |..|||||.|.|  ..||..||||||.|
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCK
Kinase MAST4.AA Akt 755-855 37 2e-41 130.14 In-house 162-264 (264) Show / Hide 
Range on Protein: 755-855
Range on HMM: 162-264/264
Sequence Identity: 37% (39 aa)

VCGTPEYIAPEVILRQGYGKPVDWWA-MGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLG--TGGAYEVKQ
.||||||.|||... .|..|.||||.  |...||.. |  ||. .  ...| .  . ... |.| ..  |...|||. ||  .| .|||   ..| |.|.
FCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKR

HRFF
| .|
HPWF
Kinase MAST4.AA SGK 756-855 40 2.1e-41 125.33 In-house 186-283 (283) Show / Hide 
Range on Protein: 756-855
Range on HMM: 186-283/283
Sequence Identity: 40% (41 aa)

CGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTG-GAYEVKQHRF
|||||| ||||.. |.... |||| .|..|||...|  ||.    .... . |. ... |    .   || |||..||  .| .||||  .. |.|.| |
CGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSN---DAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPF

F
|
F
Kinase MAST4.AA NDR 757-855 41 2.5e-37 112.21 In-house 243-350 (350) Show / Hide 
Range on Protein: 757-855
Range on HMM: 243-350/350
Sequence Identity: 41% (45 aa)

GTPEYIAPEVILR-QGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPP------PDAQDLITLLLRQNPLERLG-TG-GAY
|||.|.||||... .||.. .|||  | |.||.|||  ||..|||.| .  ... .. |..  .. |      |.|.|||. |.  .| .|||  | |. 
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

EVKQHRFF
|.|.| ||
EIKSHPFF
Kinase MAST4.AA PKA 755-855 38 2.9e-35 123.46 In-house 158-263 (263) Show / Hide 
Range on Protein: 755-855
Range on HMM: 158-263/263
Sequence Identity: 38% (42 aa)

VCGTPEYIAPEVILRQ-GYGKPVDWWAMGIILYEFLVGCVPFFGD--TPEELFGQVISDEINWPEKDEAPPPDA---QDLITLLLRQNPLERLGT--GGA
.||||||.|||.|..  |.||.||||| ||. ||.|.|  ||. .  .| ...   .. .|..|. .    .||    |||  ||  .. .|.|.  .|.
LCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFD---SDANYFKDLIKKLLQVDLTKRYGNMKNGV

YEVKQHRFF
  .| |..|
NDIKNHKWF
Kinase MAST4.AA TyrKc 582-855 19 3.5e-12 -25.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 582-855
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFA--ENPFVVSMYCSFETR-------RHLCMVMEYVEGGDCATLMK
 . .| . .||.| ||  . |   .  | |....        ..    |  |..    ..| .| .|    .          |..||||...||.    .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NMGP-LPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMS-MTTNLYEGHIEKDARE-FLDKQVCGTPEYIAPEVILR
. .| |...    .        ||||  ...||||   | ||.. ...| .|||||. .    ..    | .  ....|    | .       |||.|  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPI-RWMAPECINY

QGYGKPVDWWAMGIILYEFLVGCVPFFGD------TPEELFGQVISDEINWPEKD-------EAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFF
  .    | |. |. ..| .  . .   .      ...|.. .| . .   . ..       ..|.   | ...   . .| .|           |..|
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI-----HECF
Kinase MAST4.AA Pkinase_Tyr 692-728 43 1.1e-05 19.89 Pfam 123-159 (270) Show / Hide 
Range on Protein: 692-728
Range on HMM: 123-159/270
Sequence Identity: 43% (16 aa)

ALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSK
..|||.. ...||||   | |||. ...| .||||..
GMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase MAST4.AA S_TK_X 856-924 18 0.000246 13.29 SMART 1-79 (79) Show / Hide 
Range on Protein: 856-924
Range on HMM: 1-79/79
Sequence Identity: 18% (18 aa)

RSLDWNSLLR----QKAEFIPQLE----SEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSS------------------CSHRFSKVF
|..||. |..     .. |.|..     |. |||.||.        .|||...            ...                  .   |..||
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDP-------EFTEETPM---------LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase MAST4.AA Pkinase_C 873-919 23 0.000287 18.36 Pfam 1-46 (46) Show / Hide 
Range on Protein: 873-919
Range on HMM: 1-46/46
Sequence Identity: 23% (11 aa)

QLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHR
|..|..|||.||.  .. ..|.|  ...   .  . . |.|. ..  
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase MAST4.AA Pkinase_Tyr 654-666 46 0.671292 3.67 Pfam 81-93 (270) Show / Hide 
Range on Protein: 654-666
Range on HMM: 81-93/270
Sequence Identity: 46% (6 aa)

HLCMVMEYVEGGD
....||||...||
QIYIVMEYMPHGD
PDZ MAST4.AA PDZ 1161-1241 24 1.1e-16 62.73 SMART 1-80 (80) Show / Hide 
Range on Protein: 1161-1241
Range on HMM: 1-80/80
Sequence Identity: 24% (23 aa)

KNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAG------LKAGDLITHING-EPVHGLVHTEVIELLLKSGN-----KVSITTTPFE
. .||.|.              .... .|..|.|| .||      |..|| |. .|| .|| .. | .....| ..|.     ||..|  . .
GGLGFSIVG-------------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
PDZ MAST4.AA PDZ 1188-1238 27 4.5e-09 33.63 Pfam 33-86 (86) Show / Hide 
Range on Protein: 1188-1238
Range on HMM: 33-86/86
Sequence Identity: 27% (15 aa)

NVEEGSPACQAG--LKAGDLITHINGEPVHGLVHTEVIELLLKSGN-KVSITTT
.| .||.| ..|  ...|| |. |||... .. | ...... .|.. .|..|  
EVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ