Gene MASTL (Human)

MASTL

Species: Human
Alias: RP11-85G18.2, FLJ14813, THC2, MASTL
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 10p11.2-p12.1,

Classification

Group: AGC
Family: MAST
Subfamily: MASTL

Sequence

Name Sequence Type Origin Length Description Download
MASTL.NA RNA Sugen Kinome 3988 None Fasta, JSON
MASTL.AA Protein Sugen Kinome 879 None Fasta, JSON
MASTL.kin_dom Protein Kinase Domain Sugen Kinome 276 None Fasta, JSON

Protein domain

Protein domains of MASTL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MASTL.AA MASTL 35-310 71 3.6e-217 727.75 In-house 1-283 (283) Show / Hide 
Range on Protein: 35-310
Range on HMM: 1-283/283
Sequence Identity: 71% (203 aa)

FSIVKPISRGAFGKVYLG---QKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEE
|.||||||||||||||||   |||.|||||||.||||||||||||||||||||||||||.|.||||||||||..|||||||.||||||||||.|||||||
FVIVKPISRGAFGKVYLGYKNQKGKKLYAVKVMKKADMINKNMTHQVQAERDALALSKSQFCVHLYYSLQSASYVYLVMEYMIGGDVKSLLHMYGYFDEE

MAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDIN----MMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFNTPIAEK
||.|||||...||||||||||||||.||||||||||||||||||||||||.|||||    |||||.||...||.|||..|.|||.....|||.......|
MAIKYISEMVMALDYLHRHGIIHRDIKPDNMLISNEGHIKLTDFGLSKVTMNRDINARVSMMDILGTPDYLKPEQDYQQTHGQVVDWWASLGVCFYEFMK

NQDPANILSACLSETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQSRKRLATSSASSQSHTFI
...|....|.|......||..|..||...||.||||||||||||.|||||||..||.||..||||.|.|...|....|.||||
GIPPFCDESPCKVFQNILSRDLEWPMGDEQKSTTPYSSKLLKSCFETVASNPEVPVMCLIENLLQMRPRDRPSATDVQQHTFI
Kinase MASTL.AA MAST 35-310 37 4.5e-152 493.76 In-house 1-334 (334) Show / Hide 
Range on Protein: 35-310
Range on HMM: 1-334/334
Sequence Identity: 37% (126 aa)

FSIVKPISRGAFGKVYL--GQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEM
| ..||||.||.|||||  ..|.....|.||.||.|||||||..|||.||..||....||.|...||.|..|....||||..|||..||||.||||||.|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

AVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTP---------SMAKPRQDYSRTPG--------------
| .||.|..|.|.|||.|||.|||||||||||...|||||||||||||....|.|||....||         .|.|..||||..||              
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

-------------------QVLSLISSLGFNTPIAEKNQDPANILSACLSETSQLSQGLVCPMSVDQKDTT-PYSSKLLKSCLETVA---------SNPG
                   |.......... .|. ...|..... ... | . .....||...........  ....| ..| |.           . . 
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

MPVKCLTSNLLQS--RKRLATS--SASSQSHTFI
.....|...|||   ||||...  ......|.|.
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase MASTL.AA AGC 35-185 37 1.7e-102 265.19 In-house 1-209 (395) Show / Hide 
Range on Protein: 35-185
Range on HMM: 1-209/395
Sequence Identity: 37% (79 aa)

FSIVKPISRGAFGKVYLGQKG--------GKLYAVKVVKKAD---MINKNMTHQVQAE------------RDALALSK----------SPFIVH-LYYSL
| ..|.|..|.|||||| .|         ||.||.||.||..   ...||| .....|            |. |.. .          .||||. |.|| 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QSANN--VYLVMEYLI--------GGDVKSLLHIYG-----YFDEEMAVKYISE-------VALALDYLHR-HGIIHRD-LKPDNMLISNEGHIKLTDFG
|. ..  .|.||||..        ||.  ..||..|     .||||.|  |..|       ..|||.|||. .|||||| |||.|.|. ..|||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKVTLNRD
|.|.  |..
LCKEGMNDG
Kinase MASTL.AA MAST 35-191 47 5.5e-83 253.25 In-house 1-162 (337) Show / Hide 
Range on Protein: 35-191
Range on HMM: 1-162/337
Sequence Identity: 47% (77 aa)

FSIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQS--ANNVYLVMEYLIGGDVKSLLHIYG-YFD
| ..|.||.||.|.||| ..   ....| || .. |.| ||.  ||..||. |.  . ||.| ..|| |.   . ...||||..|||. |||. ||  ..
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDI
|.||  || |  |.|.||| .||.|||||||||||   ||||||||||||| .. . .. ..
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYE
Kinase MASTL.AA NDR 35-184 46 2.3e-80 247.44 In-house 1-157 (350) Show / Hide 
Range on Protein: 35-184
Range on HMM: 1-157/350
Sequence Identity: 46% (73 aa)

FSIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALSK--SPFIVHLYYSLQSANNVYLVMEYLIGGDVKS---LLHIYGY
| |.|.|..||||.|.| .|   |..||.|...|..|..|| . .|.|||| .| ..  .|..| |||| | ... ||||||..||| ..   ||  ...
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

FDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNR
|.|..|  ||.| ..|....|. |.||||.|||| || . ||||||||||.. .. |
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIR
Kinase MASTL.AA S_TKc 35-835 10 7.4e-65 222.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 35-835
Range on HMM: 1-231/231
Sequence Identity: 10% (89 aa)

FSIVKPISRGAFGKVYLGQKGG--KLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIG--GDVKSLLHIYGY---
. |...| .|||||||.... .  ...|.|..|           ... |.. |   . |.||.||.. |. ...|.||||. |  ||...... .|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFNTPI
   |.| .| .|. ....||.|.|.||||||||||.| |...  |||..||||...                                            
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

AEKNQDPANILSACLSETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQSRKRLATSSASSQSHTFISSVESECHSSPKWE
                                                                                                    
----------------------------------------------------------------------------------------------------

KDCQESDEALGPTMMSWNAVEKLCAKSANAIETKGFNKKDLELALSPIHNSSALPTTGRSCVNLAKKCFSGEVSWEAVELDVNNINMDTDTSQLGFHQSN
                                                                                                    
----------------------------------------------------------------------------------------------------

QWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKKTCVEYKHNEMTNCYTNQNTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQQTPEKLP
                                                                                                    
----------------------------------------------------------------------------------------------------

IPMIAKNLMCELDEDCEKNSKRDYLSSSFLCSDDDRASKNISMNSDSSFPGISIMESPLESQPLDSDRSIKESSFEESNIEDPLIVTPDCQEKTSPKGVE
                                                                                                    
----------------------------------------------------------------------------------------------------

NPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFNSHINASNNSEPSRMNMTSLDAMDISCAYSGSYPMAITPTQKRRSCMPHQQTPNQIKSGTPYRTPK
                                                                                                    
----------------------------------------------------------------------------------------------------

SVRRGVAPVDDGRILGTPDYLAPELLLGRAHGP-AVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKR
             . |||.|.|||.|    .|. ..|||..|..|.|.|.| |||   ..|..|..|.             |. | . .. .|. | .||
-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKR

AGMKELKR-------HPLF
 .  |. .       || |
PTA-EALQDEWDIKCHPWF
Kinase MASTL.AA AktR 35-179 44 2.6e-57 196.71 In-house 1-150 (268) Show / Hide 
Range on Protein: 35-179
Range on HMM: 1-150/268
Sequence Identity: 44% (67 aa)

FSIVKPISRGAFGKVYLGQKG---GKLYAVKVVKKADMINKNMTHQVQAERDALA-LSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDE
| . |.. .|||||||| ||.   .|.|| |..|| ..|..|. |... ||. .. ... |||| |.|. |. .. ...|||  ||.  . |   . |.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EMAVKYISEVALALDYLHRH-GIIHRDLKPDNMLISNEGHIKLTDFGLSK
|.| .|.... |||.||| |  || |||||.| |.  .||.|.|||||||
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK
Kinase MASTL.AA Akt 35-179 43 2.7e-57 181.67 In-house 1-149 (264) Show / Hide 
Range on Protein: 35-179
Range on HMM: 1-149/264
Sequence Identity: 43% (65 aa)

FSIVKPISRGAFGKVYLGQKGG--KLY-AVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEE
| ..| . .|.||||.| .|    |.| | || ||   |.||   ....||  |   ..|||| |.|| |.... |.||.|  ||.  ..|.  ..|.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

MAVKYISEVALALDYLHRHGIIHRD-LKPDNMLISNEGHIKLTDFGLSK
 |  |..|. ||...|| ..|| || ||| | |....|||.||||||.|
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCK
Kinase MASTL.AA SGK 35-179 36 3.8e-55 168.53 In-house 1-173 (283) Show / Hide 
Range on Protein: 35-179
Range on HMM: 1-173/283
Sequence Identity: 36% (63 aa)

FSIVKPISRGAFGKVYLGQKGGK--------------------LYAVKVVKKADMI-------NKNMTHQVQAER-DALALSKSPFIVHLYYSLQSANNV
| . | |  | |||||. .. ..                    .||.|| .|.  |       .|.    ..||| ..| . |.|||| | |. | .   
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSK
|.||.|. ||.  . |   ..| |  |  | .|...||.|||   ||.|||||.| |   .||..||||||.|
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCK
Kinase MASTL.AA RSK-Unclassified 35-179 44 5.1e-55 171.01 In-house 1-149 (283) Show / Hide 
Range on Protein: 35-179
Range on HMM: 1-149/283
Sequence Identity: 44% (66 aa)

FSIVKPISRGAFGKVYLGQKGG--KLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLH--IYGYFDE
|   . | .| |||||| .| .  ..|| || .|  || .| .  |  |.. .|... |||| ||.| |.    ||.|||  |||    |       | |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

EMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSK
. .  |.||| .|| |||. ..| ||||||| .   |||..||||.||.
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSI
Kinase MASTL.AA RSK 38-179 41 5.3e-54 185.72 In-house 1-155 (278) Show / Hide 
Range on Protein: 38-179
Range on HMM: 1-155/278
Sequence Identity: 41% (65 aa)

VKPISRGAFGKVYLGQKG-----GKLYAVKVVKKADMINKNM-THQVQAERDALALSK-SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGY---
.|   .|..|||.| .|      |..||.||.||| .....  |  . .||. |.... .||||.|.|. |    .||.|||. ||.    |   ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISN---EGHIKLTDFGLSK
|.|. |  |..|..||...|| .|||||||||.|.|  .   ||||||||||..|
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCK
Kinase MASTL.AA MAST 737-835 49 2.3e-53 170.25 In-house 223-334 (334) Show / Hide 
Range on Protein: 737-835
Range on HMM: 223-334/334
Sequence Identity: 49% (55 aa)

RILGTPDYLAPELLLGRA-HGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRD---IPWPEG-----EEKLSDNAQSAVEILLTIDDTKRAGMK
...|||||.|||..||.  ||..||||..|....|||.|.|||||.||. .|||||.|.   | ||||     .|..|  ||  .| ||. |  || | .
QCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGAN

----ELKRHPLF
    | |.|| |
NGADEVKQHPFF
Kinase MASTL.AA MAST 737-835 43 9e-53 159.2 In-house 227-337 (337) Show / Hide 
Range on Protein: 737-835
Range on HMM: 227-337/337
Sequence Identity: 43% (48 aa)

RILGTPDYLAPELLLGRA-HGPAVDWWALGVCLFEFLTGIPPFNDETPQQ-VFQNILK--RDIPWPEG-----EEKLSDNAQSAVEILLTIDDTKRAGMK
...|||||.||| .||.  .|..||||..|. ..|||.|.||||..||.  .||||..  |.| |||.     ....|. ||  .. ||. .  || | .
QCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGAN

---ELKRHPLF
   | |.|| |
GADEIKQHPFF
Kinase MASTL.AA AGC 738-835 30 3.1e-52 132.27 In-house 265-395 (395) Show / Hide 
Range on Protein: 738-835
Range on HMM: 265-395/395
Sequence Identity: 30% (41 aa)

ILG--TPDYLAPELLLGRAHGPAVDWWA--LGVCLFEFLTGIPPFNDETPQ----------QVFQNILKR------DIPWP-------EGEEKLSDNAQS
. |  ||.|.||| |    .|.|.|||.  ||....|.|||.|||....||          ..||.|...      ....|       ......|..|..
FCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKD

AVEILLTIDDTKRAG----------MKELKRHPLF
 .. ||. | .|| |           .|.|.|| |
LIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MASTL.AA Pkinase 35-183 34 2.6e-43 154.22 Pfam 1-165 (293) Show / Hide 
Range on Protein: 35-183
Range on HMM: 1-165/293
Sequence Identity: 34% (58 aa)

FSIVKPISRGAFGKVYLG--QKGGKLYAVKVVKKADMINKNMTHQVQ-AERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGG----DVKSLLH--IY
. |...| .|.||.||..  .. ||..|||..|| .   .   . .  .|   ..  ..|.|| ||.. .. ...|.||||. ||    | .....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GYF--DEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHI----KLTDFGLSKV--TLN
| |  .|. . .|. ... .|.|.|..|||||||||.| ||.|.|||    |..||||.|.  . |
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-N
Kinase MASTL.AA MASTL 731-835 40 1.4e-39 133.09 In-house 157-283 (283) Show / Hide 
Range on Protein: 731-835
Range on HMM: 157-283/283
Sequence Identity: 40% (51 aa)

APVDDGRILGTPDYLAPELLLGRAHGPAVDWWA-LGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLS---------------------DNA
| |   .||||||||.||... . ||..||||| ||||..||..|||||.||.|. |||||| ||. ||.| | .|                       .
ARVSMMDILGTPDYLKPEQDYQQTHGQVVDWWASLGVCFYEFMKGIPPFCDESPCKVFQNILSRDLEWPMGDEQKSTTPYSSKLLKSCFETVASNPEVPV

QSAVEILLTIDDTKRAGMKELKRHPLF
. ..| ||...   |   .. . |   
MCLIENLLQMRPRDRPSATDVQQHTFI
Kinase MASTL.AA NDR 740-835 34 2.6e-34 102.73 In-house 243-350 (350) Show / Hide 
Range on Protein: 740-835
Range on HMM: 243-350/350
Sequence Identity: 34% (37 aa)

GTPDYLAPELLLG-RAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPW-----PEGEEK-LSDNAQSAVEILLTIDDTKRAG-----MK
|||||.||| ... . .....||| ||. ..|.|.|.|||...||| ....|..  . |       ..|  ||. |.   . |.. |  .| |       
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

ELKRHPLF
| | || |
EIKSHPFF
Kinase MASTL.AA SGK 740-835 41 6.4e-33 98.65 In-house 187-283 (283) Show / Hide 
Range on Protein: 740-835
Range on HMM: 187-283/283
Sequence Identity: 41% (41 aa)

GTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMK----ELKRHPLF
||| ||||| |... |. .|||| ||  |.|...|.||| .   || ..||.. ..  | .    |  | .  . ||. | .|| | |    | |.|| |
GTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ---MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase MASTL.AA Akt 740-835 39 1.9e-30 94.47 In-house 164-264 (264) Show / Hide 
Range on Protein: 740-835
Range on HMM: 164-264/264
Sequence Identity: 39% (40 aa)

GTPDYLAPELLLGRAHGPAVDWWA-LGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAG-----MKELKRHP
||| ||||| |.|  |. |||||. ||. ..|...| ||| ..  .| |..|.  ..  |.  ...|..... .. ||. | .|| |      .|.||||
GTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHP

LF
 |
WF
Kinase MASTL.AA RSK-Unclassified 740-835 37 7.2e-29 87.39 In-house 184-283 (283) Show / Hide 
Range on Protein: 740-835
Range on HMM: 184-283/283
Sequence Identity: 37% (38 aa)

GTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKEL-----KRHPL
|| .|||||.. .  |. ||||| ||. ..| | |.||.  .    .|.||.| ..  |. .. .| |... .  ||.  . || | |       |||| 
GTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSY-ISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPF

F
|
F
Kinase MASTL.AA RSK 740-835 32 7.6e-29 102.16 In-house 170-278 (278) Show / Hide 
Range on Protein: 740-835
Range on HMM: 170-278/278
Sequence Identity: 32% (36 aa)

GTPDYLAPELLL----GRAHGPAVDWWALGVCLFEFLTGIPPFND---ETPQQVFQNILKRDIPWPEGE--EKLSDNAQSAVEILLTIDDTKRAG-----
.| .|.|||.|     ...|. |.||| ||| ..| ||| |||     .........|.| ..  ....  ..||..|.. .  .|. |  || |     
YTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFS-LTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQD

MKELKRHPLF
..|.|.|| |
AEEIKQHPWF
Kinase MASTL.AA Pkinase 740-835 25 1.5e-26 94.98 Pfam 173-293 (293) Show / Hide 
Range on Protein: 740-835
Range on HMM: 173-293/293
Sequence Identity: 25% (31 aa)

GTPDYLAPELLL-GRAHGPAVDWWALGVCLFEFLTGIPPFNDE------TPQQVFQNILKRDIPWPEGEE------------------KLSDNAQSAVEI
|||.|.|||... |. .||.||.|..|. |.|.|.| ||| ..      ...|....|......... ..                  ..|..... .. 
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

LLTIDDTKRAGMKELKRHPLF
.|. | .|| . .... || |
CLCKDPKKRPTAEQILQHPWF
Kinase MASTL.AA AktR 738-835 33 5.4e-23 82.72 In-house 164-268 (268) Show / Hide 
Range on Protein: 738-835
Range on HMM: 164-268/268
Sequence Identity: 33% (36 aa)

ILGTPDYLAPELLLG-RAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRD-IPWPEGEEKLSDNAQSAVE-ILLTIDDTKRAG-----MKEL
..||| |.||| ..    |. .|||||.|. ..| .||.|||...  .| ||.|.. . .. |.  ...|..... ..  ||  . .|| |      .|.
FCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPY-PSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEI

KRHPLF
|.|| |
KSHPWF
Kinase MASTL.AA Pkinase_Tyr 35-185 27 7.9e-15 50.85 Pfam 1-165 (270) Show / Hide 
Range on Protein: 35-185
Range on HMM: 1-165/270
Sequence Identity: 27% (45 aa)

FSIVKPISRGAFGKVYLGQKG------GKLYAVKVVKKADMINKNMTHQVQAERDALALS-KSPFIVHLYYSLQ-SANN--VYLVMEYLIGGDVKSLLHI
 .. | . .||||.||.|         .   |||..|   |   |.     .|   .    . | || ||           .|.||||  .|| .. |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

Y----GYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRD
     . .. .. ...  ..| ...||.....|||||   | |.......| .||||..   | |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDD
Kinase MASTL.AA TyrKc 35-249 18 1.5e-13 -3.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 35-249
Range on HMM: 1-280/280
Sequence Identity: 18% (52 aa)

FSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALS--KSPFIVHLYYSLQSA-------NNVYLVMEYLIGGDVKSLLHIY
 .  | . .||||.||.|.      |||..|.              |   .     . | || ||    .          ...||||  .|| |. |. .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GY-FDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNR-------DINMMD---ILTTPS------------------
.  .  .  ...   .|   .|||....|||||   | |.......| .|||||.   .        |  ..       |.                   
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

-------------MAKPRQDYS------RTPGQVLSLISSLGFNTPIAE--------KNQDPANILSACLSE-------TSQLSQGL
             .    | |.       .. .|. .. . .   . ..          ..  .| . |  |        |.. . .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MASTL.AA S_TK_X 836-876 15 0.00066 9.33 SMART 1-79 (79) Show / Hide 
Range on Protein: 836-876
Range on HMM: 1-79/79
Sequence Identity: 15% (12 aa)

SDVDWENLQH--QTM--PFIPQPD----DETDTSYFE-----------ARNT-------------------AQHLTVSG
...||..|..  ...  ||.|..     ..||||.|.             ..                      .| . 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase MASTL.AA Pkinase_Tyr 762-790 29 2.895313 1.52 Pfam 198-228 (270) Show / Hide 
Range on Protein: 762-790
Range on HMM: 198-228/270
Sequence Identity: 29% (9 aa)

WALGVCLFEFLT-GIPP-FNDETPQQVFQNI
|. ||...| .| |  | . . ....|.. |
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI