Gene NEK10 (Human)

NEK10

Species: Human
Alias: FLJ32685, NEK10
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , GeneCards
Annotation: Consensus chromosomal location: 3p21.33,

Classification

Group: Other
Family: NEK
Subfamily: NEK10

Sequence

Name Sequence Type Origin Length Description Download
NEK10.NA RNA Sugen Kinome 4053 None Fasta, JSON
NEK10.AA Protein Sugen Kinome 1172 None Fasta, JSON
NEK10.kin_dom Protein Kinase Domain Sugen Kinome 267 None Fasta, JSON

Protein domain

Protein domains of NEK10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Arm NEK10.AA Arm 198-238 29 0.007106 13.41 Pfam 1-41 (41) Show / Hide 
Range on Protein: 198-238
Range on HMM: 1-41/41
Sequence Identity: 29% (12 aa)

VKDQREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLAE
  .|.. |  .|. . ||.||  .|..|.  .. ||  |. 
NPEQKQAVIQCGCVPPLVQLLHHPDEEVQENACWALWNLCA
Arm NEK10.AA Arm 280-320 26 0.847917 6.32 Pfam 1-41 (41) Show / Hide 
Range on Protein: 280-320
Range on HMM: 1-41/41
Sequence Identity: 26% (11 aa)

EPQVKEQVKLYEGIPVLLSLLHSDHLKLLWSIVWILVQVCE
 |. |..|    ..|.|..|||... ...   .| |   | 
NPEQKQAVIQCGCVPPLVQLLHHPDEEVQENACWALWNLCA
Arm NEK10.AA Arm 239-279 24 13.191354 2.25 Pfam 1-41 (41) Show / Hide 
Range on Protein: 239-279
Range on HMM: 1-41/41
Sequence Identity: 24% (10 aa)

SQECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCA
..|... . ....|. |.  ||  |   ..  .  |. |||
NPEQKQAVIQCGCVPPLVQLLHHPDEEVQENACWALWNLCA
Kinase NEK10.AA NEK10 519-785 71 1.1e-229 764.81 In-house 1-279 (279) Show / Hide 
Range on Protein: 519-785
Range on HMM: 1-279/279
Sequence Identity: 71% (200 aa)

YAILDHLGSGAFGCVYKVRKHSGQN------LLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLE--NDRLYIVMELIEGA
|...||||.|||||||||||...|.      ||||||...|||||||..|.||.|.....|||.|||||..||||||||.||.|  |.|.|||||||||.
YEVYDHLGTGAFGCVYKVRKKAQQHSENPAKLLAMKEIFMHNPAFGKNDKERDKSIEDMISELKIIKEQMRHPNIVRYYRTFVEPQNHRMYIVMELIEGC

PLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVADFGLAKQKQ-ENSKLTSVVGTILYSCPEVLKSEPYGEK
||.|||.|.|||||||.|||.|..|||.|||||||||||.||||||||||||.||||.||. ||||||||| ..||.|||||||||||||...|||||||
PLYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLHKEKQIVHRDLTPNNIMMGDKDRVTITDFGLAKQKQPDPSKMTSVVGTILYSCPEIVQSEPYGEK

ADVWAVGCILYQMATLSPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTISRCLTPDAEARPDIVEVSS---MISD
|||||.||.||||.||.|||||||||.||.||||..|.||.||..|..|..||.||||||.|||||||.|||   ||.|
ADVWAFGCCLYQMCTLQPPFYSTNMLTLAMKIVEHFYDPVNEGMWSDDVRFTITRCLTPDPEARPDIVKVSSVLRMIQD
Kinase NEK10.AA NEK 519-785 35 4.7e-120 405.14 In-house 1-286 (286) Show / Hide 
Range on Protein: 519-785
Range on HMM: 1-286/286
Sequence Identity: 35% (106 aa)

YAILDHLGSGAFGCVYKVRKHSGQNL-----LAMKEVNLHNPAFGKDKKD--RDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLEND--RLYIVMELIE-
| |. ..|.|.||.|||||. | ..      ...|..|  .    |.|..  .         .  .|..|| |||||.||  |.|..  .|.||||  | 
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKIN-MGNMSEKEKQNAQN---------NEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEG

GAPLGEHFSSLKEKHH---HFTEERLWKIFIQLCLALRYLHKEK----RIVHRDLTPNNIMLGDKDK----VTVADFGLAKQKQ-ENSKLTS-VVGTILY
|  | ....|.|.. .   .| ||  |..|||.||||.|.|..|    .|.|||. |.||.| ....    | . |||..|. . ....... .|||  |
GGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYY

SCPEVLKSEPYGEKADVWAVGCILYQMATLSP--PFYST--NMLSLATKIVEA-VYEPVPEGI-YSEKVTDTISRCLTPDAEARPDIVEVSSMISD
 .|||....||..|.|.|..||.||.|.||.|  ||...  ||.||..||..   |.|.|. . ||..  . ||..|..| | ||.. .. .|   
MSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK10.AA S_TKc 519-791 32 6.8e-78 266.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 519-791
Range on HMM: 1-231/231
Sequence Identity: 32% (92 aa)

YAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEG--APLGEHF
| ||...|.||||.|||.|... . . |.|...                 ..| .|. | |.   |||||..| .| . |.||.|||...|    | .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI

SSLKEKHHH--FTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVADFGLAKQKQENSKLTSVVGTILYSCPEVLKSEPYGE-KADVW
 . . .  .  |.| . .... |.|.|| |.|.  .|.|||| | ||.| .   . ..|||||.|       |...||  |  ||||   .||  |.|.|
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWW

AVGCILYQMATLSPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTISRCLTPDAEARPDIVEVSSMISDVM-MKYL
..||||| |..  |||.  .|  .  ||.            |. . | |..||. | | || . |.  . .|.. . ..
SCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK10.AA Pkinase 519-783 29 6.2e-68 236.81 Pfam 1-293 (293) Show / Hide 
Range on Protein: 519-783
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

YAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEG--APLGEHF
| |.  .|||.|||||| .... . . |.|......   .||. .|        ||. | |.   ||||||.| .| ..|..|.|||. ||    . . |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLF

SSLK-EKHHHF--TEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKV----TVADFGLAKQ--KQENSKLTSVVGTILYSCPEVLK-SEPY
. .. ..|  |  .|. . ... |.. .| |.|. ..|.|||| | ||.. ... .     ..|||||||     || .|...||. |  |||.. ...|
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY

GEKADVWAVGCILYQMATLSPPFYST------NMLSLATKIVEAVYEPVPEGIYS-------------------EKVTDTISRCLTPDAEARPDIVEVSS
| |.|.|..|||||.|..  |||..       ... .  .| .. ..   .  .|                   |   | |..||..| . || . ..  
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

M--I
   .
HPWF
Kinase NEK10.AA CAMK 524-779 20 7.9e-65 207.55 In-house 1-419 (425) Show / Hide 
Range on Protein: 524-779
Range on HMM: 1-419/425
Sequence Identity: 20% (86 aa)

HLGSGAFGCVYKVRKHSGQ------------NLLAMKEVN-----------------LHNPAFGKDKKD-RDSSVRNIVSELTIIKE------QLYHPNI
 ||.|.|| |....  . .               |.| ..                 . .   ...... |... .|. .|. | |       .| ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYYKTFLE-------------------NDRLYIVM---ELIEGAPLGEH-FSSLKEKHH--------------HFTEERLWKIFIQLCLALRYLHKEKR
.. | ..                     ....|.||   |...|  | .  |. ..|. .              .|||.   ..| |.| |..|.|. . 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-

IVHRDLTPNNIMLGDKD-----------------KVTVADFGLAKQKQE------------------------NSKLTSVVGTILYSC-PEVLKS-----
|||||| | ||.| |..                 .. ..|||.|.....                        . |.. ..||  | . ||||..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EPYGEKADVWAVGCILYQMATLSPPFYST-------------NMLSLATKIVEAVYEPVPEGIYS----------------------EKVT
         ..||.|.|.|..|.||| | .  ||||.              |.  |  || .. |.  |. .                        . . 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DTISRCLTPDAEARPDIVEV
| |...|..| | |. | ..
DLIRKMLQVDPEKRMTIEQC
Kinase NEK10.AA STE 519-778 23 3.9e-59 202.78 In-house 1-350 (359) Show / Hide 
Range on Protein: 519-778
Range on HMM: 1-350/359
Sequence Identity: 23% (85 aa)

YAILDHLGSGAFGCVYKVRKH------SGQNL---------LAMKEVNLHN--PAFGK------DKKDRDSSVRNIVSELTIIKEQLY-HPNIVRYYKTF
. ... .|.|||| ||| ..|      . ...          |.|..|| |  .   .      .... .. . .|  |. | |.    |||||.|| ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

LEN-------DRLYIVMELIEGAPLG---E-HFSSLKEKH------HHFTEERLWKIFIQLCLA-LRYLHKEKRIVHRDLTPNNIMLGDKDKVTVADFGL
. .       | |.|.||...|  |    .  .. .|. .      |.| |. . .|  |.. . | |||. . |.|||. | ||.|     |  .|||.
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGV

AKQKQEN-----------------SKLTSVVGTILYSCPEVLKS------EPYGEKADVWAVGCILYQMATLSPPF---YSTNMLSLAT-----------
..| ...                 .| ...|||  .  |||..        .|..|.|.| .|| .  |||  ||.   . . .. ...           
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

-KIVEAVYEPVPEG------------------IYSEKVTDTISRCLTPDAEARPDIVE
 .||.    | |.                    .|..  | |..||. | . ||.  .
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase NEK10.AA Ciliate-E2-Unclassified 519-779 22 1.3e-55 191.02 In-house 1-346 (352) Show / Hide 
Range on Protein: 519-779
Range on HMM: 1-346/352
Sequence Identity: 22% (80 aa)

YAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQ------------------LYHPNIVRYYKTFLENDRL
| |.  .|.|.||.|||... . . . |||.    . .  ...|   ..  .|. |.......                  ..||.||... .|   . .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYM---KKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNI

YIVMELIEGAPLGEHFSSLKE------------KH-HHFTEERLW-----KIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKD---KVTVADFGLAKQ
|||||..||  | .. .. |             |. ..|||.        ..| |....| |||... |.|||..|.||.. ..    .. ..|||..|.
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

KQEN----------------SKLTSVVGTILYS----CPEVLKSEPYG----EKADVWAVGCILYQMATLSPPFYSTN------------------MLSL
 |.|                 ......||. |      ||||... |.    .|.|.|..|.|||.| .  .|||..|                  .|  
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

ATKIVEAVYEPVPE----GIYSEKVTDTIS----RCLTPDAEARPDIVEV
  |  .  . . |.     . |... | |.    ..|  . . |... ..
NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI
Kinase NEK10.AA NEK6 519-776 34 9.8e-55 178.47 In-house 1-252 (252) Show / Hide 
Range on Protein: 519-776
Range on HMM: 1-252/252
Sequence Identity: 34% (90 aa)

YAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSS
..|  ..| | |  ||. .    .   |.| | . .    | ..|        . |. ..| || |||...||  |.||  | ||.|| .   .      
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQD-------CIKEIDLLK-QLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKH

LKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVADFGLAK-QKQENSKLTSVVGTILYSCPEVLKSEPYGEKADVWAVGC
 | .     |  .|| |.||| ||  .| .||..|||. | |. .  . .| . | || .    .     |.|||  |  || .. . |  |.|.|..||
FKKQKRLIPERTIWKYFVQLCSALEHMH-SKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGC

ILYQMATLSPPFYS--TNMLSLATKIVEAVYEPVPEGIYSEKVTDTISRCLTPDAEARPDI
.|| || |  |||    |. ||  || .  | |.|  .|||.. . .. |. ||.| ||||
LLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase NEK10.AA Ciliate-E2 519-729 23 4.8e-54 183.9 In-house 1-296 (365) Show / Hide 
Range on Protein: 519-729
Range on HMM: 1-296/365
Sequence Identity: 23% (72 aa)

YAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHN----------PAFGKDKKDRDSS-VRNIVSELTIIK---------------EQLYHPNIVRYYK
| ..  .|.|.||.|||... . |.. |.|  . ..           .. . .|    . ...| .|. |..               ||| ||||...| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

TFL--ENDRLYIVMELIEGAPLGEHFS--SLKEKHH-----HFTEERLWKIFIQLCL---------------ALRYLHKEKRIVHRDLTPNNIMLGDKDK
.|    .. .|.|||...|  | ..    ..|..|.      |||.   .|. |..                ||.|||....|.|||. |.||..     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VTVADFGLAKQKQEN--------------------------------SKLTSVVGTILYSCPEVLKSEP---------YGEKADVWAVGCILYQMATLSP
. ..||||.|. ...                                    ...||  | .||.|....         |..|.|.|..|.|||.| .  |
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PF
||
PF
Kinase NEK10.AA NEK2 519-783 29 5.5e-54 180.12 In-house 1-319 (319) Show / Hide 
Range on Protein: 519-783
Range on HMM: 1-319/319
Sequence Identity: 29% (97 aa)

YAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFL--ENDRLYIVMELIEGAPLGEHF
| .|  .|.| || ..|||  |   .|. || .  .   .  ...        |||  | . || ||||||||      .| .||||||  ||  |.   
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGH--MQEKECQM------LVSECNILR-QLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMI

SSLKEKHHHFTEERLWKIFIQLCLALRYLHK-----------------EKR---IVHRDLTPNNIMLGDKDK----------------------------
.  .  .  . ||  |.|. |||.||.  |.                  .    | |||. | || |  ..                             
KKCRKERQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGK

-----------VTVADFGLAKQKQ-ENSKLTSVVGTILYSCPEVLKSEPYGEKADVWAVGCILYQMATLSPPFYSTNMLSLATKIVEAVYEPVPEGIYSE
           |   |||||.  . . |  .. |||  |  ||...  .| || |.|.|||..| |..|.|||  || . |..|| .  ....|. .||.
RGSPMDYSQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPY-QYSR

KVTDTISRCLTPDAEARPDIVEV--SSMI
   . |.. .  | . || | |   .. |
HLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase NEK10.AA TKL 525-783 17 7.8e-51 175.2 In-house 1-364 (364) Show / Hide 
Range on Protein: 525-783
Range on HMM: 1-364/364
Sequence Identity: 17% (67 aa)

LGSGAFGCVYKVRKHSGQ--------NLLAMKEVNLHN-PAFGKDKKD---------------RDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDR-
.|||.||.||| . .           .  |.|  . ||   | |  ..                 |  |    | . .. .| |||||...   ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKR-------IVHRDLTPNNIMLGDKDK------------
            |.||||...|  | ...            ... .. .. .... ||| ..        |.||||...||.. .. .            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--VTVADFGLAKQKQENS--------------------KLTSVVGTILYSCPEVLKSE----------------PYGEKADVWAVGCILYQMATLSPPFY
  . ..||||.. .....                    .. ...||. .  ||||. .                .| ||.||.. | .|. ..|  .|.|
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

STNMLSLA---------TKIVEAVYEPVPE------------GIYSEKVTDTISRCLTPDAEARPDIVEVSSMI
  .. .            ....  . | .                 . . . . .|  .|.|.||   |. . .
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase NEK10.AA ULK 519-773 25 3e-49 169.92 In-house 1-317 (329) Show / Hide 
Range on Protein: 519-773
Range on HMM: 1-317/329
Sequence Identity: 25% (83 aa)

YAILDHLGSGAFGCVYKVR-KHSG---QNLLAMKEVNLHNPAFGKDKKDRDSSVRN-------IVSELTIIKEQL------Y-HPNIVRYYKTFLENDR-
| . . ||.|.|| ||| | | ..   . . | | .        |.|.....  ..       . .|  |.|.        . |||||..|. | . .  
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMID-------KQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHN

-LYIVMELIEGAPLGEHFSSLKEKHH---------HFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVT------------VADFGLA
 .||.||. .|   |  .. .|....         ...|.   ..|.|.. ....||| ..|.|||. | ||.. ...  |            .||||.|
NIYIIMEYCNG---GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA

KQKQEN----SKLTSVV------GTILYSCPEVLK----SEPYG-EKADVWAVGCILYQMATLSPPFYSTNMLSLA-TKIVEAVYEPVPEG---------
|. ...      ... |      || || .|..|.     .||.  |.|.| .|||.|.| .  ||||.    ..   .| . .  | | .         
KHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQ

--------IYSEKVTDTISRCLTPDAEAR
        . |... | |.|.|. | . |
FPKDGNDPQISPECKDLIRRMLQYDEKDR
Kinase NEK10.AA TyrKc 519-783 20 1.6e-16 44.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 519-783
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

YAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQL--YHPNIVRYYKTFLEN-------DRLYIVMELIEG
   .. ||.|||| ||| .        | | .. .              .. . .|. | . .|   |||||| |   ..        . |.||||. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------------REDFMREARIMC-KLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

APLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVADFGLAKQKQEN------SKLTSV----VGT----ILY
  | ..  . ..|   .. . | .. .| .   .|||.  ...||||   |...|..  | ..||||..   .       ..  ..     |     |  
GDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

SCPEVLKSEPYGEKADVWAVGCILYQMATL-SPPFYS-----TNMLSLATKIVEAVYEPVPEG-------IYSEKVTDTISRCLTPDAEARPDIVEVSSM
  ||...   . .| |||. |  .. . |.  .| .       .   .  .. .  . | |.        . .... . ...|   |.| ||   |. . 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

I
.
F
Kinase NEK10.AA Pkinase_Tyr 581-684 29 3.6e-13 45.24 Pfam 59-165 (270) Show / Hide 
Range on Protein: 581-684
Range on HMM: 59-165/270
Sequence Identity: 29% (33 aa)

QL-YHPNIVRYYKTFL-ENDR--LYIVMELIEGAPLGEHFSSLKEK---HHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVAD
|| .||||||.|   . . .   .|||||. ..  | ..   |...    ...| ..| .. .| . .. ||. .|...||||   |...... .| ..|
QLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY---LRKHREDKQPLTMKDLLQMCWQIAKGMEYLE-SKNCIHRDLAARNCLVTENNVVKICD

FGLAKQKQENS
||||.  .. .
FGLARDIYNDD
Kinase NEK10.AA Pkinase_Tyr 519-535 52 0.042475 7.73 Pfam 1-17 (270) Show / Hide 
Range on Protein: 519-535
Range on HMM: 1-17/270
Sequence Identity: 52% (9 aa)

YAILDHLGSGAFGCVYK
  ..  ||.|||| |||
ITFGKKLGEGAFGEVYK
Kinase NEK10.AA Pkinase_Tyr 755-783 24 7.005966 0.22 Pfam 242-270 (270) Show / Hide 
Range on Protein: 755-783
Range on HMM: 242-270/270
Sequence Identity: 24% (7 aa)

SEKVTDTISRCLTPDAEARPDIVEVSSMI
.... | . .|  .|.| ||   |. ...
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL