Gene MSK1 (Human)

MSK1

Species: Human
Alias: MSK1, MSPK1, RLPK, MGC1911, RPS6KA5
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 14q32.11, Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: MSKb,

Classification

Group: AGC
Family: RSK
Subfamily: MSK

Sequence

Name Sequence Type Origin Length Description Download
MSK1.NA RNA Sugen Kinome 3883 None Fasta, JSON
MSK1.AA Protein Sugen Kinome 802 None Fasta, JSON
MSK1.kin_dom Protein Kinase Domain Sugen Kinome 270 None Fasta, JSON
MSK1.kin_dom2 Protein Kinase Domain Sugen Kinome 262 None Fasta, JSON

Protein domain

Protein domains of MSK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MSK1.AA AGC 49-318 36 1.7e-195 511.23 In-house 1-395 (395) Show / Hide 
Range on Protein: 49-318
Range on HMM: 1-395/395
Sequence Identity: 36% (148 aa)

FELLKVLGTGAYGKVFLVRKISGH---DTGKLYAMKVLKKAT-IVQKAK-TTEHTRTE------------RQVLEHIRQ---------SPFLVT-LHYAF
||.|||.|.|..|||.|||| .|.   ||||.||||||||.. ||.| | . ||| ||            |..||....         .||.|  |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTETK--LHLILDYIN---------GG-ELFTHLS---QRERFTEHEVQIYVGE-------IVLALEHLHK-LGIIYRD-IKLENILLDSNGHVVLTDFG
|....  |.....|..         || |||.||    .. ||.| ....|  |       ||||||.||. .|||.|| .|.||||||..||. |||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEFVADE-------------------------------------------------TERAYSFCG--TIEYMAPDIVRGGDSGHDKAVDWWS--LGVL
|.||.. |.                                                 ..|...|||  | ||||| |.      ..||.||||  ||.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL------YGKACDWWSFGLGCL

MYELLTGASPFTVDG------EKNSQAEISRRIL------KSEPPYP----------QEMSALAKDLIQRLLMKDPKKRLGCGPRD-----ADEIKEHLF
|||.||| .||. |       . ....|.  .|.      . ....|          ...|  |||||..|| |||.||||||..|     |.|||.| .
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

F
|
F
Kinase MSK1.AA RSK 52-318 57 1.2e-173 583.18 In-house 1-278 (278) Show / Hide 
Range on Protein: 52-318
Range on HMM: 1-278/278
Sequence Identity: 57% (160 aa)

LKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER---
|||||.|.||||||.||. .||||..|||||||||.|||..|.|.||.|||..||...|.||.||||||||||.||.||..|..||||||||.....   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDS---NGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRG--GDSGHDKAVDWWSLGV
|.|.|...|  |||||.||||..|||.||.|.||||.|.   .||..|||||..|.|..|.......||.||||||| ...   ...|||||.|||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMYELLTGASPFTVDGEKNSQAEISRRILKSE--PPYP--QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFF
||||.|||..||.  ...|...||..||.| .  .. |  |..|. |||||...|..||.|||||||.||.|||.| .|
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MSK1.AA MSK 52-313 53 2e-172 579.12 In-house 1-277 (277) Show / Hide 
Range on Protein: 52-313
Range on HMM: 1-277/277
Sequence Identity: 53% (149 aa)

LKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTE
|||||||.|||.|..||...||||||||||.|.|||.|||.||.|||.||||.||...|.|..|.||||||......|...|.||||||||...||.|.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

HEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSN---GHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRG---GDSGHDKAVDWWSLGVLM
.|......|.|.|..|.|..|||.||.|.||||.|..   |||.|.|||....|..||..|..|.|.|..||||...|.   .|.|.|.|.|||||||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

YELLTGASPFT--VDGEK---NSQAEISRRILKSEPPYP----QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIK
|..|||..||.  .|...   ||..||..||.|.|...|    |.||. ||||||.||.||||||||.....|.|.|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase MSK1.AA p70 49-318 48 4.3e-136 458.43 In-house 1-299 (299) Show / Hide 
Range on Protein: 49-318
Range on HMM: 1-299/299
Sequence Identity: 48% (148 aa)

FELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTR-------------------------TERQVLEHIRQSPFLVTLHYAFQT
|||||||| |.|||||.|||  |.||||.||||||.||.||  .| |.|||                          || .|| . ..||.. |||||||
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEV-KHPFICDLHYAFQT

ETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETE---------RAYSFC
. || |||.|. |||||.||     . |  .. |  ||..||||||..|||||| | ||..|.. ||||||||||.|| . | .            ..||
NGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFC

GTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSE--PPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEI
|||||||| |...  .||..||||||||.|||  |||. ||| .  |    ..   |||    .  |   .. ..|||..|| ..|..|.| || || .|
GTIEYMAPEILMR--CGHNHAVDWWSLGCLMYDMLTGGPPFTGENRK----KTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADI

KEHLFF
.|| ||
QEHPFF
Kinase MSK1.AA SGK 49-318 43 1.7e-132 411.69 In-house 1-283 (283) Show / Hide 
Range on Protein: 49-318
Range on HMM: 1-283/283
Sequence Identity: 43% (128 aa)

FELLKVLGTGAYGKVFLVRKISG---------------HDTGKLYAMKVLKKATIV------QKAKTTEHTRTER-QVLEHIRQSPFLVTLHYAFQTETK
|..|||.| | .|||..|.. .                   .|.||||||.|..|.       | |   |. .||  .|  .. .||.| |||||||..|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMK-HPFIVNLHYAFQTKWK

LHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVR
| . .||.||||.| ||  . .| |... .|. |||.|||.||.. ||||| | ||||||. ||..||||||.|| ......   .|||| ||.|| . |
LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDT-TFTFCGTPEYLAPEVLR

GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFF
.   .||..||||.|| ..||...|. ||    . .  ..    |....   |. ||. |.|||| || ||||||||   ||. |||.| ||
K--QPHDRTVDWWCLGCVLYEMMYGLPPF----YSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase MSK1.AA AktR 49-318 47 2.2e-129 436.16 In-house 1-268 (268) Show / Hide 
Range on Protein: 49-318
Range on HMM: 1-268/268
Sequence Identity: 47% (130 aa)

FELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER
|...|.|| ||.|||.||.|    |..|.||||..|| .  .. .  .||.|||...| . . ||.| |||.|||..|| .|..|. |||||.||.....
FHVYKCLGKGAFGKVYLVQKKR--DNQKQYAMKMIKK-KKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK

FTEHEVQIYVGEIVLALEHLHKL-GIIYRDIKLENILLDSNGHVVLTDFGLSK-EFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMY
|.| ....|  .|.||||.||.   |||||.| ||||||..||| .||||||| .|. ...|.||||||| |||||....    ||.|.||||..|.. |
FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKK-KGHNKSVDWWAFGIFIY

ELLTGASPFTVDGEKNSQAEISRRILK-SEPPYPQEMSALAKDLIQ-RLLMKDPKKRLGCGPRDADEIKEHLFF
|..||  ||..  ... |  .. .|    ..||| . |  .||||| .||.|.|.|||| .  ...|||.| .|
EMVTGCPPFYH--KNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase MSK1.AA Akt 49-255 55 1e-121 390.85 In-house 1-203 (264) Show / Hide 
Range on Protein: 49-255
Range on HMM: 1-203/264
Sequence Identity: 55% (116 aa)

FELLKVLGTGAYGKVFLVRKISGHDTGKLY-AMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRE
|..||||| |..||||||.|    ||.|.| |||||||  |.||    ||| ||| .|.|.. .||.| |||.|||..|| ...||.||||||.||....
FDFLKVLGKGSFGKVFLVKKK---DTQKWYYAMKVLKKDYIIQKN-QVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKR

RFTEHEVQIYVGEIVLALEHLHKLGIIYRD-IKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS-LGVLM
||.| .   |. ||.||.||||. .|||||  |.||||.|..||. ||||||.|| .  .......|||| ||.|| |  |   ||.||||||. ||..|
RFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNG--NGHTKAVDWWGSLGCVM

YELLTGASPF
||...|. ||
YEMMCGRPPF
Kinase MSK1.AA RSK 49-318 41 7.29999999999e-121 407.83 In-house 1-271 (271) Show / Hide 
Range on Protein: 49-318
Range on HMM: 1-271/271
Sequence Identity: 41% (114 aa)

FELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER
.||....|.|...||....|. . ||...||||..||||.. | .    . .|| .|... ..|| |.|||.||.|.|. .|.|   ||.||..|.    
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--VCWEEERIILRYG-HHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKM

FTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSN----GHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVL
|.| || .|  || ||.|.||..||..|| | ||||.|.     ||. ..|||..|. . ||.. ...||.|..|||| ...  . |||.|.||||.|||
FSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQ-LRDENGMLMTFCYTANYMAPEVLK--RQGHDQACDWWSFGVL

MYELLTGASPFTVDGEKNSQAEISRRILKSE----PPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFF
||| |||. || . . ...  .|  ||         ....  |. ||||. ..|  || .|||.|| .. .||.| .|
MYEMLTGCTPF-QNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase MSK1.AA S_TKc 49-318 34 2.5e-106 360.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 49-318
Range on HMM: 1-231/231
Sequence Identity: 34% (97 aa)

FELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYING--GELFTHLSQR
.|.|...| ||.|||...|...   ||...|.|..|           ||.| |.|.|..  . |..|.|...||. ..|.....|..|  |.||... .|
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

ER------FTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDK-AVDWW
 |      |.| ... |. .|..|||..|..|||.||.| ||||||.  |. ..||||....        ..|||| .|||| ..     |..| ..|||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-----GYGKCKCDWW

SLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADE--IKEHLFF
|.|...||.|.|  ||        .... ..|.          |  |||.|...| |||.||...    .||  || | .|
SCGCILYEMLCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MSK1.AA Pkinase 49-318 30 1e-86 299.16 Pfam 1-293 (293) Show / Hide 
Range on Protein: 49-318
Range on HMM: 1-293/293
Sequence Identity: 30% (93 aa)

FELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTR-TERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGG----ELFTHL
.......| |..|.|.. ...   .|||..|.|..|| ..  . |  .|.| .| |.. .. ..|. |.|...|...........| .||    .||...
YHIGRKIGSGSFGCVYKCHHK---GTGKIVAVKIIKKRHEK-SWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

S--QRERF--TEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHV----VLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKA
|  .. .|  .|.|.. |. .|. .||..|. |||.||.|.||||.|.|||.     ..||||.| |     . ...||||..|||| ..| |.......
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPK

VDWWSLGVLMYELLTGASPFTVDG----EKNSQAEISRRILKSEPPYPQE---------------------MSALAKDLIQRLLMKDPKKRLGCGPRDAD
||.||.|...||.|.|  ||  .     . ..| .. .||.. ..... .                     .|  .||.| ..| ||||||..     |.
VDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AE

EIKEHLFF
.|..| .|
QILQHPWF
Kinase MSK1.AA CAMK 54-318 19 8.8e-84 269.73 In-house 1-425 (425) Show / Hide 
Range on Protein: 54-318
Range on HMM: 1-425/425
Sequence Identity: 19% (86 aa)

VLGTGAYGKVFLVRKI-SG---------HDTGKLYAMKVLKKATIVQ------------------------KAKTTEHTRTERQVLEHIR------QSPF
.||.|..|||.|.. . ..          . |. .|.|...|  .                          ..|. .  | | ... ...      . | 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

LVTLHYAFQ------------TETK--------LHLIL---DYINGGEL----FTHLSQR---------------ERFTEHEVQIYVGEIVLALEHLHKL
.. |. ...            | .|        .....   .|. ||||    | .. ..                ||||.|.. |.  |. |....|..
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GIIYRDIKLENILLDSN-----------------GHVVLTDFGLSKEFVADETER----------------------AYSFCGTIEYMA-PDIVRG-G--
.|. ||.|.||||||.|                 . . ..|||....|  .| ..                       . |||| |||| | ...| |  
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------DSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKN---------SQAEISRRILKSEPP-YPQEMSA-----------------------LA
           ......| ||.||..| .|.| .||  | ...         .. |. ..|.| .   .| ..|                         .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KDLIQRLLMKDPKKRLGCGPRDADEIKEHLFF
||||...| .||.||.      ......| ..
KDLIRKMLQVDPEKRM-----TIEQCLNHPWM
Kinase MSK1.AA Ciliate-E2 49-318 24 1.2e-81 277.57 In-house 1-365 (365) Show / Hide 
Range on Protein: 49-318
Range on HMM: 1-365/365
Sequence Identity: 24% (96 aa)

FELLKVLGTGAYGKVFLVRK-ISGH-------------------DTGKLYAMKVLKKATIVQKAKTTEHTR---------TERQVLEHIRQSPFLVTLHY
....|..|.|..|.|.....   ..                   ...|.||||..||  | |. .     |          |...||.. ..|... ...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQL-NHPNIIKMYE

AFQ--TETKLHLILDYINGGELFTHLSQR-----------ERFTEHEVQ---------------IYVGEIVLALEHLHKLG-IIYRDIKLENILLDSNGH
.||  ..... |...|..||.|| .. ..           ..||| |..                |...|.||||.||. . ||.||||.||||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VVLTDFGLSKEFVADETERA------------------------------YSFCGTIEYMAPDIVRGGD-------SGHDKAVDWWSLGVLMYELLTGAS
. ..||||||..  |. .|                               ...||| .|||| |..|..        |.|...|.|||||..||.|.|  
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFTVDGEKNSQAEISRRILKSEPPYP------------------QEMSALAKDLIQR----LLMKDPKKRLGCGPRDADEIKEHLFF
||             . |.. .  .|                  .. |  .||||..    .| |||.||..    ....|..| .|
PF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase MSK1.AA S_TK_X 319-379 30 1.4e-17 65.64 SMART 1-79 (79) Show / Hide 
Range on Protein: 319-379
Range on HMM: 1-79/79
Sequence Identity: 30% (24 aa)

QKINWDDLAA--KKVPAPFKPVIR----DELDVSNFAEEFTEMDPTYSPAAL--------PQSSEKL-----FQGYSFVA
 .|.||.| .  |....|||| |.    .. |.||| .||||..|...|.          ..  | .     | |...|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase MSK1.AA Akt 271-318 52 2.1e-17 52.11 In-house 215-264 (264) Show / Hide 
Range on Protein: 271-318
Range on HMM: 215-264/264
Sequence Identity: 52% (26 aa)

ILKSEPPYP--QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFF
|. ..  .|     |  .|||| .|| |||||||| || ||.|||.| .|
IKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase MSK1.AA Pkinase_C 338-381 27 1.4e-13 51.0 Pfam 1-46 (46) Show / Hide 
Range on Protein: 338-381
Range on HMM: 1-46/46
Sequence Identity: 27% (13 aa)

VIRDELDVSNFAEEFTEMDPTYSP---AALPQSSEKLFQGYSFVAPS
 .....|.||| .|||...|...|     ....   .|.|...|.|.
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase MSK1.AA APH 165-199 17 1.907657 2.4 Pfam 164-202 (248) Show / Hide 
Range on Protein: 165-199
Range on HMM: 164-202/248
Sequence Identity: 17% (7 aa)

LEHLHKLGIIYRDIKLENILLD--SNGHVV--LTDFGLS
..|.. .... .| .. |...|  ..|  |  . |.. .
EAHWPPPCWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDA
Kinase MSK1.AA MSK 427-687 57 2.7e-181 608.6 In-house 1-277 (277) Show / Hide 
Range on Protein: 427-687
Range on HMM: 1-277/277
Sequence Identity: 57% (159 aa)

LKDK-PLGEGSFSICRKCVHKKSNQAFAVKIIS-------KRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSE
||.. ..|.|.|.|||||||.......|.||.|       ......||.|...|..|..|||||.||..|.||.||.||||..||||||..|.|..||.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

TEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPD-NQPLKTPCFTLHYAAPELLN----QNG-YDESCDLWSLGVIL
.|...|||.||.||.|||..|..||||||||.||.||.|| ..|.||||||||.|.| ....|.|||||||.|||.|.    |.| |||.||.|||||||
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

YTMLSGQVPFQ--SHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWL
||||.||||||  ..||...|.|..||||.|.||.|||.|.||.|.|..||||||.|||.||.|||.|..||..||.
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase MSK1.AA RSK 427-687 42 3.8e-152 511.77 In-house 1-278 (278) Show / Hide 
Range on Protein: 427-687
Range on HMM: 1-278/278
Sequence Identity: 42% (119 aa)

LKDK-PLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQK-------EITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKH---
||.. ..| |....||||.|....| .|.|...|.. ...||       |.. |..|..||.||.||..|.......|.||...|||||....|.||   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDN-LEIKIIDFGFARLKPPD-NQPLKTPCFTLHYAAPELLN----QNGYDESCDLWSLG
|||.||...|...|.||.|.|. |..|||||||| |..||. |  .||..||||......| ||...|.|.|..|.|||.|.    |.|.|..||.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLK-----MSGLRYNEWL
|..|.||.|..|||. ...    .. ||||.|.||.||.....|...||||||||...|..||.|||.     .. .. ..|.
VLMYEMLTGCPPFQG-PND---NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MSK1.AA CAMK 431-687 27 1.8e-121 393.39 In-house 1-425 (425) Show / Hide 
Range on Protein: 431-687
Range on HMM: 1-425/425
Sequence Identity: 27% (117 aa)

PLGEGSFSICRKCVHKKSN------------QAFAVKIISKR-------------------------------MEANTQKEITALKLCEG------HPNI
 ||.|||.. ..|.||...            | .|.|||.|.                               ...| ..||  .|.. |      ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLHEVFHD-------------------QLHTFLVM---ELLNGGEL----FERIKKKKH---------------FSETEASYIMRKLVSAVSHMHDVGV
.||.||. |                   . | ..||   |.  ||||    |..|.....               |.| ||....| ..||| ..|. ..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENLLFTDENDN--------------LEIKIIDFGFARLKPP-----------------------DNQPLKTPCFTLHYAA-PELLNQ------
|||||||||.|..| ||.                |||||||||. ..|                       ..|..||.| |..|.| ||.||.      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------NGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCT------SAVEIMKKIKKGDFSFEGEA------------WKNVSQE--------AKD
         .|...|| ||.|||||.||.|  ||.. ... .|       .  |...||.||...|. .             |...|.|        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIQGLLTVDPNKRLKMSGLRYNEWL
||...|.|||.||.. .     .|.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MSK1.AA AGC 430-687 23 1.5e-113 294.44 In-house 5-395 (395) Show / Hide 
Range on Protein: 430-687
Range on HMM: 5-395/395
Sequence Identity: 23% (95 aa)

KPLGEGSFSICRKCVHK------KSNQAFAVKIISKRM---------EANTQKE------------ITALKLCEG---------HPNIVK-LHEVFHDQL
|..|.|||. .. . .|       ... .|.|...|.          ...|. |               |..| .         ||.||| ||  |.|. 
KVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKD

H--TFLVMELLN---------GG-ELFERIK---KKKHFSETEASYIMRK-------LVSAVSHMHD-VGVVHRD-LKPENLLFTDENDNLEIKIIDFGF
|   ..|||...         || ||| ...   |...|.| .| ...         .|.|. ..|.  |..||| |||||.|....     ||. |||.
HTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLTDFGL

ARLKPPD-----------------------------------------------------NQPLKTPCFTLHYAAPELLNQNGYDESCDLWS--LGVILY
.   . |                                                     .. .  || | .| ||| |    |. .|| ||  ||...|
CKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFGLGCLMY

TMLSGQVPFQSHDRS---LTCTSAVEIMKKIKKGD-FSFEGEAW-----------KNVSQEAKDLIQGLLTVDPNKRLK----------MSGLRYNEWL
 ||.|. ||.....      ...  |...||..|. |..... .           ...|.||||||..||..||.|||            . ..  .| 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MSK1.AA S_TKc 426-687 35 4.3e-99 336.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 426-687
Range on HMM: 1-231/231
Sequence Identity: 35% (99 aa)

DLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNG--GELFERIKKKKH------FS
  . ...|.|.|. ..||.|||... .|.|||.     ....||  ||   .|||||||..||.|  | ..|||...|  |.||..|||...      |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

ETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDE-SCDLWSLGVILYTML
| .| ..|. ...|. ..|. |..||||||||.|...     .|||.|||.||.        .| | |..| |||.|   ||.  .|| ||.|.||| ||
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

SGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRY-------NEWL
.|. ||.            ...|||.              |.||||.|...|..||.||.    .          .|.
CGYPPFP---------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MSK1.AA RSK 423-676 41 4e-97 328.98 In-house 1-255 (271) Show / Hide 
Range on Protein: 423-676
Range on HMM: 1-255/271
Sequence Identity: 41% (110 aa)

YDLDLKDKPLGEGSFS---ICRKCVHKKSNQAFAVKIISKRMEANT----QKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKH
|.|    . .|.||||   .|.||.|| .|| .|.||| |   ...     .|.  .     ||.|||||.|| |. . ...|... ||.|| |. |.| 
YEL---HECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKM

FSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDE-NDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYT
||| |.. .|. . .|. . |  |.||||||||| |. ||  .   ||| |||||     .|  |.|.| |  | ||| |.. |.|..|| ||.||..|.
FSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYE

MLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRL
||.|  |||. .|  .     .| ..|| | ||. .  | ..|.|||||. ..|..||..||
MLTGCTPFQNKPRDTP----MNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRL
Kinase MSK1.AA Pkinase 427-676 32 2.4e-87 301.3 Pfam 2-282 (293) Show / Hide 
Range on Protein: 427-676
Range on HMM: 2-282/293
Sequence Identity: 32% (94 aa)

LKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQK-------EITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGG----ELFERIK--KK
 . ...|.|||. ..||.||.... .|||||.|| |   ..       ||  .| . .|||||.|...|.|  |  .|||...||    .||..|.  ..
HIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KHF--SETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNL--EIKIIDFGFARLK-PPDNQPLKTPCFTLHYAAPELLN-QNGYDESCDLWS
. |  || |.  .|. ..... ..|. |..||||||||.|.  .|...   .||.|||.|...    |. ..|.| |..|.|||... ...|. ..| ||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVS-----------------QEAKDLIQGLLTVDPNKRL
.|.||| ||.|. ||..|. . .  .  .....|......|. . | ..|                 .|.||.| ..|..||.||.
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase MSK1.AA Ciliate-E2 426-687 26 2.6e-86 293.07 In-house 1-365 (365) Show / Hide 
Range on Protein: 426-687
Range on HMM: 1-365/365
Sequence Identity: 26% (103 aa)

DLKDKPLGEGSFSICRKCVHKKSNQAFA-----------------------VKIISKRMEANTQKEITALKLCE---------------GHPNIVKLHEV
  . | .|.|.|.. .|| ..| .. ||                       .||..|..  .. .||  ..  .                ||||.|..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FH--DQLHTFLVMELLNGGELFERIKKKKHFS-----------ETEASYIMRKLVS---------------AVSHMHDVG-VVHRDLKPENLLFTDENDN
|   |. . .||||...||.||..||..|...           | |..|||.....               |. ..|  . ..|||.||||.||      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

LEIKIIDFGFARLKPPDNQ--------PLKTPCF------------------------TLHYAAPELLN---------QNGYDESCDLWSLGVILYTMLS
  |||||||...   .|||         ...  .                        |..| ||| ||         |.|||..||.|||||||| ||.
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGE--------------AWKNVSQEAKDLIQG----LLTVDPNKRLK-MSGLRYNEWL
|. ||               ...||.....|  .               ||..|||.||||.     .| .||.||.  .. .  ..|.
GKPPF---------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MSK1.AA AktR 428-677 32 9.6e-42 145.0 In-house 3-253 (268) Show / Hide 
Range on Protein: 428-677
Range on HMM: 3-253/268
Sequence Identity: 32% (85 aa)

KDKPLGEGSFSICRKCVHK-KSNQAFAVKIISK------RMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETE
  |.||.| |.    . .| .... .| |.|.|      ...  |. | . .. |  || |||||. | .. . |..||   |||||  .||||.||| .
VYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQ

ASYIMRKLVSAVSHMHDV-GVVHRDLKPENLLFTDE-NDNLEIKIIDFGFARLKPP--DNQPLKTPCFTLHYAAPELLNQ-NGYDESCDLWSLGVILYTM
|  ..   . |. . |.   .. |||||||.|   . .    .||.||| ..| .   .... .. | | .| ||| ...  |.. |.|.|..|. .| |
ARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGH----VKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ-GLLTVDPNKRLK
..|. ||.....        .. .|||. .  .. .  ...|...||||| .||  .|||||.
VTGCPPFYHKNQN-------QMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLG
Kinase MSK1.AA SGK 430-676 30 4.4e-41 124.31 In-house 5-268 (283) Show / Hide 
Range on Protein: 430-676
Range on HMM: 5-268/283
Sequence Identity: 30% (84 aa)

KPLGEGSFSICRKCVHKKS------------------NQAFAVKIISKRMEA---------NTQKEITALK----LCEGHPNIVKLHEVFHDQLHTFLVM
| .|.|||      .||.                    . .|.|...|             . || |.| .     .  || ||.||  |  .   ..||
KVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLYFVM

ELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNG
. .||||.|  ... |||.| .|   .  .|.|  . |.  ...|||||||.|  |   .  ... ||| . ..  .|.  .| | |. | ||| |.  .
DYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILL-DHQGH--CCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQP

YDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRL
.| . | |.|| .|| |..|  || | ...       .   .| ...  .     ...| .|.|||||||. || |||
HDRTVDWWCLGCVLYEMMYGLPPFYSRNKQ-------QMYDNIINQPLQIP----PQMSNDAWDLIQGLLQKDPKKRL
Kinase MSK1.AA Akt 455-676 37 2.5e-38 120.09 In-house 37-248 (264) Show / Hide 
Range on Protein: 455-676
Range on HMM: 37-248/264
Sequence Identity: 37% (85 aa)

KIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRD-LKPENLLFT
.|| |.  ..|. |   |. |  || ||.||  | .| . ..||.  ||||||  ...|. ||| .| .    ...|  | |  ... || |||||.|  
YIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMD

DE-NDNLEIKIIDFGFARLK-PPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWS-LGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEG
 . .    |.. ||| ..     |..  || | |  | ||| ||.||.. ..| |. ||...| |. |. || . |.        . .|||| ..  |  
KDGH----ICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHH-------QMFKKIKNQPVKFPD

EAWKNVSQEAKDLIQGLLTVDPNKRL
   ...|.|.|||| |||. ||.|||
K--DWISPECKDLISGLLNKDPKKRL
Kinase MSK1.AA p70 478-676 30 9.1e-31 108.54 In-house 87-283 (299) Show / Hide 
Range on Protein: 478-676
Range on HMM: 87-283/299
Sequence Identity: 30% (65 aa)

HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQ
||.|..||  |..    .|. | | |||||   ...  . |. |.. .   . |  | |  |.. ||||||| .    |    ..  |||    .  | .
HPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCML---NQQGHVVLTDFGLCKESIHDGA

P----------LKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGD--FSFEGEAWKNVSQEAKDLIQ
           . | | |  | |||.|   |..  .| ||||. .| || |. ||       |     ....|| ||    .         ..|..|||.
VDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPF-------TGENRKKTIDKILKGKQGLKL----PPYLTHEMRDLIK

GLLTVDPNKRL
 ||  .| .|.
KLLKRHPTQRW
Kinase MSK1.AA TyrKc 426-686 21 1.9e-13 -5.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 426-686
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

DLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLC-EGHPNIVKLHEVFHDQ-------LHTFLVMELLNGGELFERIKKKKH-F
  ..| |||| | . .|.. |   .  ||| . .  ..   .|.  ..     |||||.|. |  .|          ..|||.  .| | ....|... .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

SETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPD-----NQPLKTP-----C---FTLHYAAPELLNQNGYDESC
.  .  ...    .  .. |. ...||||   | | ....    .|| ||| .|    |     ..  ...     .   . .   ||| .| . . .  
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DLWSLGVILYTMLS-GQVPFQS---HDRSLTCTSAVEIMKKIKKGDFSFEGEAWKN--------VSQEAKDLIQGLLTVDPNKRLKMSGLRYNEW
| || || .. ... || |      .       |. |.....|.|.     .  .|         ..|  ....     ||..|  .| . . ..
DVWSFGVCMWEIFTYGQQPYPGMIQQ-----MMSNQEVIEYVKQGYRM---PQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MSK1.AA APH 533-574 20 0.001669 12.83 Pfam 165-207 (248) Show / Hide 
Range on Protein: 533-574
Range on HMM: 165-207/248
Sequence Identity: 20% (9 aa)

SHMHDVGVVHRDLKPENLLFTDENDNLEIK--IIDFGFARLKPP
.|... ...|.|..| |..... ... .    .||...|.. .|
AHWPPPCWCHGDFHPGNVMWDP-RPDGGRVTGVIDWDDACWGDP