Gene MLKL (Human)
MLKL
Group:
TKL
Family:
TKL-Unique
Sequence
Protein domains of MLKL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | MLKL.AA | TKL-Unique | 205-466 | 35 | 1.9e-131 | 442.98 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 205-466 Range on HMM: 1-290/290 Sequence Identity: 35% (104 aa) PWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFE-SPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLD------- .|....|..... |||.... |||||.|.. ...| ...|.|..|...|||.. .|||....|.|.|..|.||...||||||..|.|...|. FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN ---REKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQG-----YQVKLAGFELRKTQTSMSLGTTREK-----TDRVKSTAYLSPQELE ....|.. .|. ... .|.|.|.|||.|.| .|....||||||... ...|...|.|.|...... .|..|. ..|..|. ...|..|. NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR DVFYQYDVKSEIYSFGIVLWEIATGDI------PFQGCNSEKIRKLVAV--KRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKL ..|.||. ||..||||||||||||..| |.||...|.....|.. .....|....|| |.|..|..|..|||| |||.|||...| MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
|||||||||
| Kinase | MLKL.AA | TKL | 209-466 | 21 | 3.5e-68 | 232.84 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 209-466
Range on HMM: 1-364/364
Sequence Identity: 21% (79 aa)
LRENEVSTLYKGEYHR----------APVAIKVFKKLQ-----------------------AGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETV-
. . .. |||... .||.|.||. . . . |.....||. |... |||... |.|....
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
--------TPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSE------APELHGKIRSSNFLVTQGYQ--------------VK
...|. ||||||. |.|...| . .|. ..|..|||.. || .. | .| . |.| || . .. .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK
LAGFELRKT-----QTSMSLGTTRE----------KTDRVKSTAYLSPQELEDV--------------FYQYDVKSEIYSFGIVLWEIATGDIPFQ--GC
.. | | .. . ... |..| . .. ......| |.. ...|. |. .||||||||||.|. .|.. ..
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY
NSEKIR-------KLVAVKRQQEPLG------------EDCPSELREIIDECRAHDPSVRPSVDEILKKL
...... ..|..|... |. .||| ...... .| .|||. ||| .||||.|
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
|
|||||||||
| Kinase | MLKL.AA | TK | 215-466 | 15 | 8.6e-31 | 99.85 | In-house | 14-486 (486) | Show / Hide |
Range on Protein: 215-466
Range on HMM: 14-486/486
Sequence Identity: 15% (74 aa)
S--TLYKGEYHRA---------------------------PVAIKVFKKLQAGSIAIVRQ-------------TFNKEIKTMK--KFESPNILRIFGICI
| . ||||... |||.|. |. | | . .. . |.| |. ... |||.|..|.|
SFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCT
DETVTP--------PQFSIVMEYCELGT----LRELLDREKD----------------------------------------------------------
.. | . . |||||...| ||. | . ..
QGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLT
------------------LTLGKRMVLVLGAARGLYRLHHS--EAPE---LHGKIRSSNFLVTQGYQ-----------VKLAGFELRKTQTS-MSLGTTR
||. .. . .|.|. || | . |. . | ||..... .|.| | | .... .. .
TKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYS
EKTDRVKSTAY-----------------------------LSPQELEDV-------FYQYDVKSEIYSFGIVLWEIAT-GDIPFQG-CNS---------E
.. ..||. . ..| |.| . . || ..|||...||| | |. |. | .. .
DDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQ
KIRKLVAV-------------KRQQEPLGEDCP--------------SELREIIDECRAHDPSVRPSVDEILKKL
. ... | . | ..|| |. ... .| ..||. ||. ......|
EVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
|
|||||||||
| Kinase | MLKL.AA | Dicty4 | 389-468 | 36 | 9.2e-24 | 76.28 | In-house | 194-277 (277) | Show / Hide |
Range on Protein: 389-468 Range on HMM: 194-277/277 Sequence Identity: 36% (31 aa) YDVKSEIYSFGIVLWEIATGDIPFQ--GCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKK--LST |. |. ||||||||||.|...|.| . . .... .|. | |. .|| ... | .| |||..||| ||... | . YNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
|||||||||
| Kinase | MLKL.AA | S_TKc | 208-470 | 19 | 8.9e-19 | 69.63 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 208-470
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)
LLRENEV-----STLYKGEYHR--APVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCEL--GTLRELLDRE
... .. ||. .. ||||. | ... .||. .|| ||| ...... | . .|||||. |.|......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKR
KD------LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDV-
. .. .. ...| .| .| . .| |... ..|.. | | . | . . |..| | .|.
GRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL-----GYGKC
KSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILK-----KLSTFS
|. ..|.|..|.| ..| ||. . ... |.. ..|....|. | ||. ||.. |.|. |. .
KCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | MLKL.AA | LRRK | 388-468 | 29 | 3e-18 | 61.15 | In-house | 258-351 (351) | Show / Hide |
Range on Protein: 388-468 Range on HMM: 258-351/351 Sequence Identity: 29% (28 aa) QYDVKSEIYSFGIVLWEIATGD-IPFQGCN-------SEKIRKLVAVKRQQEP-LGED-CPS-----ELREIIDECRAHDPSVRPSVDEILKKLST .|. |. .||||..|||. |.. .||.. . |.|.. ...... | . .. || .. . |..| .||| ||. .|.|.||. EYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIED--KIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
|||||||||
| Kinase | MLKL.AA | Fer | 395-467 | 30 | 3.5e-18 | 58.62 | In-house | 201-283 (283) | Show / Hide |
Range on Protein: 395-467 Range on HMM: 201-283/283 Sequence Identity: 30% (25 aa) IYSFGIVLWEIAT-GDIPFQG------CNSE-KIRKLV-AVKRQQEPLGEDCPSELREIID-ECRAHDPSVRPSVDEILKKLS ..|||...||| | |. |. | .. | .. . ..|. |. . .|.|...|.. | ..||. ||. .|| .|| VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
|||||||||
| Kinase | MLKL.AA | MLK | 388-466 | 30 | 4.2e-18 | 59.51 | In-house | 212-291 (291) | Show / Hide |
Range on Protein: 388-466 Range on HMM: 212-291/291 Sequence Identity: 30% (24 aa) QYDVKSEIYSFGIVLWEIATGDIPFQ-GCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKL .|. |. ..|.|.||||. |. .|.. . .. | ||.... |.. .|| . . . .| ||. ||| ..|...| KYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
|||||||||
| Kinase | MLKL.AA | TK-Unique | 329-466 | 23 | 2.2e-16 | 53.09 | In-house | 156-294 (294) | Show / Hide |
Range on Protein: 329-466 Range on HMM: 156-294/294 Sequence Identity: 23% (34 aa) HGKIRSSNFLVTQGYQVKLAGFELRK-TQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQY-DVKSEIYSFGIVLWEIAT-GDIPFQGC-NSEKIRKLV |. . ..| |.| ....|...| . . ..| . .... . ....| | .| ||...|||...|||.| | |. | ... .... HRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIR AVKRQQEPLGEDC-PSELREIIDECRAHDPSVRPSVDEILKKL . .|.. | | | . |..... .| ..|. ||| ..|...| DGYRMPQP--EHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
|||||||||
| Kinase | MLKL.AA | TyrKc | 209-466 | 22 | 1.5e-15 | 28.52 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 209-466 Range on HMM: 1-280/280 Sequence Identity: 22% (67 aa) LRENEV------STLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKF--ESPNILRIFGICIDE---TVTPPQFSIVMEYCELGTLRELLDR .. ... . |||.. .||.|. |. |. | .|.. |.|. . |||.|..|.|... . .. |||||...| |.. | . ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK EKD-LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSM-SLGTTREKTDRV----KST-----AYLSPQELEDVF .. |.. . . .|.| ||. . | . | ||. ...|| . | | . .. . | .... |. . ..| . . HRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECI--NY YQYDVKSEIYSFGIVLWEIAT-GDIPFQG-----CNSEKIRKLVAVKRQQEPLGED-------CPSELREIIDECRAHDPSVRPSVDEILKKL . . || ..|||...||| | |. | | .. . ....| . .. .| ||.|. .|. .| ..||. ||. || ... GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | MLKL.AA | DRK | 392-468 | 32 | 2.8e-15 | 48.26 | In-house | 182-258 (258) | Show / Hide |
Range on Protein: 392-468 Range on HMM: 182-258/258 Sequence Identity: 32% (26 aa) KSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKR--QQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLST | .|||.|||||..| .|..| . . .| | | . || . .| ||. ||| .|.|. | KADVYSFAIVLWECVTRQDPYFGMPTFQV--VFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
|||||||||
| Kinase | MLKL.AA | Pkinase_Tyr | 386-466 | 31 | 1.3e-14 | 50.11 | Pfam | 188-270 (270) | Show / Hide |
Range on Protein: 386-466 Range on HMM: 188-270/270 Sequence Identity: 31% (26 aa) FYQYDVKSEIYSFGIVLWEIAT-GDIP-FQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKL .. . .|| ..|||...||| | |..| ..|. | . .... .... | |.|| |. ... .| ..||. ||. ||. .| YGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
|||||||||
| Kinase | MLKL.AA | TKL-ciliate2 | 217-329 | 34 | 3.6e-14 | 43.13 | In-house | 15-122 (273) | Show / Hide |
Range on Protein: 217-329 Range on HMM: 15-122/273 Sequence Identity: 34% (39 aa) LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDR-EKDLTLGKRMVLVLGAAR .|| . ||.| || |. | | . | ||| | | . | |.|.|||| | | || . || | . | .|| IYKAKWREIVVAVKKFKMDHDNQQQIR--DFVNECHAMEALRHPNIVMFLGACTKI----PNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRRRIALDIAR GLYRLHHSEAPELH | . || |. | .| GVHYLHSSNPPIIH |
|||||||||
| Kinase | MLKL.AA | Dicty4 | 218-348 | 30 | 4.4e-14 | 43.53 | In-house | 16-156 (277) | Show / Hide |
Range on Protein: 218-348 Range on HMM: 16-156/277 Sequence Identity: 30% (43 aa) YKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDR---------EKDLTLGKR-M ||| ||.|... .. .. . . | ||.. |.| |||. | |. .|. ..||.||. |.| .|| ..|..| || | YKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAM VLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLA . . ||||. || . .| . |.| || . ..|| . RMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVC |
|||||||||
| Kinase | MLKL.AA | Pkinase_Tyr | 218-317 | 30 | 2.1e-12 | 42.62 | Pfam | 16-124 (270) | Show / Hide |
Range on Protein: 218-317 Range on HMM: 16-124/270 Sequence Identity: 30% (35 aa) YKGEYH------RAPVAIKVFKKLQAGSIAIV--RQTFNKEIKTMKKF-ESPNILRIFGICI--DETVTPPQFSIVMEYCELGTLRELLDR----EKDLT |||... . |||.|. | |. |. | .|.|.||.. |||.| |.|. .| | |||||...| |.. | . .. || YKGTWKGDPDNTKIPVAVKMLKE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLDYLRKHREDKQPLT LGKRMVLVLGAARGL . . |.|. MKDLLQMCWQIAKGM |
|||||||||
| Kinase | MLKL.AA | TKL-ciliate2 | 389-467 | 26 | 3.6e-12 | 36.34 | In-house | 195-273 (273) | Show / Hide |
Range on Protein: 389-467 Range on HMM: 195-273/273 Sequence Identity: 26% (21 aa) YDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLS | | ...|..|.||||| . |. . . . . | . . .|| .. .... | . .||| .||.|.| YTEKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE |
|||||||||
| Kinase | MLKL.AA | Pkinase | 389-466 | 21 | 5.8e-11 | 39.84 | Pfam | 189-293 (293) | Show / Hide |
Range on Protein: 389-466 Range on HMM: 189-293/293 Sequence Identity: 21% (23 aa) YDVKSEIYSFGIVLWEIATGDIPFQGC---NSEKIRKLVAVKRQQEPLGEDCP-----------------------SELREIIDECRAHDPSVRPSVDEI |. |. ..|.|..|.| ..| ||.|. . . . ... . || .|.| .|....|. | . ||. ||. ..| YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI LKK--L |. . LQHPWF |
|||||||||
| Kinase | MLKL.AA | Fer | 218-317 | 26 | 2.8e-10 | 31.3 | In-house | 16-124 (283) | Show / Hide |
Range on Protein: 218-317 Range on HMM: 16-124/283 Sequence Identity: 26% (30 aa) YKGE-----YHR-----APVAIKVFKKLQAGSIAIVRQTFNKEIKTMKK-FESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD--LTLG |||. . .||.|| | ...... .. | .| . |.. . ||. ...|.| || | ||||.| | |.. | .|. ... YKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDE---QPIM-IVMEFCNGGSLDSYLKKNKNKTVSDN KRMVLVLGAARGL ... ...||.|. EKIRMCYQAACGM |
|||||||||
| Kinase | MLKL.AA | MLK | 218-295 | 26 | 4e-09 | 27.94 | In-house | 16-101 (291) | Show / Hide |
Range on Protein: 218-295 Range on HMM: 16-101/291 Sequence Identity: 26% (24 aa) YKGEYHRAP-----VAIKVFKKLQAGSIAIV---RQTFNKEIKTMKKFESPN----ILRIFGICIDETVTPPQFSIVMEYCELGTLRELL .||... ||.| .. .... .. |..|.. ... || | .. |.|... |..| ||||||| | | ..| WKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQP---PCHFCIVMEYCEGGSLYNVL |
|||||||||
| Kinase | MLKL.AA | Pkinase | 218-302 | 27 | 6.7e-09 | 32.56 | Pfam | 16-106 (293) | Show / Hide |
Range on Protein: 218-302 Range on HMM: 16-106/293 Sequence Identity: 27% (26 aa) YKGEYHRAP--VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELG----TLRELLD--REKDL--T ||. . . ||.|..|| . | .. . ||. ||.. .|||.|..... | .. .|||||| | | ... |.. . . YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFS |
|||||||||
| Kinase | MLKL.AA | DRK | 247-350 | 31 | 9.2e-09 | 25.85 | In-house | 44-144 (258) | Show / Hide |
Range on Protein: 247-350 Range on HMM: 44-144/258 Sequence Identity: 31% (33 aa) FNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTL-RELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQV | .|| |.. ||| | | || |.||| .| | . |.| . . .. . . .|.|. || .. .| | | || .|| FHREINLMCQLRHPNICQFMGTCNN----PPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQV KLAGF | | | KVADF |
|||||||||
| Kinase | MLKL.AA | TK-Unique | 215-295 | 27 | 1.2e-07 | 22.63 | In-house | 13-96 (294) | Show / Hide |
Range on Protein: 215-295 Range on HMM: 13-96/294 Sequence Identity: 27% (24 aa) STLYKGEYHRAP-----VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFE-SPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELL .. ..||. . . . . |.|.... .| | |||. ||. |||....|.|.. . .. |.||||. |.|. .| GQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD---EPWMIIMEYCPCGNLQHYL |
|||||||||
| Kinase | MLKL.AA | LRRK | 218-321 | 15 | 8e-06 | 16.49 | In-house | 17-181 (351) | Show / Hide |
Range on Protein: 218-321 Range on HMM: 17-181/351 Sequence Identity: 15% (27 aa) YKGEYHR----------------------------APVAIKVFKK------------------------------LQAGSIAIVRQTFNKEIKTMKKFES |.... . ..||||.... . . . . . ..| .|. | ... YRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRAFREFRHEVWIMSHLNH PNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLD---REK------DLTLGKRMVLVLGAARGLYRLH |||. ..|.||. | . .|||| .|.| ..| . . ... . . ..| |.|. || PNIVSLKGFCIH----P--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH |
|||||||||