Gene MRCKa (Human)

MRCKa

Species: Human
Alias: DKFZp686L1738, DKFZp686P1738, PK428, FLJ23347, KIAA0451, CDC42BPA, MRCKA, MRCKa, MRCK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1q42,

Classification

Group: AGC
Family: DMPK
Subfamily: GEK

Sequence

Name Sequence Type Origin Length Description Download
MRCKa.NA RNA Sugen Kinome 10628 None Fasta, JSON
MRCKa.AA Protein Sugen Kinome 1770 None Fasta, JSON
MRCKa.kin_dom Protein Kinase Domain Sugen Kinome 267 None Fasta, JSON

Protein domain

Protein domains of MRCKa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MRCKa.AA DMPK 77-343 74 1.3e-306 770.2 In-house 1-270 (270) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-270/270
Sequence Identity: 74% (200 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED
||||||||||.||||.||. |....|.|||..||||||||||||||.||||..|.|. .|||.|||||||.|.||.||.|..|||||||.|..|||.|||
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDG-KGRYGPECDWWSLGVCMYEM
||||||||||.||.|.||..||||||||||.|.|..|||.|||||||.|...||.|.|.||||||||||||.||||||. ||||||||||||.|||||||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LYGETPFYAESLVETYGKIMNH-KERFQFPAQVT-DVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF
|||||||||.|||||||||||| |....||.... ||||.|||||..|.|.||.|||.||.||||.||||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase MRCKa.AA GEK 77-343 88 8.49999999999e-214 716.55 In-house 1-269 (269) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-269/269
Sequence Identity: 88% (239 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED
|||||||||||||||||||.||.|.|.||||||||||||||||||||||||||||||..|||.|||||||.|.|||||||||||||||||||||||||||
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML
|||||.||||.|||||||||||||||||||.|.|||||||||||||||....||.|||.|||||||||||||||||||||||||||||||||||||||||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

YGETPFYAESLVETYGKIMNHKERFQFPAQVT--DVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF
||||||||||||||||||||||..||||.|.|  ||||.||||||.||||.|||||.|||.||||||||
YGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase MRCKa.AA AGC 77-343 31 1.2e-177 464.07 In-house 1-395 (395) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-395/395
Sequence Identity: 31% (126 aa)

FEILKVIGRGAFGEVAVVKLK------NADKVFAMKILNKWE--------MLKRAETAC-------FREERDVLVNGD----------NKWITT-LHYAF
||.|||||.|.||.|  |. |        .|..|||.|.|..        |.... |..       ..|||..|.. .          . .|.  |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDDNN--LYLVMDYYV---------GG-DLLTLLSK--FEDRLPEDMARFYLAE-------MVIAIDSVHQ-LHYVHRD-IKPDNILMDMNGHIRLADFG
||...  ||.||.|.          || .|.. | .   | |..|..||||.||       .| |... |. ....||| .||.|||.| .|||.|.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

SCLKLMEDG-------------------------------------------------TVQSSVAVG--TPDYISPEILQAMEDGKGRYGPECDWWS--L
.| ..| ||                                                 ... .  .|  ||.|..||||         ||..|||||  |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---------YGKACDWWSFGL

GVCMYEMLYGETPFYAESLV----------ETYGKIM------NHKERFQFP-----AQVTDVSENAKDLIRRLIC-SREHRLGQN-------GIEDFKK
|..|||||.| .|||... .          |.. |||      |.|..| ||       .  .|..|||||..|.|  .|.||| .       |.|. |.
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HPFF
||.|
HPWF
Kinase MRCKa.AA ROCK 77-343 55 1.1e-134 453.7 In-house 1-263 (263) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-263/263
Sequence Identity: 55% (148 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED
|...||||||||||| .|. | . ||.|||.|.| ||.||.. | | ||||..     .||  ||||||||  ||.||||  ||||  |.|...  .|| 
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYD--VPEK

MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML
 |||| .|.| |.|..| . ..|||.||||.|.|  ||..||||| |.|. ..| |... |||||||||||.|..   . |.|| |||||| || .||||
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQG-QDGEYGRECDWWSVGVFIYEML

YGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF
 |.|||||.||| ||.|||.||.  .|| .| ..|..|||||.. .  ||.|||.||..| |.|.||
VGDTPFYADSLVGTYSKIMDHKNSLKFPDDV-EISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase MRCKa.AA CRIK 77-343 46 4.8e-131 420.18 In-house 1-272 (272) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-272/272
Sequence Identity: 46% (127 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED
||.  .||.| ||.| ||  |    ..|||.. | ..| . . . | ||||..      |.. | |||||..||||.| |  ||||| |.. ..| . |.
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED---GKGRYGPECDWWSLGVCMY
|||||||| ..|. |.|.  ||||||||.||| |  ||| ||||||  |. ....|.|   ||||||. ||.|| |     .|| || .|||||.|.  |
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMLYGETPFYAESLVETYGKIMN------HKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF
|| .| |||   . ..|| .|||       ..   ||.    || |. |||. |.| .  ||   . |  . ||||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDP-KVSPNYRDLIQSLLCNQSKRL---KYEQLCCHPFF
Kinase MRCKa.AA S_TKc 77-343 32 7.4e-89 302.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-231/231
Sequence Identity: 32% (91 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVG--GDLLTLLSKFEDR--
.|||..||.||||.|  .. |. ....|.||..            .| |...| . . ..| .|...||| ..||.||.|  |  |||.... |   .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGP-ECDWWSL
   .|| .||||..... |..  |... .|||.||.|||.|   || ..|||.. .|        .  .|||.|..||.|         ||. .|||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--------GYGKCKCDWWSC

GVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLIC-SREHRLGQNGIED----FKKHPFF
|...||||.|..||.   . ... ||.               |. |||.||.. .   |.|..   .       |.||.|
GCILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MRCKa.AA RSK 80-343 37 1.7e-85 290.38 In-house 1-278 (278) Show / Hide 
Range on Protein: 80-343
Range on HMM: 1-278/278
Sequence Identity: 37% (106 aa)

LKVIGRGAFGEVAVVKLK---NADKVFAMKILNKWEMLKRAE-TACFREERDVLVNGD-NKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDR--
||| |.|..|.| ... .   ......|||.|.| .. .|.  |.  ..||..|      . | |||||||..  |||.|.|  ||.|.| |.| .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDM---NGHIRLADFGSCLK-LMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSL
. || |.||.|| | |..  ||.. .|||.||.||| |    .|||.| ||| | .   ...    .  ..| .|. ||.|   . ..| ..  ||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT-FCYTIEYMAPEMLKRAN-QQGGHDKACDWWSL

GVCMYEMLYGETPFYA---ESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREH-RLG--QNGIEDFKKHPFF
|| ||||| | .||..   ..  |.  .|.. |  . .|.    .|..||||||.. .  .| |||   ...|. |.||.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNW-QYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MRCKa.AA NDR 77-221 54 2.3e-85 263.15 In-house 1-149 (350) Show / Hide 
Range on Protein: 77-221
Range on HMM: 1-149/350
Sequence Identity: 54% (81 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD--NKWITTLHYAFQDDNNLYLVMDYYVGGDLLT---LLSKFED
|||.|.||.|||||| .|. |. ....||||..| ||... ..|  | |||...  |  |.|.. | |.|||...|||||.|  |||. |   ||.|. |
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKM-D

RLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFG
 ..||.|||| |||| ||.|||.. |.||||||||.|.|  ||| | |||
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase MRCKa.AA AktR 77-343 35 3.9e-81 275.85 In-house 1-268 (268) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-268/268
Sequence Identity: 35% (97 aa)

FEILKVIGRGAFGEVAVVKLK-NADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLP
|...|..|.||||.|  |. | . .|..|||.. | .. .|      . ||...    ..  |  |||.||....|...|.|. ||.|.. | |.. .. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHL-KKKKKFS

EDMARFYLAEMVIAIDSVHQL-HYVHRDIKPDNILMDMNGHIRLADFG-SC-LKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVC
|..|||| |....|..  ||  . . ||.||.|||.|..||....||| |  .. |..  .. |. .||| |..||...     || ..  .|||..|. 
EEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSF-CGTPEYMAPEMITKK---KG-HNKSVDWWAFGIF

MYEMLYGETPFYAESLVETYGKIMNHK-ERFQFPAQVTDVSENAKDLIR-RLICSR-EHRLG--QNGIEDFKKHPFF
 |||..| .|||...  . . || ..   .|..|...   |...||||  .| | . ..|||   ||.|. |.||.|
IYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYF---SSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase MRCKa.AA Pkinase 77-343 26 3.7e-61 214.3 Pfam 1-293 (293) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-293/293
Sequence Identity: 26% (82 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFR-EERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGG----DLLTLLS-KFE
..|...||.|.||.|   . |.  |..|.||..| .  .  . . .|  |  .. . . . | .|...|.|....|.||.|  ||    || ...| . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DRL--PEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHI----RLADFGSCLKL-MEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPEC
 ..  .|. ..||. ... ...  |.   .|||.||.|||.| ||||    ...|||.. ..    ..   .. .|||.|..||...    |   |||..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIR----GGQYYGPKV

DWWSLGVCMYEMLYGETPFYAE----SLVETYGKIMNHKE-RFQFP-AQVTDVS-----------------ENAKDLIRRLICSREH-RLGQNGIEDFKK
|.||.|. .|||| |..||. .    . .. . .| . .. .. |.  .  ..|                 |..||.|....|   . |..   .|. ..
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQ

HPFF
||.|
HPWF
Kinase MRCKa.AA MAST 77-221 41 2.4e-57 183.26 In-house 1-144 (334) Show / Hide 
Range on Protein: 77-221
Range on HMM: 1-144/334
Sequence Identity: 41% (60 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED
||. |.|..||.| |  || |.  . ||||...| .|...  .   . ||..| . .| ..  . |.|| .|.|..||.| .|||. .||. .  ...|.
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG-YFDEW

MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFG
||..|.||.|....  |.   ||||.||||.| | |||| |.|||
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase MRCKa.AA MAST 77-221 40 3.1e-57 173.11 In-house 1-147 (337) Show / Hide 
Range on Protein: 77-221
Range on HMM: 1-147/337
Sequence Identity: 40% (59 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQD--DNNLYLVMDYYVGGDLLTLLSKFEDRLP
||..|.|..||.| |  || |.  . ||||..|.  ....      . ||..|.. .| ..  . |.||   .. |..||.|  |||  .||. .  ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFG
|.||..|.|| |....  |    ||||.||||.| | |||| |.|||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase MRCKa.AA NDR 237-343 46 8.7e-54 163.94 In-house 241-350 (350) Show / Hide 
Range on Protein: 237-343
Range on HMM: 241-350/350
Sequence Identity: 46% (54 aa)

AVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERF-----QFPAQVTDVSENAKDLIRRLIC-SREHRLG
.||||||. ||..|  . |   |...|||||||. ||||| | .||....  ||. |||| |. .     .||...  .|. |.||||||.|  ..||||
TVGTPDYMAPEVFQQ-KTG---YNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEAN-LSPEAWDLIRRLCCPDPDHRLG

QNG--IEDFKKHPFF
 .|  ....|.||||
SHGKGVDEIKSHPFF
Kinase MRCKa.AA MAST 238-343 39 2.1e-35 105.11 In-house 229-337 (337) Show / Hide 
Range on Protein: 238-343
Range on HMM: 229-337/337
Sequence Identity: 39% (45 aa)

VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVE-TYGKIMNHKERFQFPAQ-----VTDVSENAKDLIRRLI-CSREHRLG
.||||||.||..     |.| ||.  ||||.|. ||| | |..|| ...  | . ..| ||...  .|          .|. |.|||..|       |||
CGTPDYIAPEVIL----GQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLG

QNGIEDFKKHPFF
 || .. |.||||
ANGADEIKQHPFF
Kinase MRCKa.AA MAST 238-343 37 8.4e-31 96.26 In-house 225-334 (334) Show / Hide 
Range on Protein: 238-343
Range on HMM: 225-334/334
Sequence Identity: 37% (43 aa)

VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK-ERFQFPAQ-----VTDVSENAKDLIRRLICS-REHRLG
.||||||.||..     |.| .|.  ||||.|..||| | | .||  ..  |....| |..     .|           |. |.|||..|     . |||
CGTPDYIAPEVIL----GQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLG

QN-GIEDFKKHPFF
 | | .. |.||||
ANNGADEVKQHPFF
Kinase MRCKa.AA S_TK_X 344-406 32 6.3e-18 66.81 SMART 1-79 (79) Show / Hide 
Range on Protein: 344-406
Range on HMM: 1-79/79
Sequence Identity: 32% (26 aa)

SGIDWDNIRN----CEAPYIPEVS----SPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHH--------LPFVGFTYTS
.|||||...|     |.|..|...    ||||||||| . .  . ..|...|. .. ..          .|| ||||  
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase MRCKa.AA Pkinase_C 361-408 41 5.1e-15 56.09 Pfam 1-46 (46) Show / Hide 
Range on Protein: 361-408
Range on HMM: 1-46/46
Sequence Identity: 41% (20 aa)

EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSC
.|.|||||||||..... . ..|. |..   .||...||.||||... 
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD
Kinase MRCKa.AA TyrKc 77-321 19 1.2e-11 -34.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 77-321
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG--DNKWITTLHYAFQDD-------NNLYLVMDYYVGGDLLTLLS
 . .|..|.||||||   ..|      | | |..         . |..|  .. .   ... |  |. .  ..         |..|| |  .|||.  | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KFED-RLPEDMARF---------YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMED---GTVQSSVAV----GTPD-----YIS
| ..   ..|.  |         ||...          ...|||.   |.| . |.... .||| . .. .|   |  ..   .    |. .       .
KHRPKLCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEILQAMEDGKGRYGPECDWWSLGVCMYEML-YGETPFYA-----ESLVETYGKIMNHKERFQFPA--------QVTDVSE--------------NAKDL
|| .      .|.. .. | || ||||.|.. ||..| .       |  | . .... . . | |           ... .              . ...
PECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

IRRL
....
HECF
Kinase MRCKa.AA Pkinase_Tyr 77-91 53 0.004181 11.14 Pfam 1-15 (270) Show / Hide 
Range on Protein: 77-91
Range on HMM: 1-15/270
Sequence Identity: 53% (8 aa)

FEILKVIGRGAFGEV
 ...|..|.||||||
ITFGKKLGEGAFGEV
Kinase MRCKa.AA Pkinase_Tyr 266-296 38 0.012324 9.55 Pfam 198-231 (270) Show / Hide 
Range on Protein: 266-296
Range on HMM: 198-231/270
Sequence Identity: 38% (13 aa)

WSLGVCMYEMLY-GETP-FYAESLVETYGKI-MN
|| ||.|.|..  ||.| ..  |  | | .|  .
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase MRCKa.AA Pkinase_Tyr 193-221 31 3.22799 1.36 Pfam 128-156 (270) Show / Hide 
Range on Protein: 193-221
Range on HMM: 128-156/270
Sequence Identity: 31% (9 aa)

HQLHYVHRDIKPDNILMDMNGHIRLADFG
.. ...|||.   |.| . |.... .|||
ESKNCIHRDLAARNCLVTENNVVKICDFG
BZIP_1 MRCKa.AA bZIP_1 441-477 27 4.182986 3.56 Pfam 28-64 (64) Show / Hide 
Range on Protein: 441-477
Range on HMM: 28-64/64
Sequence Identity: 27% (10 aa)

TEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTV
.| .|.|.. || |  .|  .|.. ....| |   . 
CEQLEERVEELEAENMMLRKELERLKKMCQKLKSENH
M MRCKa.AA M 453-473 28 68.080276 0.58 Pfam 1-21 (21) Show / Hide 
Range on Protein: 453-473
Range on HMM: 1-21/21
Sequence Identity: 28% (6 aa)

QEKLELSRKLQESTQTVQALQ
..| .|  ..|| ..  |.|.
EAKKQLEAEHQELEEQNQKLE
BZIP_1 MRCKa.AA bZIP_1 488-504 29 0.186535 8.42 Pfam 48-64 (64) Show / Hide 
Range on Protein: 488-504
Range on HMM: 48-64/64
Sequence Identity: 29% (5 aa)

EIKNLKEEIEKLRKQVT
|...||....||.....
ELERLKKMCQKLKSENH
TMF_DNA_bd MRCKa.AA TMF_DNA_bd 483-502 55 1.592755 4.9 Pfam 49-68 (75) Show / Hide 
Range on Protein: 483-502
Range on HMM: 49-68/75
Sequence Identity: 55% (11 aa)

ASKDLEIKNLKEEIEKLRKQ
..|| .|..| || |||.||
KEKDEQIAQLMEEGEKLSKQ
DMPK_coil MRCKa.AA DMPK_coil 488-502 46 1.722159 4.25 Pfam 47-61 (61) Show / Hide 
Range on Protein: 488-502
Range on HMM: 47-61/61
Sequence Identity: 46% (7 aa)

EIKNLKEEIEKLRKQ
|...||.|.| || .
EMEQLKKEMEMLRAR
TMF_DNA_bd MRCKa.AA TMF_DNA_bd 529-562 37 1.061446 5.53 Pfam 41-75 (75) Show / Hide 
Range on Protein: 529-562
Range on HMM: 41-75/75
Sequence Identity: 37% (13 aa)

QIKAYEKQIKTLQ-QEREDLNKELVQASERLKNQS
..|. ||||. |. .. |.|.||. .  .|||.  
KNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
BZIP_1 MRCKa.AA bZIP_1 530-563 18 16.1334 1.45 Pfam 28-64 (64) Show / Hide 
Range on Protein: 530-563
Range on HMM: 28-64/64
Sequence Identity: 18% (7 aa)

IKAYEKQIKTLQQEREDLN---KELVQASERLKNQSK
.. .|  ...|  |...|    ..| . ...||....
CEQLEERVEELEAENMMLRKELERLKKMCQKLKSENH
DMPK_coil MRCKa.AA DMPK_coil 722-749 28 0.231001 7.24 Pfam 34-61 (61) Show / Hide 
Range on Protein: 722-749
Range on HMM: 34-61/61
Sequence Identity: 28% (8 aa)

LHDSEGQQLALNKEIMILKDKLEKTRRE
| ..| .  .| .|.  ||  .|  | .
LQEAEKKNRELEQEMEQLKKEMEMLRAR
TMF_DNA_bd MRCKa.AA TMF_DNA_bd 702-736 44 0.267415 7.67 Pfam 22-57 (75) Show / Hide 
Range on Protein: 702-736
Range on HMM: 22-57/75
Sequence Identity: 44% (16 aa)

EELSKREGIHANEIKNLKKELHDSEGQQLALN-KEI
|.||| |  | |.||.|.|.. ..| |.  |. |.|
EKLSKQELKHNNTIKKLRKKNKELEKQISELKHKKI
M MRCKa.AA M 774-794 28 0.002437 15.59 Pfam 1-21 (21) Show / Hide 
Range on Protein: 774-794
Range on HMM: 1-21/21
Sequence Identity: 28% (6 aa)

EENKKLTSELDKLTTLYENLS
|..|.|..|. .|.. ...|.
EAKKQLEAEHQELEEQNQKLE
BZIP_1 MRCKa.AA bZIP_1 763-798 30 0.084356 9.66 Pfam 29-64 (64) Show / Hide 
Range on Protein: 763-798
Range on HMM: 29-64/64
Sequence Identity: 30% (11 aa)

QQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQ
.|.|..   |..||..| .||..|. ....|  .| 
EQLEERVEELEAENMMLRKELERLKKMCQKLKSENH
M MRCKa.AA M 797-815 26 10.102755 3.38 Pfam 3-21 (21) Show / Hide 
Range on Protein: 797-815
Range on HMM: 3-21/21
Sequence Identity: 26% (5 aa)

NQQLEEEVKDLADKKESVA
..||| |...|  ... . 
KKQLEAEHQELEEQNQKLE
TMF_DNA_bd MRCKa.AA TMF_DNA_bd 763-818 16 33.924168 0.15 Pfam 22-75 (75) Show / Hide 
Range on Protein: 763-818
Range on HMM: 22-75/75
Sequence Identity: 16% (9 aa)

QQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWE
.. .     .... |||.... .|..  ..|. | ...|. .|.... ... .  |
EKLSKQELKHNNTIKKLRKKNKELEKQISELK-H-KKIEKLEKEIENLEQRLKRAE
DMPK_coil MRCKa.AA DMPK_coil 881-941 68 6.7e-34 118.74 Pfam 1-61 (61) Show / Hide 
Range on Protein: 881-941
Range on HMM: 1-61/61
Sequence Identity: 68% (42 aa)

ELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSE
||||||.|||||||.|.||||||||.||..||||...|||| ||..|.|||.|..|.||..
ELQSALEAEIRAKQSIHEELNKVKAANIQFECKLQEAEKKNRELEQEMEQLKKEMEMLRAR
BZIP_1 MRCKa.AA bZIP_1 918-943 38 2.831173 4.17 Pfam 39-64 (64) Show / Hide 
Range on Protein: 918-943
Range on HMM: 39-64/64
Sequence Identity: 38% (10 aa)

EKKNLELLSEIEQLIKDTEELRSEKG
|..| .| .|.|.| |  ..|.||. 
EAENMMLRKELERLKKMCQKLKSENH
C1_1 MRCKa.AA C1_1 1051-1103 32 5.7e-14 54.93 Pfam 1-55 (55) Show / Hide 
Range on Protein: 1051-1103
Range on HMM: 1-55/55
Sequence Identity: 32% (18 aa)

HQFFVK-SFTTPTKCHQCTSLMVG-LIRQGCSCEVCGFSCHITCVNKAPTTCPVP
|.. .. .|  ||.| .| ... | |..||..|..|.. ||  |..|.|. |.  
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 MRCKa.AA C1 1051-1100 27 1e-10 42.87 SMART 1-61 (61) Show / Hide 
Range on Protein: 1051-1100
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HQFFVKSFTTPTKCHQCTSLMVGLIRQ-----GCSCEVCGFSCHITCVNKAPT-------TC
|..  ..| .||.|..| ... |. .|     | .|..|.. ||  |. |.|        .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
PH MRCKa.AA PH 1121-1241 9 7.8e-10 39.92 SMART 1-82 (82) Show / Hide 
Range on Protein: 1121-1241
Range on HMM: 1-82/82
Sequence Identity: 9% (12 aa)

TAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILML
. .||.... .    | .|..  .....  |..|.             . .|...| ....                   |...  .        .... 
VIKEGWLYKKS----K-RWKKRWFVLFNDCLYYYKDK---------KPKGSIPLSDCTVRE-P----------------CFEIHH-DR-------TYYFQ

ADTENEKNKWVGVLSELHKIL
...| |...|.  . .. . .
CESEEEMQEWMQAIQKAIHNN
PH MRCKa.AA PH 1121-1239 12 3e-06 25.26 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1121-1239
Range on HMM: 1-92/92
Sequence Identity: 12% (15 aa)

TAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILML
  .||...  .    .|.|..  ..... .|..|.    .  . |. .| . . .. . .               . |..|...  .        ...  
VIKEGWLHKKG---KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDN---------------KRPHCFQIRT-DR------RTYYFQ

ADTENEKNKWVGVLSELHK
|..| |.| |.  ......
AESEEEMNDWMQAIQSACR
CNH MRCKa.AA CNH 1270-1534 24 5.9e-101 346.5 Pfam 1-336 (336) Show / Hide 
Range on Protein: 1270-1534
Range on HMM: 1-336/336
Sequence Identity: 24% (83 aa)

AAAIIDHERIALG-NEEGLFVVHV--TKDEIIRVGDNKK----IHQIELIPNDQLVAVI--SGRNRHVRLFPMSALDGRETDFY----------------
............| ..|||.|...  |.|.. ......|    ..||..|.  .....|  ...|.|....|...||..|. .                 
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRIERI

---------KLSETKGCQTVTSGKVRHGALTCLCVAMKR-----QVLCYELFQSKTRH-------------RKFKE-IQVP----YNVQWMAIF---SEQ
         ||..||.|.. ... ...   .|||.|.||     ...|||  . . ..             |||.| ...|    .....|...    ..
MPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLPQEKPK

LCVGFQSGFLRYPLNGEGNPYSMLHSNDHT--LSFIA-HQPMDAICAVEISSK-EYLLCFNSIGIYTDCQGR-RSR--QQELMWPANPSSCCYNAPYLSV
||||.|.||  ..|.|.| |.. .. .||.  ..| |  . ...||...|... |.|||.. ...|.. ||. |||  ..|.||...| |.... ||| .
LCVGCQKGFHIVNLDGTGQPWWLHDPADHSVQQDFMARRENCKPICMHRINDDEEFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQSFACCYPYLLA

YSENAVDIFDVNSM-EW---IQTLPLKKVRPLNNEG
...|...|..|... ||   .|..|....|.|....
FHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS
CNH MRCKa.AA CNH 1266-1548 16 8.2e-18 66.42 SMART 1-375 (375) Show / Hide 
Range on Protein: 1266-1548
Range on HMM: 1-375/375
Sequence Identity: 16% (60 aa)

KTTQAAAIIDHE-----RIALGNEEGLFVVHVTK-------DEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSAL-----------------
 |..  ..|. .      . .| |.|...  . .       .  ..    . . .....   .... |||...|.. .| ..|                 
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

-----DGRETDF-YKLSETKG-CQTVTS-GKVRHGALTCLCVAMKRQVLCY-ELFQSKTRHRKFK--------EIQVPYNVQWMAIFSEQLCVGF-QSGF
     ..|      |  .||| |   .  ..   . ...||.||.  |  | . ...  .. ..|        ||  . ...  .||   ..|.| ...|
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

----LRYPLNG----EGNPYSMLHS-----------------NDHTLSFIAHQPM------DAICAVEISS------KEYLLCFNSIGIYTDCQG---RR
    . .. ..    ... . ..|.                 ||| | |   |.       ...... .         .||||.. .|....|.|   ||
ERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWRR

SRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEW-IQTLPLKKVRPLNNEGSLN----LLGLETIRLIY
.| ..|.|.  | .  |  ||. . ..|...|... . || .|..  ... .... . |       .   .....
WRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
PBD MRCKa.AA PBD 1609-1644 39 8.2e-13 49.81 SMART 1-38 (38) Show / Hide 
Range on Protein: 1609-1644
Range on HMM: 1-38/38
Sequence Identity: 39% (15 aa)

ISNPT-NFNHIAHMGPGDG-IQILKDLPMNPRPQESRT
||.|| ||.||.|.||.||  . . .||.. . .....
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC