Gene MSSK1 (Human)

MSSK1

Species: Human
Alias: MGC102944, STK23, SRPK3, MSSK1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: Xq28,

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
MSSK1.NA RNA Sugen Kinome 2002 None Fasta, JSON
MSSK1.AA Protein Sugen Kinome 567 None Fasta, JSON
MSSK1.kin_dom Protein Kinase Domain Sugen Kinome 487 None Fasta, JSON

Protein domain

Protein domains of MSSK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MSSK1.AA SRPK 79-565 51 0.0 1057.81 In-house 1-554 (554) Show / Hide 
Range on Protein: 79-565
Range on HMM: 1-554/554
Sequence Identity: 51% (287 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPS---------------------DPKRETIVQLIDDFRISGVNG
|||.||||||||||||||||.|..|.||.|.|||| |||||||||||||.|||..||.                     ||.|...|||.|.|...|.||
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

VHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQ--
.|.|||.|||||.|||||...||||.|..|||.|.||||.||||||.||.||||||||||.|||| ..||.|.|||.||||..|...||.| |.||||  
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQDYIKRMAAEWTEWQKMGMQMPSSSMVQTAPQHQ

EVLQTGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLE---------AMEAATQAEDSGLR-----------LDGGSGSTSSSGCHPGGARAGPSPASSS
   |..|.||||.|||..|.|||....|......|..|         ..|......|....           .. .. ..... ..  ... .. .....
TQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDNEDNNQEDNDNEQDNKNNQNQENNMENEQEEKENTNKQKKNQKKKEQHKDKKEQECQ

PA------PGGGRSLSAGSQTSGFSGSLFS-----------PASCSILSGSSNQRETGGLLSPSTPFG-------ASNLLVNPLEPQNAD---KIKIKIA
..      |..  | .  ||......|...            .|... ... .|...| . |.....        |...||....|.|||   |||||||
NVQKQNNDPNFE-SQN-DSQMEQETNSCNNQEHKQEKTMQCQDSTKQQNKQ-DQQKEGQKQSEESECESEDMQEQAGKFLVWWKNPRNADLDHKIKIKIA

DLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGE
|||||||||.||||||||||||..||.|||.|..||||||||||||||||||||||||||||||||.||||||.||.|.||. |||||.|||||||..||
DLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFNKKGE

LRHIHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWL
||||..||.|.|..||.|||||. |.|.||..||.||..|.|||||.|..|||||||
LRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase MSSK1.AA CMGC 79-565 16 1e-114 378.59 In-house 1-513 (513) Show / Hide 
Range on Protein: 79-565
Range on HMM: 1-513/513
Sequence Identity: 16% (110 aa)

YHVVRKLGWGHFSTVWLCWD--------------IQRKRFVALKVVKSAGHYTETAV-------------DEIKLLKCVR----------DSDPSDPKRE
|....|.|.|....|. |.|              .. ...||.| .|..  |.|.|              .|||.||...          | ||......
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

TIVQLIDDFRISGVNGV-------------HVCMVLEVLGHQLLKWIIKSN--YQG------------------------LPVPCVKSIVRQVLHGLD--
 ||.|.| |. .. .|              |...| | ..| |.. | . .  |||                        ... ... . .|.| ||.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YLHTKCK-IIHTDIKPENILLCVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQEVLQTGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAAT
|.| ... |||.|.||||||..    .|.|. .    | .      .                                                     
YCHSHWGNIIHRDLKPENILINHNCELITRM-M----W-KS-----E-----------------------------------------------------

QAEDSGLRLDGGSGSTSSSGCHPGGARAGPSPASSSPAPGGGRSLSAGSQTSGFSGSLFSPASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQN
                                                                                         . . ||.    
-----------------------------------------------------------------------------------------D-W-NPC----

ADKIKIKIADLGNACWVHKH------------------------FTEDIQTRQYRAVEVLIGAE----------YGPPADIWSTACMAFELATG------
... ..||.| |.|.|.|.|                        .|....|| ||| |.|.|..          |..| |.|| .|. .|. ||      
QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIF

--DYLFEPHSGE-----DYSRDEDHIAHIVELLGDIPPAFALSGR-------YSREFFNRRGELRHIHNLK-------------------------HWGL
  ..|| .||..     ..... |....|...|| ..  .. .|.       ...|..|. . .... ..|                          |  
RGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWP

YEVLMEKYEWPLE--------------------------------QATQFSAFLLPMMEYIPEKRASAADCLQHPWL
.  . ... |  .                                .  |.  .|  |..| |.|| .|...||||..
PKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase MSSK1.AA CLK 79-509 17 1.5e-52 155.5 In-house 1-291 (350) Show / Hide 
Range on Protein: 79-509
Range on HMM: 1-291/350
Sequence Identity: 17% (81 aa)

YHVVRKLGWGHFSTVWLCWDIQR-KRFVALKVVKSAGHYTETAVDEIK-LLKCVRDS-DPSDPKRETIVQLIDDFRI-SGVNGVHVCMVLEVLGHQLLKW
| .| .|| | |..|  ||| .. |..||||...... |.| |  ||.  .| .    ||   ..| .....| |    |    |.|.| | .|  .   
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHG----HICIVFELYGLSIYDF

IIKSN------YQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVG----DAYIRRLAAEAT-EWQQAGAPPPSRSIVSTAPQEVLQTGKL
. . |      |...|   .... .| .. .  || . |..||| |||||...      ...   .  .   .                           
MKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKIN---------------------------

SKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAATQAEDSGLRLDGGSGSTSSSGCHPGGARAGPSPASSSPAPGGGRSLSAGSQTSGFSGSLFSPASC
                                                                                                    
----------------------------------------------------------------------------------------------------

SILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNAC---WVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGD
                       .     .  . .      |.. | |.|      | | .. ..||.||| ||  |  .  | |.|| .|  ||| ||.
-----------------------KKS-NNCVCHYWHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGF

YLFEPHSGEDYSRDEDHIAHIVELLG-DIPPAFALSGR---YSREFFNRRGEL
 ||  |.        .| | . ...| .|| . . . |    ....|......
TLFQTHD------NREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLD
Kinase MSSK1.AA S_TKc 79-565 15 2.9e-49 170.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 79-565
Range on HMM: 1-231/231
Sequence Identity: 15% (77 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGH---QLLKWI
|...||.| | |..|..|...  .| ||.|..|      |..  ||..||          . . ||.|.| |.       |..||.| ...    |.. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYI

IKSNYQG----LPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYI------RRLAAEATEWQQAGAPPPSRSIVSTAPQEVLQTGKLSK
 | ...|    .|   ......|.. .|.|.| . .||| |.|||||||.     |      |.|                                   
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL-----------------------------------

NKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAATQAEDSGLRLDGGSGSTSSSGCHPGGARAGPSPASSSPAPGGGRSLSAGSQTSGFSGSLFSPASCSI
                                                                                                    
----------------------------------------------------------------------------------------------------

LSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGP-PADIWSTACMAFELATGDYLFE
                                                       |  . |. |.| |||    ||. ..|.||  |. .|...|  .|.
-------------------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP

PHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQ---
         ... . ...                                                      ..  |.  .... |||| .| ..||   
---------QMQMMFKKIG---------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

----HPWL
    |||.
DIKCHPWF
Kinase MSSK1.AA Pkinase 79-565 16 3e-40 143.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 79-565
Range on HMM: 1-293/293
Sequence Identity: 16% (85 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVD-----EIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGH----
||..||.| | |..|..| ..   . ||.|..|  .   .  .      ||...| ..         . ||.|.| |.     . |..||.| ...    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFED----KDHIYMVMEYCEGGLYV

-QLLKWIIKSNYQGL--PVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQEVLQTGKLSKN
  |  .|  ... ..  .   .|....|.| ||.|.|  ..||| |.||||||.   . .|                                       
MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID-NNGHIDA-------------------------------------

KRKKMRRKRKQQKRLLEERLRDLQRLEAMEAATQAEDSGLRLDGGSGSTSSSGCHPGGARAGPSPASSSPAPGGGRSLSAGSQTSGFSGSLFSPASCSIL
                                                                                                    
----------------------------------------------------------------------------------------------------

SGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNAC---WVHKHFTEDIQ-TRQYRAVEVLI-GAEYGPPADIWSTACMAFELATGDY
                                     ..||.| | |.   . ... . ..  |. |.| ||.  | .|||..|.||  |. .|...|  
-------------------------------------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRP

LFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQ
.|  ... .  .  |... |.. .| ...      .  . || .|    |          . ......|. |    .  |.  . .. |.|| .|...||
PFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------F-HWTFHNWSEE----CKDFIKWCLCKDPKKRPTAEQILQ

HPWL
|||.
HPWF
Kinase MSSK1.AA DYRK 79-221 31 9.2e-28 98.56 In-house 1-138 (320) Show / Hide 
Range on Protein: 79-221
Range on HMM: 1-138/320
Sequence Identity: 31% (46 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKS
| ..  .| | |. |  ||| ...  ||.|....   .  .| .|||.|.. .. || | ..  .|.. | |   .    |.|.| | |   |   . . 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYH--CVHMYDYFYHRN----HLCIVFELLSMNLYEFLKNN

NYQGL-PVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLC
. ||. ..  |... .|.|..|..||.. .||| |.|||||.|.
HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLK
Kinase MSSK1.AA DYRK2 79-220 32 1.2e-24 76.84 In-house 1-135 (318) Show / Hide 
Range on Protein: 79-220
Range on HMM: 1-135/318
Sequence Identity: 32% (46 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKS
| ..  .| | |  |  | |  .| .||.|..     . ..|. ||. |.  |  |.       .| . | |   .    |.|...| |.  | . | | 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDN--TMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKN

NYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILL
..||. .  |    ...|..|. || | .||| | |||||||
HFQGFSLQLVRRFAHSILQCLRFLH-KNNIIHCDLKPENILL
Kinase MSSK1.AA DYRK 398-565 26 4.6e-21 75.62 In-house 138-320 (320) Show / Hide 
Range on Protein: 398-565
Range on HMM: 138-320/320
Sequence Identity: 26% (51 aa)

QNA-DKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSG
... .|  ||..| | .| .|....  || | ||| ||..|  |. . |.||  |   || ||  ||   .||..    | .| |.|.|| .|. .  .|
KQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKG

--RYSREFFNR------------RG------ELRHIHNLKHWGLYEVLME--KYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWL
  |. ..||..            .       ... . ...    .   ..  ...    .  ||  |.. . .. |.|| .... |||||.
RCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase MSSK1.AA DYRK2 405-565 27 8.6e-21 64.04 In-house 143-318 (318) Show / Hide 
Range on Protein: 405-565
Range on HMM: 143-318/318
Sequence Identity: 27% (51 aa)

IKIADLGNACWVHK-HFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSG------R
||..| |  | .|  ..  .||.| ||| || .|  || . |.||  | . || ||  ||    ||..    | .| . |.|| .||.  ..       .
IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENE---NDQFACMMEVLG-MPPKKFFDTWFYIHCF

YSREFFNR-------------RGELRHIHNLKHWGLYEVLMEKYEWPLE--QATQFSAFLLPMMEYIPEKRASAADCLQHPWL
. . |||.             . |.  . .  |   .     .    |.  .   |  |..  .|  |..| .... |.|||.
RRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase MSSK1.AA CAMKL 79-220 22 1.3e-20 62.36 In-house 1-160 (297) Show / Hide 
Range on Protein: 79-220
Range on HMM: 1-160/297
Sequence Identity: 22% (38 aa)

YHVVRKLGWGHFSTVWLCWDIQR-KRFVALKVVKSAGHYTETAVD----------------EIKLLKCVRDS-DPSDPKRETIVQLIDDFRISGV---NG
| ... || |.|..| |...|.  .. || |...  .   .. ..                ||...| .. .  |       |..| . .  .     . 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPN------IIKLYEVIETPEHDIET-

VHVCMVLEVLGHQ---LLKWIIKSNYQG--LPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILL
 ....|.|  .     |. .|.|  . .  .| .  . . ||......|.| .. |.| |||||||||
KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILL
Kinase MSSK1.AA DYRK1 79-221 29 1.1e-18 61.82 In-house 1-138 (321) Show / Hide 
Range on Protein: 79-221
Range on HMM: 1-138/321
Sequence Identity: 29% (43 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKS
| .   .| | |  |   .| |.. .||.|..|    . . |  ||.||  .   |. .  .  ||.|   |        |.|.|.|.|   |   .   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEM--KYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNT

NYQGLPVPCVKSIVRQVLHGLDYLHT-KCKIIHTDIKPENILLC
...|  .  .. . .|..  | .. |   .||| |.||||||||
HFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLC
Kinase MSSK1.AA CAMK 84-221 15 5e-17 50.72 In-house 1-213 (425) Show / Hide 
Range on Protein: 84-221
Range on HMM: 1-213/425
Sequence Identity: 15% (35 aa)

KLGWGHFSTVWLCWDIQRK------------RFVALKVVKSA-----------------------------GHYTETAVDEIKLLKCVRD-----SDPSD
.|| | |..| || ... .            . || |...                               ..  .    ||...| ...     . |  
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN-

PKRETIVQLIDDFRISGV--------NGVH--------VCMVL---EVLGHQ-----LLKWIIKSNY-------------QGLPVPCVKSIVRQVLHGLD
     |..|.. .  . .        .  .        ..||.   |          |. .|..  .               ..   .. ..||.. ...
-----IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVH

YLHTKCKIIHTDIKPENILLC
|.| .  |.| |.|||||||.
YCHSHN-IVHRDLKPENILLD
Kinase MSSK1.AA DyrkP 402-463 45 2.6e-16 49.56 In-house 144-205 (323) Show / Hide 
Range on Protein: 402-463
Range on HMM: 144-205/323
Sequence Identity: 45% (28 aa)

KIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLF
| ..|| | | .|..| |    .| | ||| ||.||  |    |.||  |.  || ||  ||
KCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF
Kinase MSSK1.AA DYRK1 399-491 40 4.8e-14 45.26 In-house 139-224 (321) Show / Hide 
Range on Protein: 399-491
Range on HMM: 139-224/321
Sequence Identity: 40% (38 aa)

NADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPA
|. . .||| | | .| . .   . || | ||. |||.| ||    |.||  |.  |. ||. ||   ||   | . | . .||| || .||.
NPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SG---SNEVDQMNKIVEVLG-MPPK
Kinase MSSK1.AA CDK4 143-220 33 8.5e-13 40.02 In-house 65-143 (290) Show / Hide 
Range on Protein: 143-220
Range on HMM: 65-143/290
Sequence Identity: 33% (27 aa)

IVQLIDDFRISGVNG--VHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILL
||.|.| .  . . .  . . ||.|     |  .. |    |.| . .| . .| | |.|.||. . ||| | ||.|||.
IVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHR-IIHRDLKPQNILV
Kinase MSSK1.AA CAMK 545-565 47 2.3e-09 25.56 In-house 405-425 (425) Show / Hide 
Range on Protein: 545-565
Range on HMM: 405-425/425
Sequence Identity: 47% (10 aa)

MMEYIPEKRASAADCLQHPWL
|... ||||.....||.|||.
MLQVDPEKRMTIEQCLNHPWM
Kinase MSSK1.AA DyrkP 79-128 32 1.3e-07 20.46 In-house 1-50 (323) Show / Hide 
Range on Protein: 79-128
Range on HMM: 1-50/323
Sequence Identity: 32% (16 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLK
| ..  ||   ||    | | |  . . .|..     | . ..||||||.
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLR
Kinase MSSK1.AA CAMKL 545-565 38 8.6e-07 17.54 In-house 277-297 (297) Show / Hide 
Range on Protein: 545-565
Range on HMM: 277-297/297
Sequence Identity: 38% (8 aa)

MMEYIPEKRASAADCLQHPWL
|..  ||||... . ..|||.
MLQVNPEKRPTIHQIMNHPWM
Kinase MSSK1.AA CDK4 541-565 48 1e-06 18.87 In-house 266-290 (290) Show / Hide 
Range on Protein: 541-565
Range on HMM: 266-290/290
Sequence Identity: 48% (12 aa)

FLLPMMEYIPEKRASAADCLQHPWL
.|. |  | ..|| ||  |||||..
LLQKMLCYNHHKRMSAYQCLQHPYF
Kinase MSSK1.AA DyrkP 191-220 53 2e-06 16.32 In-house 111-139 (323) Show / Hide 
Range on Protein: 191-220
Range on HMM: 111-139/323
Sequence Identity: 53% (16 aa)

IVRQVLHGLDYLHTKCKIIHTDIKPENILL
|  |.| .|||.|   ..|| |.||||||.
ITQQILIALDYIHS-LRLIHCDLKPENILM
Kinase MSSK1.AA CLK 545-565 52 2e-06 14.88 In-house 330-350 (350) Show / Hide 
Range on Protein: 545-565
Range on HMM: 330-350/350
Sequence Identity: 52% (11 aa)

MMEYIPEKRASAADCLQHPWL
|.|| | || ...| ||||. 
MLEYDPSKRITCKDALQHPFF
Kinase MSSK1.AA CDK4 429-456 46 5e-06 16.49 In-house 175-202 (290) Show / Hide 
Range on Protein: 429-456
Range on HMM: 175-202/290
Sequence Identity: 46% (13 aa)

YRAVEVLIGAEYGPPADIWSTACMAFEL
||| |||  . |  | |.|| .|  .|.
YRAPEVLLQSYYNTPVDMWSVGCIFAEM
Kinase MSSK1.AA TyrKc 79-286 14 2.6e-05 -136.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 79-286
Range on HMM: 1-280/280
Sequence Identity: 14% (44 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCV--RDSDPSDPKRETIVQLIDDFRISGVNGV----HVCMVLEVLGHQLL
 .  .||| |.| .|...  .   . || |..|.     |   .|..... .  .         . ||.|.   . .| |       ...|.|   |  |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHH--------PNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDL

KWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGD-----------------------AYI-------RR-------LAAEAT
|  ....   |...   |.  |.  | .||| | ..|| |.   |.|.  .                         |.       ..       .| |. 
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

EWQQA---------------------GAPPPSR-----SIVSTAPQEVLQTGKLSKNKR---------------------KKMRRKRKQQKRLLEERL
  .                       |..|..         . . . | | . . . .                      .    .|   . .  |..
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MSSK1.AA DyrkP 552-565 50 0.001084 7.27 In-house 310-323 (323) Show / Hide 
Range on Protein: 552-565
Range on HMM: 310-323/323
Sequence Identity: 50% (7 aa)

KRASAADCLQHPWL
.| .| . |||||.
RRPTAKEALQHPWF
Kinase MSSK1.AA DYRK1 532-565 26 0.002211 7.17 In-house 288-321 (321) Show / Hide 
Range on Protein: 532-565
Range on HMM: 288-321/321
Sequence Identity: 26% (9 aa)

LEQATQFSAFLLPMMEYIPEKRASAADCLQHPWL
.|   .|   .. |..| |..| .  . |||...
VEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase MSSK1.AA CAMK 404-448 22 0.011505 3.61 In-house 234-319 (425) Show / Hide 
Range on Protein: 404-448
Range on HMM: 234-319/425
Sequence Identity: 22% (19 aa)

KIKIADLGNACWVHKH--------------------------FTEDIQTRQYRA-VEVLIG--------------AEYGPPADIWS
.|||.| | |. . .                           ...   |  | |  ||| |                |||..|.||
NIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWS
Kinase MSSK1.AA CDK4 79-111 39 0.039939 2.84 In-house 1-33 (290) Show / Hide 
Range on Protein: 79-111
Range on HMM: 1-33/290
Sequence Identity: 39% (13 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVK
|  |  .| | . ||.   |..  .||||| |.
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVR
Kinase MSSK1.AA CAMKL 440-448 66 0.165003 0.41 In-house 213-221 (297) Show / Hide 
Range on Protein: 440-448
Range on HMM: 213-221/297
Sequence Identity: 66% (6 aa)

YGPPADIWS
.||..||||
DGPKVDIWS