Gene MPSK1 (Human)

MPSK1

Species: Human
Alias: PKL12, STK16, MPSK, MPSK1, TSF1, FLJ39635, KRCT
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 2q35-q36,

Classification

Group: Other
Family: NAK
Subfamily: MPSK

Sequence

Name Sequence Type Origin Length Description Download
MPSK1.NA RNA Sugen Kinome 2903 None Fasta, JSON
MPSK1.AA Protein Sugen Kinome 305 None Fasta, JSON
MPSK1.kin_dom Protein Kinase Domain Sugen Kinome 271 None Fasta, JSON

Protein domain

Protein domains of MPSK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MPSK1.AA MPSK 20-290 65 1.9e-227 761.86 In-house 1-281 (281) Show / Hide 
Range on Protein: 20-290
Range on HMM: 1-281/281
Sequence Identity: 65% (184 aa)

YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAY-CLRERG-----AKHEAWLLLPFFKRGTLWNEIERL
|.|.|.|||||||||||||.||||||||||||.||||||...|||||.||..|.||||.|||.. ||..|.     .|||.||.||.||.||||....|.
YYFMQRLGEGGFSYVDLVENLHDGHFYALKRIQCHEQQDQNQAQREAEMHCQFDHPNIIRLVDWGCLKGREDIVINTKHEIWLVLPYFKHGTLWDHLQRM

KDKGNFLTEDQILWLLLGICRGLEAIH---AKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHC
||||...|||||.|..||.|.||.|||   .|.|||||.|||||.|||..|||.|||||||.|||.|.|.|||..||||||.||...|||||||.|||||
KDKGDCMTEDQIWWIFLGVCEGLKAIHEAMPKPYAHRDMKPTNICLGDDFQPVIMDLGSMNEACIQVKGQRQACALQDWAAERCSMVYRAPELFHVQSHC

VIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQN-QLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQL
|||||||.||||||||||.....||||..|.||||.||||| ...||...|.|....||...||.|||..||||...|.|.
VIDERTDIWSLGCVLYAMCYFHSPYDMIYQRGDSVHLAVQNRNFNIPENSRYSQDMHQLISYMMRVDPMERPHIFWVLNQT
Kinase MPSK1.AA NAK 20-290 37 1.9e-148 498.72 In-house 1-299 (299) Show / Hide 
Range on Protein: 20-290
Range on HMM: 1-299/299
Sequence Identity: 37% (113 aa)

YLFIQKLGEGGFSYVDLVE---------GLHDGHFYALKRILCH-EQQDREEAQREADMHRLFNHPNILRLVAY-CLRERG---AKHEAWLLLPFFKRGT
| ....|.|||||||.||.         ....|..|||||..|| ..|| ....||..|.....|.|..... . .. ||     ..|..||......|.
YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYCCHGS

LWNEIERLK-DKGNFLTEDQILWLLLGICRGLEAIH----AKGYAHRDLKPTNILLGD---EGQPVLMDLGSMNQACIHVEGSRQALT---LQDWAAQRC
||..... . |||...|||.||......|.|..|.|    .|...|||.|..||||..   .|...|.|.|||..|.|..|....|.    .|||.....
LWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYT

TISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQN---QLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQL
|..|||||.. ..|.|.|||..|.|.|||.||.|.|.. |.....|..||..||.||   ..|||...|.|.....|   |.|.||.|||.|. .|.||
TPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL
Kinase MPSK1.AA NAK-Unclassified 20-292 21 1.7e-66 227.19 In-house 1-405 (405) Show / Hide 
Range on Protein: 20-292
Range on HMM: 1-405/405
Sequence Identity: 21% (86 aa)

YLFIQKLGEGGFSYVDLV---------E-----GLHDGHFYALKRILCHEQQDREEAQREADMHRLFN-HPNILRLVAYCLR--ERG-AKHEAWLLLPFF
|  .  |.|||||.| ||               ..  .  |.|||..| ...  ... || |  ..|. ||||  .  .      ..    |  .|... 
YTIVRYLAEGGFSFVYLVKFSKYINPPDNTASVPHSNSNMYCLKRMICQDEESLNTMKREIDVMKRFRNHPNIVKYIDHHIMRENHNNQSYEVFMLMEYC

KRGTLWNEIE-----RLKD-KGNFLTEDQILWLLLGICRGLEAIHAKGY----------------------------------------------AHRDL
.||.|   .        .. ......|  .|   ...|.|. . |.                                                 .|||.
SRGSLQDFMNNQRTIYQRLTEQTRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIPLIHRDI

KPTNILLG----------------------------------------------------------DEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAA
|. |.|.                                                           ..| ..|.|.||  .. | .| . ... ||||  
KIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECIITIENRQEMQYLQDWIN

QRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKG-DSVALAVQN---QLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLL
. .|  |||||..   . |.|||. |.|.||| || |.|.  | .|  | .  ||.... .     ..|  ...|. | .|   |  .|| |||.|  .|
MHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEFPSNHNYSNQLHNLIKIMLNEDPIQRPNIYQVL

SQLEA
 ..  
NHICQ
Kinase MPSK1.AA S_TKc 20-297 22 3.2e-45 157.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-297
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKR--GTLWNEIERLKDKG
| ...|.|.|.|. | ..   ..|. .|.|.|        | ..|| ....  .|||| .|  ..       .. .. . .     |.|   |.. . .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHG

NF--LTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDE-
.   ..| ..  ..  ||..|| .| .|  |||||| |||| .  .  . | |.  |                   .  |  |.|||..        .  
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL------GYGKC

RTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLS--QLEALQPPA
. |.||.||.|| |. |. |..        ...  .. .        |. ...... ....|| .|| .  .|   .. .. |  
KCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MPSK1.AA Pkinase 20-290 20 1.2e-39 141.29 Pfam 1-293 (293) Show / Hide 
Range on Protein: 20-290
Range on HMM: 1-293/293
Sequence Identity: 20% (66 aa)

YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQD--REEAQR--EADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRG----TLWNEIE
| ...|.|.|.|. | .     .|. .|.|.|  ... .  .... |  |. ... .|||||.||  .. .    | . .. ...   |     |.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLF---D

RLK-DKGNFL--TEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQP----VLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELF
... .... .  .|...   .. |.|||| .|..|  |||||| |||. ..|..     . | |.  |.             .      .|. |.|||. 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPEV-

SVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGD----------SVALAVQNQLSIPQSPRHS-------------------SALRQLLNSMMTV
 ....  .. . |.||.||.|| |..|.      |. |.           ...  . .|. . .  .|                   .......... ..
-IRGGQYYGPKVDMWSCGCILYEMLCGR----PPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

DPHQRPHIPLLLSQ--L
||..|| .. .|    .
DPKKRPTAEQILQHPWF
Kinase MPSK1.AA TKL 26-290 16 3.3e-33 116.66 In-house 1-364 (364) Show / Hide 
Range on Protein: 26-290
Range on HMM: 1-364/364
Sequence Identity: 16% (61 aa)

LGEGGFSYVDLVEGLHDG----------HFYALKRILCHE---------------------------QQDREEAQREADMHRLFNHPNILRLVAYCLRER
.|.|||.      | . |             | |..  |.                           .. |..  .|. |.. ..||||.....||....
IGSGGFG--EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

G--AKHE-------AWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHA--------KGYAHRDLKPTNILLGDEGQ----------
.  . ..        ..   . ..|.|.. .            .|.. . |.|.||..  |.        .. .|||||. |||. . ..          
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPN

----PVLMDLGSMNQACIHVEGSRQALTLQDWAA------------QRCTISYRAPELFS---VQSHCV----------IDERTDVWSLGCVLYAMMFGE
    . . |.|     . . . .... | .                |. |. . |||..      ...|           .|..||.| | ||. .. ..
ADWCCKICDFGLSRFMSQSGNMNDTMTTMME--SAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC

GPY---DMVFQKGD-------SVALAVQNQLSIPQSPRH-------SSA---LRQLLNSMMTVDPHQRPHIPLLLSQL
 ||   ..  ...        ...   .... ||  ...       ...   ...|.   .  ||..||    .|..|
RPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MPSK1.AA Ciliate-E2 20-281 19 7.1e-30 99.73 In-house 1-353 (365) Show / Hide 
Range on Protein: 20-281
Range on HMM: 1-353/365
Sequence Identity: 19% (72 aa)

YLFIQKLGEGGFS-----YVDLVEGL------------------HDGHFYALKRILCHEQQDREEAQREADMHR----------------LFNHPNILRL
| ||.|.|.|.|.      |..|  .                   .. .||.|..   .... |.  .| .. |                . |||||...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIM---KKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKM

VAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFL-------TEDQILWLLLGICR---------------GLEAIHAKG-YAHRDLKPTNILLG
. .   .   ..   | . ... |.|.  |.  | | |.        || .|. .   |..               .|| .| |.   |||.|| |||. 
YECFQEK--DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-

DEGQPVLMDLGS------MNQACIHVEGSRQALTLQD------------------WAAQRCTISYRAPELFSVQS------HCVIDERTDVWSLGCVLYA
    . . |.|        || ..|    .. ..                        . .|  | ||| .. ..      .   |.  |.||||..|| 
----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

MMFGEGPYDMVFQKGDSVALAVQN-QLSIP----------------QSPRHSSALRQLLNS----MMTVDPHQRP
|.||. |.              .. ....|                    .|    .|..     |. .|| .|.
MLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI
Kinase MPSK1.AA STE 20-293 19 6.8e-26 88.48 In-house 1-359 (359) Show / Hide 
Range on Protein: 20-293
Range on HMM: 1-359/359
Sequence Identity: 19% (72 aa)

YLFIQKLGEGGFS--YVDLVEG---LH----------DGHFYALKRILCHEQ-----------------QDREEAQREADMHRLFN--HPNILRLVAYCL
. .|.|.|.|.|   |  .      .|           | ..| |..   ..                 ..... ..| .... .|  |||| .   ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

RE---RGAKHEAWLLLPFFKRGTLWNEIERLKDKGN----------FLTEDQILWLLLGICRG-LEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMN
.|    ....| |. . .   |.|   |.. . .|.          .. |.|| . .  |..| |. .| ... |||.|| ||||       | | |   
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QACIHVEGSRQALTLQDWA---------AQRC-----TISYRAPELFSVQSHC---VIDERTDVWSLGCVLYAMMFGEGPY---DMV---FQKGDSV---
|   .. .. |       .         .|..     |  . |||  . ....     |.. |.|||||..  |  |. |.         |.. ..    
QLTDSMANI-Q-S-----NNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ

----ALAVQNQLSIPQSPRH--------------------SSALRQLLNSMMTVDPHQRPHIPLLLSQ-LEAL
     |  ...  .|. | |                    |. ... .|   . ||..||    ||.   . .
QQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MPSK1.AA BIKE 24-290 29 1.5e-24 84.85 In-house 5-267 (267) Show / Hide 
Range on Protein: 24-290
Range on HMM: 5-267/267
Sequence Identity: 29% (80 aa)

QKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREAD-MHRLFNHPNILRLVAYCLRERGAK-HEAWLLLPFFKRGTLWNEIERLKDKGNFLT
..| ||||. | || . |.|  .||||     ..| . . ||   |. .  | ||   |       |    |  .| .. ..  . | . .   .| ..|
EQLAEGGFAMVFLVRD-HKGNKCALKRMYVNNEHDLNVCCREHQIMKQCSGHKNIVGYVDCYINCIGNGVWECMILMEYCRH-QVVNMMNQRLQQGQYFT

EDQILWLLLGICRGLEAIHAKGY--AHRDLKPTNILLGDEG--QPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTD
|. .|     .|     .|       |||||  |||| |.|    || | ||       ..        .|   .  |..|||||.    |   |  . |
EQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENILLHDHGPPHYVLCDFGSATNKFLNPQ-KHGVNYVKDEIEKYTTMCYRAPEMIDLYSGKEITTKAD

VWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQN-QLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQL
.| ||| || . |   |.      | |  ||... . .|| ... |  ...|   |. .|. .|| |    |..
IWALGCMLYKLCFFCLPF------GES-QLAICDGNFTIPDNSKYSREMHCLIRYMLEPDMEKRPDI-YQVSHV
Kinase MPSK1.AA Ciliate-E2-Unclassified 20-281 18 2.6e-24 81.22 In-house 1-341 (352) Show / Hide 
Range on Protein: 20-281
Range on HMM: 1-341/352
Sequence Identity: 18% (67 aa)

YLFIQKLGEGGFSYVDLVEGLHDGHFY-----ALKRILCH----EQQDREEAQREADMHRL------------------FNHPNILRLVAY---------
| .|...|.|||. | ...   .. .|     . | . ..    ...| |. . .  | ..                  ..||.|.... .         
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

------------CLRERGA---KHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQIL-----WLLLGICRGLEAIHAKG-YAHRDLKPTNILLGDEG--
            ....|.    |                |.. . . ... .|| |..      ..  |. ||| .| |.   |||.|| |||. ..|  
VMEYCEGGDLWQYIKKRKKQKQK---------------GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKN

-QPVLMDLGSMN------------QACIHVEGSRQALTLQDWAAQRC-TISYR----APELFSVQSHCVIDER----TDVWSLGCVLYAMMFGEGPYDMV
 .. . |.|.              |        ... . |. . ..| |..|     |||..  | .   |..     |.||||..||.|.||. |..  
YYIKIIDFGISKKYQQNNNCDTNQQ-------QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNY---DHSKAYKCDIWSLGVILYEMLFGYYPFYDN

FQKG---------------DSVALAVQNQLSIPQSP------RHSSALRQLLN----SMMTVDPHQRP
 ..                       |.....| .|      . |     ..|    .|. ..| .|.
NCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI
Kinase MPSK1.AA CAMK 25-283 15 2.6e-24 74.65 In-house 1-416 (425) Show / Hide 
Range on Protein: 25-283
Range on HMM: 1-416/425
Sequence Identity: 15% (64 aa)

KLGEGGFSYVDLVEGLHDG------------HFYALKRILCH----------------------------EQQDREEAQREADMHRL-------FNHPNI
.||.|.|. | |..  ...            . .| | |                               ...||.. .|| .....        .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRLVAYCL--------RERG-AKHE--------AWLLL---PFFKRGTLWNE-IERLKDKGNF--------------LTEDQILWLLLGICRGLEAIHAK
..|  .          .. .              .. .    .   | |  .  ......|..              .||..   .   || ... .| .
IKLYEVYEDPHYFKNTND-YET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GYAHRDLKPTNILL-GDE----------------GQPVLMDLGSMNQACI---------HVEGSRQALT-------LQDWAAQRCTISYRA-PELFSVQS
. .|||||| ||||  ..                ..  . | |  |.            . .|. .  .        |    .  | .| | ||... ..
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG

-----------HCVIDERTDVWSLGCVLYAMMFGEGPYD-----MVFQKGDSVA-----------LAVQNQLS-IPQSPRHSSA----------------
           .  ... .|.||.|..||.|  |. |..     . .. .   .              . . . .|    ..|.                
HCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D---EWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH

-----LRQLLNSMMTVDPHQRPHI
      ..|...|..||| .|. |
FVSQECKDLIRKMLQVDPEKRMTI
Kinase MPSK1.AA TyrKc 20-290 20 2.4e-12 -23.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-290
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLF--NHPNILRLVAYCLRE--RGAK---HEAWLLLPFFKRGTLWNEIER
  ...||||| |  | . .        | | .  .    ||.  ||| . . .  .||||.||...|. .  .      .  .... . . | |    ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDL---KDY

LKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIH------VEGSR-------QALTLQDWAAQR--CTIS
|..... |. .. |   . |..| | .| |.. ||||   |.|.|...           .. |         ..        .  . .     .    | 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

YRAPELFSVQSHCVIDERTDVWSLGCVLY-AMMFGEGPYD-MVF--QKGDSVALAVQNQLSIPQSPR--------HSSALRQLLNSMMTVDPHQRPHIPL
  ||| .    ...  . .|||| | ...  . .|. ||  |..   . . |   |..    || |          .... |.  .    ||..||    
WMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

LLSQL
. ...
IHECF
Kinase MPSK1.AA NEK 20-77 30 4e-10 32.24 In-house 1-66 (286) Show / Hide 
Range on Protein: 20-77
Range on HMM: 1-66/286
Sequence Identity: 30% (20 aa)

YLFIQKLGEGGFSYVDLVEGLHDGHF-----YALKRILCHE--QQDREEAQ-READMHRLFNHPNI
|  |.|.|.| |. | .|.   ||       |..|.|   .  ......||  |.   .  .||||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNI
Kinase MPSK1.AA NEK 103-160 29 1e-09 30.76 In-house 90-156 (286) Show / Hide 
Range on Protein: 103-160
Range on HMM: 90-156/286
Sequence Identity: 29% (20 aa)

R-GTLWNE---IERLKDKGNFLTEDQILWLLLGICRGLEAIHAK-----GYAHRDLKPTNILLGDEG
. |.| .    |.. |.|| .. |.||.. .  .| .|  .| .        |||.|| || | ...
GGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNN
Kinase MPSK1.AA Pkinase_Tyr 56-149 26 1.3e-05 19.58 Pfam 42-137 (270) Show / Hide 
Range on Protein: 56-149
Range on HMM: 42-137/270
Sequence Identity: 26% (26 aa)

QQD--REEAQREADMHRLF-NHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDK---GNFLTEDQILWLLLGICRGLEAIHAKGYAHRDL
...  ||.  ||| . . . .||||.||.. |..... . . .. ... . | |    . |...   .. ||  ..|   . |..|.|  ..|.. ||||
HEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDL---LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase MPSK1.AA NEK 213-226 64 2.6e-05 15.1 In-house 202-215 (286) Show / Hide 
Range on Protein: 213-226
Range on HMM: 202-215/286
Sequence Identity: 64% (9 aa)

DERTDVWSLGCVLY
... |.||||||||
NNKSDIWSLGCVLY
Kinase MPSK1.AA NEK 262-292 32 0.001414 8.92 In-house 256-286 (286) Show / Hide 
Range on Protein: 262-292
Range on HMM: 256-286/286
Sequence Identity: 32% (10 aa)

SSALRQLLNSMMTVDPHQRPHIPLLLSQLEA
|. |..|...| ..||.||| .  .|..   
SQDLQNLISQMLQKDPEQRPSCNQILEMPFI